product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb
catalog :
9751S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/DilutionReference
  • chromatin immunoprecipitation; mouse; fig s1
Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-beta signaling promotes human pancreatic beta cell replication. Diabetes. 2016;: pubmed
  • chromatin immunoprecipitation; mouse; fig 3
Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, et al. Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells. Oncotarget. 2016;7:11424-33 pubmed publisher
  • chromatin immunoprecipitation; rat
Zhang Y, Laumet G, Chen S, Hittelman W, Pan H. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem. 2015;290:14647-55 pubmed publisher
  • chromatin immunoprecipitation; human
Yang S, Zhang J, Zhang Y, Wan X, Zhang C, Huang X, et al. KDM1A triggers androgen-induced miRNA transcription via H3K4me2 demethylation and DNA oxidation. Prostate. 2015;75:936-46 pubmed publisher
  • immunocytochemistry; human; fig 7
  • western blot; human; fig 6
Hendriks I, Treffers L, Verlaan-de Vries M, Olsen J, Vertegaal A. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. Cell Rep. 2015;: pubmed publisher
  • chromatin immunoprecipitation; human; fig 1
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig s8
Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher
  • western blot; human; fig 6g
Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed publisher
  • chromatin immunoprecipitation; human; 2 ugs
Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, et al. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nat Commun. 2014;5:5425 pubmed publisher
  • chromatin immunoprecipitation; human; fig 3
Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, et al. Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. elife. 2014;3: pubmed publisher
  • chromatin immunoprecipitation; mouse
Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, et al. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol. 2014;192:5012-22 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Chen Y, Kao S, Wang H, Yang M. Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma. Cancer. 2013;119:4259-67 pubmed publisher
Mendoza-Parra M, Saravaki V, Cholley P, Blum M, Billoré B, Gronemeyer H. Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification. F1000Res. 2016;5:54 pubmed publisher
Pandey S, Simmons G, Malyarchuk S, Calhoun T, Pruitt K. A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. Genes Cancer. 2015;6:408-21 pubmed
Matsuda Y, Kobayashi-Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed publisher
Jakobsen J, Bagger F, Hasemann M, Schuster M, Frank A, Waage J, et al. Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq. BMC Genomics. 2015;16:46 pubmed publisher
Tarayrah L, Li Y, Gan Q, Chen X. Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity. Biol Open. 2015;4:1518-27 pubmed publisher
Laumet G, Garriga J, Chen S, Zhang Y, Li D, Smith T, et al. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015;18:1746-55 pubmed publisher
Sin H, Kartashov A, Hasegawa K, Barski A, Namekawa S. Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline. BMC Biol. 2015;13:53 pubmed publisher
Takahashi R, Yamagishi M, Nakano K, Yamochi T, Yamochi T, Fujikawa D, et al. Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia. Cancer Sci. 2014;105:1160-9 pubmed publisher
Blattler A, Yao L, Witt H, Guo Y, Nicolet C, Berman B, et al. Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes. Genome Biol. 2014;15:469 pubmed publisher
Ishida S, Tanaka R, Yamaguchi N, Ogata G, Mizutani T, Kawabata K, et al. Epithelial sheet folding induces lumen formation by Madin-Darby canine kidney cells in a collagen gel. PLoS ONE. 2014;9:e99655 pubmed publisher
Miyata K, Yotsumoto F, Nam S, Odawara T, Manabe S, Ishikawa T, et al. Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma. Cancer Med. 2014;3:1159-69 pubmed publisher
Theisen E, Gajiwala S, Bearss J, Sorna V, Sharma S, Janat-Amsbury M. Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. BMC Cancer. 2014;14:752 pubmed publisher
Kim W, Bird G, Neff T, Guo G, Kerenyi M, Walensky L, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013;9:643-50 pubmed publisher
Chen K, Johnston J, Shao W, Meier S, Staber C, Zeitlinger J. A global change in RNA polymerase II pausing during the Drosophila midblastula transition. elife. 2013;2:e00861 pubmed publisher
Paige S, Thomas S, Stoick-Cooper C, Wang H, Maves L, Sandstrom R, et al. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell. 2012;151:221-32 pubmed publisher
Pasini D, Malatesta M, Jung H, Walfridsson J, Willer A, Olsson L, et al. Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res. 2010;38:4958-69 pubmed publisher
Peach S, Rudomin E, Udeshi N, Carr S, Jaffe J. Quantitative assessment of chromatin immunoprecipitation grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules. Mol Cell Proteomics. 2012;11:128-37 pubmed publisher
Thurman R, Rynes E, Humbert R, Vierstra J, Maurano M, Haugen E, et al. The accessible chromatin landscape of the human genome. Nature. 2012;489:75-82 pubmed publisher
Schmitz S, Albert M, Malatesta M, Morey L, Johansen J, Bak M, et al. Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J. 2011;30:4586-600 pubmed publisher
Hu Y, Shen Y, Conde e Silva N, Zhou D. The role of histone methylation and H2A.Z occupancy during rapid activation of ethylene responsive genes. PLoS ONE. 2011;6:e28224 pubmed publisher
product information
SKU :
9751S
Product-Name :
Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, Dm, Sc, (X, Z)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17
Host :
Rabbit
Target :
H3 (Lys5) trimethylate
Primary-Protein :
H3
Alt-Names :
H3 histone family, member A,H3/A,H31,H3FA,H3FB,H3FC,H3FD,H3FF,H3FH,H3FI,H3FJ,H3FK,H3FL,HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1,Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l,histone 1, H3a,histone cluster 1, H3a
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.