product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Caspase-3 (8G10) Rabbit mAb
catalog :
9665
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
8G10
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 207
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5h
Rinastiti P, Ikeda K, Rahardini E, Miyagawa K, Tamada N, Kuribayashi Y, et al. Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition. PLoS ONE. 2020;15:e0226049 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher
  • western blot; mouse; loading ...; fig s2d
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer K, Cedillo L, et al. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell. 2019;177:299-314.e16 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Wang S, Liu A, Wu G, Ding H, Huang S, Nahman S, et al. The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation. Nat Commun. 2018;9:1234 pubmed publisher
  • western blot; human; loading ...; fig 9b
Yin R, Guo L, Gu J, Li C, Zhang W. Over expressing miR-19b-1 suppress breast cancer growth by inhibiting tumor microenvironment induced angiogenesis. Int J Biochem Cell Biol. 2018;97:43-51 pubmed publisher
  • western blot; human; loading ...; fig 3f
Shuang W, Hou L, Zhu Y, Li Q, Hu W. Mcl-1 stabilization confers resistance to taxol in human gastric cancer. Oncotarget. 2017;8:82981-82990 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1h
Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Lang M, Jenkins S, Balzano P, Owoyele A, Patel A, Bamezai A. Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4+ T-cell lines. Immun Inflamm Dis. 2017;5:448-460 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
  • western blot; mouse; loading ...; fig 2
Lan P, Fan Y, Zhao Y, Lou X, Monsour H, Zhang X, et al. TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017;127:2222-2234 pubmed publisher
  • western blot; human; loading ...; fig 7a
Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, et al. Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2017;5:363-375 pubmed publisher
  • western blot; human; loading ...; fig 2c
Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, et al. RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res. 2017;45:4590-4605 pubmed publisher
  • western blot; human; loading ...; fig 3f
Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher
  • western blot; mouse; 1:1000; fig 4h
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  • western blot; mouse; fig 2b
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher
  • western blot; mouse; fig 4b
Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
  • western blot; human; fig 4c
Mori J, Tanikawa C, Ohnishi N, Funauchi Y, Toyoshima O, Ueda K, et al. EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Neoplasia. 2017;19:185-195 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Cai L, Wang H, Yang Q. CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma. Oncol Lett. 2017;13:51-56 pubmed publisher
  • western blot; human; loading ...; fig 2d
Cao H, Yu S, Chen D, Jing C, Wang Z, Ma R, et al. Liver X receptor agonist T0901317 reverses resistance of A549 human lung cancer cells to EGFR-TKI treatment. FEBS Open Bio. 2017;7:35-43 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6e
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3e
Muranen T, Iwanicki M, Curry N, Hwang J, DuBois C, Coloff J, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989 pubmed publisher
  • western blot; human; loading ...; fig 4b
Janakiraman H, House R, Talwar S, Courtney S, Hazard E, Hardiman G, et al. Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. Oncogene. 2017;36:3137-3148 pubmed publisher
  • western blot; human; fig 5a
Okondo M, Johnson D, Sridharan R, Go E, Chui A, Wang M, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017;13:46-53 pubmed publisher
  • western blot; human; loading ...; fig 2b
Shi D, Liu Y, Xi R, Zou W, Wu L, Zhang Z, et al. Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells. Int J Nanomedicine. 2016;11:5823-5835 pubmed
  • western blot; human; fig 3c
Park J, Lee C, Kim H, Kim D, Son J, Ko E, et al. Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling. Oncotarget. 2016;7:83308-83318 pubmed publisher
  • western blot; mouse; loading ...; fig s3c
