product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Histone H2A.X (Ser139) (20E3) Rabbit mAb
catalog :
9718
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
20E3
reactivity :
African green monkey, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 242
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2500; loading ...; fig 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed publisher
  • immunocytochemistry; rat; 1:400; loading ...; fig 1a
Li W, Lin Y, Luo Y, Wang Y, Lu Y, Li Y, et al. Vitamin D Receptor Protects against Radiation-Induced Intestinal Injury in Mice via Inhibition of Intestinal Crypt Stem/Progenitor Cell Apoptosis. Nutrients. 2021;13: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...
Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig s2c
Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3d
Saha J, Bae J, Wang S, Lu H, Chappell L, Gopal P, et al. Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma. Nucleic Acids Res. 2021;49:9836-9850 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s9b
Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed publisher
  • western blot; mouse; loading ...; fig 2h
Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Signal Transduct Target Ther. 2021;6:223 pubmed publisher
  • western blot; mouse; loading ...; fig 1j
Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed publisher
  • western blot; human; loading ...; fig 5l
Pettinato A, Yoo D, VanOudenhove J, Chen Y, Cohn R, Ladha F, et al. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 2021;35:109088 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1f
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12:2259 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2g
Park K, Ryoo J, Jeong H, Kim M, Lee S, Hwang S, et al. Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions. PLoS Genet. 2021;17:e1009523 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1d
Corbin J, Georgescu C, Wren J, Xu C, Asch A, Ruiz Echevarría M. Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Mol Ther Nucleic Acids. 2021;24:337-351 pubmed publisher
  • immunohistochemistry; mouse; 1:480; loading ...; fig 4a
Zhang J, Saravanabavan S, Rangan G. Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease. Cells. 2021;10: pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Ditano J, Donahue K, Tafe L, McCleery C, Eastman A. Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Sci Rep. 2021;11:7077 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 3e
Lagnado A, Leslie J, Ruchaud Sparagano M, Victorelli S, Hirsova P, Ogrodnik M, et al. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 2021;40:e106048 pubmed publisher
  • immunohistochemistry; mouse; fig 2a
Swiader A, Camaré C, Guerby P, Salvayre R, Negre Salvayre A. 4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 6g
Chi R, van der Watt P, Wei W, Birrer M, Leaner V. Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. BMC Cancer. 2021;21:106 pubmed publisher
  • western blot; human; loading ...; fig 6g
Nabil M, El Raey M, Abdo W, Abdelfattah M, El Shazly A, Sobeh M, et al. Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies. Antioxidants (Basel). 2021;10: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 1c
  • immunohistochemistry; mouse; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 1b
Zhang D, Liu C, Li H, Jiao J. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. Adv Sci (Weinh). 2020;7:2002117 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5g
Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher
  • western blot; human; 1:700; loading ...; fig s3-3b
Hao Q, Zong X, Sun Q, Lin Y, Song Y, Hashemikhabir S, et al. The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 3b
Moses N, Zhang M, Wu J, Hu C, Xiang S, Geng X, et al. HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1. Cells. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6e, 6f
  • western blot; human; 1:1000; loading ...; fig 5c
Jin H, Wang S, Zaal E, Wang C, Wu H, Bosma A, et al. A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 6j
Wertman J, Melong N, Stoyek M, Piccolo O, Langley S, Orr B, et al. The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. elife. 2020;9: pubmed publisher
  • flow cytometry; human; loading ...; fig 1f, 3s2b
  • immunocytochemistry; human; loading ...; fig 2s2d, 3s2c
  • western blot; human; loading ...; fig 1s1e, 1s1g, 3g
Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, et al. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2g
  • western blot; human; 1:1000; loading ...; fig s5g
Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1c
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4b
Gallo S, Spilinga M, Albano R, Ferrauto G, Di Gregorio E, Casanova E, et al. Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. Br J Pharmacol. 2020;177:3107-3122 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5c
  • western blot; human; 1:1000; loading ...; fig 5b
