This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human FASLG, FLAG-tagged
catalog :
FASLG-2424H
product information
Cat :
FASLG-2424H
Product Name :
Recombinant Human FASLG, FLAG-tagged
Brand :
Creative Biomart
gene symbal :
FASLG
gene name :
Fas ligand (TNF superfamily, member 6)
Synonyms :
FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; soluble form; APO1L; Apoptosis antigen ligand 1; CD178 antigen; CD95; L CD95L protein; Fas L; Fas ligand; Fasl Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; Gld; TNF superfamily member 6; TNFL6_HUMAN
Product Overview :
Recombinant extracellular domain of human FasL (aa 103-281) produced inHEK 293 cellsis fused at the N-terminus to a linker peptide (26 aa) and a FLAG-tag. Glycosylation of rhsSuperFasLigandTM is similar to natural human FasL. 32kDa (nonglycosylated), 35kDa (glycosylated).
Description :
Recombinant extracellular domain of human FasL (aa 103-281) produced inHEK 293 cellsis fused at the N-terminus to a linker peptide (26 aa) and a FLAG-tag. Glycosylation of rhsSuperFasLigandTM is similar to natural human FasL. 32kDa (nonglycosylated), 35kDa (glycosylated).Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. The Fas molecule is comprised of 319 amino acids of which 145 amino acids constitute the cytoplasmic region, 17 amino acids the transmembrane domain and 157 amino acids the extracellular region. The extracellular portion of Fas is called sFasR. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD and processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
Purity :
≥95% (SDS-PAGE).
Concentration :
0.1mg/ml after reconstitution.
UniProt ID :
P48023
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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