| Published Application/Species/Dilution | Reference |
|---|
- western blot; human; fig 5
| Natarelli L, Ranaldi G, Leoni G, Roselli M, Guantario B, Comitato R, et al. Nanomolar Caffeic Acid Decreases Glucose Uptake and the Effects of High Glucose in Endothelial Cells. PLoS ONE. 2015;10:e0142421 pubmed publisher |
- western blot; human; fig 3 a-c
| Philipp S, Sosna J, Plenge J, Kalthoff H, Adam D. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal. 2015;13:25 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Yanagi T, Shi R, Aza-Blanc P, Reed J, Matsuzawa S. PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. PLoS ONE. 2015;10:e0119404 pubmed publisher |
| Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J. Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE. 2015;10:e0135929 pubmed publisher |
- immunocytochemistry; human
| Kanda M, Sugimoto H, Nomoto S, Oya H, Hibino S, Shimizu D, et al. B‑cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. Int J Oncol. 2015;46:641-8 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Sung M, Giannakakou P. BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling. Oncogene. 2014;33:1418-28 pubmed publisher |
| Roh J, Huang J, Hu W, Yang X, Jennings N, Sehgal V, et al. Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. Clin Cancer Res. 2014;20:2740-50 pubmed publisher |
| Liu W, Han F, Du X, Jiang X, Li Y, Liu Y, et al. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer. Int J Cancer. 2014;134:1311-22 pubmed publisher |
| Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, et al. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. BMC Cancer. 2014;14:668 pubmed publisher |
| Watanabe T, Nakamura S, Ono T, Ui S, Yagi S, Kagawa H, et al. Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun. 2014;451:93-100 pubmed publisher |
- immunocytochemistry; human
| Olsson M, Zhivotovsky B. Measurement of caspase activation in mammalian cell cultures. Methods Mol Biol. 2014;1133:155-73 pubmed publisher |
| Garimella S, Gehlhaus K, Dine J, Pitt J, Grandin M, Chakka S, et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. Breast Cancer Res. 2014;16:R41 pubmed |
| Jin T, Kurakin A, Benhaga N, Abe K, Mohseni M, Sandra F, et al. Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. J Biol Chem. 2004;279:55594-601 pubmed |
- western blot; human; fig 2
| Lamottke B, Kaiser M, Mieth M, Heider U, Gao Z, Nikolova Z, et al. The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. Eur J Haematol. 2012;88:406-15 pubmed publisher |
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| Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, et al. PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Mol Cell Biol. 2015;35:1741-53 pubmed publisher |
| Kitagawa M, Shiozaki A, Ichikawa D, Nakashima S, Kosuga T, Konishi H, et al. Tumor necrosis factor-α-induced apoptosis of gastric cancer MKN28 cells: accelerated degradation of the inhibitor of apoptosis family members. Arch Biochem Biophys. 2015;566:43-8 pubmed publisher |
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| Mo J, Alam K, Kang I, Park W, Seo G, Choi S, et al. MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells. Oncotarget. 2015;6:2843-55 pubmed |
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| Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher |
| Guo M, Cao Y, Wang T, Song X, Liu Z, Zhou E, et al. Baicalin inhibits Staphylococcus aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands. Eur J Pharmacol. 2014;723:481-8 pubmed publisher |
| Hurley K, Lacey N, O'Dwyer C, Bergin D, McElvaney O, O'Brien M, et al. Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals. J Immunol. 2014;193:3978-91 pubmed publisher |
| Cantarella G, Di Benedetto G, Ribatti D, Saccani-Jotti G, Bernardini R. Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). FEBS J. 2014;281:1505-13 pubmed publisher |
| Lin X, Yi Z, Diao J, Shao M, Zhao L, Cai H, et al. ShaoYao decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition. J Transl Med. 2014;12:105 pubmed publisher |
| Huang E, Wang F, Chen Y, Chen Y, Wang C, Lin I, et al. Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation. Oncotarget. 2014;5:9756-69 pubmed |
| Ganapathy S, Xiao S, Seo S, Lall R, Yang M, Xu T, et al. Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation. Oncogene. 2014;33:1359-66 pubmed publisher |
| Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, et al. The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells. Endocrinology. 2014;155:240-8 pubmed publisher |
| Lawhorn I, Ferreira J, Wang C. Evaluation of sgRNA target sites for CRISPR-mediated repression of TP53. PLoS ONE. 2014;9:e113232 pubmed publisher |
| Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, et al. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors. Cancer Sci. 2014;105:1609-15 pubmed publisher |
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| Li Z, Zhao C, Li Z, Zhao Y, Shan S, Shi T, et al. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol. 2014;47:68-75 pubmed publisher |
