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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Angiopoietin 1, Myc-tagged
catalog :
ANGPT1-115H
product information
Cat :
ANGPT1-115H
Product Name :
Recombinant Human Angiopoietin 1, Myc-tagged
Brand :
Creative Biomart
gene symbal :
ANGPT1
gene name :
Angiopoietin 1
Synonyms :
ANGPT1; AGP1; AGPT; ANG1; ANG-1
Product Overview :
Recombinant Human Angiopoitin-1 (Ang-1), a 66 kDa protein consisting of 476 amino acid residues (N21-F496) is fused to an N-terminal myc-tag and produced ininsect cells.
Description :
Recombinant Human Angiopoitin-1 (Ang-1), a 66 kDa protein consisting of 476 amino acid residues (N21-F496) is fused to an N-terminal myc-tag and produced ininsect cells.The Angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase. The factor enhances endothelial cell survival and capillary morphogenesis, and also limits capillary permeability. Ang-2 binds the same receptor but fails to activate it: hence, it is a natural inhibitor of Ang-1. Ang-2 destabilizes capillary integrity, facilitating sprouting when ambient vascular endothelial growth factor (VEGF) levels are high, but causing vessel regression when VEGF levels are low. Tie-1 is a Tie-2 homologue but its ligands are unknown. Angiopoietin and Tie genes are expressed in the mammalian metanephros, the precursor of the adult kidney, where they may play a role in endothelial precursor growth. Tie-1-expressing cells can be detected in the metanephros when it first forms and, based on transplantation experiments, these precursors contribute to the generation of glomerular capillaries. During glomerular maturation, podocyte-derived Ang-1 and mesangial-cell-derived Ang-2 may affect growth of nascent capillaries.
Source :
Insect Cells
Purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Storage :
ANG-1 although stable at 14℃ 1 week, should be stored desiccated below -18℃. Please prevent freeze-thaw cycles.
UniProt ID :
Q15389
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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