This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Interleukin-12
catalog :
IL12-21H
product information
Cat :
IL12-21H
Product Name :
Recombinant Human Interleukin-12
Brand :
Creative Biomart
gene symbal :
IL12A
gene name :
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Synonyms :
IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
Product Overview :
Recombinant human interleukin 12 is a heterodimeric cytokine composed of covalently disulfide linked a light chain of p35 (P35, IL-12 ) and a heavy chain of p40 (P40, IL-12 ) with PI 4.5-5.5. Specifically, the heavy chain (P40) is consisted of 306 amino acids, while the light chain (P35) compounds 197 amino acids. It is approximately 75 kDa, containing 503 amino acids, non-glycosylated.
Description :
Recombinant human interleukin 12 is a heterodimeric cytokine composed of covalently disulfide linked a light chain of p35 (P35, IL-12 ) and a heavy chain of p40 (P40, IL-12 ) with PI 4.5-5.5. Specifically, the heavy chain (P40) is consisted of 306 amino acids, while the light chain (P35) compounds 197 amino acids. It is approximately 75 kDa, containing 503 amino acids, non-glycosylated.Inerleukin-12 (IL-12), as a potent factor, plays an important role in the networks of immune system. It is a multifunctional cytokine, the properties of which bridge innate and adaptive immunity, acting as a key regulator of cell-mediated immune responses through the induction of T helper 1differentiation. By promoting IFN- production, proliferation, and cytolytic activity of natural killer and T cells, IL-12 induces cellular immunity. IL-12 not only can facilitate the maturation of antigen presenting cells (APC), especially for dendritic cells (DC), but also can be the third signal to change properties of CD8 T cells and increase generation of effector and memory cells. Treatment with IL-12 can inhibit bacterial, virus and intracellular parasites, produce an effect of anti-tumor, and enhance autoimmunity.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Storage :
The lyophilized is stable for 3 months at room temperature, can be stored for 2 years at 4 C , but best stored at -20 C . Reconstituted IL-12 should be stored in working aliquots at -20 C .
UniProt ID :
P29459
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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