Cleaved Caspase-3 (Asp175) Antibody | Cell Signaling Technology 9661L product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Cleaved Caspase-3 (Asp175) Antibody

catalog :

9661L

quantity :

300 ul

price :

658 USD

clonality :

polyclonal

host :

rabbit

reactivity :

, human, mouse, rat, dog, cow, fruit fly, common platanna

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section

more info or order :

Cell Signaling Technology product webpage

citations: 132

Published Application/Species/Dilution	Reference
western blot; mouse; fig 6	Wang S, Ni H, Dorko K, Kumer S, Schmitt T, Nawabi A, et al. Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury. Oncotarget. 2016;7:17681-98 pubmed publisher
western blot; human	Scala F, Brighenti E, Govoni M, Imbrogno E, Fornari F, Trere D, et al. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. 2016;35:977-89 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:500	James R, Hillis J, Adorjan I, Gration B, Mundim M, Iqbal A, et al. Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis. Glia. 2016;64:105-21 pubmed publisher
western blot; human	Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J. Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE. 2015;10:e0135929 pubmed publisher
western blot; mouse	Kapodistria K, Tsilibary E, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015;400:112-28 pubmed publisher
immunohistochemistry - paraffin section; fruit fly; 1:150	Bras-Pereira C, Casares F, Janody F. The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex. Development. 2015;142:1470-9 pubmed publisher
immunocytochemistry; human; 1:60	Meadows S, Cleaver O. Annexin A3 Regulates Early Blood Vessel Formation. PLoS ONE. 2015;10:e0132580 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200	You L, Yan K, Zou J, Zhao H, Bertos N, Park M, et al. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. J Biol Chem. 2015;290:11349-64 pubmed publisher
western blot; human; fig s5	Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher
immunohistochemistry; mouse; 1:200	You L, Zou J, Zhao H, Bertos N, Park M, Wang E, et al. Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. J Biol Chem. 2015;290:7114-29 pubmed publisher
immunohistochemistry; human	Wagner R, Luciani F, Cario-Andre M, Rubod A, Petit V, Benzekri L, et al. Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo. J Invest Dermatol. 2015;135:1810-9 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200	Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprüssel A, et al. A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene. 2015;34:3357-68 pubmed publisher
immunohistochemistry; rat; 1:500	Rivera P, Bindila L, Pastor A, Perez-Martin M, Pavón F, Serrano A, et al. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Front Cell Neurosci. 2015;9:98 pubmed publisher
immunohistochemistry; mouse; 1:200-1:500; fig 2	Imajo M, Ebisuya M, Nishida E. Dual role of YAP and TAZ in renewal of the intestinal epithelium. Nat Cell Biol. 2015;17:7-19 pubmed publisher
western blot; rat	Liu H, Xie Q, Xin B, Liu J, Liu Y, Li Y, et al. Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension. Life Sci. 2015;121:1-9 pubmed publisher
flow cytometry; human	Zaric M, Mitrovic M, Nikolic I, Baskic D, Popovic S, Djurdjevic P, et al. Chrysin induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia. Anticancer Agents Med Chem. 2015;15:189-95 pubmed
western blot; human; 1:2000	Zhang W, Cai J, Chen S, Zheng X, Hu S, Dong W, et al. Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. Mol Med Rep. 2015;12:1506-14 pubmed publisher
western blot; human	Holland W, Chinn D, Lara P, Gandara D, Mack P. Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines. J Cancer Res Clin Oncol. 2015;141:615-26 pubmed publisher
western blot; human	Martinez-Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher
western blot; rat; 1:500	Liu S, Sarkar C, Dinizo M, Faden A, Koh E, Lipinski M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 2015;6:e1582 pubmed publisher
immunohistochemistry - free floating section; mouse; 1:5000	Heng Y, Zhou B, Harris L, Harvey T, Smith A, Horne E, et al. NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche. Cereb Cortex. 2015;25:3758-78 pubmed publisher
immunocytochemistry; mouse	Higashi T, Katsuno T, Kitajiri S, Furuse M. Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. PLoS ONE. 2015;10:e0120674 pubmed publisher
western blot; human	Li X, Liang Q, Liu W, Zhang N, Xu L, Zhang X, et al. Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. Oncogene. 2015;: pubmed publisher
immunocytochemistry; mouse; 1:250	Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, et al. Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J Biol Chem. 2015;290:11515-25 pubmed publisher
immunohistochemistry - paraffin section; mouse	Ahlers K, Karacay B, Fuller L, Bonthius D, Dailey M. Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration. Glia. 2015;63:1694-713 pubmed publisher
