product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Caspase-3 (Asp175) Antibody
catalog :
9661S
quantity :
100 ul
price :
274 USD
clonality :
polyclonal
host :
rabbit
reactivity :
, medaka, human, mouse, rat, dog, chicken, cow, pig, fruit fly, common platanna
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Cell Signaling Technology product webpage
citations: 283
Published Application/Species/DilutionReference
  • immunohistochemistry; rat; 1:200; fig 1
Viringipurampeer I, Metcalfe A, Bashar A, Sivak O, Yanai A, Mohammadi Z, et al. NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration. Hum Mol Genet. 2016;25:1501-16 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig 7
Shruthi K, Reddy S, Reddy P, Shivalingam P, Harishankar N, Reddy G. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016;33:73-81 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
James R, Hillis J, Adorjan I, Gration B, Mundim M, Iqbal A, et al. Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis. Glia. 2016;64:105-21 pubmed publisher
  • immunocytochemistry; dog; 1:200; fig 1
Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, et al. Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun. 2016;7:11373 pubmed publisher
  • western blot; human
Scala F, Brighenti E, Govoni M, Imbrogno E, Fornari F, Trere D, et al. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. 2016;35:977-89 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:300; tbl here were only a few cells in each section immunohistochemically positive for Ki67 and cleaved caspase-3 (data not shown).
Hellstrom M, Moreno-Moya J, Bandstein S, Bom E, Akouri R, Miyazaki K, et al. Bioengineered uterine tissue supports pregnancy in a rat model. Fertil Steril. 2016;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3
Waasdorp M, Duitman J, Florquin S, Spek C. Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice. Sci Rep. 2016;6:33030 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 7
Körbelin J, Dogbevia G, Michelfelder S, Ridder D, Hunger A, Wenzel J, et al. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med. 2016;8:609-25 pubmed publisher
  • western blot; mouse; fig s2
Park J, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, et al. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. PLoS ONE. 2016;11:e0156334 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400
Fujimura N, Klimova L, Antosova B, Smolikova J, Machon O, Kozmik Z. Genetic interaction between Pax6 and β-catenin in the developing retinal pigment epithelium. Dev Genes Evol. 2015;225:121-8 pubmed publisher
  • western blot; human; 1:2000
Zhang W, Cai J, Chen S, Zheng X, Hu S, Dong W, et al. Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. Mol Med Rep. 2015;12:1506-14 pubmed publisher
  • immunocytochemistry; human; 1:60
Meadows S, Cleaver O. Annexin A3 Regulates Early Blood Vessel Formation. PLoS ONE. 2015;10:e0132580 pubmed publisher
  • western blot; human; fig f4
Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed
  • western blot; mouse
Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher
  • western blot; mouse
Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015;10:e0136952 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Iyer R, Patterson N, Zouein F, Ma Y, Dive V, de Castro Brás L, et al. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. Int J Cardiol. 2015;185:198-208 pubmed publisher
  • western blot; rat; 1:500
Liu S, Sarkar C, Dinizo M, Faden A, Koh E, Lipinski M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 2015;6:e1582 pubmed publisher
  • western blot; mouse; 1:1000
Hung S, Huang W, Liou H, Fu W. LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacology. 2015;93:243-51 pubmed publisher
  • immunocytochemistry; human
Barcus C, Holt E, Keely P, Eliceiri K, Schuler L. Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells. PLoS ONE. 2015;10:e0116891 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Zang G, Sandberg M, Carlsson P, Welsh N, Jansson L, Barbu A. Activated pancreatic stellate cells can impair pancreatic islet function in mice. Ups J Med Sci. 2015;120:169-80 pubmed publisher
  • immunocytochemistry; rat; 1:400
Zajkowski T, Nieznanska H, Nieznanski K. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015;1853:2228-39 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprüssel A, et al. A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene. 2015;34:3357-68 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
You L, Yan K, Zou J, Zhao H, Bertos N, Park M, et al. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. J Biol Chem. 2015;290:11349-64 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; fig 3
Ostrowski S, Wright M, Bolock A, Geng X, Maricich S. Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. Development. 2015;142:2533-44 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Roux C, Aligny C, Lesueur C, Girault V, Brunel V, Ramdani Y, et al. NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice. Exp Neurol. 2015;267:177-93 pubmed publisher
  • western blot; human
Gargalionis A, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136:1515-27 pubmed publisher
  • immunohistochemistry; human
Wagner R, Luciani F, Cario-Andre M, Rubod A, Petit V, Benzekri L, et al. Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo. J Invest Dermatol. 2015;135:1810-9 pubmed publisher
  • western blot; human; 1:160; fig 4b
Krossa S, Schmitt A, Hattermann K, Fritsch J, Scheidig A, Mehdorn H, et al. Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1. Oncotarget. 2015;6:21029-45 pubmed
  • immunohistochemistry; mouse; 1:200
You L, Zou J, Zhao H, Bertos N, Park M, Wang E, et al. Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. J Biol Chem. 2015;290:7114-29 pubmed publisher
  • immunohistochemistry; mouse
Sivaraj K, Li R, Albarrán-Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
  • western blot; rat; fig 4
Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher
  • immunohistochemistry; human
Patsialou A, Wang Y, Pignatelli J, Chen X, Entenberg D, Oktay M, et al. Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells. Oncogene. 2015;34:2721-31 pubmed publisher
  • flow cytometry; human