Li K, Zhao S, Long J, Su J, Wu L, Tao J, et al. A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. Cancer Cell Int. 2020;20:36 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig s6d
Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 9a
Sharma S, Plotkin M. Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury. FEBS Open Bio. 2020;: pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 1c
Aimé P, Karuppagounder S, Rao A, Chen Y, Burke R, Ratan R, et al. The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiol Dis. 2020;136:104725 pubmed publisher
  • western blot; human; loading ...; fig s11j
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 6b, s7b
  • immunocytochemistry; mouse; 1:400; loading ...; fig 2b
Matsuno Y, Atsumi Y, Shimizu A, Katayama K, Fujimori H, Hyodo M, et al. Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro. Nat Commun. 2019;10:3925 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3b
  • western blot; human; loading ...; fig 3c
Schaser A, Osterberg V, Dent S, Stackhouse T, Wakeham C, Boutros S, et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019;9:10919 pubmed publisher
  • western blot; mouse; fig 4a
Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s4b
Hsu C, Altschuler S, Wu L. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5a
Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Singh R, Peng S, Viswanath P, Sambandam V, Shen L, Rao X, et al. Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis. EMBO Mol Med. 2019;: pubmed publisher
  • western blot; human; loading ...; fig s1a
Kucab J, Zou X, Morganella S, Joel M, Nanda A, Nagy E, et al. A Compendium of Mutational Signatures of Environmental Agents. Cell. 2019;177:821-836.e16 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2e, 4a, e10b
Chan E, Shibue T, McFarland J, Gaeta B, Ghandi M, Dumont N, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568:551-556 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3b
  • western blot; human; loading ...; fig 3a
Liu W, Wang G, Palovcak A, Li Y, Hao S, Liu Z, et al. Impeding the single-strand annealing pathway of DNA double-strand break repair by withaferin A-mediated FANCA degradation. DNA Repair (Amst). 2019;77:10-17 pubmed publisher
  • western blot; mouse; loading ...; fig s5h
Fu T, Coulter S, Yoshihara E, Oh T, Fang S, Cayabyab F, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019;176:1098-1112.e18 pubmed publisher
  • immunocytochemistry; mouse; 1:400; loading ...; fig 4a
Zhang Q, Ji S, Busayavalasa K, Yu C. SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019;5:eaau9780 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1a
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J. 2019;38: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2f
Gronke K, Hernandez P, Zimmermann J, Klose C, Kofoed Branzk M, Guendel F, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019;566:249-253 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 7a
  • western blot; human; loading ...; fig 7d
Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, et al. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019;38:2967-2983 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s3a
Bonath F, Domingo Prim J, Tarbier M, Friedländer M, Visa N. Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks. Nucleic Acids Res. 2018;46:11869-11882 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1b
Craxton A, Munnur D, Jukes Jones R, Skalka G, Langlais C, Cain K, et al. PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. Nat Commun. 2018;9:3877 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3d
Saldivar J, Hamperl S, Bocek M, Chung M, Bass T, Cisneros Soberanis F, et al. An intrinsic S/G2 checkpoint enforced by ATR. Science. 2018;361:806-810 pubmed publisher
  • western blot; mouse; fig 2b
Lee C, Hsieh T. Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts. Cell Signal. 2018;47:16-26 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2d
Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández Mateos J, Khan K, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018;359:920-926 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1f
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 5
Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy J. DNA polymerase beta participates in DNA End-joining. Nucleic Acids Res. 2018;46:242-255 pubmed publisher
  • western blot; human; loading ...; fig s2b
Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed publisher
  • flow cytometry; human; loading ...; fig 2c
Miles M, Hawkins C. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine. Cell Death Dis. 2017;8:e3062 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 2d
  • western blot; human; loading ...; fig 2c
Zhao Z, Jia Q, Wu M, Xie X, Wang Y, Song G, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018;24:130-144 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Moody H, Lind M, Maher S. MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma. Mol Ther Nucleic Acids. 2017;8:317-329 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 6c
