product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb
catalog :
9664L
quantity :
300 ul
price :
658 USD
clonality :
monoclonal
host :
rabbit
reactivity :
African green monkey, human, mouse, rat, dog, zebrafish , purple sea urchin
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 152
Published Application/Species/DilutionReference
  • western blot; mouse; fig 1
Barroso-González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 5
Lian Y, Yuan J, Cui Q, Feng Q, Xu M, Bei J, et al. Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma. PLoS ONE. 2016;11:e0152820 pubmed publisher
  • immunohistochemistry; purple sea urchin; 1:250; fig 4
Krupke O, Zysk I, Mellott D, Burke R. Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, et al. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016;6:29588 pubmed publisher
  • western blot; human; 1:1000; fig 4
Belvedere R, Bizzarro V, Forte G, Dal Piaz F, Parente L, Petrella A. Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway. Sci Rep. 2016;6:29660 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 4
Jun S, Jung Y, Suh H, Wang W, Kim M, Oh Y, et al. LIG4 mediates Wnt signalling-induced radioresistance. Nat Commun. 2016;7:10994 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3
Silva S, Levy D, Ruiz J, de Melo T, Isaac C, Fidelis M, et al. Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. J Steroid Biochem Mol Biol. 2016;: pubmed publisher
  • western blot; human; fig 4
Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 2
Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, et al. Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. J Pathol. 2016;239:97-108 pubmed publisher
  • western blot; human; fig 2
  • western blot; rat; fig 6
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;: pubmed
  • western blot; human; fig 4
Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 10
Xue H, Yuan G, Guo X, Liu Q, Zhang J, Gao X, et al. A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway. Autophagy. 2016;12:1129-52 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 7
  • western blot; mouse; 1:1000; fig 7
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher
  • western blot; African green monkey; fig s4
Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, et al. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016;107:734-45 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; mouse; fig 1
Ashraf M, Schwelberger H, Brendel K, Feurle J, Andrassy J, Kotsch K, et al. Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation. Am J Transplant. 2016;16:808-20 pubmed publisher
  • western blot; mouse; fig 7
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, et al. Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: involvement in the modulation of blood-brain barrier integrity. Oncotarget. 2016;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, et al. ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016;19:53-65 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher
  • western blot; human; 1:1000; fig s5
Hong A, Tseng Y, Cowley G, Jonas O, Cheah J, Kynnap B, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016;7:11987 pubmed publisher
  • western blot; human; 1:1000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • western blot; human; 1:1000; fig 5
Meinhardt G, Saleh L, Otti G, Haider S, Velicky P, Fiala C, et al. Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep. 2016;6:28127 pubmed publisher
  • western blot; human; 1:1000; fig 4
Cheng C, Jiao J, Qian Y, Guo X, Huang J, Dai M, et al. Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells. Mol Med Rep. 2016;13:3763-70 pubmed publisher
  • western blot; human; 1:1000; fig 3
Long C, Guo W, Zhou H, Wang J, Wang H, Sun X. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells. Int J Oncol. 2016;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s3
Chatterjee I, Baruah J, Lurie E, Wary K. Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res. 2016;: pubmed
  • western blot; human; fig 2
Podmirseg S, Jakel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;: pubmed publisher
  • western blot; human; 1:500; fig 5
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig s8
Eriksson J, Le Joncour V, Nummela P, Jahkola T, Virolainen S, Laakkonen P, et al. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget. 2016;7:15065-92 pubmed publisher
  • western blot; mouse; fig 5
Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
  • western blot; human; fig 2
Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016;35:1541-53 pubmed publisher
  • western blot; human; 1:400; fig 4
Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
  • western blot; human; fig 3
Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed publisher
  • western blot; human; fig 2
Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Jiao L, Inhoffen J, Gan-Schreier H, Tuma-Kellner S, Stremmel W, Sun Z, et al. Deficiency of Group VIA Phospholipase A2 (iPLA2β) Renders Susceptibility for Chemical-Induced Colitis. Dig Dis Sci. 2015;60:3590-602 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7A