| Villa-Morales M, Cobos M, González-Gugel E, Alvarez-Iglesias V, Martinez B, Piris M, et al. FAS system deregulation in T-cell lymphoblastic lymphoma. Cell Death Dis. 2014;5:e1110 pubmed publisher |
| Wu Y, Zhang Y, Wang M, Li Q, Qu Z, Shi V, et al. Downregulation of HER3 by a novel antisense oligonucleotide, EZN-3920, improves the antitumor activity of EGFR and HER2 tyrosine kinase inhibitors in animal models. Mol Cancer Ther. 2013;12:427-37 pubmed publisher |
| Büneker C, Yu R, Deedigan L, Mohr A, Zwacka R. IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells. Cancer Lett. 2012;316:168-77 pubmed publisher |
| Wenzel M, Wunderlich M, Besch R, Poeck H, Willms S, Schwantes A, et al. Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. J Immunol. 2012;188:394-403 pubmed publisher |
| van Dijk M, Halpin-McCormick A, Sessler T, Samali A, Szegezdi E. Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways. Cell Death Dis. 2013;4:e702 pubmed publisher |
| Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, et al. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013;191:3614-23 pubmed publisher |
| Ikner A, Ashkenazi A. TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem. 2011;286:21546-54 pubmed publisher |
| Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, et al. miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS. Mol Carcinog. 2013;52:634-46 pubmed publisher |
| Donauer J, Schreck I, Liebel U, Weiss C. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Arch Toxicol. 2012;86:329-37 pubmed publisher |
| Faccenda D, Tan C, Seraphim A, Duchen M, Campanella M. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013;20:686-97 pubmed publisher |
| Kolb R, Greer P, Cao P, Cowan K, Yan Y. ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation. PLoS ONE. 2012;7:e50281 pubmed publisher |
| Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ. 2012;19:1482-94 pubmed publisher |
| Termén S, Tan E, Heldin C, Moustakas A. p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β. J Cell Physiol. 2013;228:801-13 pubmed publisher |
| Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M, et al. Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy. Cell Death Differ. 2012;19:768-78 pubmed publisher |
| Li J, Zhang K, Meng W, Yang Y. Tanshinone IIA in acute promyelocytic leukemia. Am J Med Sci. 2012;344:283-8 pubmed |
| Garimella S, Rocca A, Lipkowitz S. WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis. Mol Cancer Res. 2012;10:75-85 pubmed publisher |
| Deng X, Wang S, Deng A, Liu B, Edgerton S, Lind S, et al. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle. 2012;11:367-76 pubmed publisher |
| Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed publisher |
| He S, Wang L, Miao L, Wang T, Du F, Zhao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137:1100-11 pubmed publisher |
| Wang S, Huang J, Lyu H, Cai B, Yang X, Li F, et al. Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer. Breast Cancer Res. 2013;15:R101 pubmed |
| Förster A, Falcone F, Gibbs B, Preussner L, Fiebig B, Altunok H, et al. Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils. Leuk Lymphoma. 2013;54:835-42 pubmed publisher |
| Kusio-Kobialka M, Wolanin K, Podszywalow-Bartnicka P, Sikora E, Skowronek K, McKenna S, et al. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis. 2012;17:950-63 pubmed publisher |
| Miura Y, Sakurai Y, Endo T. O-GlcNAc modification affects the ATM-mediated DNA damage response. Biochim Biophys Acta. 2012;1820:1678-85 pubmed publisher |
| Chiu S, Chen S, Huang S, Wang M, Lin S, Harn H, et al. Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. PLoS ONE. 2012;7:e33742 pubmed publisher |
| Hao J, Jin W, Li X, Wang S, Zhang X, Fan H, et al. Inhibition of alpha interferon (IFN-α)-induced microRNA-122 negatively affects the anti-hepatitis B virus efficiency of IFN-α. J Virol. 2013;87:137-47 pubmed publisher |
| Tan S, Hougardy B, Meersma G, Schaap B, de Vries E, van der Zee A, et al. Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells. Mol Pharmacol. 2012;81:701-9 pubmed publisher |
| Gillissen B, Richter A, Overkamp T, Essmann F, Hemmati P, Preissner R, et al. Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode. Cell Death Dis. 2013;4:e643 pubmed publisher |
| Paunovic V, Carter N, Thalhamer T, Blair D, Gordon B, Lacey E, et al. Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus. J Autoimmun. 2012;39:332-46 pubmed publisher |
| Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem. 2012;287:18937-52 pubmed publisher |
| Burgeiro A, Bento A, Gajate C, Oliveira P, Mollinedo F. Rapid human melanoma cell death induced by sanguinarine through oxidative stress. Eur J Pharmacol. 2013;705:109-18 pubmed publisher |
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| Sistrunk C, Kim S, Wang X, Lee S, Kim Y, Macias E, et al. Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. Am J Pathol. 2013;182:1854-64 pubmed publisher |