Zaric M, Mitrovic M, Nikolic I, Baskic D, Popovic S, Djurdjevic P, et al. Chrysin induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia. Anticancer Agents Med Chem. 2015;15:189-95 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Owens P, Pickup M, Novitskiy S, Giltnane J, Gorska A, Hopkins C, et al. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. 2015;34:2437-49 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Kato R, Hasegawa K, Torii Y, Udagawa Y, Fukasawa I. Factors affecting platinum sensitivity in cervical cancer. Oncol Lett. 2015;10:3591-3598 pubmed
  • immunocytochemistry; human; 1:300
Takasato M, Er P, Chiu H, Maier B, Baillie G, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015;526:564-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400
Pechriggl E, Bitsche M, Glueckert R, Rask-Andersen H, Blumer M, Schrott-Fischer A, et al. Development of the innervation of the human inner ear. Dev Neurobiol. 2015;75:683-702 pubmed publisher
  • immunohistochemistry; mouse; 1:5000
Chen Y, Huang W, Séjourné J, Clipperton-Allen A, Page D. Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling. J Neurosci. 2015;35:10252-67 pubmed publisher
  • immunohistochemistry; rat; 1:500
Rivera P, Bindila L, Pastor A, Perez-Martin M, Pavón F, Serrano A, et al. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Front Cell Neurosci. 2015;9:98 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Angliker N, Burri M, Zaichuk M, Fritschy J, Ruegg M. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur J Neurosci. 2015;42:2595-612 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:600
  • immunocytochemistry; mouse; 1:600
Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick J. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Hum Gene Ther Methods. 2015;26:107-22 pubmed publisher
  • immunocytochemistry; human; 1:300; fig 1
Aoto K, Trainor P. Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival. Hum Mol Genet. 2015;24:698-713 pubmed publisher
  • flow cytometry; human; 1:250
Neradil J, Pavlasova G, Srámek M, Kyr M, Veselska R, Sterba J. DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: the same outcome of treatment with different doses in sensitive cell lines. Oncol Rep. 2015;33:2169-75 pubmed publisher
  • western blot; mouse
Gomez-Cavazos J, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015;208:671-81 pubmed publisher
  • western blot; human
Tebbi A, Guittet O, Tuphile K, Cabrié A, Lepoivre M. Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis. J Biol Chem. 2015;290:14077-90 pubmed publisher
  • western blot; rat; 1:1000
Liu G, Wang Z, Wang Z, Yang D, Liu Z, Wang L. Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead. Arch Toxicol. 2015;: pubmed
  • immunohistochemistry; human; fig 2d
  • immunocytochemistry; human; fig 2c
Zhou W, Cheng L, Shi Y, Ke S, Huang Z, Fang X, et al. Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth. Oncotarget. 2015;6:37300-15 pubmed publisher
  • western blot; rat
Liu H, Xie Q, Xin B, Liu J, Liu Y, Li Y, et al. Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension. Life Sci. 2015;121:1-9 pubmed publisher
  • immunocytochemistry; mouse; 1:250
Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, et al. Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J Biol Chem. 2015;290:11515-25 pubmed publisher
  • western blot; human
De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Urness L, Wang X, Shibata S, Ohyama T, Mansour S. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015;400:59-71 pubmed publisher
  • western blot; human
Moon J, Eo S, Lee J, Park S. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375-81 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Lohse I, Borgida A, Cao P, Cheung M, Pintilie M, Bianco T, et al. BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. Br J Cancer. 2015;113:425-32 pubmed publisher
  • western blot; human; fig 3 a-c
Philipp S, Sosna J, Plenge J, Kalthoff H, Adam D. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal. 2015;13:25 pubmed publisher
  • immunocytochemistry; mouse
Higashi T, Katsuno T, Kitajiri S, Furuse M. Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. PLoS ONE. 2015;10:e0120674 pubmed publisher
  • western blot; human
Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher
  • immunohistochemistry; mouse; 1:1200
Wende C, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, et al. Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. PLoS ONE. 2015;10:e0127681 pubmed publisher
  • immunohistochemistry; fruit fly; fig 6
Xiao X, Zhang R, Pang X, Liang G, Wang P, Cheng G. A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes. PLoS Pathog. 2015;11:e1004848 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Pickup M, Hover L, Polikowsky E, Chytil A, Gorska A, Novitskiy S, et al. BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. Mol Oncol. 2015;9:179-91 pubmed publisher
  • immunohistochemistry - paraffin section; human
Zhang D, Zhu L, Li C, Mu J, Fu Y, Zhu Q, et al. Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction. Basic Res Cardiol. 2015;110:28 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800
Jarry A, Crémet L, Caroff N, Bou-Hanna C, Mussini J, Reynaud A, et al. Subversion of human intestinal mucosa innate immunity by a Crohn's disease-associated E. coli. Mucosal Immunol. 2015;8:572-81 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:5000
Heng Y, Zhou B, Harris L, Harvey T, Smith A, Horne E, et al. NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche. Cereb Cortex. 2015;25:3758-78 pubmed publisher
  • western blot; human; fig 7
Thiyagarajan D, Rekvig O, Seredkina N. TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form. PLoS ONE. 2015;10:e0129485 pubmed publisher
  • western blot; mouse
Kapodistria K, Tsilibary E, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015;400:112-28 pubmed publisher
  • western blot; human
Martinez-Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher
  • immunohistochemistry; mouse; 1:200-1:500; fig 2
Imajo M, Ebisuya M, Nishida E. Dual role of YAP and TAZ in renewal of the intestinal epithelium. Nat Cell Biol. 2015;17:7-19 pubmed publisher
  • western blot; human; 1:1000
Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-76 pubmed
  • immunocytochemistry; human; 1:1600; fig 5
Pérès E, Gérault A, Valable S, Roussel S, Toutain J, Divoux D, et al. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget. 2015;6:2101-19 pubmed
  • western blot; human; 1:1000; fig 5d
