This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Rat ADP-ribosyltransferase 2b, His-tagged
catalog :
Art2b-2067R
product information
Cat :
Art2b-2067R
Product Name :
Recombinant Rat ADP-ribosyltransferase 2b, His-tagged
Brand :
Creative Biomart
gene symbal :
Art2b
gene name :
ADP-ribosyltransferase 2b
Synonyms :
ART2B; ADP-ribosyltransferase 2b; T-cell ecto-ADP-ribosyltransferase 2; ADP ribosyltransferase 2b; Art; ART2.2; Ly92b; RT 6; Rt6 2; Rt6; Rt6.2; T cell differentiation marker Rt6 homolog 2; T cell ecto ADP ribosyltransferase 2; OTTMUSP00000045199; mono(ADP-ribosyl)transferase 2B; T-cell mono(ADP-ribosyl)transferase 2; T-cell differentiation marker Rt6 homolog 2; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2; Rt-6; Rt6-2
Product Overview :
Recombinant Rat ADP-ribosyltransferase 2b is produced inE. coliwith a C-terminus His-tag.
Description :
Recombinant Rat ADP-ribosyltransferase 2b is produced inE. coliwith a C-terminus His-tag.Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain. This modification is catalyzed by ART2.2, a GPI-anchored ADP-ribosyltransferase (ART) that is constitutively expressed in murine T cells. We previously reported that ART2.1, a related ecto-ART, is up-regulated in inflammatory murine macrophages that constitutively express P2X(7)R. Thus, we tested the hypothesis that extracellular NAD acts via ART2.1 to regulate P2X(7)R function in murine macrophages. Coexpression of the cloned murine P2X(7)R with ART2.1 or ART2.2 in HEK293 cells verified that P2X(7)R is an equivalent substrate for ADP-ribosylation by either ART2.1 or ART2.2. However, in contrast with T cells, the stimulation of macrophages or HEK293 cells with NAD alone did not activate the P2X(7)R. Rather, NAD potentiated ATP-dependent P2X(7)R activation as indicated by a left shift in the ATP dose-response relationship.
Source :
E coli
Purity :
≥98%.
Concentration :
0.5mg/ml.
Storage :
-80 C. Avoid freeze/thaw cycles.
UniProt ID :
P17982
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
questions and comments