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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant human TGFB2
catalog :
TGFB2-519H
product information
Cat :
TGFB2-519H
Product Name :
Recombinant human TGFB2
Brand :
Creative Biomart
gene symbal :
TGFB2
gene name :
transforming growth factor, beta 2
Synonyms :
TGFB2; transforming growth factor, beta 2; transforming growth factor beta-2; G-TSF; cetermin; polyergin; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor; TGF-beta2; MGC116892
Product Overview :
Recombinant Human TGF-Beta 2 Protein (rhTGFB2) Ala 303 - Ser 414 (Accession # NP_003229.1 ) was produced in human HEK293 cells.
Description :
Recombinant Human TGF-Beta 2 Protein (rhTGFB2) Ala 303 - Ser 414 (Accession # NP_003229.1 ) was produced in human HEK293 cells.Transforming growth factor beta 2 (TGFB2) is also known as TGF-β2, TGF-beta2, Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin, and is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development. Mature human TGF-β2 shows 100% aa identity with porcine, canine, equine and bovine TGF-β2, and 97% aa identity with mouse and rat TGF-β2. It demonstrates crossspecies activity. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. The increased levels of TGF beta 2 triggered a neuronal cell death pathway related to Alzheimer"s disease (AD) by binding to the extracellular domain of amyloid beta precursor protein (APP). The upregulation of the TGF beta 2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy.
Source :
HEK293
Form :
Lyophilized from 0.22 μm filtered solution in TFA, acetonitrile. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Purity :
>98% as determined by SDS-PAGE of reduced (+) and non-reduced (-) rhTGFB2.
Storage :
Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade-8 centigrade); After reconstitution under sterile conditions for 1 month (4 centigrade-8 centigrade) or 3 months (-20 centigrade to -70 centigrade).
UniProt ID :
P61812
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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