product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved Caspase-3 (Asp175) Antibody
catalog :
9661
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, chicken, bovine, pigs , zebrafish , fruit fly , domestic sheep, domestic rabbit, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 686
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 3d
  • western blot; human; loading ...; fig 4d
Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig 1
Grootaert M, Schrijvers D, Hermans M, Van Hoof V, De Meyer G, Martinet W. Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice. Oxid Med Cell Longev. 2016;2016:3087469 pubmed
  • immunohistochemistry; mouse; loading ...
Zimmerli D, Brambillasca C, Talens F, Bhin J, Linstra R, Romanens L, et al. MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nat Commun. 2022;13:6579 pubmed publisher
  • western blot; rat; loading ...; fig 5g
  • western blot; mouse; loading ...; fig 2g
Song M, Cui X, Zhang J, Li Y, Li J, Zang Y, et al. Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155. Pharm Biol. 2022;60:2011-2024 pubmed publisher
  • western blot; rat; loading ...; fig 5a
Wen S, Unuma K, Funakoshi T, Aki T, Uemura K. Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022;23: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Liu Y, Xu Y, Yao Y, Cao Y, Chen G, Cai Y, et al. I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway. Front Physiol. 2022;13:934899 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig s3-1c
Pribluda A, Daemen A, Lima A, Wang X, Hafner M, Poon C, et al. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation. elife. 2022;11: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig e3a
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608:778-783 pubmed publisher
  • western blot; mouse; fig 2g
Chi R, Yao C, Chen S, Liu Y, He Y, Zhang J, et al. Elevated BCAA Suppresses the Development and Metastasis of Breast Cancer. Front Oncol. 2022;12:887257 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Zheng S, Liu D, Wang F, Jin Y, Zhao S, Sun S, et al. ABCA12 Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway. Front Genet. 2022;13:906326 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s2b
Park S, Lee C, Choi J, Kim J, Lee W, Jang T, et al. Dysadherin awakens mechanical forces and promotes colorectal cancer progression. Theranostics. 2022;12:4399-4414 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 1e
Mao L, Xin F, Ren J, Xu S, Huang H, Zha X, et al. 5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression. Theranostics. 2022;12:3928-3945 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5o
  • western blot; mouse; loading ...; fig 1b, 3a, 3f
Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
  • immunohistochemistry - frozen section; rat; loading ...; fig 5c
Lan T, Wu Y, Zhang Y, Li S, Zhu Z, Wang L, et al. Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway. J Neuroinflammation. 2022;19:117 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3a
Yu D, Li T, Delpech J, Zhu B, Kishore P, Koshi T, et al. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 2022;8:eabm2545 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2a
Matilionyte G, Tharmalingam M, Sanou I, Lopes F, Lane S, Stukenborg J, et al. Maintenance of Sertoli Cell Number and Function in Immature Human Testicular Tissues Exposed to Platinum-Based Chemotherapy-Implications for Fertility Restoration. Front Toxicol. 2022;4:825734 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig s5c
Pantasis S, Friemel J, Brütsch S, Hu Z, Krautbauer S, Liebisch G, et al. Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation. J Cell Sci. 2022;135: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1d
Simpson D, Pang J, Weir A, Kong I, Fritsch M, Rashidi M, et al. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55:423-441.e9 pubmed publisher
  • immunocytochemistry; rat; 1:200; fig 2m
Aberle T, Piefke S, Hillg xe4 rtner S, Tamm E, Wegner M, K xfc spert M. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Nucleic Acids Res. 2022;50:1951-1968 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1e
  • western blot; mouse; fig 6b
Rusu I, Mennillo E, Bain J, Li Z, Sun X, Ly K, et al. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022;132: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig s1c
Grinat J, Kosel F, Goveas N, Kranz A, Alexopoulou D, Rajewsky K, et al. Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells. Life Sci Alliance. 2022;5: pubmed publisher
  • western blot; human; loading ...; fig 1b, 2d, 4a
  • western blot; mouse; loading ...; fig 3e, 5a
Chen G, Ahn E, Kang S, Xia Y, Liu X, Zhang Z, et al. UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Adv Sci (Weinh). 2022;9:e2103396 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 5m
  • western blot; human; 1:1000; fig 5a
Wang S, Luke C, Pak S, Shi V, Chen L, Moore J, et al. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun Biol. 2022;5:46 pubmed publisher
  • western blot; human; loading ...; fig 6e
Yang J, Liao Q, Price M, Moriarity B, Wolf N, Felices M, et al. Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation. Transl Oncol. 2022;16:101318 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1f
Karpinski B, Maynard T, Bryan C, Yitsege G, Horvath A, Lee N, et al. Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022;15: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 8b
Kattan W, Liu J, Montufar Solis D, Liang H, Brahmendra Barathi B, van der Hoeven R, et al. Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s6a
Correia de Sousa M, Calo N, Sobolewski C, Gjorgjieva M, Clement S, Maeder C, et al. Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis. Cancers (Basel). 2021;13: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 1b
Schünke H, Göbel U, Dikic I, Pasparakis M. OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun. 2021;12:5912 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2e
Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, et al. OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity. Nat Commun. 2021;12:5913 pubmed publisher
  • immunohistochemistry; mouse
Ban Y, Yu T, Feng B, Lorenz C, Wang X, Baker C, et al. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Sci Adv. 2021;7:eabh2974 pubmed publisher
  • immunohistochemistry; mouse; fig 3e
Kurth I, Yamaguchi N, Andreu Agullo C, Tian H, Sridhar S, Takeda S, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021;7:eabi7511 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4i
Sun L, Li Y, Misumi I, Gonzalez Lopez O, Hensley L, Cullen J, et al. IRF3-mediated pathogenicity in a murine model of human hepatitis A. PLoS Pathog. 2021;17:e1009960 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5a
Mangold N, Pippin J, Unnersjoe Jess D, Koehler S, Shankland S, Brähler S, et al. The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells. 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8f
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5d
  • western blot; mouse; loading ...; fig 5c
Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, et al. TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis. Cell Death Dis. 2021;12:853 pubmed publisher
  • western blot; human; loading ...; fig 5a
Chiang C, Hong Y. In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy. Sci Rep. 2021;11:18172 pubmed publisher
  • immunohistochemistry; rat; fig s1b
Chen Y, Li J, Menon R, Jayaraman A, Lee K, Huang Y, et al. Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes. 2021;13:1972756 pubmed publisher
  • immunocytochemistry; human; 1:300; fig 2d
Lo Cascio C, McNamara J, Melendez E, Lewis E, Dufault M, Sanai N, et al. Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. JCI Insight. 2021;6: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 6g
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang C, et al. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat Commun. 2021;12:5321 pubmed publisher
  • immunocytochemistry; human; 1:250; fig 5k
Cui M, Atmanli A, Morales M, Tan W, Chen K, Xiao X, et al. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat Commun. 2021;12:5270 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 1c
Solano Fonseca R, Metang P, Egge N, Liu Y, Zuurbier K, Sivaprakasam K, et al. Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 1j
De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2g
  • western blot; human; loading ...; fig 3h
Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, et al. Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30. Cell Death Discov. 2021;7:211 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8g
Yuan S, Zhang P, Wen L, Jia S, Wu Y, Zhang Z, et al. miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma. Oncogene. 2021;40:5799-5813 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 2a
Keil Stietz K, Kennedy C, Sethi S, Valenzuela A, Nunez A, Wang K, et al. In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder. Curr Res Toxicol. 2021;2:1-18 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 6d