Tahmasebi S, Jafarnejad S, Tam I, Gonatopoulos Pournatzis T, Matta Camacho E, Tsukumo Y, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016;113:12360-12367 pubmed
  • western blot; human; 1:1000; fig s5c
Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
  • western blot; rat; loading ...; fig 5b
Ulbrich F, Kaufmann K, Meske A, Lagrèze W, Augustynik M, Buerkle H, et al. The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells. PLoS ONE. 2016;11:e0165182 pubmed publisher
  • western blot; human; loading ...; fig 2d
Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, et al. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Mol Med Rep. 2016;14:4559-4566 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
  • western blot; human; loading ...; fig 1a
Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. Mol Cell Biol. 2016;36:3010-3018 pubmed
  • western blot; human; 1:2000; loading ...; fig 6c
Cao R, Meng Z, Liu T, Wang G, Qian G, Cao T, et al. Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway. Oncotarget. 2016;7:72941-72960 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7d
Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed publisher
  • western blot; human; 1:1000; fig 1
Anta B, Pérez Rodríguez A, Castro J, García Domínguez C, Ibiza S, Martínez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher
  • western blot; human; fig 7
Jeong H, Cho Y, Kim K, Kim Y, Kim K, Na Y, et al. Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. BMC Complement Altern Med. 2016;16:239 pubmed publisher
  • western blot; human; 1:1000; fig 2
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, et al. A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria. Mol Med Rep. 2016;14:1970-8 pubmed publisher
  • western blot; human; 1:1000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • western blot; mouse; fig 7
Roychowdhury S, McCullough R, Sanz Garcia C, Saikia P, Alkhouri N, Matloob A, et al. Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. Hepatology. 2016;64:1518-1533 pubmed publisher
  • western blot; human; 1:1000; fig 1
Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y. Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep. 2016;14:655-60 pubmed publisher
  • western blot; human; 1:1000; fig 2
Maza P, Suzuki E. Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment. Front Microbiol. 2016;7:580 pubmed publisher
  • western blot; human; loading ...; fig 2c
Wang W, Zhan M, Li Q, Chen W, Chu H, Huang Q, et al. FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. Oncotarget. 2016;7:34617-29 pubmed publisher
  • western blot; human; loading ...; fig 2d
Zhang Y, Shen L, Stupack D, Bai N, Xun J, Ren G, et al. JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget. 2016;7:29387-99 pubmed publisher
  • western blot; rat; 1:500; fig 3
Negis Y, Karabay A. Expression of cell cycle proteins in cortical neurons-Correlation with glutamate-induced neurotoxicity. Biofactors. 2016;42:358-67 pubmed publisher
  • western blot; rat; fig 1
Hong M, Nam K, Kim K, Kim S, Kim I. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016;21:485-97 pubmed publisher
  • western blot; human; 1:1000; fig s8
Yan Y, Tan K, Li C, Tran T, Chao S, Sugrue R, et al. Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro. J Allergy Clin Immunol. 2016;138:276-281.e15 pubmed publisher
  • western blot; human; loading ...; fig 5b
Draney C, Hobson A, Grover S, Jack B, Tessem J. Cdk5r1 Overexpression Induces Primary β-Cell Proliferation. J Diabetes Res. 2016;2016:6375804 pubmed publisher
  • western blot; human; loading ...; fig 6c
Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Park K, Yun H, Quang T, Oh H, Lee D, Auh Q, et al. 4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway. Oncotarget. 2016;7:6960-71 pubmed publisher
  • western blot; human; 1:500; fig 5
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
  • western blot; human; fig 5
Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. 2016;7:4062-76 pubmed publisher
  • western blot; human; loading ...; fig 2a
García V, Lara Chica M, Cantarero I, Sterner O, Calzado M, Muñoz E. Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget. 2016;7:4490-506 pubmed publisher
  • western blot; mouse; fig 3
Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3h
Dahlke C, Saberi D, Ott B, Brand Saberi B, Schmitt John T, Theiss C. Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model. J Neuroinflammation. 2015;12:215 pubmed publisher