Duan H, Li Y, Lim H, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015;23:4514-21 pubmed publisher
  • immunocytochemistry; human; 1:100
  • immunocytochemistry; cow; 1:100
El Zaoui I, Behar-Cohen F, Torriglia A. Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms. Toxicol Sci. 2015;143:441-53 pubmed publisher
  • western blot; mouse
Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Ahlers K, Karacay B, Fuller L, Bonthius D, Dailey M. Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration. Glia. 2015;63:1694-713 pubmed publisher
  • immunohistochemistry; medaka; 1:200; fig s1
Yasuda T, Oda S, Hibi Y, Satoh S, Nagata K, Hirakawa K, et al. Embryonic Medaka Model of Microglia in the Developing CNS Allowing In Vivo Analysis of Their Spatiotemporal Recruitment in Response to Irradiation. PLoS ONE. 2015;10:e0127325 pubmed publisher
  • immunohistochemistry; mouse; 1:500
PFISTER S, Weber T, Hartig W, Schwerdel C, Elsaesser R, Knuesel I, et al. Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis. J Comp Neurol. 2015;523:406-30 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 0.2 ug/ml
Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed publisher
  • western blot; human
Li X, Liang Q, Liu W, Zhang N, Xu L, Zhang X, et al. Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. Oncogene. 2015;: pubmed publisher
  • western blot; human; 1:1000
Shen Z, Stanger B. YAP regulates S-phase entry in endothelial cells. PLoS ONE. 2015;10:e0117522 pubmed publisher
  • western blot; human
Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J. Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE. 2015;10:e0135929 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000
  • western blot; mouse; 1:1000
Subbanna S, Nagre N, Shivakumar M, Umapathy N, Psychoyos D, Basavarajappa B. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. Neuroscience. 2014;258:422-32 pubmed publisher
  • immunohistochemistry; mouse; fig 7
Cicchini M, Chakrabarti R, Kongara S, Price S, Nahar R, Lozy F, et al. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy. 2014;10:2036-52 pubmed publisher
  • immunocytochemistry; mouse; 1:250
Erturk A, Wang Y, Sheng M. Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci. 2014;34:1672-88 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher
  • western blot; human
Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, et al. Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21:1914-24 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Doughton G, Wei J, Tapon N, Welham M, Chalmers A. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS ONE. 2014;9:e95434 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250
Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed
  • immunocytochemistry; human
Van Der Meer R, Song H, Park S, Abdulkadir S, Roh M. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clin Cancer Res. 2014;20:3211-21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Vapola M, Rokka A, Sormunen R, Alhonen L, Schmitz W, Conzelmann E, et al. Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice. Dev Biol. 2014;391:66-80 pubmed publisher
  • western blot; human; fig 4
Moskwa P, Zinn P, Choi Y, Shukla S, Fendler W, Chen C, et al. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014;12:1767-78 pubmed publisher
  • western blot; human
Charan R, Johnson B, Zaganelli S, Nardozzi J, LaVoie M. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis. 2014;5:e1313 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100
Xu M, Yang L, Rong J, Ni Y, Gu W, Luo Y, et al. Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway. Glia. 2014;62:855-80 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Das R, Xu S, Quan X, Nguyen T, Kong I, Chung C, et al. Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes. Am J Physiol Renal Physiol. 2014;306:F155-67 pubmed publisher
  • flow cytometry; human; 1:800
  • immunocytochemistry; human; 1:800
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed publisher
  • western blot; human
Ginet V, Pittet M, Rummel C, Osterheld M, Meuli R, Clarke P, et al. Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic. Ann Neurol. 2014;76:695-711 pubmed publisher
  • western blot; mouse
Soares F, Tattoli I, Rahman M, Robertson S, Belcheva A, Liu D, et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem. 2014;289:19317-30 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:100
Farioli-Vecchioli S, Ceccarelli M, Saraulli D, Micheli L, Cannas S, d'Alessandro F, et al. Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids. Front Cell Neurosci. 2014;8:98 pubmed
  • immunohistochemistry; mouse; 1:200
Konsavage W, Yochum G. The myc 3' wnt-responsive element suppresses colonic tumorigenesis. Mol Cell Biol. 2014;34:1659-69 pubmed publisher
  • western blot; human; 1:500
Malaviya A, Sylvester P. Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells. PPAR Res. 2014;2014:439146 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Son A, Sheleg M, Cooper M, Sun Y, Kleiman N, Zhou R. Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. Invest Ophthalmol Vis Sci. 2014;55:1594-606 pubmed publisher
  • western blot; mouse; fig 4
Takahashi N, Vereecke L, Bertrand M, Duprez L, Berger S, Divert T, et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature. 2014;513:95-9 pubmed publisher
  • western blot; human
George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed
  • western blot; human; fig s1b
Chipumuro E, Marco E, Christensen C, Kwiatkowski N, Zhang T, Hatheway C, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell. 2014;159:1126-39 pubmed publisher
  • western blot; human
Yanagi T, Krajewska M, Matsuzawa S, Reed J. PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells. Cancer Res. 2014;74:5795-807 pubmed publisher
  • western blot; mouse
Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014;322:43-50 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Roberts J, Ennajdaoui H, Edmondson C, Wirth B, Sanford J, Chen B. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014;522:372-92 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Mathieu M, Miles A, Ahmad M, Buczek M, Pockley A, Rees R, et al. The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. Cell Death Dis. 2014;5:e1061 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Domitrovic R, Cvijanovic O, Susnić V, Katalinić N. Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. Toxicology. 2014;324:98-107 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:100