Wang Z, Liu N, Liu K, Zhou G, Gan J, Wang Z, et al. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy. 2015;11:2358-69 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Veselá B, Svandová E, Vanden Berghe T, Tucker A, Vandenabeele P, Matalova E. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. J Mol Histol. 2015;46:443-55 pubmed publisher
  • western blot; human
Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  • western blot; human; 1:800; fig  4
Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, et al. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015;150:139-49 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4a
Deutsch M, Graffeo C, Rokosh R, Pansari M, Ochi A, Levie E, et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015;6:e1759 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800
Sarr D, Bracken T, Owino S, Cooper C, Smith G, Nagy T, et al. Differential roles of inflammation and apoptosis in initiation of mid-gestational abortion in malaria-infected C57BL/6 and A/J mice. Placenta. 2015;36:738-49 pubmed publisher
  • immunocytochemistry; human; fig 2
Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed
  • western blot; human; fig 4
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed publisher
  • western blot; mouse; fig 5
Kaizuka T, Mizushima N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol Cell Biol. 2015;36:585-95 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; 1:100
Werner A, Iwasaki S, McGourty C, Medina-Ruíz S, Teerikorpi N, Fedrigo I, et al. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015;525:523-7 pubmed publisher
  • western blot; human; fig 4
Bida O, Gidoni M, Ideses D, Efroni S, Ginsberg D. A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel. Oncotarget. 2015;6:27880-90 pubmed publisher
  • western blot; human
Shen X, Sun W, Shi Y, Xing Z, Su X. Altered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009. Mediators Inflamm. 2015;2015:976575 pubmed publisher
  • western blot; mouse; 1:200; fig 8
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
  • western blot; mouse
Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; fig 7
Pértega-Gomes N, Felisbino S, Massie C, Vizcaíno J, Coelho R, Sandi C, et al. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy. J Pathol. 2015;236:517-30 pubmed publisher
  • western blot; human
Girotti M, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015;27:85-96 pubmed publisher
  • western blot; mouse
Liu L, Zou P, Zheng L, Linarelli L, Amarell S, Passaro A, et al. Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis. 2015;6:e1586 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig s8
Klotz L, Norman S, Vieira J, Masters M, Rohling M, Dubé K, et al. Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature. 2015;522:62-7 pubmed
  • western blot; human; fig 3
Long J, Schoonen P, Graczyk D, O'Prey J, Ryan K. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. 2015;34:5152-62 pubmed publisher
  • western blot; mouse; 1:1000
  • immunocytochemistry; mouse; 1:200
Kaneko Y, Ota A, Nakashima A, Nagasaki H, Kodani Y, Mori K, et al. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis. J Neural Transm (Vienna). 2015;122:187-99 pubmed publisher
  • western blot; human; 1:1000; fig 5
Han Y, Lee J, Lee S. Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways. Mol Med Rep. 2015;12:3446-52 pubmed publisher
  • western blot; human; 1:1000
Liu W, Lin Y, Yan X, Ding Y, Wu Y, Chen W, et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 2015;29:1113-23 pubmed publisher
  • immunocytochemistry; mouse
Yuri S, Nishikawa M, Yanagawa N, Jo O, Yanagawa N. Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor. PLoS ONE. 2015;10:e0129242 pubmed publisher
  • western blot; rat; fig 6
Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, Hotter G, et al. Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE. 2015;10:e0134499 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2015;: pubmed publisher
  • western blot; human
Sirohi K, Kumari A, Radha V, Swarup G. A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS ONE. 2015;10:e0138289 pubmed publisher
  • immunocytochemistry; mouse; fig 6d
Quintana P, Soto D, Poirot O, Zonouzi M, Kellenberger S, Muller D, et al. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. J Physiol. 2015;593:4373-86 pubmed publisher
  • western blot; human; 1:5000
Demel H, Feuerecker B, Piontek G, Seidl C, Blechert B, Pickhard A, et al. Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. Am J Cancer Res. 2015;5:1649-64 pubmed
  • western blot; human; fig 6
Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 5
He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed
  • immunohistochemistry; mouse; 1:200
Vong K, Leung C, Behringer R, Kwan K. Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25 pubmed publisher
  • immunohistochemistry - paraffin section; human
Somsouk M, Estes J, Deléage C, Dunham R, Albright R, Inadomi J, et al. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015;29:43-51 pubmed publisher
  • western blot; rat; fig 3c
Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, et al. Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis. Sci Rep. 2015;5:13737 pubmed publisher
  • immunohistochemistry - paraffin section; human
Hirt C, Papadimitropoulos A, Muraro M, Mele V, Panopoulos E, Cremonesi E, et al. Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo". Biomaterials. 2015;62:138-46 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4
