| Published Application/Species/Dilution | Reference |
|---|
- immunohistochemistry - frozen section; mouse; fig s2
| Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, et al. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016;9:335-45 pubmed publisher |
- immunocytochemistry; human; fig 2
| Choi Y, Meghani K, Brault M, Leclerc L, He Y, Day T, et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016;14:429-39 pubmed publisher |
- western blot; human; fig 1
| Pecháčková S, Burdova K, Benada J, Kleiblova P, Jenikova G, Macurek L. Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget. 2016;7:14458-75 pubmed publisher |
- immunohistochemistry; mouse; 1:400; fig 7
| Gygli P, Chang J, Gokozan H, Catacutan F, Schmidt T, Kaya B, et al. Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY). 2016;8:1540-70 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Bristol M, Wang X, Smith N, Son M, Evans M, Morgan I. DNA Damage Reduces the Quality, but Not the Quantity of Human Papillomavirus 16 E1 and E2 DNA Replication. Viruses. 2016;8: pubmed publisher |
- immunohistochemistry; human; 1:250; fig 4
| Jun S, Jung Y, Suh H, Wang W, Kim M, Oh Y, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016;7:10994 pubmed publisher |
- western blot; mouse; fig 4
| Li W, Zou J, Yue F, Song K, Chen Q, McKeehan W, et al. Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell. 2016;15:370-9 pubmed publisher |
- western blot; mouse; fig 3
| Zhao B, Tan T, Mei Y, Yang J, Yu Y, Verma A, et al. H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Sci Rep. 2016;6:19589 pubmed publisher |
- western blot; human; fig 5
- immunocytochemistry; human; fig 5
| Ceccon M, Merlo M, Mologni L, Poggio T, Varesio L, Menotti M, et al. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. 2016;35:3854-65 pubmed publisher |
- immunocytochemistry; human; fig 4
| Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, et al. Influence of aging on the quantity and quality of human cardiac stem cells. Sci Rep. 2016;6:22781 pubmed publisher |
- western blot; human; 1:1000
| Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 5
- western blot; human; fig 4
| Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016;35:1541-53 pubmed publisher |
- western blot; human; fig 1
| Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher |
- immunocytochemistry; mouse; 1:200; fig 5
- western blot; mouse; 1:1000; fig 5
| Ma X, Lin F, Wang Z, Hu M, Huang L, Meng T, et al. Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility. Mol Biol Cell. 2016;27:768-75 pubmed publisher |
- flow cytometry; human; fig 5
| Rebolleda N, Losada-Fernandez I, Perez-Chacon G, Castejon R, Rosado S, Morado M, et al. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS ONE. 2016;11:e0154159 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:400; fig 1
- western blot; human; fig 7
| Birch J, Anderson R, Correia-Melo C, Jurk D, Hewitt G, Marques F, et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1124-37 pubmed publisher |
- immunohistochemistry; mouse; 1:50; fig 1
- western blot; mouse; 1:5000; fig 1
- immunocytochemistry; mouse; 1:50; fig 1
| Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher |
- immunocytochemistry; human; fig 2
| Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed publisher |
- western blot; human; 1:1000; fig 4
- immunocytochemistry; human; 1:100; fig 1
| Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505 pubmed publisher |
- western blot; human; fig 3
| Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed publisher |
- immunocytochemistry; human; 1:400
| He X, Zhang P. Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair. Mol Cancer. 2015;14:158 pubmed publisher |
- immunocytochemistry; human; fig 5
- western blot; human; fig 6
| Bouley J, Saad L, Grall R, Schellenbauer A, Biard D, Paget V, et al. A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines. Oncotarget. 2015;6:27980-8000 pubmed publisher |
- western blot; human; fig 5
| Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker-Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher |
- western blot; human; fig 5
| Cruz-Bermudez A, Vallejo C, Vicente-Blanco R, Gallardo M, Fernández-Moreno M, Quintanilla M, et al. Enhanced tumorigenicity by mitochondrial DNA mild mutations. Oncotarget. 2015;6:13628-43 pubmed |
- western blot; human; fig 4
| Huhn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed publisher |
- western blot; human; 1:5000
| Tu Z, Xu B, Qu C, Tao Y, Chen C, Hua W, et al. BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro. Radiat Oncol. 2015;10:123 pubmed publisher |
- immunocytochemistry; mouse; 1:1000; fig 3
| Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed publisher |
- western blot; human; 1:1000; fig 4a
| Masuda Y, Takahashi H, Sato S, Tomomori-Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher |
- immunohistochemistry; human; fig 4
| Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed publisher |
- western blot; human; fig s1
| Jeong H, Gil N, Lee H, Cho S, Kim K, Chun K, et al. Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression. J Cell Biochem. 2015;116:1602-12 pubmed publisher |
- western blot; human; fig 4
| Moskwa P, Zinn P, Choi Y, Shukla S, Fendler W, Chen C, et al. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014;12:1767-78 pubmed publisher |
| Kaistha B, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, et al. Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells. Br J Cancer. 2014;111:1780-7 pubmed publisher |
| Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher |
- western blot; human
- western blot; mouse
- western blot; rat
| Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Sharma N, Zhu Q, Wani G, He J, Wang Q, Wani A. USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15. Cell Cycle. 2014;13:106-14 pubmed publisher |
