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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Rat Rab Geranylgeranyltransferase, Alpha Subunit
catalog :
Rabggta-326R
product information
Cat :
Rabggta-326R
Product Name :
Recombinant Rat Rab Geranylgeranyltransferase, Alpha Subunit
Brand :
Creative Biomart
gene symbal :
Rabggta
gene name :
Rab geranylgeranyltransferase, alpha subunit
Synonyms :
RABGGTA; Rab geranylgeranyltransferase, alpha subunit; geranylgeranyl transferase type-2 subunit alpha; protein prenyltransferase alpha subunit repeat containing 3; PTAR3; Geranylgeranyl transferase type 2 subunit alpha; Geranylgeranyl transferase type II subunit alpha; PGTA_HUMAN; Rab geranyl geranyltransferase subunit alpha; Rab geranyl-geranyltransferase subunit alpha; Rab geranylgeranyltransferase alpha subunit; Rab geranylgeranyltransferase subunit alpha; Rab GG transferase alpha; Rab GGTase alpha
Product Overview :
Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.
Description :
GGTase-II (Geranylgeranyltransferase-II) catalyzes the transfer of geranylgeranyl moiety onto two C-terminal cysteines of Rab proteins. Composed of an and heterodimer (50 and 38 kDa, respectively) and requires Rab escort protein for its catalytic activity. GGTase-II was shown to exhibit higher affinity towards geranylgeranyl pyrophosphate (Kd = 8 nM) than farnesyl pyrophosphate (Kd = 60 nM). Like FTase and GGTase-I, RabGGT functions as a heterodimer. The subunit has 27% identity to that of CaaX prenylases but contains additional domains, while the subunit shows 29% identity to that of FTase. The protein substrates of RabGGT have heterogeneous C termini that usually contain two cysteine residues (CXC), both of which are modified by geranylgeranyl groups. Unlike the CaaX prenylases, RabGGT requires specific accessory proteins known as REPs to guide the interaction with its targets. Some farnesyltransferase inhibitors (FTIs) were identified to inhibit RabGGT activity and induce p53 independent apoptosis in C. elegans.
Source :
E Coli
Form :
Liquid. Supplied in 25 mM HEPES, pH 7.2, 25 mM NaCl and 5 mM DTT.
Purity :
95% by SDS-PAGE.
Storage :
Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles.
UniProt ID :
Q08602
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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