western blot; mouse	Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100	Iyer R, Patterson N, Zouein F, Ma Y, Dive V, de Castro Brás L, et al. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. Int J Cardiol. 2015;185:198-208 pubmed publisher
flow cytometry; human; 1:250	Neradil J, Pavlasova G, Srámek M, Kyr M, Veselska R, Sterba J. DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: the same outcome of treatment with different doses in sensitive cell lines. Oncol Rep. 2015;33:2169-75 pubmed publisher
immunocytochemistry; rat; 1:400	Zajkowski T, Nieznanska H, Nieznanski K. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015;1853:2228-39 pubmed publisher
immunohistochemistry; mouse; 1:1200	Wende C, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, et al. Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. PLoS ONE. 2015;10:e0127681 pubmed publisher
western blot; human; 1:500	Martin S, Lovat P, Redfern C. Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells. J Cell Biochem. 2015;116:438-49 pubmed publisher
western blot; human	Gargalionis A, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136:1515-27 pubmed publisher
immunocytochemistry; human	Barcus C, Holt E, Keely P, Eliceiri K, Schuler L. Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells. PLoS ONE. 2015;10:e0116891 pubmed publisher
western blot; human; 1:1000	Shen Z, Stanger B. YAP regulates S-phase entry in endothelial cells. PLoS ONE. 2015;10:e0117522 pubmed publisher
immunohistochemistry - paraffin section; human; 1:800	Jarry A, Crémet L, Caroff N, Bou-Hanna C, Mussini J, Reynaud A, et al. Subversion of human intestinal mucosa innate immunity by a Crohn's disease-associated E. coli. Mucosal Immunol. 2015;8:572-81 pubmed publisher
western blot; mouse; 1:1000	Hung S, Huang W, Liou H, Fu W. LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacology. 2015;93:243-51 pubmed publisher
western blot; human; 1:160; fig 4b	Krossa S, Schmitt A, Hattermann K, Fritsch J, Scheidig A, Mehdorn H, et al. Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1. Oncotarget. 2015;6:21029-45 pubmed
immunohistochemistry; human	Patsialou A, Wang Y, Pignatelli J, Chen X, Entenberg D, Oktay M, et al. Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells. Oncogene. 2015;34:2721-31 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200	Lohse I, Borgida A, Cao P, Cheung M, Pintilie M, Bianco T, et al. BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. Br J Cancer. 2015;113:425-32 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400	Pechriggl E, Bitsche M, Glueckert R, Rask-Andersen H, Blumer M, Schrott-Fischer A, et al. Development of the innervation of the human inner ear. Dev Neurobiol. 2015;75:683-702 pubmed publisher
immunohistochemistry; mouse; 1:100	Urness L, Wang X, Shibata S, Ohyama T, Mansour S. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015;400:59-71 pubmed publisher
western blot; human; 1:1000; fig 5d	Duan H, Li Y, Lim H, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015;23:4514-21 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:600 immunocytochemistry; mouse; 1:600	Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick J. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Hum Gene Ther Methods. 2015;26:107-22 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:400	Fujimura N, Klimova L, Antosova B, Smolikova J, Machon O, Kozmik Z. Genetic interaction between Pax6 and β-catenin in the developing retinal pigment epithelium. Dev Genes Evol. 2015;225:121-8 pubmed publisher
western blot; human; 1:1000	El Zaoui I, Behar-Cohen F, Torriglia A. Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms. Toxicol Sci. 2015;143:441-53 pubmed publisher
western blot; mouse	Gomez-Cavazos J, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015;208:671-81 pubmed publisher
western blot; human; fig 7	Thiyagarajan D, Rekvig O, Seredkina N. TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form. PLoS ONE. 2015;10:e0129485 pubmed publisher
immunohistochemistry; fruit fly; fig 6	Xiao X, Zhang R, Pang X, Liang G, Wang P, Cheng G. A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes. PLoS Pathog. 2015;11:e1004848 pubmed publisher
immunohistochemistry - paraffin section; mouse	Zimberlin C, Lancini C, Sno R, Rosekrans S, McLean C, Vlaming H, et al. HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J. 2015;29:2070-80 pubmed publisher
immunohistochemistry; mouse	Sivaraj K, Li R, Albarrán-Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
western blot; mouse	Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015;10:e0136952 pubmed publisher
immunocytochemistry; mouse western blot; mouse	Roux C, Aligny C, Lesueur C, Girault V, Brunel V, Ramdani Y, et al. NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice. Exp Neurol. 2015;267:177-93 pubmed publisher
western blot; mouse	Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher
western blot; rat; 1:1000	Liu G, Wang Z, Wang Z, Yang D, Liu Z, Wang L. Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead. Arch Toxicol. 2015;: pubmed