  • western blot; mouse; fig 1
  • western blot; human; fig 1
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher
  • western blot; human; fig 1
Ahn H, Kim K, Shin K, Lim K, Kim J, Lee J, et al. Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells. Oncotarget. 2015;6:44523-37 pubmed publisher
  • western blot; human; fig 5
Zhou X, Wei J, Chen F, Xiao X, Huang T, He Q, et al. Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma. Oncotarget. 2015;6:41077-91 pubmed publisher
  • western blot; human; 1:1000; fig 2
  • western blot; mouse; 1:1000; fig 3
Kyathanahalli C, Organ K, Moreci R, Anamthathmakula P, Hassan S, Caritis S, et al. Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci U S A. 2015;112:14090-5 pubmed publisher
  • western blot; human; fig 5
Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, et al. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015;4:e173 pubmed publisher
  • western blot; rat; fig 2
Nichols C, Shepherd D, Knuckles T, Thapa D, Stricker J, Stapleton P, et al. Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter. Am J Physiol Heart Circ Physiol. 2015;309:H2017-30 pubmed publisher
  • western blot; human; loading ...; fig 6d
Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, et al. Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget. 2015;6:38079-92 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 7c
Guo W, Zhang Y, Ling Z, Liu X, Zhao X, Yuan Z, et al. Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner. Cell Death Dis. 2015;6:e1919 pubmed publisher
  • western blot; human; fig 6
Spiesberger K, Paulfranz F, Egger A, Reiser J, Vogl C, Rudolf Scholik J, et al. Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle. PLoS ONE. 2015;10:e0140471 pubmed publisher
  • western blot; human; fig s1
Courtaut F, Derangère V, Chevriaux A, Ladoire S, Cotte A, Arnould L, et al. Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization. Oncotarget. 2015;6:26651-62 pubmed publisher
  • western blot; human
Mattiolo P, Yuste V, Boix J, Ribas J. Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation. Biochem Pharmacol. 2015;98:573-86 pubmed publisher
  • western blot; mouse; loading ...; fig s4f
Sorrell S, Golder Z, Johnstone D, Frankl F. Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis. Kidney Int. 2016;89:105-112 pubmed publisher
  • western blot; human; fig 1b
Barros B, Maza P, Alcantara C, Suzuki E. Paracoccidioides brasiliensis induces recruitment of α3 and α5 integrins into epithelial cell membrane rafts, leading to cytokine secretion. Microbes Infect. 2016;18:68-77 pubmed publisher
  • western blot; human; fig 4
Machado Neto J, de Melo Campos P, Favaro P, Lazarini M, da Silva Santos Duarte A, Lorand Metze I, et al. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells. Oncotarget. 2015;6:29573-84 pubmed publisher
  • western blot; human; 1:1000; fig s7
Cañeque T, Gomes F, Mai T, Maestri G, Malacria M, Rodriguez R. Synthesis of marmycin A and investigation into its cellular activity. Nat Chem. 2015;7:744-51 pubmed publisher
  • western blot; human; 1:800; fig 5d
Iansante V, Choy P, Fung S, Liu Y, Chai J, Dyson J, et al. PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. Nat Commun. 2015;6:7882 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4b
Marzagalli M, Casati L, Moretti R, Montagnani Marelli M, Limonta P. Estrogen Receptor β Agonists Differentially Affect the Growth of Human Melanoma Cell Lines. PLoS ONE. 2015;10:e0134396 pubmed publisher
  • western blot; human; loading ...; fig 3c, 4a
Yang S, Lin H, Chang V, Chen C, Liu Y, Wang J, et al. Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo. Oncotarget. 2015;6:23857-73 pubmed
  • western blot; human; fig 2
Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  • western blot; human; fig 6
Shan C, Lin J, Hou J, Liu H, Chen S, Chen A, et al. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule. Nucleic Acids Res. 2015;43:6677-91 pubmed publisher
  • western blot; mouse
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16:859-70 pubmed publisher
  • western blot; human; loading ...; fig 4K
Wiersma V, de Bruyn M, Wei Y, van Ginkel R, Hirashima M, Niki T, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11:1373-88 pubmed publisher
  • western blot; human
