| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; fig 1
| Grassian A, Scales T, Knutson S, Kuntz K, McCarthy N, Lowe C, et al. A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality. Biol Proced Online. 2015;17:15 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 2n
| Leone R, Zhao L, Englert J, Sun I, Oh M, Sun I, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013-1021 pubmed publisher |
- immunocytochemistry; mouse; loading ...
| Hamilton W, Mosesson Y, Monteiro R, Emdal K, Knudsen T, Francavilla C, et al. Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature. 2019;: pubmed publisher |
- ChIP-Seq; Xenopus laevis; loading ...; fig 3e
| Kuznetsov J, Agüero T, Owens D, Kurtenbach S, Field M, Durante M, et al. BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers. Sci Adv. 2019;5:eaax1738 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s3d
| Piunti A, Smith E, Morgan M, Ugarenko M, Khaltyan N, Helmin K, et al. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019;5:eaax2887 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 5b
| Traynor S, Møllegaard N, Jørgensen M, Brückmann N, Pedersen C, Terp M, et al. Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins. Nucleic Acids Res. 2019;47:6668-6684 pubmed publisher |
- immunohistochemistry; mouse; 1:200; fig e10k
- western blot; human; 1:1000; loading ...; fig 3d
| Eckert M, Coscia F, Chryplewicz A, Chang J, Hernandez K, Pan S, et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019;: pubmed publisher |
- western blot; mouse; 1:5000; loading ...; fig 4s3d
| Greenberg M, Teissandier A, Walter M, Noordermeer D, Bourc his D. Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. elife. 2019;8: pubmed publisher |
- mass cytometry; human; loading ...; fig 3a
| Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 5a
- western blot; mouse; 1:1000; loading ...; fig 1b
| Lavarone E, Barbieri C, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10:1679 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
| Lin C, Hsu Y, Huang Y, Shih Y, Wang C, Chiang W, et al. A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO Mol Med. 2019;11: pubmed publisher |
- immunohistochemistry; human; 1:200; loading ...; fig 2a
| Lima Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat Commun. 2019;10:1436 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig s4h
| Chakraborty A, Laukka T, Myllykoski M, Ringel A, Booker M, Tolstorukov M, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019;363:1217-1222 pubmed publisher |
- ChIP-Seq; rat; loading ...; fig 3e
| Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567:535-539 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4b
| Lee J, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, et al. Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a. Life Sci Alliance. 2019;2: pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 1a
| Zheng Y, Liu A, Wang Z, Cao Q, Wang W, Lin L, et al. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain. 2019;142:787-807 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig s6d
| Żylicz J, Bousard A, Zumer K, Dossin F, Mohammad E, da Rocha S, et al. The Implication of Early Chromatin Changes in X Chromosome Inactivation. Cell. 2019;176:182-197.e23 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 5b
- flow cytometry; mouse; loading ...; fig 5a
| Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. J Cell Biol. 2018;217:2951-2974 pubmed publisher |
| Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors. Cancer Cell. 2018;33:512-526.e8 pubmed publisher |
- western blot; human; fig 1e
| Wu Y, Zhang Z, Cenciarini M, Proietti C, Amasino M, Hong T, et al. Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 2018;78:671-684 pubmed publisher |
- western blot; human; loading ...; fig 5b
| Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q, et al. Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells. Sci Rep. 2017;7:46276 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 7h
| Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 6
- immunohistochemistry; mouse; fig 3b
- western blot; mouse; fig 3b
| Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, et al. Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochim Biophys Acta Gene Regul Mech. 2017;1860:427-437 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig s6c
| Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, et al. CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017;18:1499-1511 pubmed publisher |
- other; human; 1:2500; loading ...; fig 3
- western blot; human; 1:1000; loading ...; fig s10
| He Y, Selvaraju S, Curtin M, Jakob C, Zhu H, Comess K, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017;13:389-395 pubmed publisher |
- ChIP-Seq; human; loading ...; fig 2f
- western blot; human; 1:2000; loading ...; fig 1e
| Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Wu R, Wang Z, Zhang H, Gan H, Zhang Z. H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. Nucleic Acids Res. 2017;45:169-180 pubmed publisher |
- ChIP-Seq; human; loading ...; tbl 2
- ChIP-Seq; mouse; loading ...; tbl 2
| Busby M, Xue C, Li C, Farjoun Y, Gienger E, Yofe I, et al. Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. Epigenetics Chromatin. 2016;9:49 pubmed |