Cutuli D, De Bartolo P, Caporali P, Laricchiuta D, Foti F, Ronci M, et al. n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Front Aging Neurosci. 2014;6:220 pubmed
  • immunohistochemistry; fruit fly; 1:100
Stickel S, Su T. Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins. Biol Open. 2014;3:201-9 pubmed publisher
  • immunohistochemistry - paraffin section; human
Ueda J, Ho J, Lee K, Kitajima S, Yang H, Sun W, et al. The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth. Mol Cell Biol. 2014;34:3702-20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet A, et al. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014;17:1171-9 pubmed publisher
  • immunohistochemistry; rat; 1:50
Yurube T, Hirata H, Kakutani K, Maeno K, Takada T, Zhang Z, et al. Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model. Arthritis Res Ther. 2014;16:R31 pubmed publisher
  • western blot; human
Matsumoto T, Tabata K, Suzuki T. The GANT61, a GLI inhibitor, induces caspase-independent apoptosis of SK-N-LO cells. Biol Pharm Bull. 2014;37:633-41 pubmed
  • western blot; human
Shi J, Fung G, Piesik P, Zhang J, Luo H. Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection. Cell Death Differ. 2014;21:1432-41 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Qi Y, Zhang M, Li H, Frank J, Dai L, Liu H, et al. MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade. J Biol Chem. 2014;289:10201-10 pubmed publisher
  • immunohistochemistry - frozen section; human
Sider K, Zhu C, Kwong A, Mirzaei Z, de Lange C, Simmons C. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol. 2014;23:289-97 pubmed publisher
  • immunohistochemistry; mouse
Kim M, Ryu J, Kwon Y, Lee S, Bae Y, Yoon J, et al. Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice. Antioxid Redox Signal. 2014;21:1803-18 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
  • western blot; mouse; 1:1000
Stein L, Wozniak D, Dearborn J, Kubota S, Apte R, Izumi Y, et al. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci. 2014;34:5800-15 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Aligny C, Roux C, Dourmap N, Ramdani Y, do-Rego J, Jegou S, et al. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice. Cell Death Dis. 2014;5:e1311 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Huang T, Krimm R. BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014;386:308-20 pubmed publisher
  • immunohistochemistry - free floating section; mouse
  • immunocytochemistry; mouse
Toyo-oka K, Wachi T, Hunt R, Baraban S, Taya S, Ramshaw H, et al. 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014;34:12168-81 pubmed publisher
  • immunocytochemistry; cow
  • western blot; cow
Zielniok K, Motyl T, Gajewska M. Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures. Biomed Res Int. 2014;2014:382653 pubmed publisher
  • western blot; rat; 1:1000
Cong B, Wang L, Zhu X, Li X, Liu B, Ni X. SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes. Can J Cardiol. 2014;30:687-95 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; human; 1:1000
  • western blot; mouse; 1:1000
Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, et al. MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis. 2014;5:e1132 pubmed publisher
  • western blot; rat
Codeluppi S, Fernandez-Zafra T, Sandor K, Kjell J, Liu Q, Abrams M, et al. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling. PLoS ONE. 2014;9:e92649 pubmed publisher
  • western blot; mouse; fig 5
Costes S, Gurlo T, Rivera J, Butler P. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014;10:1004-14 pubmed publisher
  • western blot; human
Blaabjerg L, Christensen G, Matsumoto M, van der Meulen T, Huising M, Billestrup N, et al. CRFR1 activation protects against cytokine-induced β-cell death. J Mol Endocrinol. 2014;53:417-27 pubmed publisher
  • western blot; human
Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher
  • western blot; rat; 1:1000
Reddy V, Kumar C, Raghu G, Reddy G. Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys. 2014;558:1-9 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Cordero J, Ridgway R, Valeri N, Nixon C, Frame M, Muller W, et al. c-Src drives intestinal regeneration and transformation. EMBO J. 2014;33:1474-91 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Steffensen M, Fenger C, Christensen J, Jørgensen C, Bassi M, Christensen J, et al. Suppressors of cytokine signaling 1 and 3 are upregulated in brain resident cells in response to virus-induced inflammation of the central nervous system via at least two distinctive pathways. J Virol. 2014;88:14090-104 pubmed publisher
  • western blot; human
Trembley J, Unger G, Gomez O, Abedin J, Korman V, Vogel R, et al. Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation. Mol Cell Pharmacol. 2014;6:15-25 pubmed
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Otero J, Kalaszczynska I, Michowski W, Wong M, Gygli P, Gokozan H, et al. Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014;385:328-39 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100
Gallaher Z, Johnston S, Czaja K. Neural proliferation in the dorsal root ganglia of the adult rat following capsaicin-induced neuronal death. J Comp Neurol. 2014;522:3295-307 pubmed publisher
  • immunohistochemistry; mouse
Tepavcevic V, Kerninon C, Aigrot M, Meppiel E, Mozafari S, Arnould-Laurent R, et al. Early netrin-1 expression impairs central nervous system remyelination. Ann Neurol. 2014;76:252-68 pubmed publisher
  • western blot; human
  • immunocytochemistry; human
Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Satoh J, Motohashi N, Kino Y, Ishida T, Yagishita S, Jinnai K, et al. LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains. Orphanet J Rare Dis. 2014;9:68 pubmed publisher
  • immunohistochemistry; common platanna; 1:50; fig s9
Sojka S, Amin N, Gibbs D, Christine K, Charpentier M, Conlon F. Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity. Development. 2014;141:3040-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Marusyk A, Tabassum D, Altrock P, Almendro V, Michor F, Polyak K. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014;514:54-8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Caswell D, Chuang C, Yang D, Chiou S, Cheemalavagu S, Kim-Kiselak C, et al. Obligate progression precedes lung adenocarcinoma dissemination. Cancer Discov. 2014;4:781-9 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500