  • western blot; human; loading ...; fig 3d
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, et al. A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein. Cell Death Discov. 2021;7:198 pubmed publisher
  • western blot; mouse; fig 6b
Chen H, Zhang Brotzge X, Morozov Y, Li Y, Wang S, Zhang H, et al. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021;6: pubmed publisher
  • western blot; human; loading ...; fig 3e, 3f
Zhang Y, Ma Y, Wu G, Xie M, Luo C, Huang X, et al. SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression. Cell Death Discov. 2021;7:192 pubmed publisher
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse; 1:200
Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 1g
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5d
Lertpatipanpong P, Lee J, Kim I, Eling T, Oh S, Seong J, et al. The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice. Sci Rep. 2021;11:15027 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2f
Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, et al. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Front Cell Dev Biol. 2021;9:706143 pubmed publisher
  • immunohistochemistry; human; fig s3i
Prekovic S, Schuurman K, Mayayo Peralta I, Manjón A, Buijs M, Yavuz S, et al. Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. Nat Commun. 2021;12:4360 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2i
Johnston S, Parylak S, Kim S, Mac N, Lim C, Gallina I, et al. AAV ablates neurogenesis in the adult murine hippocampus. elife. 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6e
Marquez Exposito L, Tejedor Santamaria L, Santos Sánchez L, Valentijn F, Cantero Navarro E, Rayego Mateos S, et al. Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes. Front Pharmacol. 2021;12:662020 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Mandal P, Lyons J, Burd E, Koval M, Mocarski E, Coopersmith C. Integrated evaluation of lung disease in single animals. PLoS ONE. 2021;16:e0246270 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6g
  • western blot; rat; loading ...; fig 2a
Kim Y, Lee J, Kim H, Jang J, Choung Y. Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway. Int J Mol Sci. 2021;22: pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 3b
  • western blot; rat; loading ...; fig 3c
Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, et al. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell Death Dis. 2021;12:642 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6h
Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, et al. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021;48:403-410 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s5e
Fei A, Wu W, Tan L, Tang C, Xu Z, Huo X, et al. Coordination of two enhancers drives expression of olfactory trace amine-associated receptors. Nat Commun. 2021;12:3798 pubmed publisher
  • western blot; human; fig 4b
Iampietro M, Dumont C, Mathieu C, Spanier J, Robert J, Charpenay A, et al. Activation of cGAS/STING pathway upon paramyxovirus infection. iScience. 2021;24:102519 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 2e
Thies K, Cole M, Schafer R, Spehar J, Richardson D, Steck S, et al. The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. Breast Cancer Res. 2021;23:65 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 5c
  • immunohistochemistry - paraffin section; human; loading ...; fig s9
Ostriker A, Xie Y, Chakraborty R, Sizer A, Bai Y, Ding M, et al. TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy. Circulation. 2021;144:455-470 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4g
  • western blot; human; fig s4h
Yi J, Sias Garcia O, Nasholm N, Hu X, Iniguez A, Hall M, et al. The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53. Neoplasia. 2021;23:624-633 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2b
Barthet V, Brucoli M, Ladds M, Nössing C, Kiourtis C, Baudot A, et al. Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry; human; 1:50; loading ...; fig 5d, e5d
Wu S, Fukumoto T, Lin J, Nacarelli T, Wang Y, Ong D, et al. Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma. Nat Cancer. 2021;2:189-200 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig 2g
  • immunohistochemistry - paraffin section; human; 1:250; loading ...; fig s8d
Totten S, Im Y, Cepeda Cañedo E, Najyb O, Nguyen A, Hebert S, et al. STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. Nat Commun. 2021;12:3299 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 2a
Yen Y, Chien M, Wu P, Hung S. PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021;4:658 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b, 1e, 1h
Sanchez Rivera F, Ryan J, Soto Feliciano Y, Clare Beytagh M, Xuan L, Feldser D, et al. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • immunohistochemistry; human; loading ...; fig s10f
Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, et al. SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth. Adv Sci (Weinh). 2021;8:e2004846 pubmed publisher
  • western blot; human; 1:700; loading ...; fig 2
Lee J, Hsu Y, Li Y, Cheng S. Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. Int J Endocrinol. 2021;2021:5583491 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2k
Haan N, Westacott L, Carter J, Owen M, Gray W, Hall J, et al. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Transl Psychiatry. 2021;11:313 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4f
  • western blot; mouse; 1:1000; loading ...; fig 4e
Liu M, Rao H, Liu J, Li X, Feng W, Gui L, et al. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021;43:102004 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Zhang W, Li J, Yao H, Li T. Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6. Nanoscale Res Lett. 2021;16:89 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7a
Song X, Chen H, Shang Z, Du H, Li Z, Wen Y, et al. Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons. Neurosci Bull. 2021;37:985-998 pubmed publisher
  • immunohistochemistry; mouse
Hendley A, Rao A, Leonhardt L, Ashe S, Smith J, Giacometti S, et al. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. elife. 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a
Li Q, Liu M, Sun Y, Jin T, Zhu P, Wan X, et al. SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress. J Exp Clin Cancer Res. 2021;40:168 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Lindfors S, Polianskyte Prause Z, Bouslama R, Lehtonen E, Mannerla M, Nisen H, et al. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo. Diabetologia. 2021;64:1866-1879 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Tan S, Liu X, Chen L, Wu X, Tao L, Pan X, et al. Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis. Cell Death Dis. 2021;12:474 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200; fig 2a
Delepine C, Pham V, Tsang H, Sur M. GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration. PLoS ONE. 2021;16:e0251173 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1a, 1b
  • immunohistochemistry; mouse; loading ...; fig 5a
Guillermin O, Angelis N, Sidor C, Ridgway R, Baulies A, Kucharska A, et al. Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration. EMBO J. 2021;40:e105770 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s2b
Malik N, Yan H, Yang H, Ayaz G, DuBois W, Tseng Y, et al. CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PLoS Genet. 2021;17:e1009553 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1i
  • western blot; mouse; 1:1000; loading ...; fig 8d
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4d
Ezan J, Moreau M, Mamo T, Shimbo M, Decroo M, Richter M, et al. Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity. Sci Rep. 2021;11:9106 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...
Ofek S, Wiszniak S, Kagan S, Tondl M, Schwarz Q, Kalcheim C. Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube. BMC Biol. 2021;19:84 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Wang S, Li S, Li Y, Jiang Q, Li X, Wang Y, et al. Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation. Stem Cell Reports. 2021;16:1290-1301 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7a
Jang S, Economides K, Moniz R, Sia C, Lewis N, McCoy C, et al. ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance. Commun Biol. 2021;4:497 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a, 4b, 4c
Low H, Wong Z, Wu B, Kong L, Png C, Cho Y, et al. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nat Commun. 2021;12:2284 pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig s6h
Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
  • immunohistochemistry; mouse
Meng L, Coleman V, Zhao Y, Ost M, Voigt A, Bunschoten A, et al. Pseudo-Starvation Driven Energy Expenditure Negatively Affects Ovarian Follicle Development. Int J Mol Sci. 2021;22: pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 4a
Zhang J, Saravanabavan S, Rangan G. Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease. Cells. 2021;10: pubmed publisher
  • immunocytochemistry; human; 1:300; loading ...