- ChIP-Seq; mouse; 1:40
- immunocytochemistry; mouse; loading ...; fig 2f
- western blot; human; loading ...; fig 1b
| Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, et al. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A. 2016;113:10370-5 pubmed publisher |
- chromatin immunoprecipitation; human; fig 5
- western blot; human; fig 5
| Wang Y, Sun H, Wang J, Wang H, Meng L, Xu C, et al. DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity. Cell Death Dis. 2016;7:e2316 pubmed publisher |
- western blot; human; 1:1000; fig 3d,4b,7b
| Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed publisher |
- ELISA; human; 1:1000; fig s3
- western blot; human; fig s1
| Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS ONE. 2016;11:e0158888 pubmed publisher |
- western blot; human; loading ...; fig 1b
| Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed publisher |
- immunocytochemistry; mouse; fig s6c
- chromatin immunoprecipitation; Drosophila melanogaster; loading ...; fig s11b
| Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 12a
| Perez R, Shen H, Duan L, Kim R, Kim T, Park N, et al. Modeling the Etiology of p53-mutated Cancer Cells. J Biol Chem. 2016;291:10131-47 pubmed publisher |
- ChIP-Seq; mouse; fig 4
- immunocytochemistry; mouse; 1:200; fig 4
- western blot; mouse; 1:1000; fig 4
| Walter M, Teissandier A, Pérez Palacios R, Bourc his D. An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells. elife. 2016;5: pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; fig 7
| Misuraca K, Hu G, Barton K, Chung A, Becher O. A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells. Neoplasia. 2016;18:60-70 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 7e
| Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, et al. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation. Nat Immunol. 2016;17:331-43 pubmed publisher |
- immunohistochemistry; human; 1:200; fig s4
| Toledo R, Qin Y, Cheng Z, Gao Q, Iwata S, Silva G, et al. Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. Clin Cancer Res. 2016;22:2301-10 pubmed publisher |
- immunohistochemistry; human; fig 2c
| Wassef M, Rodilla V, Teissandier A, Zeitouni B, Gruel N, Sadacca B, et al. Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis. Genes Dev. 2015;29:2547-62 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
| Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6c
- chromatin immunoprecipitation; human; loading ...; fig 4a
- western blot; human; 1:2000; loading ...; fig 1c, 3a, 2c
| Sengupta D, Byrum S, Avaritt N, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016;15:765-75 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; fig s5
- chromatin immunoprecipitation; mouse; fig 3
| Zemke M, Draganova K, Klug A, Schöler A, Zurkirchen L, Gay M, et al. Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015;13:103 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
- immunocytochemistry; human; fig 4
- western blot; human; fig 1
| Hernando H, Gelato K, Lesche R, Beckmann G, Koehr S, Otto S, et al. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes. Mol Cancer Ther. 2016;15:287-98 pubmed publisher |
| Laumet G, Garriga J, Chen S, Zhang Y, Li D, Smith T, et al. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015;18:1746-55 pubmed publisher |
- chromatin immunoprecipitation; human; fig 6
| Hu P, Chu J, Wu Y, Sun L, Lv X, Zhu Y, et al. NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2. Oncotarget. 2015;6:32410-25 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 1
| Kim S, Yang W, Min Y, Ko Y, Yoon S. The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications. Tumour Biol. 2016;37:2037-47 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Bravo M, Nicolini F, Starowicz K, Barroso S, Calés C, Aguilera A, et al. Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression. J Cell Sci. 2015;128:3660-71 pubmed publisher |
- chromatin immunoprecipitation; human; fig 5
| Kang S, Kim S, Chai J, Kim S, Won K, Lee Y, et al. Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation. PLoS ONE. 2015;10:e0135276 pubmed publisher |
- immunocytochemistry; mouse; fig 4
| McCleland M, Soukup T, Liu S, Esensten J, De Sousa E Melo F, Yaylaoglu M, et al. Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. J Pathol. 2015;237:508-19 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig s8
| Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 6a,6b,6c,7b
- western blot; human; loading ...; fig 7a
| Kotomura N, Harada N, Ishihara S. The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. PLoS ONE. 2015;10:e0128282 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
- flow cytometry; human; fig s3
| Nishioka C, Ikezoe T, Yang J, Yokoyama A. Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLoS ONE. 2015;10:e0125017 pubmed publisher |
| Poirier J, Gardner E, Connis N, Moreira A, de Stanchina E, Hann C, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene. 2015;34:5869-78 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; fig 6
- chromatin immunoprecipitation; human; 1:1000; fig 4
| Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed publisher |
- chromatin immunoprecipitation; human; 2 ugs
| Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed publisher |
