protein

Recombinant Human STIP1 Homology And U-box Containing Protein 1

STUB1-336H

Recombinant Human STIP1 Homology And U-box Containing Protein 1

Creative Biomart

STUB1

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; CHIP; UBOX1; HSPABP2; NY-CO-7; SDCCAG7; E3 ubiquitin-protein ligase CHIP; antigen NY-CO-7; CLL-associated antigen KW-8; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; carboxy terminus of Hsp70-interacting protein; heat shock protein A binding protein 2 (c-terminal);

Recombinant human CHIP protein was expressed in E.coli and purified by using conventional chromatography techniques (303 aa, 34.8 kDa).

Recombinant human CHIP protein was expressed in E.coli and purified by using conventional chromatography techniques (303 aa, 34.8 kDa).CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two.

Ecoli

90% by SDS – PAGE.

1 mg/ml (determined by Bradford assay).

Can be stored at +4 C short term (1-2 weeks). For long term storage, aliquot and store at -20 C or -70 C. Avoid repeated freezing and thawing cycles.

Q9UNE7