product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb
catalog :
9748
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
11G10
reactivity :
human, mouse
application :
western blot, immunohistochemistry, flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3d
Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher
  • western blot; mouse; fig 2
Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
  • flow cytometry; human; fig 2
Difranco K, Johnson Farley N, Bertino J, Elson D, Vega B, Belinka B, et al. LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes. Leuk Res. 2015;39:649-56 pubmed publisher
  • western blot; human; fig s3
Orzáez M, Guevara T, Sancho M, Perez Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher
  • immunohistochemistry; mouse
Martin L, Liu Z, Chen K, Price A, Pan Y, Swaby J, et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol. 2007;500:20-46 pubmed
Alexeev V, Lash E, Aguillard A, Corsini L, Bitterman A, Ward K, et al. Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Mol Cancer Ther. 2014;13:2968-77 pubmed publisher
Lange T, Kim K, Singh R, Strongin R, McCourt C, Brard L. Iron(III)-salophene: an organometallic compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells. PLoS ONE. 2008;3:e2303 pubmed publisher
product information
SKU :
9748S
Product-Name :
Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
10
Host :
Mouse
Target :
Casp8 (Asp384) cleaved
Primary-Protein :
Casp8
Alt-Names :
ALPS2B,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,CASP-8,CASP8,Caspase-8,Caspase-8 subunit p10,Caspase-8 subunit p18,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,FLJ17672,ICE-like apoptotic protease 5,MACH,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,MCH5,MGC78473,MORT1-associated ced-3 homolog,caspase 8, apoptosis-related cysteine peptidase,caspase 8, apoptosis-related cysteine protease
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.