Okusa C, Oeschger F, Ginet V, Wang W, Hoerder-Suabedissen A, Matsuyama T, et al. Subplate in a rat model of preterm hypoxia-ischemia. Ann Clin Transl Neurol. 2014;1:679-91 pubmed publisher
  • western blot; mouse
Huang Y, Liu H, Li S, Tang Y, Wei B, Yu H, et al. MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection. PLoS Pathog. 2014;10:e1004020 pubmed publisher
  • western blot; pig; 1:1000
Hsu W, Chen C, Huang S, Wu C, Chen I, Nadar M, et al. The untranslated regions of classic swine fever virus RNA trigger apoptosis. PLoS ONE. 2014;9:e88863 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250
Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Grande V, Manassero G, Vercelli A. Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. PLoS ONE. 2014;9:e114554 pubmed publisher
  • western blot; human
Wei N, Chu E, Wipf P, Schmitz J. Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Mol Cancer Ther. 2014;13:1130-41 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Fernández-Nogales M, Cabrera J, Santos-Galindo M, Hoozemans J, Ferrer I, Rozemuller A, et al. Huntington's disease is a four-repeat tauopathy with tau nuclear rods. Nat Med. 2014;20:881-5 pubmed publisher
  • western blot; mouse
Li J, Tan H, Wang X, Li Y, Samuelson L, Li X, et al. Circulating fibrocytes stabilize blood vessels during angiogenesis in a paracrine manner. Am J Pathol. 2014;184:556-71 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Hilliard S, Yao X, El-Dahr S. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014;387:1-14 pubmed publisher
  • western blot; human
Subramani R, Lopez-Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:600
McKinstry S, Karadeniz Y, Worthington A, Hayrapetyan V, Ozlu M, Serafin-Molina K, et al. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. J Neurosci. 2014;34:9455-72 pubmed publisher
  • western blot; human
Model L, Hall M, Wong D, Muto A, Kondo Y, Ziegler K, et al. Arterial shear stress reduces eph-b4 expression in adult human veins. Yale J Biol Med. 2014;87:359-71 pubmed
  • immunohistochemistry; fruit fly; 1:400; fig 3s
Burman J, Itsara L, Kayser E, Suthammarak W, Wang A, Kaeberlein M, et al. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis Model Mech. 2014;7:1165-74 pubmed publisher
  • immunohistochemistry - free floating section; mouse
Roux C, Lesueur C, Aligny C, Brasse-Lagnel C, Genty D, Marret S, et al. 3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis. Cell Transplant. 2014;23:1425-50 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250
Moding E, Lee C, Castle K, Oh P, Mao L, Zha S, et al. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest. 2014;124:3325-38 pubmed publisher
  • western blot; human
Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
  • western blot; rat; 1:1000
Farkas D, Kraskauskas D, Drake J, Alhussaini A, Kraskauskiene V, Bogaard H, et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats. PLoS ONE. 2014;9:e89810 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Godde N, Sheridan J, Smith L, Pearson H, Britt K, Galea R, et al. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet. 2014;10:e1004323 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Baker G, Chockley P, Yadav V, Doherty R, Ritt M, Sivaramakrishnan S, et al. Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity. Cancer Res. 2014;74:5079-90 pubmed publisher
  • immunohistochemistry; fruit fly; 1:200; fig 4
Castanieto A, Johnston M, Nystul T. EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells. elife. 2014;3: pubmed publisher
  • immunocytochemistry; mouse; 1:300
Tsuneki M, Madri J. CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. J Biol Chem. 2014;289:5357-70 pubmed publisher
  • western blot; human
  • western blot; mouse
  • western blot; rat
Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher
  • western blot; human
Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Douglas N, Arora R, Chen C, Sauer M, Papaioannou V. Investigating the role of tbx4 in the female germline in mice. Biol Reprod. 2013;89:148 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Audouard E, Schakman O, Ginion A, Bertrand L, Gailly P, Clotman F. The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development. Mol Cell Neurosci. 2013;56:159-68 pubmed publisher
  • flow cytometry; mouse
Wu N, Kurosu T, Oshikawa G, Nagao T, Miura O. PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells. Int J Oncol. 2013;42:419-28 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Bray K, Gillette M, Young J, Loughran E, Hwang M, Sears J, et al. Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 2013;15:R91 pubmed
  • immunocytochemistry; rat
Belzil C, Neumayer G, Vassilev A, Yap K, Konishi H, Rivest S, et al. A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600. J Biol Chem. 2013;288:24452-64 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Hori T, Gardner L, Hata T, Chen F, Baine A, Uemoto S, et al. Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Ann Transplant. 2013;18:299-313 pubmed publisher
  • immunohistochemistry - frozen section; chicken; 1:4000
Shirazi Fard S, Jarrin M, Boije H, Fillon V, All-Eriksson C, Hallböök F. Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome. PLoS ONE. 2013;8:e59133 pubmed publisher
  • western blot; human
Mobasher M, Gonzalez-Rodriguez A, Santamaria B, Ramos S, Martin M, Goya L, et al. Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 2013;4:e626 pubmed publisher
  • western blot; human
  • western blot; rat
Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher
  • western blot; human
Balaburski G, Leu J, Beeharry N, Hayik S, Andrake M, Zhang G, et al. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013;11:219-29 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Wahlin K, Enke R, Fuller J, Kalesnykas G, Zack D, Merbs S. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS ONE. 2013;8:e79140 pubmed publisher
  • western blot; human
Jelinek M, Balu Íková K, Kopperová D, N McOvá-Fürstová V, Rámek J, Fidlerova J, et al. Caspase-2 is involved in cell death induction by taxanes in breast cancer cells. Cancer Cell Int. 2013;13:42 pubmed
  • immunocytochemistry; human
