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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, His-tagged
catalog :
FLT4-86H
product information
Cat :
FLT4-86H
Product Name :
Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, His-tagged
Brand :
Creative Biomart
gene symbal :
FLT4
gene name :
Fms-related tyrosine kinase 4
Synonyms :
Fms-Related Tyrosine Kinase 4; Flt-4; Fms-related tyrosine kinase 4; FLT-4
Product Overview :
Recombinant Human Soluble Fms-related Tyrosine Kinase 4 fused with a carboxy-terminal 6X his-tag produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a total molecular mass of 240 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding. The VEGFR3 is purified by proprietary chromatographic techniques.
Description :
Recombinant Human Soluble Fms-related Tyrosine Kinase 4 fused with a carboxy-terminal 6X his-tag produced in baculovirus is a monomeric, glycosylated, polypeptide containing 774 amino acids and having a total molecular mass of 240 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding. The VEGFR3 is purified by proprietary chromatographic techniques.All three VEGF receptors belong to the class III subfamily of receptor tyrosine kinases (RTKs) characterised by the seven immunoglobulin-like loops in the extracellular domain. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. They play key roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The FLT-4 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide. Mature VEGFR-3/FLT-4 is composed of a 751 aa residue extracellular domain, a 22 aa transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF family members VEGF-C and VEGF-D have been shown to bind and activate VEGFR-3/FLT-4. The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stages of development. It is important for lymphangiogenesis.
Source :
Insect Cells
Purity :
Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Storage :
Lyophilized sVEGFR3 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution VEGFR-3 should be stored at4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
UniProt ID :
P35916
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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