Yoon M, Choi B, Kim E, Ohk J, Yang C, Choi Y, et al. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy. Nat Commun. 2021;12:1955 pubmed publisher
  • western blot; human; fig 3h
Hirano M, Imai Y, Kaito Y, Murayama T, Sato K, Ishida T, et al. Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. J Exp Clin Cancer Res. 2021;40:110 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 6a
Courtland J, Bradshaw T, Waitt G, Soderblom E, Ho T, Rajab A, et al. Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s5a
Parveen S, Siddharth S, Cheung L, Kumar A, Shen J, Murphy J, et al. Therapeutic targeting with DABIL-4 depletes myeloid suppressor cells in 4T1 triple-negative breast cancer model. Mol Oncol. 2021;15:1330-1344 pubmed publisher
  • western blot; human; loading ...; fig s9b
  • western blot; mouse; 1:500; loading ...; fig s9b
Mrouj K, Andrés Sánchez N, Dubra G, Singh P, Sobecki M, Chahar D, et al. Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • western blot; human; loading ...; fig 3d
  • immunohistochemistry; mouse; loading ...; fig 5j
Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, et al. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry - frozen section; chicken; 1:200; loading ...; fig 3s2
Baeriswyl T, Dumoulin A, Schaettin M, Tsapara G, Niederkofler V, Helbling D, et al. Endoglycan plays a role in axon guidance by modulating cell adhesion. elife. 2021;10: pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3d
Bressan R, Southgate B, Ferguson K, Blin C, Grant V, Alfazema N, et al. Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants. Cell Stem Cell. 2021;28:877-893.e9 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6b
Cao Y, Li L, Liu Y, Chen G, Tao Z, Wang R, et al. I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice. Oxid Med Cell Longev. 2021;2021:6429197 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:75; fig e2h
Newman A, Serbulea V, Baylis R, Shankman L, Bradley X, Alencar G, et al. Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. Nat Metab. 2021;3:166-181 pubmed publisher
  • western blot; human; loading ...; fig s7a
Fu C, Zhang Q, Wang A, Yang S, Jiang Y, Bai L, et al. EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis. Mol Oncol. 2021;15:1543-1565 pubmed publisher
  • immunohistochemistry - paraffin section; rat; loading ...; fig 2d
Helms T, Mullins R, Thomas Ahner J, Kulp S, Campbell M, Lucas F, et al. Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. Sci Rep. 2021;11:3646 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5c
Decotret L, Wadsworth B, Li L, Lim C, Bennewith K, Pallen C. Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion. Mol Biol Cell. 2021;32:567-578 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Xia W, Li Y, Wu M, Jin Q, Wang Q, Li S, et al. Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation. Cell Death Dis. 2021;12:139 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s4i
Sweat M, Sweat Y, Yu W, Su D, Leonard R, Eliason S, et al. The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche. Stem Cells. 2021;39:761-775 pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 2e
  • western blot; rat; 1:1000; fig 1e
  • immunohistochemistry; human; 1:200; loading ...; fig 7g
McGuire J, Frieling J, Lo C, Li T, Muhammad A, Lawrence H, et al. Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer. Nat Commun. 2021;12:723 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s3a
Hidalgo Sastre A, Kuebelsbeck L, Jochheim L, Staufer L, Altmayr F, Johannes W, et al. Toll-like receptor 3 expression in myeloid cells is essential for efficient regeneration after acute pancreatitis in mice. Eur J Immunol. 2021;51:1182-1194 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s2c
Fleming Martinez A, D xf6 ppler H, Bastea L, Edenfield B, Patel T, Leitges M, et al. Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells. iScience. 2021;24:102019 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2g
Wang H, Huang J, Sue M, Ho W, Hsu Y, Chang K, et al. Interleukin-24 protects against liver injury in mouse models. EBioMedicine. 2021;64:103213 pubmed publisher
  • western blot; human; loading ...
Wang H, Guo S, Kim S, Shao F, Ho J, Wong K, et al. Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel. Theranostics. 2021;11:2442-2459 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s2h
Steele N, Biffi G, Kemp S, Zhang Y, Drouillard D, Syu L, et al. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8d
  • western blot; mouse; 1:1000; loading ...; fig 1a, s2a
Kong Y, Zhao X, Qiu M, Lin Y, Feng P, Li S, et al. Tubular Mas receptor mediates lipid-induced kidney injury. Cell Death Dis. 2021;12:110 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 3c
Li Y, Ritchie E, Steinke C, Qi C, Chen L, Zheng B, et al. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5d
Sharma N, Hans C. Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways. J Am Heart Assoc. 2021;10:e017633 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:250; fig 3a
Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo Radji M, et al. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021;: pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig s2f
Saiyang X, QingQing W, Man X, Chen L, Min Z, Yun X, et al. Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction. Clin Transl Med. 2021;11:e266 pubmed publisher
  • immunohistochemistry; human; 1:400; loading ...; fig 7k
Jing C, Duan Y, Zhou M, Yue K, Zhuo S, Li X, et al. Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness. Theranostics. 2021;11:2655-2669 pubmed publisher
  • western blot; mouse; loading ...; fig 5a, s5b
Feng Y, Liu S, Zha R, Sun X, Li K, ROBLING A, et al. Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Li S, Zhu Z, Xue M, Pan X, Tong G, Yi X, et al. The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice. Redox Biol. 2021;40:101859 pubmed publisher
  • western blot; mouse; 1:1000; fig s6a
Yang J, Kitami M, Pan H, Nakamura M, Zhang H, Liu F, et al. Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation. Sci Signal. 2021;14: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Zhang K, Wang D, Cai H, Cao M, Zhang Y, Zhuang P, et al. IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer. Oncol Rep. 2021;45:1105-1117 pubmed publisher
  • western blot; human; loading ...; fig 2a
Xiong M, Wu M, Dan Peng -, Huang W, Chen Z, Ke H, et al. LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells. Cell Death Dis. 2021;12:24 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig e1j
Aslam M, Alemdehy M, Kwesi Maliepaard E, Muhaimin F, Caganova M, Pardieck I, et al. Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation. EMBO Rep. 2021;22:e51184 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4h, 5e, s2a
Humpton T, Nomura K, Weber J, Magnussen H, Hock A, Nixon C, et al. Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021;35:117-132 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2b
  • western blot; mouse; loading ...; fig s3d
Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2a
Chung W, Challagundla L, Zhou Y, Li M, Atfi A, Xu K. Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms. Life Sci Alliance. 2021;4: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5d
Deland K, Starr B, Mercer J, Byemerwa J, Crabtree D, Williams N, et al. Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models. J Clin Invest. 2021;131: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Hua X, Sun D, Zhang W, Fu J, Tong J, Sun S, et al. P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway. Br J Pharmacol. 2021;178:2111-2130 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:300; loading ...; fig s7h
Yang S, Michel K, Jokhi V, Nedivi E, Arlotta P. Neuron class-specific responses govern adaptive myelin remodeling in the neocortex. Science. 2020;370: pubmed publisher
  • western blot; human; fig 5h
Hewitt G, Borel V, Segura Bayona S, Takaki T, Ruis P, Bellelli R, et al. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Mol Cell. 2020;: pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Sun Q, Chen J, Xu L, Kang J, Wu X, Ren Y, et al. MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model. Oxid Med Cell Longev. 2020;2020:4828256 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Ruan H, Li X, Xu X, Leibowitz B, Tong J, Chen L, et al. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; loading ...
Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3d
Li Z, Murakoshi M, Ichikawa S, Koshida T, Adachi E, Suzuki C, et al. The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice. FEBS Open Bio. 2020;10:2761-2770 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
  • western blot; human; loading ...; fig 6e
Tan Y, Sementino E, Liu Z, Cai K, Testa J. Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Sci Rep. 2020;10:15837 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6b
Ifuku M, Hinkelmann L, Kuhrt L, Efe I, Kumbol V, Buonfiglioli A, et al. Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury. Acta Neuropathol Commun. 2020;8:159 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Zhou S, Zhang W, Cai G, Ding Y, Wei C, Li S, et al. Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Res. 2020;30:1063-1077 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 3a
Zhou W, Shao W, Zhang Y, Liu D, Liu M, Jin T. Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 2020;319:E568-E578 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1a
Lim C, Or Y, Ong Z, Chung H, Hayashi H, Shrestha S, et al. Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism. elife. 2020;9: pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig 5a
Mancia Leon W, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, et al. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. elife. 2020;9: pubmed publisher
  • immunohistochemistry; fruit fly ; loading ...; fig 1s1a
Upadhyay A, Peterson A, Kim M, O Connor M. Muscle-derived Myoglianin regulates Drosophila imaginal disc growth. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 2e
Coelho R, Ricardo S, Amaral A, Huang Y, Nunes M, Neves J, et al. Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation. Oncogenesis. 2020;9:61 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6a
Luna Sánchez M, Benincá C, Cerutti R, Brea Calvo G, Yeates A, Scorrano L, et al. Opa1 Overexpression Protects from Early-Onset Mpv17-/--Related Mouse Kidney Disease. Mol Ther. 2020;28:1918-1930 pubmed publisher
  • western blot; human; loading ...; fig 4d
Zhou X, Chen N, Xu H, Zhou X, Wang J, Fang X, et al. Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma. J Hematol Oncol. 2020;13:77 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 3c
Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed publisher
  • western blot; mouse; 1:400; loading ...; fig 4b
Kim E, Woodruff M, Grigoryan L, Maier B, Lee S, Mandal P, et al. Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Hastings J, González Rajal A, Latham S, Han J, McCloy R, O Donnell Y, et al. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Liu Y, Jiang B, Cao Y, Chen W, Yin L, Xu Y, et al. High expression levels and localization of Sox5 in dilated cardiomyopathy. Mol Med Rep. 2020;22:948-956 pubmed publisher
  • western blot; human; 0.05 ug/ml; loading ...; fig 2
Sola M, Magrin C, Pedrioli G, Pinton S, Salvade A, Papin S, et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol. 2020;3:245 pubmed publisher
  • immunohistochemistry; rat; 1:50; loading ...; fig 4a
Tan J, Zhang X, Li D, Liu G, Wang Y, Zhang D, et al. scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries. Mol Ther Methods Clin Dev. 2020;17:894-903 pubmed publisher
  • western blot; dogs; 1:500; fig 3c
Shinada M, Kato D, Kamoto S, Yoshimoto S, Tsuboi M, Yoshitake R, et al. PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma. Cells. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 1b, 1c
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  • immunohistochemistry; mouse; 1:4000; loading ...; fig 6d
Clé M, Barthelemy J, Desmetz C, Foulongne V, Lapeyre L, Bollore K, et al. Study of Usutu virus neuropathogenicity in mice and human cellular models. PLoS Negl Trop Dis. 2020;14:e0008223 pubmed publisher
  • western blot; rhesus macaque; 1:1000; loading ...; fig 2e
Du T, Zhu G, Chen Y, Shi L, Liu D, Liu Y, et al. Anterior thalamic nucleus stimulation protects hippocampal neurons by activating autophagy in epileptic monkeys. Aging (Albany NY). 2020;12:6324-6339 pubmed publisher
  • western blot; fruit fly ; 1:1000; loading ...; fig 5s2a
Ma X, Zhu Y, Lu J, Xie J, Li C, Shin W, et al. Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau. elife. 2020;9: pubmed publisher
  • western blot; rat; loading ...; fig 4s5b
Ruiz Velasco A, Zi M, Hille S, Azam T, Kaur N, Jiang J, et al. Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 4h
Chu J, Niu X, Chang J, Shao M, Peng L, Xi Y, et al. Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma. Theranostics. 2020;10:3488-3502 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6d
  • western blot; mouse; loading ...; fig 6b
Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2b
  • western blot; mouse; 1:500; loading ...; fig 2d
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, et al. Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling. Front Pharmacol. 2020;11:204 pubmed publisher
  • immunocytochemistry; mouse; 1:250; loading ...; fig 3f
Chan K, Nestor J, Huerta T, Certain N, Moody G, Kowal C, et al. Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory. Nat Commun. 2020;11:1403 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4h
Zhao J, He L, Yin L. lncRNA NEAT1 Binds to MiR-339-5p to Increase HOXA1 and Alleviate Ischemic Brain Damage in Neonatal Mice. Mol Ther Nucleic Acids. 2020;20:117-127 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Zhang J, Huang J, Zhang Y, Zhang X, Zhao L, Li C, et al. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3. EBioMedicine. 2020;53:102701 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4d
Doll J, Hoebe K, Thompson R, Sawtell N. Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. PLoS Pathog. 2020;16:e1008296 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:2000; loading ...; fig 8c
Liu J, Liu Z, Liu G, Gao K, Zhou H, Zhao Y, et al. Spinal cord injury and its underlying mechanism in rats with temporal lobe epilepsy. Exp Ther Med. 2020;19:2103-2112 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2e
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 4d
  • western blot; mouse; 1:1000; loading ...; fig 2f
Wan G, An Y, Tao J, Wang Y, Zhou Q, Yang R, et al. MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway. Biosci Rep. 2020;40: pubmed publisher
  • western blot; human; loading ...; fig 6d
Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 6c
  • western blot; human; 1:1000; loading ...; fig 6g
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 5h, 2h
  • western blot; mouse; 1:1000; loading ...; fig 3g
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig s3e
Eom T, Han S, Kim J, Blundon J, Wang Y, Yu J, et al. Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice. Nat Commun. 2020;11:912 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit; loading ...; fig 2c
Morgaz J, Ventura S, Muñoz Rascón P, Navarrete R, Perez J, Granados M, et al. Assessment of effects of methylene blue on intestinal ischemia and reperfusion in a rabbit model: hemodynamic, histological and immunohistochemical study. BMC Vet Res. 2020;16:54 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; fig 6k
Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 6
Li J, Zhang W, Zhu S, Shi F. Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. Animals (Basel). 2020;10: pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5a
Li T, Li K, Zhang S, Wang Y, Xu Y, Cronin S, et al. Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death Dis. 2020;11:77 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5e
Plemel J, Stratton J, Michaels N, Rawji K, Zhang E, Sinha S, et al. Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Sci Adv. 2020;6:eaay6324 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s10d
Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al. Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Ju L, Shan L, Yin B, Song Y. δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes. Cancer Med. 2020;9:2201-2212 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Cui J, Duan J, Chu J, Guo C, Xi M, Li Y, et al. Chikusetsu saponin IVa protects pancreatic β cell against intermittent high glucose-induced injury by activating Wnt/β-catenin/TCF7L2 pathway. Aging (Albany NY). 2020;12:1591-1609 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig s2
Su J, Charalambakis N, Sabbagh U, Somaiya R, Monavarfeshani A, Guido W, et al. Retinal inputs signal astrocytes to recruit interneurons into visual thalamus. Proc Natl Acad Sci U S A. 2020;117:2671-2682 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3c
Cai H, Han B, Hu Y, Zhao X, He Z, Chen X, et al. Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways. Int J Mol Med. 2020;45:715-730 pubmed publisher
  • western blot; human; loading ...; fig 2c
Singh V, Khalil M, De Benedetti A. The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. Cell Cycle. 2020;19:363-375 pubmed publisher
  • immunohistochemistry; mouse; fig 2c
Lalaoui N, Boyden S, Oda H, Wood G, Stone D, Chau D, et al. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020;577:103-108 pubmed publisher
  • western blot; human; loading ...; fig 6d
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, et al. LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer. Cancer Med. 2020;9:724-736 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Wang Y, Lan Y, Lu H. Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway. Photochem Photobiol. 2020;96:83-93 pubmed publisher
  • western blot; human; fig 2k
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 6e
Zhuang K, Zuo Y, Sherchan P, Wang J, Yan X, Liu F. Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats. Front Neurosci. 2019;13:1441 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5e
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; mouse; loading ...; fig s5f
Zhou Y, Lei J, Xie Q, Wu L, Jin S, Guo B, et al. Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5. Sci Adv. 2019;5:eaax0629 pubmed publisher
  • western blot; mouse; loading ...; fig 4d
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1f
Sun C, Guo E, Zhou B, Shan W, Huang J, Weng D, et al. A reactive oxygen species scoring system predicts cisplatin sensitivity and prognosis in ovarian cancer patients. BMC Cancer. 2019;19:1061 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig e2b
Canon J, Rex K, Saiki A, Mohr C, Cooke K, Bagal D, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575:217-223 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s1c
Rival C, Xu W, Shankman L, Morioka S, Arandjelovic S, Lee C, et al. Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization. Nat Commun. 2019;10:4456 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 2a
Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, et al. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Front Neurosci. 2019;13:925 pubmed publisher
  • western blot; human; loading ...; fig 8e
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, et al. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochem Pharmacol. 2019;170:113642 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Robinson M, Maximov V, Lallani S, Farooq H, Taylor M, Read R, et al. Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma. Sci Rep. 2019;9:13611 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 7d
Meier S, Alfonsi F, Kurniawan N, Milne M, Kasherman M, Delogu A, et al. The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development. 2019;146: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6g
Wu Q, Yuan X, Bai J, Han R, Li Z, Zhang H, et al. MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. Aging (Albany NY). 2019;11:6120-6133 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 8e
  • western blot; human; 1:1000; loading ...; fig 2g
Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, et al. GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Nat Commun. 2019;10:3882 pubmed publisher
  • western blot; human; loading ...; fig 10
Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
  • western blot; human; loading ...; fig 3b
Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, et al. Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells. Oncol Lett. 2019;18:3081-3091 pubmed publisher
  • western blot; human; loading ...