Moon J, Eo S, Lee J, Park S. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375-81 pubmed publisher
  • western blot; human
Fisher M, Keillor J, Xu W, Eckert R, Kerr C. Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival. Mol Cancer Res. 2015;13:1083-94 pubmed publisher
  • western blot; human
Maity G, De A, Das A, Banerjee S, Sarkar S, Banerjee S. Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition. Lab Invest. 2015;95:702-17 pubmed publisher
  • western blot; human; fig s5
Xia X, Gholkar A, Senese S, Torres J. A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size. Cell Cycle. 2015;14:1938-47 pubmed publisher
  • western blot; rat; 1:1000
Ding Y, Xu Y, Shuai X, Shi X, Chen X, Huang W, et al. Reg3? Overexpression Protects Pancreatic ? Cells from Cytokine-Induced Damage and Improves Islet Transplant Outcome. Mol Med. 2015;20:548-558 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Wong M, Nicholson C, Holloway A, Hardy D. Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta. PLoS ONE. 2015;10:e0122295 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
  • western blot; human; 1:1000; fig 3c
Wei Z, Yu D, Bi Y, Cao Y. A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. Mol Med Rep. 2015;12:63-70 pubmed publisher
  • western blot; human; fig s1
Morlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisher
  • western blot; mouse; fig 8f
Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy. 2015;11:271-84 pubmed publisher
  • western blot; human; fig s4
Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher
  • western blot; human; 1:1000
Tao Y, Xu L, Lu J, Hu S, Fang F, Cao L, et al. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia. J Exp Clin Cancer Res. 2015;34:4 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5A
Xiao Y, Ma C, Yi J, Wu S, Luo G, Xu X, et al. Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression. Physiol Rep. 2015;3: pubmed publisher
  • western blot; human; fig 6b
Wang S, Geng Z, Shi N, Li X, Wang Z. Dose-dependent effects of selenite (Se(4+)) on arsenite (As(3+))-induced apoptosis and differentiation in acute promyelocytic leukemia cells. Cell Death Dis. 2015;6:e1596 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1A
Xia J, Chen S, Lv Y, Lu L, Hu W, Zhou Y. ZGDHu-1 induces Gâ‚‚/M phase arrest and apoptosis in Kasumi-1 cells. Mol Med Rep. 2015;11:3398-404 pubmed publisher
  • western blot; mouse; fig 1
Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M. Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis. 2015;6:e1587 pubmed publisher
  • western blot; rat; fig 1f
Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher
  • western blot; human; 1:1000
Zanotto Filho A, Braganhol E, Klafke K, Figueiró F, Terra S, Paludo F, et al. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett. 2015;358:220-31 pubmed publisher
  • western blot; rat; fig 1
  • western blot; mouse; fig s1
Wang S, Park S, Kodali V, Han J, Yip T, Chen Z, et al. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell. 2015;26:594-604 pubmed publisher
  • western blot; human; loading ...; fig 3a
Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher
  • western blot; mouse; loading ...; fig s7c
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3
  • western blot; human; fig 5
Guo L, Shen Y, Zhao X, Guo L, Yu Z, Wang D, et al. Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. Phytother Res. 2015;29:357-65 pubmed publisher
  • western blot; human; 1:1000
Dejos C, Voisin P, Bernard M, Régnacq M, Bergès T. Canthin-6-one displays antiproliferative activity and causes accumulation of cancer cells in the G2/M phase. J Nat Prod. 2014;77:2481-7 pubmed publisher
  • western blot; human; fig 6
Li S, Song Y, Zhang H, Jin B, Liu Y, Liu W, et al. UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer. Sci Rep. 2014;4:6910 pubmed publisher
  • western blot; mouse; fig 4
Lin H, Lin S, Chung Y, Vonderfecht S, Camden J, Flodby P, et al. Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis. 2014;5:e1478 pubmed publisher
  • western blot; human
Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. 2014;5:7540-8 pubmed
  • western blot; human; fig 4
Moskwa P, Zinn P, Choi Y, Shukla S, Fendler W, Chen C, et al. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014;12:1767-78 pubmed publisher
  • western blot; rat; 1:500; fig 4b