| Clewell R, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen P, et al. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci. 2014;142:56-73 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Brand S, Amann K, Mandel P, Zimnol A, Schupp N. Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors. PLoS ONE. 2014;9:e115715 pubmed publisher |
| Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher |
- western blot; human
- immunocytochemistry; human
| Choi Y, Pan Y, Park E, Konstantinopoulos P, De S, D'ANDREA A, et al. MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability. elife. 2014;3:e02445 pubmed publisher |
| Schweikl H, Petzel C, Bolay C, Hiller K, Buchalla W, Krifka S. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. 2014;35:2890-904 pubmed publisher |
- western blot; human; 1:1000
| Stimpson K, Sullivan L, Kuo M, Sullivan B. Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. PLoS ONE. 2014;9:e92432 pubmed publisher |
- western blot; human
- western blot; rat
| Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher |
- immunocytochemistry; mouse
| Zimmermann M, Lottersberger F, Buonomo S, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science. 2013;339:700-4 pubmed publisher |
- immunocytochemistry; human; 1:1000
| Gao M, Rendtlew Danielsen J, Wei L, Zhou D, Xu Q, Li M, et al. A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity. PLoS ONE. 2012;7:e49687 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher |
- immunocytochemistry; human
| Orzáez M, Guevara T, Sancho M, Perez-Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher |
- immunocytochemistry; human
| Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher |
| Lovric M, Hawkins C. TRAIL treatment provokes mutations in surviving cells. Oncogene. 2010;29:5048-60 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher |
| Abu-Odeh M, Hereema N, Aqeilan R. WWOX modulates the ATR-mediated DNA damage checkpoint response. Oncotarget. 2016;7:4344-55 pubmed publisher |
| Kang J, Han M, Kim G, Kim C, Chung H, Hwang H, et al. Schisandrae semen essential oil attenuates oxidative stress-induced cell damage in C2C12 murine skeletal muscle cells through Nrf2‑mediated upregulation of HO‑1. Int J Mol Med. 2015;35:453-9 pubmed publisher |
| Weaver A, Cooper T, Rodriguez M, Trummell H, Bonner J, Rosenthal E, et al. DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. Oncotarget. 2015;6:26995-7007 pubmed publisher |
| Ahmad T, Sundar I, Lerner C, Gerloff J, Tormos A, Yao H, et al. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 2015;29:2912-29 pubmed publisher |
| Augello M, Berman-Booty L, Carr R, Yoshida A, Dean J, Schiewer M, et al. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015;7:628-47 pubmed publisher |
| Sasi S, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, et al. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int. 2015;2015:496512 pubmed publisher |
| Cheung J, Dickinson D, Moss J, Schuler M, Spellman R, Heard P. Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay. Mutat Res Genet Toxicol Environ Mutagen. 2015;777:7-16 pubmed publisher |
| Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Kyne B, Saban D, Stepp M. Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Lab Invest. 2015;95:1305-18 pubmed publisher |
| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, et al. DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells. J Biol Chem. 2014;289:27314-26 pubmed publisher |
| Sasi S, Song J, Park D, Enderling H, McDonald J, Gee H, et al. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2014;289:14178-93 pubmed publisher |
| Choi Y, Battelli C, Watson J, Liu J, Curtis J, Morse A, et al. Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. Oncotarget. 2014;5:2678-87 pubmed |
| Yu Z, Xu Z, Disante G, Wright J, Wang M, Li Y, et al. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. 2014;5:1083-90 pubmed |
| Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, et al. Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem. 2014;289:5730-46 pubmed publisher |
| Guevara T, Sancho M, Pérez-Payá E, Orzáez M. Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells. Cell Cycle. 2014;13:1617-26 pubmed publisher |
| Hall M, Telma K, Chang K, Lee T, Madigan J, Lloyd J, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74:3913-22 pubmed publisher |
| Kilic Eren M, Tabor V. The role of hypoxia inducible factor-1 alpha in bypassing oncogene-induced senescence. PLoS ONE. 2014;9:e101064 pubmed publisher |
| Nasuno T, Mimaki S, Okamoto M, Esumi H, Tsuchihara K. Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. Cancer Sci. 2014;105:202-10 pubmed publisher |
| Hewish M, Martin S, Elliott R, Cunningham D, Lord C, Ashworth A. Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress. Br J Cancer. 2013;108:983-92 pubmed publisher |
| Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem. 2012;287:18937-52 pubmed publisher |
| Lu H, Hu L, Li T, Lahiri S, Shen C, Wason M, et al. A novel role of Krüppel-like factor 8 in DNA repair in breast cancer cells. J Biol Chem. 2012;287:43720-9 pubmed publisher |
| Bakkenist C, Czambel R, Clump D, Greenberger J, Beumer J, Schmitz J. Radiation therapy induces the DNA damage response in peripheral blood. Oncotarget. 2013;4:1143-8 pubmed |
| Sun B, Ross S, Trask O, Carmichael P, Dent M, White A, et al. Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Toxicol In Vitro. 2013;27:1877-87 pubmed publisher |
| Hirashima K, Migita T, Sato S, Muramatsu Y, Ishikawa Y, Seimiya H. Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol. 2013;33:2988-95 pubmed publisher |
| Wei S, Xiong M, Zhan D, Liang B, Wang Y, Gutmann D, et al. Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway. Carcinogenesis. 2012;33:538-47 pubmed publisher |