Casoni F, Croci L, Bosone C, D Ambrosio R, Badaloni A, Gaudesi D, et al. Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors. Development. 2017;144:3686-3697 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 2b
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 7c
Giroux V, Lento A, Islam M, Pitarresi J, Kharbanda A, Hamilton K, et al. Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. J Clin Invest. 2017;127:2378-2391 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2
  • western blot; mouse; loading ...; fig 3
Jha K, Tripurani S, Johnson G. TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis. J Cell Sci. 2017;130:1835-1844 pubmed publisher
  • western blot; human; loading ...; fig 5a
Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 9a
Li X, Burton E, Bhaduri McIntosh S. Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. PLoS Pathog. 2017;13:e1006249 pubmed publisher
  • western blot; human; loading ...; fig 3a
Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, et al. TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Oncogene. 2017;36:3740-3748 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 3d
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4b
  • flow cytometry; mouse; loading ...; fig 6b
Weeden C, Chen Y, Ma S, Hu Y, Ramm G, Sutherland K, et al. Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway. PLoS Biol. 2017;15:e2000731 pubmed publisher
  • immunohistochemistry; mouse; fig 5a
Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar -, et al. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell. 2016;167:1264-1280.e18 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4
  • western blot; mouse; loading ...; fig 2a
Oben K, Gachuki B, Alhakeem S, McKenna M, Liang Y, St Clair D, et al. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1). PLoS ONE. 2017;12:e0169767 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6a
Hu M, Chen S, Wang B, Ou T, Gu L, Tan J, et al. Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Res. 2017;45:1606-1618 pubmed publisher
  • western blot; human; loading ...; fig 4c
Huang Z, Zhou X, He Y, Ke X, Wen Y, Zou F, et al. Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. Sci Rep. 2016;6:38072 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:480; fig 4F
Kostrzak A, Caval V, Escande M, Pliquet E, Thalmensi J, Bestetti T, et al. APOBEC3A intratumoral DNA electroporation in mice. Gene Ther. 2017;24:74-83 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1b
Kim E, Davidson L, Zoh R, Hensel M, Salinas M, Patil B, et al. Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. Cell Death Dis. 2016;7:e2460 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s4b
  • immunocytochemistry; mouse; 1:500
Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, et al. In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016;7:13304 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 4b
Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016;7:71841-71855 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1c
Narayanaswamy P, Tkachuk S, Haller H, Dumler I, Kiyan Y. CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Cell Death Dis. 2016;7:e2383 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Jayapal S, Ang H, Wang C, Bisteau X, Caldez M, Xuan G, et al. Cyclin A2 regulates erythrocyte morphology and numbers. Cell Cycle. 2016;15:3070-3081 pubmed
  • immunocytochemistry; rat; loading ...; fig 9c
Hayes H, Zhang L, Becker T, Haldeman J, Stephens S, Arlotto M, et al. A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. Mol Cell Biol. 2016;36:2918-2930 pubmed publisher
  • flow cytometry; human; fig 5f
Muller Durovic B, Lanna A, Covre L, Mills R, Henson S, Akbar A. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. J Immunol. 2016;197:2891-2899 pubmed publisher
  • western blot; human; fig s2a
Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, et al. ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy. 2016;12:2167-2182 pubmed
  • immunocytochemistry; human; loading ...; fig 5b
  • western blot; human; loading ...; fig 5a
Chien J, Tsen S, Chien C, Liu H, Tung C, Lin C. ?TAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells. Cell Death Discov. 2016;2:16006 pubmed publisher
  • flow cytometry; human; loading ...; fig 2f
Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners K, Shatnyeva O, et al. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017;36:933-941 pubmed publisher
  • western blot; human; fig 2
Ah Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4
Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, et al. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun. 2016;7:12235 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 7
Gygli P, Chang J, Gokozan H, Catacutan F, Schmidt T, Kaya B, et al. Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY). 2016;8:1540-70 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1e