Schlehe J, Journel M, Taylor K, Amodeo K, LaVoie M. The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. Neurobiol Dis. 2013;58:57-67 pubmed publisher
  • western blot; mouse
Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, et al. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell Death Dis. 2013;4:e483 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:5000
Domitrovic R, Cvijanovic O, Pugel E, Zagorac G, Mahmutefendić H, Skoda M. Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. Toxicology. 2013;310:115-23 pubmed publisher
  • immunohistochemistry; chicken
Boije H, Ring H, Shirazi Fard S, Grundberg I, Nilsson M, Hallböök F. Alternative splicing of the chromodomain protein Morf4l1 pre-mRNA has implications on cell differentiation in the developing chicken retina. J Mol Neurosci. 2013;51:615-28 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Domitrovic R, Cvijanovic O, Pernjak-Pugel E, Skoda M, Mikelić L, Crncevic-Orlic Z. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol. 2013;62:397-406 pubmed publisher
  • western blot; human; 1:500
Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed publisher
  • western blot; mouse; 1:1000
Subbanna S, Shivakumar M, Umapathy N, Saito M, Mohan P, Kumar A, et al. G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. Neurobiol Dis. 2013;54:475-85 pubmed publisher
  • western blot; mouse
Dai J, Shen D, Bian Z, Zhou H, Gan H, Zong J, et al. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PLoS ONE. 2013;8:e53412 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Rungarunlert S, Klincumhom N, Tharasanit T, Techakumphu M, Pirity M, Dinnyes A. Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells. Cell Reprogram. 2013;15:443-58 pubmed publisher
  • western blot; human
Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1500
Cedervall J, Zhang Y, Ringvall M, Thulin A, Moustakas A, Jahnen-Dechent W, et al. HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. Angiogenesis. 2013;16:889-902 pubmed publisher
  • western blot; human
Meijer A, Kruyt F, van der Zee A, Hollema H, Le P, Ten Hoor K, et al. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br J Cancer. 2013;109:2685-95 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Willaredt M, Gorgas K, Gardner H, Tucker K. Multiple essential roles for primary cilia in heart development. Cilia. 2012;1:23 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Donovan M, Yazdani U, Norris R, Games D, German D, Eisch A. Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease. J Comp Neurol. 2006;495:70-83 pubmed
  • western blot; human; 1:1000
Wang R, Dashwood W, Nian H, LOHR C, Fischer K, Tsuchiya N, et al. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer. 2011;128:2581-90 pubmed publisher
  • western blot; mouse; 1:1000
Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed
  • immunohistochemistry - frozen section; mouse; 1:200
Trifunovic D, Dengler K, Michalakis S, Zrenner E, Wissinger B, Paquet-Durand F. cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina. J Comp Neurol. 2010;518:3604-17 pubmed publisher
  • immunohistochemistry; chicken; 1:50
Brunet N, Tarabal O, Portero-Otin M, Oppenheim R, Esquerda J, Caldero J. Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration. J Comp Neurol. 2007;501:669-90 pubmed
  • immunohistochemistry - frozen section; mouse; 1:200
Eckler M, McKenna W, Taghvaei S, McConnell S, Chen B. Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J Comp Neurol. 2011;519:1829-46 pubmed publisher
  • western blot; human; 1:1000
Straud S, Zubovych I, De Brabander J, Roth M. Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. PLoS ONE. 2010;5:e11629 pubmed publisher
  • western blot; human
Rieger J, Lemke D, Maurer G, Weiler M, Frank B, Tabatabai G, et al. Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL. J Neurochem. 2008;106:2436-48 pubmed publisher
  • western blot; mouse
  • immunohistochemistry; mouse
Syu L, El-Zaatari M, Eaton K, Liu Z, Tetarbe M, Keeley T, et al. Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 2012;181:2114-25 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200-400
Zhao Y, Flandin P, Long J, Cuesta M, Westphal H, Rubenstein J. Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol. 2008;510:79-99 pubmed publisher
  • western blot; mouse
  • immunocytochemistry; mouse
Walls K, Ghosh A, Franklin A, Klocke B, Ballestas M, Shacka J, et al. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem. 2010;285:10497-507 pubmed publisher
  • immunohistochemistry; mouse
Martin L, Liu Z, Chen K, Price A, Pan Y, Swaby J, et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol. 2007;500:20-46 pubmed
  • immunohistochemistry - frozen section; mouse; 1:200
Sammeta N, McClintock T. Chemical stress induces the unfolded protein response in olfactory sensory neurons. J Comp Neurol. 2010;518:1825-36 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200
Schwartz C, Cheng A, Mughal M, Mattson M, Yao P. Clathrin assembly proteins AP180 and CALM in the embryonic rat brain. J Comp Neurol. 2010;518:3803-18 pubmed publisher
  • western blot; mouse; 1:1000
Kohn E, Yang Y, Du Z, Nagano Y, Van Schyndle C, Herrmann M, et al. Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression. Mol Cancer Res. 2012;10:1389-99 pubmed publisher
  • western blot; human
Chen M, Huang C, Hsu S, Lin E, Ku C, Lin H, et al. Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation. Evid Based Complement Alternat Med. 2012;2012:580736 pubmed publisher
  • western blot; human; 1:1500
Valdez B, Nieto Y, Murray D, Li Y, Wang G, Champlin R, et al. Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines. Exp Hematol. 2012;40:800-10 pubmed publisher
  • western blot; mouse
O'Brien T, Gorentla B, Xie D, Srivatsan S, McLeod I, He Y, et al. Regulation of T-cell survival and mitochondrial homeostasis by TSC1. Eur J Immunol. 2011;41:3361-70 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Gardner L, Hori T, Chen F, Baine A, Hata T, Uemoto S, et al. Effect of specific activation of γ-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy. Hepatol Res. 2012;42:1131-40 pubmed publisher
  • western blot; human
Wolff S, Erster S, Palacios G, Moll U. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res. 2008;18:733-44 pubmed publisher
  • western blot; human
