protein

Recombinant Human Polo-like Kinase 1 (Drosophila)

PLK1-189H

Recombinant Human Polo-like Kinase 1 (Drosophila)

Creative Biomart

PLK1

polo-like kinase 1

PLK1; polo-like kinase 1; PLK; STPK13; serine/threonine-protein kinase PLK1; PLK-1; polo like kinase; polo (Drosophia)-like kinase; serine/threonine-protein kinase 13; cell cycle regulated protein kinase;

Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.

The human polo-like kinase (PLK) gene encodes a 603- amino acid polypeptide. By Northern blot analysis, they showed PLK1 was not expressed in any adult human tissues except placenta. PLK1 localizes to the mitotic spindle, suggesting that it is involved in regulating mitotic spindle function. It has been observed that PLK1 transcripts are present at high levels in tumors of various origins and may be involved in the promotion or progression of cancers. It has been proposed as a diagnostic marker for several tumors. Data supports the notion that disruption of PLK1 function could be an important application in cancer therapy. The PLK1 was expressed in Baculovirus system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 95% homogeneous and contains no detectable protease, DNase and RNase activity. MW = 66 kDa.

Baculovirus

Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.

95% by SDS-PAGE.

Quality guaranteed for 12 months store at -80 C. Avoid freeze / thaw cycles.

P53350