Pearson H, McGlinn E, Phesse T, Schlüter H, Srikumar A, Godde N, et al. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Mol Cancer. 2015;14:169 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400; fig 6
Hasan S, Sultana S. Geraniol attenuates 2-acetylaminofluorene induced oxidative stress, inflammation and apoptosis in the liver of wistar rats. Toxicol Mech Methods. 2015;25:559-73 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig s2
Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher
  • western blot; rat; fig 8
Matsumoto T, Urushido M, Ide H, Ishihara M, Hamada-Ode K, Shimamura Y, et al. Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE. 2015;10:e0126229 pubmed publisher
  • western blot; human
Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher
  • western blot; mouse; 1:200; fig s6
Suzuki D, Sahu R, Leu N, Senoo M. The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. 2015;142:282-90 pubmed publisher
  • western blot; mouse; fig 5
Bettaieb A, Jiang J, Sasaki Y, Chao T, Kiss Z, Chen X, et al. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015;149:468-80.e10 pubmed publisher
  • western blot; mouse; 1:1000
ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
  • western blot; human; fig 8c
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  • western blot; mouse; 1:1000
Nashine S, Liu Y, Kim B, Clark A, Pang I. Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. Invest Ophthalmol Vis Sci. 2015;56:221-31 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Szabo N, Da Silva R, Sotocinal S, Zeilhofer H, Mogil J, Kania A. Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015;35:5233-46 pubmed publisher
  • western blot; human
Waters A, Stewart J, Atigadda V, Mroczek-Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015;14:1559-69 pubmed publisher
  • western blot; human; 1:1000
Velicky P, Haider S, Otti G, Fiala C, Pollheimer J, Knöfler M. Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts. Mol Hum Reprod. 2014;20:756-66 pubmed publisher
  • immunohistochemistry; human; 1:50
Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
  • western blot; human
Wang C, Wang J, Liu Z, Ma X, Wang X, Jin H, et al. Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma. Carcinogenesis. 2014;35:1500-9 pubmed publisher
  • western blot; human
Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher
  • western blot; human
Kemp M, Gaddameedhi S, Choi J, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014;289:26574-83 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Bailey K, Rahimi Balaei M, Mannan A, Del Bigio M, Marzban H. Purkinje cell compartmentation in the cerebellum of the lysosomal Acid phosphatase 2 mutant mouse (nax - naked-ataxia mutant mouse). PLoS ONE. 2014;9:e94327 pubmed publisher
  • immunocytochemistry; human; 1:100
Clave S, Joya X, Salat-Batlle J, Garcia-Algar O, Vall O. Ethanol cytotoxic effect on trophoblast cells. Toxicol Lett. 2014;225:216-21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; rat
Li J, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, et al. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014;86:86-102 pubmed publisher
  • immunohistochemistry; human; 1:200
Hassan H, Varney M, Jain S, Weisenburger D, Singh R, Dave B. Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma. Leuk Lymphoma. 2014;55:2924-31 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1e
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen-Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:800
Soares F, Tattoli I, Rahman M, Robertson S, Belcheva A, Liu D, et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem. 2014;289:19317-30 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Kukreja L, Kujoth G, Prolla T, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2014;9:16 pubmed publisher
  • immunohistochemistry; zebrafish; 1:200
McGraw H, Culbertson M, Nechiporuk A. Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development. 2014;141:3212-21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  • western blot; rat; 1:1000
Borkham-Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher
  • western blot; mouse; fig 4
Ying Y, Kim J, Westphal S, Long K, Padanilam B. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol. 2014;25:2707-16 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Ostapoff K, Cenik B, Wang M, Ye R, Xu X, Nugent D, et al. Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res. 2014;74:4996-5007 pubmed publisher
  • western blot; mouse
Resch U, Cuapio A, Sturtzel C, Hofer E, de Martin R, Holper-Schichl Y. Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem. 2014;289:25088-100 pubmed publisher
  • western blot; human; fig 5
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product information
SKU :
9664L
Product-Name :
Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb
Size :
300 ul
Price-(USD) :
658 USD
Species-x-Reactivity :
H, M, R, Mk, (Dg)
Applications :
Flow cytometry
Product-Category :
Apoptosis
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
17, 19
Host :
Rabbit
Target :
Casp3 (Asp175) cleaved
Primary-Protein :
Casp3
Alt-Names :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.