Debruyne D, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. 2019;572:676-680 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s5d
Zhu Y, Huang M, Bushong E, Phan S, Uytiepo M, Beutter E, et al. Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription. Nat Commun. 2019;10:3469 pubmed publisher
  • western blot; human; 1:250; loading ...; fig 5b
El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7a
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher
  • immunohistochemistry; human; fig 5f
  • immunohistochemistry; mouse; loading ...; fig s6a
Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Sole L, et al. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell. 2019;75:669-682.e5 pubmed publisher
  • western blot; human; loading ...; fig 7a
Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Jain A, Agostini L, McCarthy G, Chand S, Ramirez A, Nevler A, et al. Poly (ADP) ribose glycohydrolase can be effectively targeted in pancreatic cancer. Cancer Res. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3s2a
Zhang H, Sathyamurthy A, Liu F, Li L, Zhang L, Dong Z, et al. Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6h
Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
Liu F, Fan D, Yang Z, Tang N, Guo Z, Ma S, et al. TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis. Cell Death Dis. 2019;10:480 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1d
Pascual García M, Bonfill Teixidor E, Planas Rigol E, Rubio Perez C, Iurlaro R, Arias A, et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun. 2019;10:2416 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5g
Das R, Schwintzer L, Vinopal S, Roca E, Sylvester M, Oprişoreanu A, et al. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. J Cell Sci. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4d
Lee Y, Chen M, Lee J, Zhang J, Lin S, Fu T, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1j
Ellis S, Gomez N, Levorse J, Mertz A, Ge Y, Fuchs E. Distinct modes of cell competition shape mammalian tissue morphogenesis. Nature. 2019;: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5c
Slobodnyuk K, Radic N, Ivanova S, Lladó A, Trempolec N, Zorzano A, et al. Autophagy-induced senescence is regulated by p38α signaling. Cell Death Dis. 2019;10:376 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s2b
  • western blot; mouse; loading ...; fig s2a
Hernández Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177:881-895.e17 pubmed publisher
  • western blot; human; loading ...; fig 4d
Song T, Spillmann D. Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells. J Cell Mol Med. 2019;23:4559-4568 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Singh R, Peng S, Viswanath P, Sambandam V, Shen L, Rao X, et al. Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis. EMBO Mol Med. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 1b, 2a
Klicks J, Maßlo C, Kluth A, Rudolf R, Hafner M. A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells. BMC Cancer. 2019;19:402 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig e5j
Shi Y, Gao W, Lytle N, Huang P, Yuan X, Dann A, et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019;569:131-135 pubmed publisher
  • immunohistochemistry; pigs ; 1:200; loading ...; fig s10c
Vrselja Z, Daniele S, Silbereis J, Talpo F, Morozov Y, Sousa A, et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature. 2019;568:336-343 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Krishna Subramanian S, Singer S, Armaka M, Banales J, Hölzer K, Schirmacher P, et al. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019;: pubmed publisher
  • immunocytochemistry; mouse; 1:300; loading ...; fig s4b
Montalbán Loro R, Lozano Ureña A, Ito M, Krueger C, Reik W, Ferguson Smith A, et al. TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn. Nat Commun. 2019;10:1726 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 2s1a
Noguchi H, Castillo J, Nakashima K, Pleasure S. Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells. elife. 2019;8: pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig s18
  • western blot; mouse; 1:1000; loading ...; fig 4a
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
  • immunohistochemistry; human; 1:600; loading ...; fig s7c
Lima Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat Commun. 2019;10:1436 pubmed publisher
  • western blot; human; loading ...; fig 2e
Luo H, Jing B, Xia Y, Zhang Y, Hu M, Cai H, et al. WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia. Cancer Cell Int. 2019;19:56 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6e
Wang Z, Feng X, Molinolo A, Martin D, Vitale Cross L, Nohata N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019;: pubmed publisher
  • western blot; mouse; 1:1000; fig 5b
Le Vasseur M, Chen V, Huang K, Vogl W, Naus C. Pannexin 2 Localizes at ER-Mitochondria Contact Sites. Cancers (Basel). 2019;11: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4d
Kon N, Wang D, Gu W. Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo. Cell Death Dis. 2019;10:237 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s7b
Johansson J, Nászai M, Hodder M, Pickering K, Miller B, Ridgway R, et al. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Cell Stem Cell. 2019;24:592-607.e7 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, et al. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Aging Cell. 2019;18:e12941 pubmed publisher
  • western blot; human; loading ...; fig 2f
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, et al. CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin. Mol Cell Probes. 2019;44:57-62 pubmed publisher
  • western blot; mouse; 1:1000; fig 3b
Kurelac I, Iommarini L, Vatrinet R, Amato L, De Luise M, Leone G, et al. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nat Commun. 2019;10:903 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Wang M, Hu J, Yan L, Yang Y, He M, Wu M, et al. High glucose-induced ubiquitination of G6PD leads to the injury of podocytes. FASEB J. 2019;33:6296-6310 pubmed publisher
  • western blot; human; loading ...; fig s1a
Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. Breast Cancer Res. 2019;21:27 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Arora H, Wilcox S, Johnson L, Munro L, Eyford B, Pfeifer C, et al. The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Immunity. 2019;50:418-431.e6 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 7c
Nagaoka K, Bai X, Ogawa K, Dong X, Zhang S, Zhou Y, et al. Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma. Cancer Lett. 2019;449:87-98 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 7b
Lee J, Sung J, Choi E, Yoon H, Kang B, Hong E, et al. C/EBPβ Is a Transcriptional Regulator of Wee1 at the G₂/M Phase of the Cell Cycle. Cells. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig s1c
  • immunocytochemistry; human; loading ...; fig 3b
Haikala H, Anttila J, Marques E, Raatikainen T, Ilander M, Hakanen H, et al. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019;10:620 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6i
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed publisher
  • western blot; human; loading ...; fig 1b
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5l
  • western blot; mouse; loading ...; fig 5a
Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, et al. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation. Toxicology. 2019;414:45-56 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5h
  • immunocytochemistry; human; loading ...; fig 5e
  • immunohistochemistry - paraffin section; rat; loading ...; fig 4g
Ren G, Whittaker J, Leonard C, De Rantere D, Pang D, Salo P, et al. CCL22 is a biomarker of cartilage injury and plays a functional role in chondrocyte apoptosis. Cytokine. 2019;115:32-44 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1g
LeBlanc L, Lee B, Yu A, Kim M, Kambhampati A, Dupont S, et al. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. elife. 2018;7: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig s3e
  • immunocytochemistry; mouse; 1:500; loading ...; fig s4a
Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry. 2018;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1b
He S, Nian F, Chen W, Yin L, Auchoybur M, Tao Z, et al. I-κB kinase-ε knockout protects against angiotensin II induced aortic valve thickening in apolipoprotein E deficient mice. Biomed Pharmacother. 2019;109:1287-1295 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
Chen X, Chanda A, Ikeuchi Y, Zhang X, Goodman J, Reddy N, et al. The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain. J Neurosci. 2019;39:44-62 pubmed publisher
  • western blot; human; loading ...; fig 3k
Tan P, Ye Y, He L, Xie J, Jing J, Ma G, et al. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 2018;16:e3000051 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 4d, 4e