Hewitt G, Carroll B, Sarallah R, Correia Melo C, Ogrodnik M, Nelson G, et al. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 2016;12:1917-1930 pubmed
  • western blot; human; 1:1000; loading ...; fig 3f
Heckler M, Zeleke T, Divekar S, Fernandez A, Tiek D, Woodrick J, et al. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget. 2016;7:47201-47220 pubmed publisher
  • western blot; human; 1:1000; fig 2
Bristol M, Wang X, Smith N, Son M, Evans M, Morgan I. DNA Damage Reduces the Quality, but Not the Quantity of Human Papillomavirus 16 E1 and E2 DNA Replication. Viruses. 2016;8: pubmed publisher
  • western blot; human; loading ...; fig 3c
Ono H, Basson M, Ito H. P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer. Oncotarget. 2016;7:51301-51310 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 6d
Yard B, Adams D, Chie E, Tamayo P, Battaglia J, Gopal P, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nat Commun. 2016;7:11428 pubmed publisher
  • flow cytometry; human; fig 5
Rebolleda N, Losada Fernandez I, Perez Chacon G, Castejon R, Rosado S, Morado M, et al. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS ONE. 2016;11:e0154159 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s1d
Del Bel Belluz L, Guidi R, Pateras I, Levi L, Mihaljevic B, Rouf S, et al. The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection. PLoS Pathog. 2016;12:e1005528 pubmed publisher
  • western blot; human; fig 1
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  • immunohistochemistry; human; 1:250; fig 4
Jun S, Jung Y, Suh H, Wang W, Kim M, Oh Y, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016;7:10994 pubmed publisher
  • immunocytochemistry; human; fig 4
Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, et al. Influence of aging on the quantity and quality of human cardiac stem cells. Sci Rep. 2016;6:22781 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 4
Nair S, Zhang X, Chiang H, Jahid M, Wang Y, Garza P, et al. Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun. 2016;7:10913 pubmed publisher
  • western blot; human; fig 1b
Kemp M, Sancar A. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. J Biol Chem. 2016;291:9330-42 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig s2
Valenzuela N, Fan Q, Fa ak F, Soibam B, Nagandla H, Liu Y, et al. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016;9:335-45 pubmed publisher
  • western blot; human; fig 1
Pecháčková S, Burdova K, Benada J, Kleiblova P, Jenikova G, Macurek L. Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget. 2016;7:14458-75 pubmed publisher
  • flow cytometry; mouse; fig 3
Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660 pubmed publisher
  • western blot; human; 1:1000
Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed publisher
  • western blot; mouse; fig 1
Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, et al. cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation. Sci Rep. 2016;6:20930 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4d
  • western blot; human; loading ...; fig 4c
Preet R, Siddharth S, Satapathy S, Das S, Nayak A, Das D, et al. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016;105:23-33 pubmed publisher
  • western blot; mouse; fig 3
Zhao B, Tan T, Mei Y, Yang J, Yu Y, Verma A, et al. H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Sci Rep. 2016;6:19589 pubmed publisher
  • immunocytochemistry; human; fig 2
Choi Y, Meghani K, Brault M, Leclerc L, He Y, Day T, et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016;14:429-439 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 5
  • western blot; mouse; 1:1000; fig 5
Ma X, Lin F, Wang Z, Hu M, Huang L, Meng T, et al. Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility. Mol Biol Cell. 2016;27:768-75 pubmed publisher
  • western blot; mouse; fig 4
Li W, Zou J, Yue F, Song K, Chen Q, McKeehan W, et al. Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell. 2016;15:370-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 8d
  • western blot; human; loading ...; fig 5c
García V, Lara Chica M, Cantarero I, Sterner O, Calzado M, Muñoz E. Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget. 2016;7:4490-506 pubmed publisher
  • western blot; human; fig 2
Abu Odeh M, Hereema N, Aqeilan R. WWOX modulates the ATR-mediated DNA damage checkpoint response. Oncotarget. 2016;7:4344-55 pubmed publisher
  • immunocytochemistry; human; fig 5
  • western blot; human; fig 5
Ceccon M, Merlo M, Mologni L, Poggio T, Varesio L, Menotti M, et al. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. 2016;35:3854-3865 pubmed publisher
  • western blot; human; 1:1000
Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, et al. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016;18:202-12 pubmed publisher
  • western blot; human; fig 5
Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher
  • western blot; human; fig 2