| Knutson S, Warholic N, Johnston L, Klaus C, Wigle T, Iwanowicz D, et al. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS ONE. 2014;9:e111840 pubmed publisher |
- immunocytochemistry; human
| Luense S, Denner P, Fernández Montalván A, Hartung I, Husemann M, Stresemann C, et al. Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors. J Biomol Screen. 2015;20:190-201 pubmed publisher |
- ChIP-Seq; human; 1:50
- immunohistochemistry - paraffin section; human; 1:500
- immunocytochemistry; human; 1:800
- western blot; human; 1:1000
| Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014;20:1394-6 pubmed publisher |
- western blot; human; fig 5
- western blot; mouse; fig 3
| Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood. 2015;125:13-21 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
| Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, et al. Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. elife. 2014;3: pubmed publisher |
- immunohistochemistry - paraffin section; rat; 0.07 ug/mL
- chromatin immunoprecipitation; human
| Knutson S, Kawano S, Minoshima Y, Warholic N, Huang K, Xiao Y, et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther. 2014;13:842-54 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human; 1:1000
| Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed publisher |
- immunocytochemistry; human; 1:500
| Liu Y, Platchek M, Kement B, Bee W, Truong M, Zeng X, et al. A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation. Mol Biosyst. 2014;10:251-7 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 3
| Subramanian V, Mazumder A, Surface L, Butty V, Fields P, Alwan A, et al. H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation. PLoS Genet. 2013;9:e1003725 pubmed publisher |
| Lee S, Phipson B, Hyland C, Leong H, Allan R, Lun A, et al. Polycomb repressive complex 2 (PRC2) suppresses E?-myc lymphoma. Blood. 2013;122:2654-63 pubmed publisher |
- chromatin immunoprecipitation; mouse; 1:50
| Huang S, Scruggs A, Donaghy J, Horowitz J, Zaslona Z, Przybranowski S, et al. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. Cell Death Dis. 2013;4:e621 pubmed publisher |
- chromatin immunoprecipitation; human
| Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, et al. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science. 2012;337:971-5 pubmed publisher |
- western blot; human; 1:10000
| Sneeringer C, Scott M, Kuntz K, Knutson S, Pollock R, Richon V, et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A. 2010;107:20980-5 pubmed publisher |
| Escobar T, Oksuz O, Saldaña Meyer R, Descostes N, Bonasio R, Reinberg D. Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication. Cell. 2019;179:953-963.e11 pubmed publisher |
| LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed publisher |
| Hirukawa A, Singh S, Wang J, Rennhack J, Swiatnicki M, Sanguin Gendreau V, et al. Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy. Cell Rep. 2019;29:249-257.e8 pubmed publisher |
| Smith H, Hirukawa A, Sanguin Gendreau V, Nandi I, Dufour C, Zuo D, et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nat Commun. 2019;10:2901 pubmed publisher |
| Scelfo A, Fernandez Perez D, Tamburri S, Zanotti M, Lavarone E, Soldi M, et al. Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities. Mol Cell. 2019;74:1037-1052.e7 pubmed publisher |
| Oppel F, Tao T, Shi H, Ross K, Zimmerman M, He S, et al. Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies. PLoS Genet. 2019;15:e1008039 pubmed publisher |
| Larson J, Kasper L, Paugh B, Jin H, Wu G, Kwon C, et al. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression. Cancer Cell. 2019;35:140-155.e7 pubmed publisher |
| Tischler J, Gruhn W, Reid J, Allgeyer E, Buettner F, Marr C, et al. Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate. EMBO J. 2019;38: pubmed publisher |
| Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, et al. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. Acta Neuropathol Commun. 2018;6:134 pubmed publisher |
| Nishiguchi M, Spencer C, Leung D, Leung T. Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration. Cell Rep. 2018;24:3383-3392.e5 pubmed publisher |
| Stringer J, Forster S, Qu Z, Prokopuk L, O Bryan M, Gardner D, et al. Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance. BMC Biol. 2018;16:104 pubmed publisher |
| Basilicata M, Bruel A, Semplicio G, Valsecchi C, Aktas T, Duffourd Y, et al. De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nat Genet. 2018;50:1442-1451 pubmed publisher |
| Garczyk S, Schneider U, Lurje I, Becker K, Vögeli T, Gaisa N, et al. ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response?. PLoS ONE. 2018;13:e0202965 pubmed publisher |
| Prokopuk L, Stringer J, White C, Vossen R, White S, Cohen A, et al. Loss of maternal EED results in postnatal overgrowth. Clin Epigenetics. 2018;10:95 pubmed publisher |
| Tatavosian R, Duc H, Huynh T, Fang D, Schmitt B, Shi X, et al. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018;9:2080 pubmed publisher |
| Lee C, Yu J, Kumar S, Jin Y, LeRoy G, Bhanu N, et al. Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Mol Cell. 2018;70:422-434.e6 pubmed publisher |