Noack M, Richter Landsberg C. Activation of autophagy by rapamycin does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition. J Mol Neurosci. 2015;55:99-108 pubmed publisher
  • western blot; human
Shieh J, Shen C, Chang W, Cheng H, Chan Y, Huang W, et al. An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death. PLoS ONE. 2014;9:e99242 pubmed publisher
  • western blot; human
Cazanave S, Wang X, Zhou H, Rahmani M, Grant S, Durrant D, et al. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ. 2014;21:1303-12 pubmed publisher
  • western blot; human; 1:1000
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed publisher
  • western blot; human; 1:1000
Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher
  • western blot; human; fig 3a
Iwasaki K, Sudo H, Yamada K, Ito M, Iwasaki N. Cytotoxic effects of the radiocontrast agent iotrolan and anesthetic agents bupivacaine and lidocaine in three-dimensional cultures of human intervertebral disc nucleus pulposus cells: identification of the apoptotic pathways. PLoS ONE. 2014;9:e92442 pubmed publisher
  • western blot; human
Guerzoni C, Amatori S, Giorgi L, Manara M, Landuzzi L, Lollini P, et al. An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas. BMC Cancer. 2014;14:137 pubmed publisher
  • western blot; mouse
Mahajan I, Chen M, Muro I, Robertson J, Wright C, Bratton S. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS ONE. 2014;9:e84388 pubmed publisher
  • western blot; human; fig s1
Wang W, Wang Y, Chen H, Xing Y, Li F, Zhang Q, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014;10:133-40 pubmed publisher
  • western blot; human; fig 5
Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher
  • western blot; human; loading ...; fig 4c
Yu P, Yan M, Lai H, Huang R, Chou Y, Lin W, et al. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer. 2014;134:542-51 pubmed publisher
  • western blot; human; fig 2
Huang B, Ray P, Iwasaki K, Tsuji Y. Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J. 2013;27:3763-74 pubmed publisher
Chang X, Wang L, Wang Z, Wu S, Zhu X, Hu S, et al. TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3. Sci Rep. 2017;7:16111 pubmed publisher
Zhang P, Zheng Z, Ling L, Yang X, Zhang N, Wang X, et al. w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway. Autophagy. 2017;13:1093-1112 pubmed publisher
Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, et al. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. Sci Rep. 2017;7:43010 pubmed publisher
Oh T, Yun J, Park E, Kim Y, Lee Y, Lim J. Plumbagin Suppresses ?-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity. Int J Mol Sci. 2017;18: pubmed publisher
Manna D, Pust S, Torgersen M, Cordara G, Kunzler M, Krengel U, et al. Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis. PLoS ONE. 2017;12:e0170716 pubmed publisher
Roy P, Mukherjee T, Chatterjee B, Vijayaragavan B, Banoth B, Basak S. Non-canonical NF?B mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NF?B pathway. Oncogene. 2017;36:1417-1429 pubmed publisher
Huang W, Chen H, Chen H, Peng K, Lee Y, Huang L, et al. Galectin-3 and Its Genetic Variation rs4644 Modulate Enterovirus 71 Infection. PLoS ONE. 2016;11:e0168627 pubmed publisher
Li C, Wang J, Wang Q, Zhang Y, Zhang N, Lu L, et al. Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism. Sci Rep. 2016;6:36949 pubmed publisher
Zhang X, Li S, Li M, Huang H, Li J, Zhou C. Hypoxia-inducible factor-1? mediates the toll-like receptor 4 signaling pathway leading to anti-tumor effects in human hepatocellular carcinoma cells under hypoxic conditions. Oncol Lett. 2016;12:1034-1040 pubmed
Zhang Q, Ma S, Liu B, Liu J, Zhu R, Li M. Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Exp Ther Med. 2016;12:469-474 pubmed
Chen X, Li M, Li L, Xu S, Huang D, Ju M, et al. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Sci Rep. 2016;6:28423 pubmed publisher
Liu F, Wang B, Wang Q, Qi Z, Chen C, Kong L, et al. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget. 2016;7:45562-45574 pubmed publisher
Zhou J, Zhang T, Song D, Xia Y, Qin Z, Sheng R. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. Sci Rep. 2016;6:27096 pubmed publisher
Balakrishnan K, Fu M, Onida F, Wierda W, Keating M, Gandhi V. Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic. Oncotarget. 2016;7:39458-39472 pubmed publisher