Waye S, Naeem A, Choudhry M, Parasido E, Tricoli L, Sivakumar A, et al. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY). 2015;7:854-68 pubmed
  • immunocytochemistry; African green monkey; 1:80; fig 2
Bridoux L, Deneyer N, Bergiers I, Rezsohazy R. Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. PLoS ONE. 2015;10:e0141347 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 8
Geister K, Brinkmeier M, Cheung L, Wendt J, Oatley M, Burgess D, et al. LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. PLoS Genet. 2015;11:e1005569 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5a
  • western blot; human; 1:1000; loading ...; fig 4c, d
Xiong Y, Su H, Lv P, Ma Y, Wang S, Miao H, et al. A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region. Oncotarget. 2015;6:35625-35 pubmed publisher
  • immunohistochemistry; human; fig 4a
Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, et al. The role of APC/C(Cdh1) in replication stress and origin of genomic instability. Oncogene. 2016;35:3062-70 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig 1
  • immunohistochemistry; mouse; 1:50; fig 1
  • western blot; mouse; 1:5000; fig 1
Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
  • western blot; human; fig 7
Birch J, Anderson R, Correia Melo C, Jurk D, Hewitt G, Marques F, et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1124-37 pubmed publisher
  • immunocytochemistry; human; fig 5
  • western blot; human; fig 6
Bouley J, Saad L, Grall R, Schellenbauer A, Biard D, Paget V, et al. A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines. Oncotarget. 2015;6:27980-8000 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1a
Weaver A, Cooper T, Rodriguez M, Trummell H, Bonner J, Rosenthal E, et al. DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma. Oncotarget. 2015;6:26995-7007 pubmed publisher
  • immunocytochemistry; human; 1:400
He X, Zhang P. Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair. Mol Cancer. 2015;14:158 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6a
Pajoohesh Ganji A, Pal Ghosh S, Tadvalkar G, Kyne B, Saban D, Stepp M. Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Lab Invest. 2015;95:1305-18 pubmed publisher
  • immunocytochemistry; human; 1:400; fig st1
Jones A, Gokhale P, Allison T, Sampson B, Athwal S, Grant S, et al. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep. 2015;5:11694 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Jang C, Shibata Y, Starmer J, Yee D, Magnuson T. Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 2015;29:1377-92 pubmed publisher
  • western blot; human; fig 3
Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 4
Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016;35:1541-53 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
  • western blot; human; 1:1000; fig 4
Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Masuda Y, Takahashi H, Sato S, Tomomori Sato C, Saraf A, Washburn M, et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun. 2015;6:7299 pubmed publisher
  • western blot; human; 1:5000
Tu Z, Xu B, Qu C, Tao Y, Chen C, Hua W, et al. BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro. Radiat Oncol. 2015;10:123 pubmed publisher
  • immunocytochemistry; human; fig 2
Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed publisher
  • western blot; human; fig 5
Cruz Bermúdez A, Vallejo C, Vicente Blanco R, Gallardo M, Fernández Moreno M, Quintanilla M, et al. Enhanced tumorigenicity by mitochondrial DNA mild mutations. Oncotarget. 2015;6:13628-43 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6
Wilson C, Jurk D, Fullard N, Banks P, Page A, Luli S, et al. NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818 pubmed publisher
  • western blot; human; 1:400; fig 1
Raymond A, Benhamouche S, Neaud V, Di Martino J, Javary J, Rosenbaum J. Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma. PLoS ONE. 2015;10:e0123333 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; fig s8
Ngo J, Matsuyama M, Kim C, Poventud Fuentes I, Bates A, Siedlak S, et al. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death Dis. 2015;6:e1706 pubmed publisher
  • immunohistochemistry; human; fig 4
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig s2
Gergics P, Brinkmeier M, Camper S. Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015;29:597-612 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 3
Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed publisher
  • western blot; human; fig s1
Jeong H, Gil N, Lee H, Cho S, Kim K, Chun K, et al. Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression. J Cell Biochem. 2015;116:1602-12 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3
Gao X, Ma W, Nie J, Zhang C, Zhang J, Yao G, et al. A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis. 2015;6:e1610 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Brand S, Amann K, Mandel P, Zimnol A, Schupp N. Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors. PLoS ONE. 2014;9:e115715 pubmed publisher