Asnaghi L, White D, Key N, Choi J, Mahale A, Alkatan H, et al. ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma. Oncogene. 2019;38:2056-2075 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3d
  • western blot; mouse; 1:1000; loading ...; fig s14d
Koren E, Yosefzon Y, Ankawa R, Soteriou D, Jacob A, Nevelsky A, et al. ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat Commun. 2018;9:4582 pubmed publisher
  • western blot; human; fig s1g
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1d
Yue D, Sun X. Idelalisib promotes Bim-dependent apoptosis through AKT/FoxO3a in hepatocellular carcinoma. Cell Death Dis. 2018;9:935 pubmed publisher
  • western blot; mouse; loading ...; fig 4d
Killackey S, Rahman M, Soares F, Zhang A, Abdel Nour M, Philpott D, et al. The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1. Mol Cell Biochem. 2019;453:187-196 pubmed publisher
  • western blot; human; loading ...; fig 5g
Mohamud Y, Qu J, Xue Y, Liu H, Deng H, Luo H. CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation. Cell Death Differ. 2019;26:1062-1076 pubmed publisher
  • western blot; human; loading ...; fig s15a
Zhao D, Kim Y, Jeong S, Greenson J, Chaudhry M, Hoepting M, et al. Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. J Clin Invest. 2018;128:4970-4979 pubmed publisher
  • western blot; human; loading ...; fig 3c
Leslie P, Franklin D, Liu Y, Zhang Y. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell Rep. 2018;24:1484-1495 pubmed publisher
  • western blot; human; loading ...; fig s7b
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Xie H, Wang Y, Zhang H, Fan Q, Dai D, Zhuang L, et al. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. J Cell Mol Med. 2018;22:4985-4996 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4c
Chute C, Yang X, Meyer K, Yang N, O Neil K, Kasza I, et al. Syndecan-1 induction in lung microenvironment supports the establishment of breast tumor metastases. Breast Cancer Res. 2018;20:66 pubmed publisher
  • immunocytochemistry; human; 1:800; loading ...; fig s5c
Zimmermann M, Murina O, Reijns M, Agathanggelou A, Challis R, Tarnauskaitė Ž, et al. CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Nature. 2018;559:285-289 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
Wang B, Joo J, Mount R, Teubner B, Krenzer A, Ward A, et al. The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018;128:3319-3332 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3k
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed publisher
  • western blot; mouse; loading ...; fig 1h
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 3k
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
  • western blot; human; loading ...; fig 2d
Pearce M, Gamble J, Kopparapu P, O Donnell E, Mueller M, Jang H, et al. Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Oncotarget. 2018;9:26072-26085 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s14f, s15g, s17d
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s17b
  • western blot; human; loading ...; fig 4f
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2c
  • western blot; mouse; 1:1000; loading ...; fig 7a
Vera Ramirez L, Vodnala S, Nini R, Hunter K, Green J. Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Nat Commun. 2018;9:1944 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s4a
Rossow L, Veitl S, Vorlova S, Wax J, Kuhn A, Maltzahn V, et al. LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy. Oncogene. 2018;37:4921-4940 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s9d
Chakrabarti R, Celià Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s7a
  • western blot; mouse; loading ...; fig s7c
Miyamoto Y, Torii T, Tago K, Tanoue A, Takashima S, Yamauchi J. BIG1/Arfgef1 and Arf1 regulate the initiation of myelination by Schwann cells in mice. Sci Adv. 2018;4:eaar4471 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3d
Fan L, Zhang F, Xu S, Cui X, Hussain A, Fazli L, et al. Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells. Proc Natl Acad Sci U S A. 2018;115:E4584-E4593 pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:1000; loading ...; fig 4a, 4b
Gussenhoven R, Westerlaken R, Ophelders D, Jobe A, Kemp M, Kallapur S, et al. Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. J Neuroinflammation. 2018;15:113 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6
Seidi K, Jahanban Esfahlan R, Monhemi H, Zare P, Minofar B, Daei Farshchi Adli A, et al. NGR (Asn-Gly-Arg)-targeted delivery of coagulase to tumor vasculature arrests cancer cell growth. Oncogene. 2018;37:3967-3980 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, et al. Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep. 2018;8:5927 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
Schönrogge M, Kerndl H, Zhang X, Kumstel S, Vollmar B, Zechner D. α-cyano-4-hydroxycinnamate impairs pancreatic cancer cells by stimulating the p38 signaling pathway. Cell Signal. 2018;47:101-108 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 7d
Clemente C, Rius C, Alonso Herranz L, Martín Alonso M, Pollán A, Camafeita E, et al. MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Nat Commun. 2018;9:910 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s3c
Duchamp de Lageneste O, Julien A, Abou Khalil R, Frangi G, Carvalho C, Cagnard N, et al. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat Commun. 2018;9:773 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s1c
Rogerson C, Gissen P. VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1609-1621 pubmed publisher
  • flow cytometry; mouse; fig 4g
Tavazoie M, Pollack I, Tanqueco R, Ostendorf B, Reis B, Gonsalves F, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018;172:825-840.e18 pubmed publisher
  • western blot; human; fig 5f
Cao B, Luo L, Feng L, Ma S, Chen T, Ren Y, et al. A network-based predictive gene-expression signature for adjuvant chemotherapy benefit in stage II colorectal cancer. BMC Cancer. 2017;17:844 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 5c
Wu Y, Zhang Z, Cenciarini M, Proietti C, Amasino M, Hong T, et al. Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 2018;78:671-684 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Kim M, Morales L, Baek M, Slaga T, DiGiovanni J, Kim D. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3? axis inhibits keratinocyte survival and proliferation. Oncotarget. 2017;8:90674-90692 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Sagulenko V, Vitak N, Vajjhala P, Vince J, Stacey K. Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. J Mol Biol. 2018;430:238-247 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s7b
Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 2l
Nakagawa N, Li J, Yabuno Nakagawa K, Eom T, Cowles M, Mapp T, et al. APC sets the Wnt tone necessary for cerebral cortical progenitor development. Genes Dev. 2017;31:1679-1692 pubmed publisher
  • western blot; human; loading ...; fig 2e
Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed publisher
  • western blot; mouse; 1:1000; fig 1g
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
  • western blot; human; loading ...; fig 1b
Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4e
Moncsek A, Al Suraih M, Trussoni C, O Hara S, Splinter P, Zuber C, et al. Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice. Hepatology. 2017;: pubmed publisher
  • western blot; human; loading ...; fig 4f
Zhou Y, Huang T, Zhang J, Wong C, Zhang B, Dong Y, et al. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene. 2017;36:6518-6530 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Bitler B, Wu S, Park P, Hai Y, Aird K, Wang Y, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017;19:962-973 pubmed publisher
  • western blot; human; loading ...; fig 4i
Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, et al. SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia. Leuk Lymphoma. 2018;59:918-930 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Button R, Roberts S, Willis T, Hanemann C, Luo S. Accumulation of autophagosomes confers cytotoxicity. J Biol Chem. 2017;292:13599-13614 pubmed publisher
  • western blot; mouse; fig e4c
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm N, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546:667-670 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2d
  • western blot; mouse; loading ...; fig 1d
Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Xu P, Tao X, Zhao C, Huang Q, Chang H, Ban N, et al. DTX3L is upregulated in glioma and is associated with glioma progression. Int J Mol Med. 2017;40:491-498 pubmed publisher
  • western blot; human; loading ...; fig 1c
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed publisher
  • immunocytochemistry; dogs; loading ...; fig 4a
Zhang K, Myllymäki S, Gao P, Devarajan R, Kytölä V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed publisher
  • western blot; human; fig 2d
