product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
FGF Receptor 1 (D8E4) XP® Rabbit mAb
catalog :
9740
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D8E4
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3g
Potilinski M, Ortiz G, Salica J, Lopez E, Fernández Acquier M, Chuluyan E, et al. Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy. PLoS ONE. 2020;15:e0228895 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3c
Kon E, Calvo Jiménez E, Cossard A, Na Y, Cooper J, Jossin Y. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. elife. 2019;8: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 7d
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6s1a
Javidi Sharifi N, Martinez J, English I, Joshi S, Scopim Ribeiro R, Viola S, et al. FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells. elife. 2019;8: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1b
Gammelgaard K, Vad Nielsen J, Clement M, Weiss S, Daugaard T, Dagnæs Hansen F, et al. Up-Regulated FGFR1 Expression as a Mediator of Intrinsic TKI Resistance in EGFR-Mutated NSCLC. Transl Oncol. 2019;12:432-440 pubmed publisher
  • western blot; human; loading ...; fig 1b
Kostas M, Haugsten E, Zhen Y, Sørensen V, Szybowska P, Fiorito E, et al. Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Mol Cell Proteomics. 2018;17:850-870 pubmed publisher
  • western blot; human; fig 4b
Wang N, Li J, Zhao T, Li S, Shen C, Li D, et al. FGF-21 Plays a Crucial Role in the Glucose Uptake of Activated Monocytes. Inflammation. 2018;41:73-80 pubmed publisher
  • western blot; human; fig 2i
Yu P, Wilhelm K, Dubrac A, Tung J, Alves T, Fang J, et al. FGF-dependent metabolic control of vascular development. Nature. 2017;545:224-228 pubmed publisher
  • western blot; mouse; 1:1000; fig 9c
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3f
Jiang M, Qiu J, Zhang L, Lu D, Long M, Chen L, et al. Changes in tension regulates proliferation and migration of fibroblasts by remodeling expression of ECM proteins. Exp Ther Med. 2016;12:1542-1550 pubmed
  • immunocytochemistry; mouse; fig 5d
Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s9b
Seo H, Jeong H, Joo H, Choi S, Park C, Kim J, et al. Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system. Sci Rep. 2016;6:28832 pubmed publisher
  • western blot; human; 1:2000
Pillay S, Meyer N, Puschnik A, Davulcu O, Diep J, Ishikawa Y, et al. An essential receptor for adeno-associated virus infection. Nature. 2016;530:108-12 pubmed publisher
  • western blot; human; 0.2 ug/ml; loading ...; fig 6b
Menz C, Parsi M, Adams J, Sideek M, Kopecki Z, Cowin A, et al. LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation. PLoS ONE. 2015;10:e0135577 pubmed publisher
  • western blot; mouse; fig 6d
Mohankumar K, Currle D, White E, Boulos N, Dapper J, Eden C, et al. An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. Nat Genet. 2015;47:878-87 pubmed publisher
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 4
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. Stem Cell Reports. 2017;8:84-94 pubmed publisher
Weekes D, Kashima T, Zandueta C, Perurena N, Thomas D, Sunters A, et al. Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1. Oncogene. 2016;35:2852-61 pubmed publisher
Xu J, Wang T, Cao Z, Huang H, Li J, Liu W, et al. MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis. Oncotarget. 2014;5:6983-93 pubmed
Wang R, Wang L, Li Y, Hu H, Shen L, Shen X, et al. FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. Clin Cancer Res. 2014;20:4107-14 pubmed publisher
Lin D, Hao J, Nagata Y, Xu L, Shang L, Meng X, et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014;46:467-73 pubmed publisher
product information
SKU :
9740P
Product-Name :
FGF Receptor 1 (D8E4) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
RTK
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
92 , 120, 145
Host :
Rabbit
Target :
FGFR1
Primary-Protein :
FGFR1
Alt-Names :
BFGFR,Basic fibroblast growth factor receptor 1,CD331,CEK,FGFBR,FGFR-1,FGFR1,FLG,FLJ99988,FLT-2,FLT2,Fms-like tyrosine kinase 2,HBGFR,KAL2,N-SAM,OGD,Proto-oncogene c-Fgr,bFGF-R-1,fibroblast growth factor receptor 1,fms-related tyrosine kinase 2,heparin-binding growth factor receptor,hydroxyaryl-protein kinase,soluble FGFR1 variant 1,soluble FGFR1 variant 2
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.