  • immunohistochemistry; mouse
Nikolaou K, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, et al. Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015;34:430-47 pubmed publisher
  • flow cytometry; human; 1:50; loading ...; fig 3i
Greve K, Lindgreen J, Terp M, Pedersen C, Schmidt S, Mollenhauer J, et al. Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. Mol Oncol. 2015;9:437-49 pubmed publisher
  • western blot; human; fig 4
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed publisher
  • western blot; human; fig 4
Moskwa P, Zinn P, Choi Y, Shukla S, Fendler W, Chen C, et al. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014;12:1767-78 pubmed publisher
  • western blot; human; fig 3b
Harashima N, Minami T, Uemura H, Harada M. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer. 2014;13:217 pubmed publisher
  • western blot; human
Kaistha B, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, et al. Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells. Br J Cancer. 2014;111:1780-7 pubmed publisher
  • western blot; human
Clewell R, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen P, et al. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci. 2014;142:56-73 pubmed publisher
  • western blot; mouse
  • western blot; rat
  • western blot; human
Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Choi Y, Pan Y, Park E, Konstantinopoulos P, De S, D ANDREA A, et al. MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability. elife. 2014;3:e02445 pubmed publisher
  • western blot; human; 1:1000
Stimpson K, Sullivan L, Kuo M, Sullivan B. Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. PLoS ONE. 2014;9:e92432 pubmed publisher
  • western blot; human
Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher
  • western blot; mouse
Schweikl H, Petzel C, Bolay C, Hiller K, Buchalla W, Krifka S. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. 2014;35:2890-904 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Sharma N, Zhu Q, Wani G, He J, Wang Q, Wani A. USP3 counteracts RNF168 via deubiquitinating H2A and ?H2AX at lysine 13 and 15. Cell Cycle. 2014;13:106-14 pubmed publisher
  • western blot; human
Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher
  • western blot; human; fig 4
  • western blot; rat
Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher
  • immunocytochemistry; human
Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher
  • immunocytochemistry; mouse
Zimmermann M, Lottersberger F, Buonomo S, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science. 2013;339:700-4 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed publisher
  • immunocytochemistry; human; 1:1000
Gao M, Rendtlew Danielsen J, Wei L, Zhou D, Xu Q, Li M, et al. A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity. PLoS ONE. 2012;7:e49687 pubmed publisher
  • immunocytochemistry; human
Orzáez M, Guevara T, Sancho M, Perez Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher
  • western blot; human; fig 3
Lovric M, Hawkins C. TRAIL treatment provokes mutations in surviving cells. Oncogene. 2010;29:5048-60 pubmed publisher
Rockfield S, Flores I, Nanjundan M. Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Oncotarget. 2018;9:5344-5367 pubmed publisher
Su Y, Chen R, Wang H, Song H, Zhang Q, Chen L, et al. Novel Targeting of Transcription and Metabolism in Glioblastoma. Clin Cancer Res. 2018;24:1124-1137 pubmed publisher
Wang Y, Hariharan A, Bastianello G, Toyama Y, Shivashankar G, Foiani M, et al. DNA damage causes rapid accumulation of phosphoinositides for ATR signaling. Nat Commun. 2017;8:2118 pubmed publisher
Venkataramani V, Küffer S, Cheung K, Jiang X, Trumper L, Wulf G, et al. CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas. Clin Cancer Res. 2018;24:460-473 pubmed publisher
Hai J, Liu S, Bufe L, Do K, Chen T, Wang X, et al. Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers. Clin Cancer Res. 2017;23:6993-7005 pubmed publisher
Liu L, He J, Wei X, Wan G, Lao Y, Xu W, et al. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017;36:5874-5884 pubmed publisher
Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, et al. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 2017;36:2161-2176 pubmed publisher
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017;546:168-172 pubmed publisher
Yang H, Wang H, Ren J, Chen Q, Chen Z. cGAS is essential for cellular senescence. Proc Natl Acad Sci U S A. 2017;114:E4612-E4620 pubmed publisher
Nyquist M, Corella A, Burns J, Coleman I, Gao S, Tharakan R, et al. Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155. Mol Cancer Res. 2017;15:521-531 pubmed publisher
Day T, Layer J, Cleary J, Guha S, Stevenson K, Tivey T, et al. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun. 2017;8:15110 pubmed publisher
Barr A, Cooper S, Heldt F, Butera F, Stoy H, Mansfeld J, et al. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun. 2017;8:14728 pubmed publisher