Zhang F, Zhu J, Li J, Zhu F, Zhang P. IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival. Gene. 2017;627:9-14 pubmed publisher
  • western blot; human; loading ...; fig s6
Shin C, Lee M, Han J, Jeong S, Ryu B, Chi S. Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. Proc Natl Acad Sci U S A. 2017;114:5683-5688 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4j
Chatzeli L, Gaete M, Tucker A. Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development. Development. 2017;144:2294-2305 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4c
Feldner A, Adam M, Tetzlaff F, Moll I, Komljenovic D, Sahm F, et al. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. 2017;9:890-905 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig s1d
Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed publisher
  • western blot; rat; fig 1d
  • western blot; mouse; loading ...; fig 7f
Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44:760-770 pubmed publisher
  • western blot; mouse; fig s1
Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  • western blot; human; loading ...; fig 4a
Deng H, Fung G, Qiu Y, Wang C, Zhang J, Jin Z, et al. Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection. Front Cell Infect Microbiol. 2017;7:85 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s7b
Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, et al. Visualization and targeting of LGR5+ human colon cancer stem cells. Nature. 2017;545:187-192 pubmed publisher
  • immunohistochemistry; rat; 1:5000; loading ...; fig 1e
Keistler C, Hammarlund E, Barker J, Bond C, DiLeone R, Pittenger C, et al. Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. J Neurosci. 2017;37:4462-4471 pubmed publisher
  • immunocytochemistry; mouse; fig 3e
Leal Lasarte M, Franco J, Labrador Garrido A, Pozo D, Roodveldt C. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. 2017;31:2797-2816 pubmed publisher
  • immunocytochemistry; human; 1:250; loading ...; fig s3e
Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed publisher
  • immunohistochemistry; fruit fly ; 1:500; loading ...; fig 1e
Foo L, Song S, Cohen S. miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain. EMBO J. 2017;36:1215-1226 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3d
  • western blot; mouse; 1:200; loading ...; fig 3e
Feng W, Kawauchi D, Körkel Qu H, Deng H, Serger E, Sieber L, et al. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 2017;8:14758 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4b
Riascos Bernal D, Chinnasamy P, Gross J, Almonte V, Egaña Gorroño L, Parikh D, et al. Inhibition of Smooth Muscle ?-Catenin Hinders Neointima Formation After Vascular Injury. Arterioscler Thromb Vasc Biol. 2017;37:879-888 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500; loading ...; fig 8
  • western blot; rat; 1:1000; loading ...; fig 1f
Rong H, Zhao Z, Feng J, Lei Y, Wu H, Sun R, et al. The effects of dexmedetomidine pretreatment on the pro- and anti-inflammation systems after spinal cord injury in rats. Brain Behav Immun. 2017;64:195-207 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3g
Boutin A, Liao W, Wang M, Hwang S, Karpinets T, Cheung H, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017;31:370-382 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3k, 5i, 6f
Cho H, Um J, Lee J, Kim W, Kang W, Kim S, et al. ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes. Sci Rep. 2017;7:44186 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; tbl 1
Sharma R, Ishimaru Y, Davison I, Ikegami K, Chien M, You H, et al. Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice. elife. 2017;6: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 4e
Fu S, Xu H, Gu M, Liu C, Wang Q, Wan X, et al. Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity. Sci Rep. 2017;7:43771 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7d
Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, et al. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. Theranostics. 2017;7:664-676 pubmed publisher
  • flow cytometry; human; 1:500; loading ...; fig 10b
  • immunocytochemistry; human; 1:500; loading ...; fig 8b
Menges S, Minakaki G, Schaefer P, Meixner H, Prots I, Schlötzer Schrehardt U, et al. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017;7:42942 pubmed publisher
  • western blot; human; 1:250; loading ...; fig 6A
Wang C, Guo L, Wang S, Wang J, Li Y, Dou Y, et al. Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells. Int J Mol Med. 2017;39:645-653 pubmed publisher
  • flow cytometry; human; 1:250; fig s1l
Shi Z, Lee K, Yang D, Amin S, Verma N, Li Q, et al. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2017;20:675-688.e6 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3b
Schatton D, Pla Martín D, Marx M, Hansen H, Mourier A, Nemazanyy I, et al. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017;216:675-693 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s7h
Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 2b
Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, et al. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Sci Rep. 2017;7:41916 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...
Whittaker D, Riegman K, Kasah S, Mohan C, Yu T, Sala B, et al. The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. J Clin Invest. 2017;127:874-887 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4e
Wu N, Jia D, Bates B, Basom R, Eberhart C, MacPherson D. A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence. J Clin Invest. 2017;127:888-898 pubmed publisher
  • immunocytochemistry; zebrafish ; 1:100; loading ...; fig s6
  • immunocytochemistry; mouse; 1:100; loading ...; fig s6
Chen W, Wang Z, Missinato M, Park D, Long D, Liu H, et al. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Sci Adv. 2016;2:e1600844 pubmed publisher
  • western blot; human; loading ...; fig 4a
Ha S, Jin F, Kwak C, Abekura F, Park J, Park N, et al. Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells. Peerj. 2017;5:e2895 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4e
Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, et al. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun. 2017;8:14182 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1b
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability. Nat Commun. 2017;8:14186 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig st4
Qi Y, Zhang X, Renier N, Wu Z, Atkin T, Sun Z, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017;35:154-163 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1f
Bershteyn M, Nowakowski T, Pollen A, Di Lullo E, Nene A, Wynshaw Boris A, et al. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia. Cell Stem Cell. 2017;20:435-449.e4 pubmed publisher
  • western blot; human; 1:600; loading ...; fig 2e
Gan J, Wang F, Mu D, Qu Y, Luo R, Wang Q. RNA interference targeting Aurora-A sensitizes glioblastoma cells to temozolomide chemotherapy. Oncol Lett. 2016;12:4515-4523 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2m
Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, et al. The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. J Exp Med. 2017;214:339-358 pubmed publisher
  • western blot; human; loading ...; fig 7a
  • western blot; mouse; loading ...; fig 2e
Adams C, Kim A, Mitra R, Choi J, Gong J, Eischen C. BCL-W has a fundamental role in B cell survival and lymphomagenesis. J Clin Invest. 2017;127:635-650 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 3b
Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher
  • western blot; human; loading ...; fig 1f
Pal D, Pertot A, Shirole N, Yao Z, Anaparthy N, Garvin T, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. elife. 2017;6: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 7h
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, et al. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nat Commun. 2017;8:14002 pubmed publisher
  • flow cytometry; mouse; 1:800; loading ...; fig 1a
Oben K, Gachuki B, Alhakeem S, McKenna M, Liang Y, St Clair D, et al. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1). PLoS ONE. 2017;12:e0169767 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:50; loading ...; fig 2a
  • western blot; rat; 1:1000; loading ...; fig 4d
Bai H, Lee J, Chen E, Wang M, Xing Y, Fahmy T, et al. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia. Sci Rep. 2017;7:40142 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2a
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 1c
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...; fig 3f
Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf Klingebiel M, Gigina A, et al. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med. 2017;9:265-279 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1600; loading ...; fig 5b
Hennika T, Hu G, Olaciregui N, Barton K, Ehteda A, Chitranjan A, et al. Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. PLoS ONE. 2017;12:e0169485 pubmed publisher
