This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human C-src Tyrosine Kinase
catalog :
CSK-170H
product information
Cat :
CSK-170H
Product Name :
Recombinant Human C-src Tyrosine Kinase
Brand :
Creative Biomart
gene symbal :
CSK
gene name :
c-src tyrosine kinase
Synonyms :
CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393
Product Overview :
Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.
Description :
The C-terminal Src kinase (Csk) phosphorylates and downregulates Src family tyrosine kinases Cell transformation by src oncoproteins is caused by several oncogenic mechanisms, which interfere with this phosphorylation. The CSK gene could therefore potentially function as an antioncogene. The Csk-binding protein (Cbp) localizes Csk close to its substrates at the plasma membrane, and increasesthe specific activity of the kinase. It has been reported prior to occurrence of neoplastic lesions in the colon carcinogenesis; the tumor suppressor gene CterminalSrc kinase (Csk) was down-regulated with a concomitant increase in Src activity. Furthermore, pharmacological or genetic (RNA interference) inhibition of Csk resultedin increased proliferation in colon cancer cell lines through the mitogen-activated protein kinase dependent pathway. Csk, which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases, downregulated Fyn- and Lck-mediated stimulation of the serum response element and Fynmediated enhancement of IL-2 promoter activity.
Source :
E coli
Form :
Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
Purity :
95% by SDS-PAGE.
Storage :
Quality guaranteed for 12 months, Store at -80℃. Avoid freeze / thaw cycles.
UniProt ID :
P41240
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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