Chen X, Clark J, Wunderlich M, Fan C, Davis A, Chen S, et al. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy. 2017;13:955-966 pubmed publisher
Duan T, Sun W, Zhang M, Ge J, He Y, Zhang J, et al. Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile. Sci Rep. 2017;7:43745 pubmed publisher
Oh T, Yun J, Park E, Kim Y, Lee Y, Lim J. Plumbagin Suppresses ?-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity. Int J Mol Sci. 2017;18: pubmed publisher
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, et al. Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. J Cell Biol. 2017;216:409-424 pubmed publisher
Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
Connelly K, Martin E, Dykhuizen E. CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme. Yale J Biol Med. 2016;89:431-440 pubmed
Swidnicka Siergiejko A, Gomez Chou S, Cruz Monserrate Z, Deng D, Liu Y, Huang H, et al. Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53. Oncogene. 2017;36:3149-3158 pubmed publisher
Hu M, Meng T, Jiang Z, Dong M, Schatten H, Xu X, et al. Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. 2016;12:e1006513 pubmed publisher
Sokolova M, Turunen M, Mortusewicz O, Kivioja T, Herr P, Vähärautio A, et al. Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle. 2017;16:189-199 pubmed publisher
Pawlak A, Ziolo E, Fiedorowicz A, Fidyt K, Strzadala L, Kalas W. Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors. BMC Cancer. 2016;16:893 pubmed
Fedoseienko A, Wieringa H, Wisman G, Duiker E, Reyners A, Hofker M, et al. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PLoS ONE. 2016;11:e0165385 pubmed publisher
Potapova T, Seidel C, Box A, Rancati G, Li R. Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell. 2016;27:3065-3084 pubmed
Cruickshank M, Ford J, Cheung L, Heng J, Singh S, Wells J, et al. Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin. Leukemia. 2017;31:40-50 pubmed publisher
Zhao C, Chen X, Zang D, Lan X, Liao S, Yang C, et al. Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy. Biochem Pharmacol. 2016;116:22-38 pubmed publisher
Wang H, Feng W, Lu Y, Li H, Xiang W, Chen Z, et al. Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide. Sci Rep. 2016;6:28948 pubmed publisher
Sriraman A, Radovanović M, Wienken M, Najafova Z, Li Y, Dobbelstein M. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity. Oncotarget. 2016;7:31623-38 pubmed publisher
Harrison J, Wang X, Studzinski G. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7:36447-36460 pubmed publisher
Lipinski K, Britschgi C, Schrader K, Christinat Y, Frischknecht L, Krek W. Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. Oncotarget. 2016;7:29635-47 pubmed publisher
Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher
Miller C, Muthupalani S, Shen Z, Drees F, Ge Z, Feng Y, et al. Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. PLoS ONE. 2016;11:e0152940 pubmed publisher
Moles A, Butterworth J, Sanchez A, Hunter J, Leslie J, Sellier H, et al. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. Oncogene. 2016;35:4623-32 pubmed publisher
Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed publisher
Lee M, Oprea Ilies G, Saavedra H. Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis. Oncotarget. 2015;6:37316-34 pubmed publisher
Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, et al. Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015;17:1036-48 pubmed publisher
Black J, Harrell J, Leisner T, Fellmeth M, George S, Reinhold D, et al. CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. Breast Cancer Res Treat. 2015;152:337-46 pubmed publisher
Mei Y, Wang Y, Kumari P, Shetty A, Clark D, Gable T, et al. A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells. Nat Commun. 2015;6:7316 pubmed publisher
Spurlock C, Tossberg J, Olsen N, Aune T. Cutting Edge: Chronic NF-κB Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles. J Immunol. 2015;195:791-5 pubmed publisher
Sasi S, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, et al. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int. 2015;2015:496512 pubmed publisher
Ahmad T, Sundar I, Lerner C, Gerloff J, Tormos A, Yao H, et al. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 2015;29:2912-29 pubmed publisher
Augello M, Berman Booty L, Carr R, Yoshida A, Dean J, Schiewer M, et al. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015;7:628-47 pubmed publisher
Cheung J, Dickinson D, Moss J, Schuler M, Spellman R, Heard P. Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay. Mutat Res Genet Toxicol Environ Mutagen. 2015;777:7-16 pubmed publisher
Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed publisher
Shen H, Decollogne S, Dilda P, Hau E, Chung S, Luk P, et al. Dual-targeting of aberrant glucose metabolism in glioblastoma. J Exp Clin Cancer Res. 2015;34:14 pubmed publisher
Kang J, Han M, Kim G, Kim C, Chung H, Hwang H, et al. Schisandrae semen essential oil attenuates oxidative stress-induced cell damage in C2C12 murine skeletal muscle cells through Nrf2‑mediated upregulation of HO‑1. Int J Mol Med. 2015;35:453-9 pubmed publisher