Park J, Lim C, Bang O, Kim N. Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors. BMC Complement Altern Med. 2016;16:115 pubmed publisher
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed publisher
He J, Wang C, Sun Y, Lu B, Cui J, Dong N, et al. Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress. Int J Mol Med. 2016;37:889-900 pubmed publisher
Shi M, Su F, Xu X, Liu X, Wang H, Zhang W, et al. Cilostazol suppresses angiotensin II-induced apoptosis in endothelial cells. Mol Med Rep. 2016;13:2597-605 pubmed publisher
Li X, Wen J, Jia C, Wang T, Li X, Dong M, et al. MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells. Oncol Lett. 2015;10:2691-2698 pubmed
Nilsson L, Madsen K, Krag S, Frøkiær J, Jensen B, Nørregaard R. Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy. Am J Physiol Renal Physiol. 2015;309:F1035-48 pubmed publisher
Ming J, Ruan S, Wang M, Ye D, Fan N, Meng Q, et al. A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. Oncotarget. 2015;6:40692-703 pubmed publisher
DaMata J, Mendes B, Maciel Lima K, Menezes C, Dutra W, Sousa L, et al. Distinct Macrophage Fates after in vitro Infection with Different Species of Leishmania: Induction of Apoptosis by Leishmania (Leishmania) amazonensis, but Not by Leishmania (Viannia) guyanensis. PLoS ONE. 2015;10:e0141196 pubmed publisher
Cao J, Xie H, Sun Y, Zhu J, Ying M, Qiao S, et al. Sevoflurane post-conditioning reduces rat myocardial ischemia reperfusion injury through an increase in NOS and a decrease in phopshorylated NHE1 levels. Int J Mol Med. 2015;36:1529-37 pubmed publisher
Feng X, Tian L, Zhang Z, Yu Y, Cheng J, Gong Y, et al. Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. Oncotarget. 2015;6:32353-67 pubmed publisher
Bergstralh D, Lovegrove H, St Johnston D. Lateral adhesion drives reintegration of misplaced cells into epithelial monolayers. Nat Cell Biol. 2015;17:1497-1503 pubmed publisher
Ding Y, Xie L, Chang C, Chen Z, Ai H. Activation of γ-aminobutyric Acid (A) Receptor Protects Hippocampus from Intense Exercise-induced Synapses Damage and Apoptosis in Rats. Chin Med J (Engl). 2015;128:2330-9 pubmed publisher
Liu G, Xu C, Feng L, Wang F. The augmentation of O-GlcNAcylation reduces glyoxal-induced cell injury by attenuating oxidative stress in human retinal microvascular endothelial cells. Int J Mol Med. 2015;36:1019-27 pubmed publisher
Deschoemaeker S, Di Conza G, Lilla S, Martín Pérez R, Mennerich D, Boon L, et al. PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med. 2015;7:1350-65 pubmed publisher
Zhang C, Jiang Y, Zhang J, Huang J, Wang J. 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells. Int J Mol Sci. 2015;16:14979-96 pubmed publisher
Adhikary G, Grun D, Balasubramanian S, Kerr C, Huang J, Eckert R. Survival of skin cancer stem cells requires the Ezh2 polycomb group protein. Carcinogenesis. 2015;36:800-10 pubmed publisher
Matsumoto T, Urushido M, Ide H, Ishihara M, Hamada Ode K, Shimamura Y, et al. Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE. 2015;10:e0126229 pubmed publisher
Pourbakhsh H, Taghiabadi E, Abnous K, Hariri A, Hosseini S, Hosseinzadeh H. Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci. 2014;17:1020-31 pubmed
Lee Sherick A, Zhang W, Menachof K, Hill A, Rinella S, Kirkpatrick G, et al. Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia. Oncotarget. 2015;6:6722-36 pubmed
Liang S, Peng X, Li X, Yang P, Xie L, Li Y, et al. Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. Oncotarget. 2015;6:1020-30 pubmed
Knievel J, Schulz W, Greife A, Hader C, Lübke T, Schmitz I, et al. Multiple mechanisms mediate resistance to sorafenib in urothelial cancer. Int J Mol Sci. 2014;15:20500-17 pubmed publisher
Nie C, Luo Y, Zhao X, Luo N, Tong A, Liu X, et al. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis. Cell Death Dis. 2014;5:e1495 pubmed publisher
Li Z, Yu J, Liu L, Wei Z, Ehrlich E, Liu G, et al. Coxsackievirus A16 infection induces neural cell and non-neural cell apoptosis in vitro. PLoS ONE. 2014;9:e111174 pubmed publisher
Wang Y, Kuramitsu Y, Tokuda K, Baron B, Kitagawa T, Akada J, et al. Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer. PLoS ONE. 2014;9:e109076 pubmed publisher
Ye L, Yu J, Liang Y, Zeng J, Huang R, Liao S. Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis. Atherosclerosis. 2014;237:146-54 pubmed publisher