Eisele G, Roth P, Hasenbach K, Aulwurm S, Wolpert F, Tabatabai G, et al. APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo. Neuro Oncol. 2011;13:155-64 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400
Zogbi C, Tesser R, Encinas G, Miraglia S, Stumpp T. Gonocyte development in rats: proliferation, distribution and death revisited. Histochem Cell Biol. 2012;138:305-22 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Espana A, Clotman F. Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. J Comp Neurol. 2012;520:1424-41 pubmed publisher
  • western blot; human
Hsin I, Hsiao Y, Wu M, Jan M, Tang S, Lin Y, et al. Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. Toxicol Appl Pharmacol. 2012;263:330-7 pubmed publisher
Bouge A, Parmentier M. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Dis Model Mech. 2016;9:307-19 pubmed publisher
Sahoo B, Arduini I, Drombosky K, Kodali R, Sanders L, Greenamyre J, et al. Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. PLoS ONE. 2016;11:e0155747 pubmed publisher
Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher
Cheng C, Tang N, Kao S, Hsieh C. Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats. PLoS ONE. 2016;11:e0155748 pubmed publisher
Frame F, Savoie H, Bryden F, Giuntini F, Mann V, Simms M, et al. Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis. Cancer Med. 2016;5:61-73 pubmed publisher
Rowald K, Mantovan M, Passos J, Buccitelli C, Mardin B, Korbel J, et al. Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. Cell Rep. 2016;15:2679-91 pubmed publisher
Wang N, Li Z, Zhao H, Tao Y, Xu L, Lu J, et al. Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int J Mol Sci. 2015;16:1266-92 pubmed publisher
Zhao S, Fei X, Liu T, Liu Y. Low temperature induces cryoinjury in mouse corneal endothelial cells by stimulating the Stk11-p53 signal pathway. Mol Med Rep. 2015;12:6612-6 pubmed publisher
Cheng C, Lin J, Tang N, Kao S, Hsieh C. Electroacupuncture at different frequencies (5Hz and 25Hz) ameliorates cerebral ischemia-reperfusion injury in rats: possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 2015;15:241 pubmed publisher
Hall J, Messenger Z, Tam H, Phillips S, Recio L, Smart R. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death Dis. 2015;6:e1700 pubmed publisher
Pallangyo C, Ziegler P, Greten F. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed publisher
Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L. Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell. 2015;26:3578-95 pubmed publisher
Martin E, Buzza M, Driesbaugh K, Liu S, Fortenberry Y, Leppla S, et al. Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget. 2015;6:33534-53 pubmed publisher
Kancharla A, Maoz M, Jaber M, Agranovich D, Peretz T, Grisaru-Granovsky S, et al. PH motifs in PAR1&2 endow breast cancer growth. Nat Commun. 2015;6:8853 pubmed publisher
Buijs J, Matula K, Cheung H, Kruithof-de Julio M, van der Mark M, Snoeks T, et al. Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase. J Pathol. 2015;235:745-59 pubmed publisher
Choi H, Choi Y, Park E, Park S, Lee S, Seo J, et al. Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response. Nat Commun. 2015;6:7390 pubmed publisher
Shankman L, Gomez D, Cherepanova O, Salmon M, Alencar G, Haskins R, et al. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015;21:628-37 pubmed publisher
B'chir W, Chaveroux C, Carraro V, Averous J, Maurin A, Jousse C, et al. Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. Cell Signal. 2014;26:1385-91 pubmed publisher
Minter M, Zhang M, Ates R, Taylor J, Crack P. Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells. J Neuroinflammation. 2014;11:43 pubmed publisher
Cheng C, Lin J, Tang N, Kao S, Hsieh C. Electroacupuncture-like stimulation at the Baihui (GV20) and Dazhui (GV14) acupoints protects rats against subacute-phase cerebral ischemia-reperfusion injuries by reducing S100B-mediated neurotoxicity. PLoS ONE. 2014;9:e91426 pubmed publisher
Chen X, Quan Y, Wang H, Luo H. Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe. PLoS ONE. 2014;9:e101433 pubmed publisher
Park J, Lee H, Makaryus R, Yu M, Smith S, Sayed K, et al. Metabolic profiling of dividing cells in live rodent brain by proton magnetic resonance spectroscopy (1HMRS) and LCModel analysis. PLoS ONE. 2014;9:e94755 pubmed publisher
Maya-Mendoza A, Merchut-Maya J, Bartkova J, Bartek J, Streuli C, Jackson D. Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis. 2014;5:e1351 pubmed publisher
Goodall M, Wang T, Martin K, Kortus M, Kauffman A, Trent J, et al. Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy. 2014;10:1120-36 pubmed publisher
Fiory F, Parrillo L, Raciti G, Zatterale F, Nigro C, Mirra P, et al. PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1. PLoS ONE. 2014;9:e113655 pubmed publisher
Shen P, Sun J, Xu G, Zhang L, Yang Z, Xia S, et al. KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells. Prostate. 2014;74:946-58 pubmed publisher
Cheng J, Koenig S, Kuivaniemi H, Garg V, Hans C. Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model. J Am Heart Assoc. 2014;3:e001064 pubmed publisher
Bagci H, Laurin M, Huber J, Muller W, Cote J. Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling. Cell Death Dis. 2014;5:e1375 pubmed publisher
Gaudichon J, Milano F, Cahu J, DaCosta L, Martens A, Renoir J, et al. Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche. PLoS ONE. 2014;9:e107009 pubmed publisher
Shi K, An J, Shan L, Jiang Q, Li F, Ci Y, et al. Survivin-2B promotes autophagy by accumulating IKK alpha in the nucleus of selenite-treated NB4 cells. Cell Death Dis. 2014;5:e1071 pubmed publisher
Maitra R, Seetharam R, Tesfa L, Augustine T, Klampfer L, Coffey M, et al. Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. Oncotarget. 2014;5:2807-19 pubmed
Chen Y, Wei H, Liu F, Guan J. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. J Biol Chem. 2014;289:1164-73 pubmed publisher
Amini N, Boyle J, Moers B, Warboys C, Malik T, Zakkar M, et al. Requirement of JNK1 for endothelial cell injury in atherogenesis. Atherosclerosis. 2014;235:613-8 pubmed publisher
Moreira Sousa C, McGuire J, Thion M, Gentien D, de la Grange P, Tezenas du Montcel S, et al. The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling. EMBO Mol Med. 2013;5:309-25 pubmed publisher
Boer J, Domanska U, Timmer-Bosscha H, Boer I, de Haas C, Joseph J, et al. Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis Inhibitory Protein of S. aureus. Br J Cancer. 2013;108:587-96 pubmed publisher