Insolera R, Bazzi H, Shao W, Anderson K, Shi S. Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014;17:1528-35 pubmed publisher
Tan P, Du S, Ren C, Yao Q, Zheng R, Li R, et al. MicroRNA-207 enhances radiation-induced apoptosis by directly targeting Akt3 in cochlea hair cells. Cell Death Dis. 2014;5:e1433 pubmed publisher
Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, et al. DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells. J Biol Chem. 2014;289:27314-26 pubmed publisher
Kilic Eren M, Tabor V. The role of hypoxia inducible factor-1 alpha in bypassing oncogene-induced senescence. PLoS ONE. 2014;9:e101064 pubmed publisher
Hall M, Telma K, Chang K, Lee T, Madigan J, Lloyd J, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74:3913-22 pubmed publisher
Choi Y, Battelli C, Watson J, Liu J, Curtis J, Morse A, et al. Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. Oncotarget. 2014;5:2678-87 pubmed
Airik R, Slaats G, Guo Z, Weiss A, Khan N, Ghosh A, et al. Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling. J Am Soc Nephrol. 2014;25:2573-83 pubmed publisher
Sasi S, Song J, Park D, Enderling H, McDonald J, Gee H, et al. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2014;289:14178-93 pubmed publisher
Guevara T, Sancho M, Perez Paya E, Orzáez M. Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells. Cell Cycle. 2014;13:1617-26 pubmed publisher
Yu Z, Xu Z, Disante G, Wright J, Wang M, Li Y, et al. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. 2014;5:1083-90 pubmed
Leung J, Agarwal P, Canny M, Gong F, Robison A, Finkelstein I, et al. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014;10:e1004178 pubmed publisher
Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, et al. Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem. 2014;289:5730-46 pubmed publisher
Lambert L, Walker S, Feltham J, Lee H, Reik W, Houseley J. Etoposide induces nuclear re-localisation of AID. PLoS ONE. 2013;8:e82110 pubmed publisher
Nasuno T, Mimaki S, Okamoto M, Esumi H, Tsuchihara K. Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. Cancer Sci. 2014;105:202-10 pubmed publisher
Ellis L, Ku S, Ramakrishnan S, Lasorsa E, Azabdaftari G, Godoy A, et al. Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer. Oncotarget. 2013;4:2225-36 pubmed
Bakkenist C, Czambel R, Clump D, Greenberger J, Beumer J, Schmitz J. Radiation therapy induces the DNA damage response in peripheral blood. Oncotarget. 2013;4:1143-8 pubmed
Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS ONE. 2013;8:e66558 pubmed publisher
Sun B, Ross S, Trask O, Carmichael P, Dent M, White A, et al. Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Toxicol In Vitro. 2013;27:1877-87 pubmed publisher
Hirashima K, Migita T, Sato S, Muramatsu Y, Ishikawa Y, Seimiya H. Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol. 2013;33:2988-95 pubmed publisher
Ganapathy S, Xiao S, Seo S, Lall R, Yang M, Xu T, et al. Low-dose arsenic induces chemotherapy protection via p53/NF-?B-mediated metabolic regulation. Oncogene. 2014;33:1359-66 pubmed publisher
Neelsen K, Zanini I, Herrador R, Lopes M. Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol. 2013;200:699-708 pubmed publisher
Legrand A, Choul Li S, Spriet C, Idziorek T, Vicogne D, Drobecq H, et al. The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage. PLoS ONE. 2013;8:e55883 pubmed publisher
Hewish M, Martin S, Elliott R, Cunningham D, Lord C, Ashworth A. Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress. Br J Cancer. 2013;108:983-92 pubmed publisher
Lu H, Hu L, Li T, Lahiri S, Shen C, Wason M, et al. A novel role of Krüppel-like factor 8 in DNA repair in breast cancer cells. J Biol Chem. 2012;287:43720-9 pubmed publisher
Ruan J, Liao Y, Lua I, Li M, Hsu C, Chen J. Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells. Breast Cancer Res. 2012;14:R106 pubmed publisher
Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem. 2012;287:18937-52 pubmed publisher
Wei S, Xiong M, Zhan D, Liang B, Wang Y, Gutmann D, et al. Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway. Carcinogenesis. 2012;33:538-47 pubmed publisher
Driskell I, Oda H, Blanco S, Nascimento E, Humphreys P, Frye M. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J. 2012;31:616-29 pubmed publisher
Carragher L, Snell K, Giblett S, Aldridge V, Patel B, Cook S, et al. V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med. 2010;2:458-71 pubmed publisher
Kawamura T, Suzuki J, Wang Y, Menendez S, Morera L, Raya A, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009;460:1140-4 pubmed publisher
product information
SKU :
9718S
Product-Name :
Phospho-Histone H2A.X (Ser139) (20E3) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
15
Host :
Rabbit
Target :
H2AX (Ser140) phosphate
Primary-Protein :
H2AX
Alt-Names :
H2A histone family, member X,H2A.X,H2AFX,H2AX,H2AX histone,H2a/x,Histone H2A.x
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.