Zeng C, Wang Y, Lu Q, Chen J, Zhang J, Liu T, et al. SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer. J Exp Clin Cancer Res. 2014;33:75 pubmed publisher
Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014;74:5855-65 pubmed publisher
Kaistha B, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, et al. Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells. Br J Cancer. 2014;111:1780-7 pubmed publisher
Fatfat M, Merhi R, Rahal O, Stoyanovsky D, Zaki A, Haidar H, et al. Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species. BMC Cancer. 2014;14:527 pubmed publisher
Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, et al. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS ONE. 2014;9:e102831 pubmed publisher
Amin B, Hajhashemi V, Abnous K, Hosseinzadeh H. Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain. Biomed Res Int. 2014;2014:937568 pubmed publisher
Jaenisch N, Popp A, Guenther M, Schnabel J, Witte O, Frahm C. Pro-apoptotic function of GABA-related transcripts following stroke. Neurobiol Dis. 2014;70:237-44 pubmed publisher
Stengel C, Newman S, Day J, Chander S, Jourdan F, Leese M, et al. In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer. Br J Cancer. 2014;111:300-8 pubmed publisher
GAO P, Tao N, Ma Q, Fan W, Ni C, Wang H, et al. DH332, a synthetic β-carboline alkaloid, inhibits B cell lymphoma growth by activation of the caspase family. Asian Pac J Cancer Prev. 2014;15:3901-6 pubmed
Wu J, Wang Y, Liang S, Ma H. Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis. Drug Des Devel Ther. 2014;8:583-600 pubmed publisher
Huang S, He R, Rong M, Dang Y, Chen G. Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. Biomed Res Int. 2014;2014:384121 pubmed publisher
Hirschi B, Gallmeier E, Ziesch A, Marschall M, Kolligs F. Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells. Mol Cancer. 2014;13:122 pubmed publisher
Eisfeld A, Schwind S, Patel R, Huang X, Santhanam R, Walker C, et al. Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway. Sci Signal. 2014;7:ra36 pubmed publisher
Vreeland A, Yu S, Levi L, de Barros Rossetto D, Noy N. Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2. Mol Cell Biol. 2014;34:2135-46 pubmed publisher
Minter M, Zhang M, Ates R, Taylor J, Crack P. Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells. J Neuroinflammation. 2014;11:43 pubmed publisher
Jia G, Kong R, Ma Z, Han B, Wang Y, Pan S, et al. The activation of c-Jun NH?-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells. J Exp Clin Cancer Res. 2014;33:8 pubmed publisher
Benz A, Renne C, Maronde E, Koch M, Grabiec U, Kallendrusch S, et al. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS ONE. 2013;8:e81675 pubmed publisher
Li Z, Zhao C, Li Z, Zhao Y, Shan S, Shi T, et al. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol. 2014;47:68-75 pubmed publisher
Malhotra U, Zaidi A, Kosovec J, Kasi P, Komatsu Y, Rotoloni C, et al. Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium. PLoS ONE. 2013;8:e78343 pubmed publisher
Wang S, Huang J, Lyu H, Cai B, Yang X, Li F, et al. Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer. Breast Cancer Res. 2013;15:R101 pubmed
Jang Y, Byun Y, Lee K, Park E, Lee Y, Lee Y, et al. Host defense mechanism-based rational design of live vaccine. PLoS ONE. 2013;8:e75043 pubmed publisher
O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed publisher
Guerrero J, Alfaro I, Gomez F, Protter A, Bernales S. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013;73:1291-305 pubmed publisher
Watanabe K, Shibuya S, Koyama H, Ozawa Y, Toda T, Yokote K, et al. Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis. Int J Mol Sci. 2013;14:10998-1010 pubmed publisher
Li X, Chen T, Lin S, Zhao J, Chen P, Ba Q, et al. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Curr Cancer Drug Targets. 2013;13:472-83 pubmed
Fedorchenko O, Stiefelhagen M, Peer Zada A, Barthel R, Mayer P, Eckei L, et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood. 2013;121:4126-36 pubmed publisher
Judson R, Gray S, Walker C, Carroll A, Itzstein C, Lionikas A, et al. Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy. PLoS ONE. 2013;8:e59622 pubmed publisher
Taghiabadi E, Imenshahidi M, Abnous K, Mosafa F, Sankian M, Memar B, et al. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evid Based Complement Alternat Med. 2012;2012:352091 pubmed publisher