Ren D, Wang X, Ha T, Liu L, Kalbfleisch J, Gao X, et al. SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages. Biochim Biophys Acta. 2013;1832:336-46 pubmed publisher
Yin X, Yan J, Hou X, Wu S, Zhang G. Neuroprotection of S-nitrosoglutathione against ischemic injury by down-regulating Fas S-nitrosylation and downstream signaling. Neuroscience. 2013;248:290-8 pubmed publisher
Jellema R, Lima Passos V, Zwanenburg A, Ophelders D, De Munter S, Vanderlocht J, et al. Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep. J Neuroinflammation. 2013;10:13 pubmed publisher
Zhou L, Luo H. Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development. J Neurosci. 2013;33:2873-88 pubmed publisher
Kuypers E, Jellema R, Ophelders D, Dudink J, Nikiforou M, Wolfs T, et al. Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep. PLoS ONE. 2013;8:e81644 pubmed publisher
Zhang R, Yang G, Wu X, Xie J, Yang X, Li T. Disruption of Wnt/β-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth. Int J Biol Sci. 2013;9:228-36 pubmed publisher
Gonzalez L, Williamson I, Piedrahita J, Blikslager A, Magness S. Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. PLoS ONE. 2013;8:e66465 pubmed publisher
Jo H, Lee H, Kim C, Son J, Jung S. 8-Hydroxycalamenene isolated from the rhizomes of Reynoutria elliptica exerts neuroprotective effects both in vitro and in vivo. Food Chem Toxicol. 2013;51:231-41 pubmed publisher
Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, et al. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal. 2013;18:1739-52 pubmed publisher
Chu Q, Orr B, Semenkow S, Bar E, Eberhart C. Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade. Clin Cancer Res. 2013;19:3224-33 pubmed publisher
Ulukaya E, Frame F, Cevatemre B, Pellacani D, Walker H, Mann V, et al. Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. PLoS ONE. 2013;8:e64278 pubmed publisher
Tan S, Hougardy B, Meersma G, Schaap B, de Vries E, van der Zee A, et al. Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells. Mol Pharmacol. 2012;81:701-9 pubmed publisher
Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, et al. Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes). Cell Death Dis. 2012;3:e395 pubmed publisher
Faber A, Corcoran R, Ebi H, Sequist L, Waltman B, Chung E, et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011;1:352-65 pubmed publisher
Campbell J, Davidenko N, Caffarel M, Cameron R, Watson C. A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology. PLoS ONE. 2011;6:e25661 pubmed publisher
Dokmanovic-Chouinard M, Chung W, Chevre J, Watson E, Yonan J, Wiegand B, et al. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008;4:e1000137 pubmed publisher
Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, et al. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009;7:e1000196 pubmed publisher
Dinicola S, Cucina A, Pasqualato A, D'Anselmi F, Proietti S, Lisi E, et al. Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. Int J Mol Sci. 2012;13:651-64 pubmed publisher
Hall C, Wang R, Miao J, Oliva E, Shen X, Wheeler T, et al. Hippo pathway effector Yap is an ovarian cancer oncogene. Cancer Res. 2010;70:8517-25 pubmed publisher
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton M, Sudhof T. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010;329:1663-7 pubmed publisher
Hartley T, Siva M, Lai E, Teodoro T, Zhang L, Volchuk A. Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol. 2010;11:59 pubmed publisher
Nolan-Stevaux O, Lau J, Truitt M, Chu G, Hebrok M, Fernandez-Zapico M, et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009;23:24-36 pubmed publisher
Gonzalez-Mejia M, Voss O, Murnan E, Doseff A. Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death Dis. 2010;1:e64 pubmed publisher
Ishii T, Seike T, Nakashima T, Jüliger S, Maharaj L, Soga S, et al. Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012;2:e68 pubmed
Horie T, Baba O, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, et al. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice. J Am Heart Assoc. 2012;1:e003376 pubmed publisher
Marais A, Ji Z, Child E, Krause E, Mann D, Sharrocks A. Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes. J Biol Chem. 2010;285:35728-39 pubmed publisher
Burga L, Hu H, Juvekar A, Tung N, Troyan S, Hofstatter E, et al. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res. 2011;13:R30 pubmed publisher
Cheng C, Su S, Tang N, Ho T, Lo W, Hsieh C. Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats. Acta Pharmacol Sin. 2010;31:889-99 pubmed publisher
Schurgers L, Joosen I, Laufer E, Chatrou M, Herfs M, Winkens M, et al. Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PLoS ONE. 2012;7:e43229 pubmed publisher
Patel A, Krimm R. BDNF is required for the survival of differentiated geniculate ganglion neurons. Dev Biol. 2010;340:419-29 pubmed publisher
Reefman E, de Jong M, Kuiper H, Jonkman M, Limburg P, Kallenberg C, et al. Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?. Arthritis Res Ther. 2006;8:R156 pubmed
Kaiser C, Chapman B, Guidi J, Terry C, Mangiardi D, Cotanche D. Comparison of activated caspase detection methods in the gentamicin-treated chick cochlea. Hear Res. 2008;240:1-11 pubmed publisher
Dive C, Smith R, Garner E, Ward T, George-Smith S, Campbell F, et al. Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. Br J Cancer. 2010;102:577-82 pubmed publisher
Ioannides A, Massa V, Ferraro E, Cecconi F, Spitz L, Henderson D, et al. Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death. Dev Biol. 2010;337:351-62 pubmed publisher
Kuypers E, Collins J, Jellema R, Wolfs T, Kemp M, Nitsos I, et al. Ovine fetal thymus response to lipopolysaccharide-induced chorioamnionitis and antenatal corticosteroids. PLoS ONE. 2012;7:e38257 pubmed publisher
Thomé C, Dos Santos G, Ferreira G, Scheucher P, Izumi C, Leopoldino A, et al. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity. Mol Cell Proteomics. 2012;11:1898-912 pubmed publisher
product information
SKU :
9661S
Product-Name :
Cleaved Caspase-3 (Asp175) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (B, Dg, Pg)
Applications :
Flow cytometry
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
17, 19
Host :
Rabbit
Target :
Casp3 (Asp175) cleaved
Primary-Protein :
Casp3
Alt-Names :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.