| Lee C, Holder M, Grau D, Saldaña Meyer R, Yu J, Ganai R, et al. Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2. Mol Cell. 2018;70:435-448.e5 pubmed publisher |
| Prokopuk L, Hogg K, Western P. Pharmacological inhibition of EZH2 disrupts the female germline epigenome. Clin Epigenetics. 2018;10:33 pubmed publisher |
| Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, et al. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018;9:700 pubmed publisher |
| Cho Y, Kim S, Kim E, Han J, Shin K, Hu H, et al. Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma. BMC Cancer. 2018;18:158 pubmed publisher |
| Colón Caraballo M, Torres Reveron A, Soto Vargas J, Young S, Lessey B, Mendoza A, et al. Effects of histone methyltransferase inhibition in endometriosis. Biol Reprod. 2018;99:293-307 pubmed publisher |
| Thakur J, Henikoff S. Unexpected conformational variations of the human centromeric chromatin complex. Genes Dev. 2018;32:20-25 pubmed publisher |
| Papaspyropoulos A, Bradley L, Thapa A, Leung C, Toskas K, Koennig D, et al. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 2018;9:424 pubmed publisher |
| Stephens A, Liu P, Banigan E, Almassalha L, Backman V, Adam S, et al. Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins. Mol Biol Cell. 2018;29:220-233 pubmed publisher |
| Kang H, Jung Y, McElroy K, Zee B, Wallace H, Woolnough J, et al. Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila. Genes Dev. 2017;31:1988-2002 pubmed publisher |
| Wang A, Juan A, Ko K, Tsai P, Zare H, Dell Orso S, et al. The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins. Mol Cell. 2017;68:398-413.e6 pubmed publisher |
| Agathocleous M, Meacham C, Burgess R, Piskounova E, Zhao Z, Crane G, et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature. 2017;549:476-481 pubmed publisher |
| Hanssen L, Kassouf M, Oudelaar A, Biggs D, Preece C, Downes D, et al. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nat Cell Biol. 2017;19:952-961 pubmed publisher |
| Gabriele M, Vulto van Silfhout A, Germain P, Vitriolo A, Kumar R, Douglas E, et al. YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. Am J Hum Genet. 2017;100:907-925 pubmed publisher |
| Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher |
| Mendoza Parra M, Saravaki V, Cholley P, Blum M, Billoré B, Gronemeyer H. Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification. F1000Res. 2016;5:54 pubmed publisher |
| Duren R, Boudreaux S, Conneely O. Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells. PLoS ONE. 2016;11:e0150450 pubmed publisher |
| Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna J, Riedel S, et al. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Rep. 2016;14:1953-65 pubmed publisher |
| Baker T, Nerle S, Pritchard J, Zhao B, Rivera V, Garner A, et al. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors. Oncotarget. 2015;6:32646-55 pubmed publisher |
| Barsotti A, Ryskin M, Zhong W, Zhang W, Giannakou A, Loreth C, et al. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth. Oncotarget. 2015;6:2928-38 pubmed |
| Jakobsen J, Bagger F, Hasemann M, Schuster M, Frank A, Waage J, et al. Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq. BMC Genomics. 2015;16:46 pubmed publisher |
| Watson M, Hedley D. Whole blood measurement of histone modifications linked to the epigenetic regulation of gene expression. Curr Protoc Cytom. 2015;71:6.36.1-9 pubmed publisher |
| Theisen E, Gajiwala S, Bearss J, Sorna V, Sharma S, JANAT AMSBURY M. Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. BMC Cancer. 2014;14:752 pubmed publisher |
| Oh E, Yang W, Cheong J, Choi S, Yoon S. Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression. Hum Pathol. 2014;45:2043-50 pubmed publisher |
| Shpargel K, Starmer J, Yee D, Pohlers M, Magnuson T. KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014;10:e1004507 pubmed publisher |
| Riquelme E, Suraokar M, Behrens C, Lin H, Girard L, Nilsson M, et al. VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy. Clin Cancer Res. 2014;20:3849-61 pubmed publisher |
| Kim W, Bird G, Neff T, Guo G, Kerenyi M, Walensky L, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013;9:643-50 pubmed publisher |
| Howard L, Mackenzie R, Pchelintsev N, McBryan T, McClure J, McBride M, et al. Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Res Ther. 2013;4:36 pubmed publisher |
| Lee H, Yoon S, Jeong W, Kim H, Kim A, Kim B. Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer. Hum Pathol. 2012;43:1704-10 pubmed publisher |
| Peach S, Rudomin E, Udeshi N, Carr S, Jaffe J. Quantitative assessment of chromatin immunoprecipitation grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules. Mol Cell Proteomics. 2012;11:128-37 pubmed publisher |
| Ohhata T, Senner C, Hemberger M, Wutz A. Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice. Genes Dev. 2011;25:1702-15 pubmed publisher |
| Kim K, Hysolli E, Park I. Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2011;108:14169-74 pubmed publisher |
| Pasini D, Malatesta M, Jung H, Walfridsson J, Willer A, Olsson L, et al. Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res. 2010;38:4958-69 pubmed publisher |
| Szulwach K, Li X, Smrt R, Li Y, Luo Y, Lin L, et al. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol. 2010;189:127-41 pubmed publisher |