Förster A, Falcone F, Gibbs B, Preussner L, Fiebig B, Altunok H, et al. Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils. Leuk Lymphoma. 2013;54:835-42 pubmed publisher
Wang L, Xiang S, Williams K, Dong H, Bai W, Nicosia S, et al. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PLoS ONE. 2012;7:e44265 pubmed publisher
Fang E, Zhang C, Zhang L, Wong J, Chan Y, Pan W, et al. Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis. PLoS ONE. 2012;7:e41592 pubmed publisher
Um J, Nygaard H, Heiss J, Kostylev M, Stagi M, Vortmeyer A, et al. Alzheimer amyloid-? oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci. 2012;15:1227-35 pubmed publisher
Ahn H, Cha Y, Moon S, Jung J, Park K. Ell3 enhances differentiation of mouse embryonic stem cells by regulating epithelial-mesenchymal transition and apoptosis. PLoS ONE. 2012;7:e40293 pubmed publisher
Carnini A, Scott L, Ahrendt E, Proft J, Winkfein R, Kim S, et al. Cell line specific modulation of extracellular a?42 by Hsp40. PLoS ONE. 2012;7:e37755 pubmed publisher
Cheng F, Zhong X, Lu Y, Wang X, Song W, Guo S, et al. Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. Evid Based Complement Alternat Med. 2012;2012:567872 pubmed publisher
Sun S, Xia S, Ji Y, Kersten S, Qi L. The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue. Diabetes. 2012;61:1471-8 pubmed publisher
Yamauchi Y, Izumi Y, Asakura K, Hayashi Y, Nomori H. Curcumin induces autophagy in ACC-MESO-1 cells. Phytother Res. 2012;26:1779-83 pubmed publisher
Venkataramani V, Thiele K, Behnes C, Wulf G, Thelen P, Opitz L, et al. Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells. Am J Pathol. 2012;180:1636-52 pubmed publisher
Zhou Y, Li G, Ji Y, Liu C, Zhu J, Lu Y. Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic carcinoma cell line. J Biomed Sci. 2012;19:15 pubmed publisher
Zhang J, Fang L, Zhu X, Qiao Y, Yu M, Wang L, et al. Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L). Cell Biol Int. 2012;36:463-8 pubmed publisher
Velarde M, Flynn J, Day N, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4:3-12 pubmed
Zeng M, Southern P, Reilly C, Beilman G, Chipman J, Schacker T, et al. Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog. 2012;8:e1002437 pubmed publisher
Deng X, Wang S, Deng A, Liu B, Edgerton S, Lind S, et al. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle. 2012;11:367-76 pubmed publisher
Bartoli K, Jakovljevic J, Woolford J, Saunders W. Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell. 2011;22:3420-30 pubmed publisher
Resch U, Semlitsch M, Hammer A, Susani Etzerodt H, Walczak H, Sattler W, et al. Hypochlorite-modified low-density lipoprotein induces the apoptotic machinery in Jurkat T-cell lines. Biochem Biophys Res Commun. 2011;410:895-900 pubmed publisher
Wang S, Martin S, Harris P, Knudson C. Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma. PLoS ONE. 2011;6:e19786 pubmed publisher
Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W, Sereda S, et al. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011;22:2235-45 pubmed publisher
Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-? feedforward signaling. Cell. 2011;145:92-103 pubmed publisher
Zhang J, Ye J, Altafaj A, Cardona M, Bahi N, Llovera M, et al. EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes. PLoS ONE. 2011;6:e17998 pubmed publisher
Sakamoto K, Huang B, Iwasaki K, Hailemariam K, Ninomiya Tsuji J, Tsuji Y. Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. Mol Biol Cell. 2010;21:2966-74 pubmed publisher
Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, et al. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009;185:291-303 pubmed publisher
Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009;13:701-11 pubmed publisher
Wright K, Smith M, Farrag L, Deshmukh M. Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons. J Cell Biol. 2007;179:825-32 pubmed
Wright K, Linhoff M, Potts P, Deshmukh M. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. J Cell Biol. 2004;167:303-13 pubmed
product information
SKU :
9665S
Product-Name :
Caspase-3 (8G10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Apoptosis
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17, 19, 35
Host :
Rabbit
Target :
Casp3 (Asp175) cleaved
Primary-Protein :
Casp3
Alt-Names :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.