immunocytochemistry; mouse; 1:200	Zang G, Sandberg M, Carlsson P, Welsh N, Jansson L, Barbu A. Activated pancreatic stellate cells can impair pancreatic islet function in mice. Ups J Med Sci. 2015;120:169-80 pubmed publisher
immunocytochemistry; human; 1:300	Takasato M, Er P, Chiu H, Maier B, Baillie G, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015;526:564-8 pubmed publisher
western blot; human; fig 3 a-c	Philipp S, Sosna J, Plenge J, Kalthoff H, Adam D. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal. 2015;13:25 pubmed publisher
western blot; human	Tebbi A, Guittet O, Tuphile K, Cabrié A, Lepoivre M. Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis. J Biol Chem. 2015;290:14077-90 pubmed publisher
western blot; rat; fig 4	Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher
immunohistochemistry - paraffin section; human	Zhang D, Zhu L, Li C, Mu J, Fu Y, Zhu Q, et al. Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction. Basic Res Cardiol. 2015;110:28 pubmed publisher
immunohistochemistry; mouse; 1:300	Angliker N, Burri M, Zaichuk M, Fritschy J, Ruegg M. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur J Neurosci. 2015;42:2595-612 pubmed publisher
western blot; human; 1:1000	Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-76 pubmed
immunohistochemistry; human	de Leeuw R, Berman-Booty L, Schiewer M, Ciment S, Den R, Dicker A, et al. Novel actions of next-generation taxanes benefit advanced stages of prostate cancer. Clin Cancer Res. 2015;21:795-807 pubmed publisher
immunohistochemistry - paraffin section; mouse; 0.2 ug/ml	Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed publisher
immunocytochemistry; human; fig 7.43.6	Cappella P, Pulici M, Gasparri F. Application of click chemistry conditions for 5-bromo-2'-deoxyuridine determination through fenton and related reactions. Curr Protoc Cytom. 2015;71:7.43.1-17 pubmed publisher
western blot; human	Moon J, Eo S, Lee J, Park S. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375-81 pubmed publisher
western blot; human	De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed publisher
immunohistochemistry; mouse	Tepavcevic V, Kerninon C, Aigrot M, Meppiel E, Mozafari S, Arnould-Laurent R, et al. Early netrin-1 expression impairs central nervous system remyelination. Ann Neurol. 2014;76:252-68 pubmed publisher
western blot; human	Subramani R, Lopez-Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
immunocytochemistry; mouse; 1:200	Doughton G, Wei J, Tapon N, Welham M, Chalmers A. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS ONE. 2014;9:e95434 pubmed publisher
immunocytochemistry; cow western blot; cow	Zielniok K, Motyl T, Gajewska M. Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures. Biomed Res Int. 2014;2014:382653 pubmed publisher
immunohistochemistry; common platanna; 1:50; fig s9	Sojka S, Amin N, Gibbs D, Christine K, Charpentier M, Conlon F. Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity. Development. 2014;141:3040-9 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200	Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher
immunohistochemistry; mouse; 1:500	Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet A, et al. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014;17:1171-9 pubmed publisher
western blot; human; 1:500	Malaviya A, Sylvester P. Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells. PPAR Res. 2014;2014:439146 pubmed publisher
immunohistochemistry - paraffin section; mouse	Caswell D, Chuang C, Yang D, Chiou S, Cheemalavagu S, Kim-Kiselak C, et al. Obligate progression precedes lung adenocarcinoma dissemination. Cancer Discov. 2014;4:781-9 pubmed publisher
immunohistochemistry - free floating section; mouse	Roux C, Lesueur C, Aligny C, Brasse-Lagnel C, Genty D, Marret S, et al. 3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis. Cell Transplant. 2014;23:1425-50 pubmed publisher
immunohistochemistry; fruit fly; 1:100	Stickel S, Su T. Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins. Biol Open. 2014;3:201-9 pubmed publisher
western blot; human	Model L, Hall M, Wong D, Muto A, Kondo Y, Ziegler K, et al. Arterial shear stress reduces eph-b4 expression in adult human veins. Yale J Biol Med. 2014;87:359-71 pubmed
western blot; rat; 1:1000	Farkas D, Kraskauskas D, Drake J, Alhussaini A, Kraskauskiene V, Bogaard H, et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats. PLoS ONE. 2014;9:e89810 pubmed publisher
western blot; human	Ginet V, Pittet M, Rummel C, Osterheld M, Meuli R, Clarke P, et al. Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic. Ann Neurol. 2014;76:695-711 pubmed publisher
western blot; mouse; 1:1000; fig 1	Das R, Xu S, Quan X, Nguyen T, Kong I, Chung C, et al. Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes. Am J Physiol Renal Physiol. 2014;306:F155-67 pubmed publisher
immunohistochemistry; fruit fly; 1:400; fig 3s	Burman J, Itsara L, Kayser E, Suthammarak W, Wang A, Kaeberlein M, et al. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis Model Mech. 2014;7:1165-74 pubmed publisher
western blot; rat; 1:1000	Cong B, Wang L, Zhu X, Li X, Liu B, Ni X. SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes. Can J Cardiol. 2014;30:687-95 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Marusyk A, Tabassum D, Altrock P, Almendro V, Michor F, Polyak K. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014;514:54-8 pubmed publisher
western blot; human	Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, et al. Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21:1914-24 pubmed publisher
western blot; human	Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
immunohistochemistry; mouse; fig 7	Cicchini M, Chakrabarti R, Kongara S, Price S, Nahar R, Lozy F, et al. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy. 2014;10:2036-52 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 6	Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
immunohistochemistry - frozen section; rat; 1:500	Okusa C, Oeschger F, Ginet V, Wang W, Hoerder-Suabedissen A, Matsuyama T, et al. Subplate in a rat model of preterm hypoxia-ischemia. Ann Clin Transl Neurol. 2014;1:679-91 pubmed publisher
western blot; mouse; fig 4	Takahashi N, Vereecke L, Bertrand M, Duprez L, Berger S, Divert T, et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature. 2014;513:95-9 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:200	Deng M, Hofacer R, Jiang C, Joseph B, Hughes E, Jia B, et al. Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions. Br J Anaesth. 2014;113:443-51 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:500	Domitrovic R, Cvijanovic O, Susnić V, Katalinić N. Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. Toxicology. 2014;324:98-107 pubmed publisher
western blot; mouse	Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014;322:43-50 pubmed publisher
immunohistochemistry; mouse	Kim M, Ryu J, Kwon Y, Lee S, Bae Y, Yoon J, et al. Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice. Antioxid Redox Signal. 2014;21:1803-18 pubmed publisher
immunohistochemistry; mouse; 1:200	Son A, Sheleg M, Cooper M, Sun Y, Kleiman N, Zhou R. Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. Invest Ophthalmol Vis Sci. 2014;55:1594-606 pubmed publisher
immunohistochemistry; mouse; 1:1000	Qi Y, Zhang M, Li H, Frank J, Dai L, Liu H, et al. MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade. J Biol Chem. 2014;289:10201-10 pubmed publisher
western blot; human	Trembley J, Unger G, Gomez O, Abedin J, Korman V, Vogel R, et al. Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation. Mol Cell Pharmacol. 2014;6:15-25 pubmed
immunohistochemistry - paraffin section; mouse	Vapola M, Rokka A, Sormunen R, Alhonen L, Schmitz W, Conzelmann E, et al. Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice. Dev Biol. 2014;391:66-80 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100	Roberts J, Ennajdaoui H, Edmondson C, Wirth B, Sanford J, Chen B. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014;522:372-92 pubmed publisher
immunohistochemistry - frozen section; human	Sider K, Zhu C, Kwong A, Mirzaei Z, de Lange C, Simmons C. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol. 2014;23:289-97 pubmed publisher
immunocytochemistry; mouse; 1:250	Erturk A, Wang Y, Sheng M. Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci. 2014;34:1672-88 pubmed publisher
western blot; human; fig 4	Moskwa P, Zinn P, Choi Y, Shukla S, Fendler W, Chen C, et al. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014;12:1767-78 pubmed publisher
western blot; human; fig s1b	Chipumuro E, Marco E, Christensen C, Kwiatkowski N, Zhang T, Hatheway C, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell. 2014;159:1126-39 pubmed publisher
immunohistochemistry - paraffin section; human; 1:250	Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed
immunohistochemistry - paraffin section; mouse; 1:250	Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed publisher
western blot; human	Wei N, Chu E, Wipf P, Schmitz J. Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Mol Cancer Ther. 2014;13:1130-41 pubmed publisher
western blot; human immunocytochemistry; human	Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher
immunocytochemistry; human	Van Der Meer R, Song H, Park S, Abdulkadir S, Roh M. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clin Cancer Res. 2014;20:3211-21 pubmed publisher
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product information

SKU :

9661L

Product-Name :

Cleaved Caspase-3 (Asp175) Antibody

Size :

300 ul

Price-(USD) :

658 USD

Species-x-Reactivity :

H, M, R, Mk, (B, Dg, Pg)

Applications :

Flow cytometry

Product-Category :

Apoptosis

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Polyclonal Antibody

MW :

17, 19

Host :

Rabbit

Target :

Casp3 (Asp175) cleaved

Primary-Protein :

Casp3

Alt-Names :

Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3

more info or order :

Cell Signaling Technology product webpage