  • western blot; human; loading ...; fig 2c
Kim H, Lee S, Kim C, Kim Y, Ju W, Kim S. Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells. Oncotarget. 2017;8:6608-6622 pubmed publisher
  • western blot; mouse; loading ...; fig 5e
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; fig 5f
Braganza A, Li J, Zeng X, Yates N, Dey N, Andrews J, et al. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. 2017;292:2470-2484 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s2
Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed publisher
  • western blot; rat; fig 9a
Kirschmer N, Bandleon S, von Ehrlich Treuenstätt V, Hartmann S, Schaaf A, Lamprecht A, et al. TRPC4? and TRPC4? Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation. PLoS ONE. 2016;11:e0168446 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s13
Lloyd Lewis B, Davis F, Harris O, Hitchcock J, Lourenco F, Pasche M, et al. Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods. Breast Cancer Res. 2016;18:127 pubmed
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1h
Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, et al. The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. Mol Cell Biol. 2017;37: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2c
Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig s8e
Cai H, Liu A. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016;113:14751-14756 pubmed publisher
  • western blot; human; fig 1g
Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
  • western blot; human; loading ...; fig 1c
Park S, Jwa E, Shin S, Ju E, Park I, Pak J, et al. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. Int J Biochem Cell Biol. 2017;83:47-55 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s3a
Retallack H, Di Lullo E, Arias C, Knopp K, Laurie M, Sandoval Espinosa C, et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016;113:14408-14413 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig 6a
Li M, Bozzacco L, Hoffmann H, Breton G, Loschko J, Xiao J, et al. Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. J Exp Med. 2016;213:2931-2947 pubmed
  • immunohistochemistry; fruit fly ; 1:100; loading ...; fig 5b
Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed publisher
  • western blot; human; loading ...; fig 7g
McKenzie C, D Avino P. Investigating cytokinesis failure as a strategy in cancer therapy. Oncotarget. 2016;7:87323-87341 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2a
Mosteiro L, Pantoja C, Alcazar N, Marion R, Chondronasiou D, Rovira M, et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science. 2016;354: pubmed
  • western blot; mouse; 1:1000; loading ...; fig 8c
Hu J, Li B, Apisa L, Yu H, Entenman S, Xu M, et al. ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice. Cell Death Dis. 2016;7:e2485 pubmed publisher
  • western blot; mouse; fig 1a
Su F, Myers V, Knezevic T, Wang J, Gao E, Madesh M, et al. Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury. JCI Insight. 2016;1:e90931 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4a
Bosch P, Fuller L, Sleeth C, Weiner J. Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016;11:21 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 1g
Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3d
Ravà M, D Andrea A, Doni M, Kress T, Ostuni R, Bianchi V, et al. Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18. Hepatology. 2017;65:1708-1719 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s10a
Zeltner N, Fattahi F, Dubois N, Saurat N, Lafaille F, Shang L, et al. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016;22:1421-1427 pubmed publisher
  • western blot; human; fig s10a
Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2c
  • western blot; mouse; loading ...; fig 2d
Filliol A, Piquet Pellorce C, Le Seyec J, Farooq M, Genet V, Lucas Clerc C, et al. RIPK1 protects from TNF-α-mediated liver damage during hepatitis. Cell Death Dis. 2016;7:e2462 pubmed publisher
  • western blot; human; fig 3c
Park J, Lee C, Kim H, Kim D, Son J, Ko E, et al. Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling. Oncotarget. 2016;7:83308-83318 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig st1
Cousins F, Kirkwood P, Saunders P, Gibson D. Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling. Sci Rep. 2016;6:36748 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 10
Yu W, Parakramaweera R, Teng S, Gowda M, Sharad Y, Thakker Varia S, et al. Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. J Neurosci. 2016;36:11084-11096 pubmed
  • immunohistochemistry; mouse; 1:100; loading ...; fig s3a
Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
  • western blot; human; 1:1000; fig s5c
Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 4b
Takai K, Le A, Weaver V, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016;7:82889-82901 pubmed publisher
  • western blot; human; fig 3
Hrgovic I, Doll M, Kleemann J, Wang X, Zoeller N, Pinter A, et al. The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. BMC Cancer. 2016;16:763 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:600; loading ...; fig 7c
  • western blot; mouse; 1:1000; loading ...; fig 7b
Seemann S, Lupp A. Administration of AMD3100 in endotoxemia is associated with pro-inflammatory, pro-oxidative, and pro-apoptotic effects in vivo. J Biomed Sci. 2016;23:68 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s4a
Parween S, Kostromina E, Nord C, Eriksson M, Lindstrom P, Ahlgren U. Intra-islet lesions and lobular variations in ?-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas. Sci Rep. 2016;6:34885 pubmed publisher
  • western blot; human; loading ...; fig 2c
Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed publisher
  • western blot; human; fig 3c
Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. Mol Cell Biol. 2016;36:3010-3018 pubmed
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1b
  • western blot; human; 1:1000; loading ...; fig 1g
Choi Y, Maki T, Mandeville E, Koh S, Hayakawa K, Arai K, et al. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016;22:1335-1341 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 5c
Asnaghi L, Tripathy A, Yang Q, Kaur H, Hanaford A, Yu W, et al. Targeting Notch signaling as a novel therapy for retinoblastoma. Oncotarget. 2016;7:70028-70044 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6d
D Andrea A, Gritti I, Nicoli P, Giorgio M, Doni M, Conti A, et al. The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas. Oncotarget. 2016;7:72415-72430 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...
Bain V, Gordon J, O Neil J, Ramos I, Richie E, Manley N. Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016;143:4027-4037 pubmed
  • immunohistochemistry - paraffin section; human; loading ...; fig 4c
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed publisher
  • western blot; mouse; loading ...; fig s7
Pérez Cañamás A, Benvegnù S, Rueda C, Rábano A, Satrústegui J, Ledesma M. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017;22:711-723 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3
Waasdorp M, Duitman J, Florquin S, Spek C. Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice. Sci Rep. 2016;6:33030 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s7b
Thamodaran V, Bruce A. p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development. Open Biol. 2016;6: pubmed publisher
  • western blot; human; fig 4f
Park S, Jo D, Jo S, Shin D, Shim S, Jo Y, et al. Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death. Oncotarget. 2016;7:65957-65967 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:1000; loading ...; fig 8a
  • western blot; rat; 1:1000; loading ...; fig 8c
Cudré Cung H, Zavadakova P, Do Vale Pereira S, Remacle N, Henry H, Ivanisevic J, et al. Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. Mol Genet Metab. 2016;119:57-67 pubmed publisher
  • western blot; human; 1:1000; fig 5B
Edinger N, Lebendiker M, Klein S, Zigler M, Langut Y, Levitzki A. Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF. PLoS ONE. 2016;11:e0162321 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig s3i
Chen Y, Kuo H, Bornschein U, Takahashi H, Chen S, Lu K, et al. Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c. Nat Neurosci. 2016;19:1513-1522 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4j
Magalhães A, Rivera C. NKCC1-Deficiency Results in Abnormal Proliferation of Neural Progenitor Cells of the Lateral Ganglionic Eminence. Front Cell Neurosci. 2016;10:200 pubmed publisher
  • immunohistochemistry; human; loading ...
Jones R, Robinson T, Liu J, Shrestha M, Voisin V, Ju Y, et al. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. J Clin Invest. 2016;126:3739-3757 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 3
  • flow cytometry; mouse; 1:50; fig 4
  • western blot; mouse; 1:1000; fig 3
Fern ndez Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:500; loading ...; fig 2d
Kasica N, Podlasz P, Sundvik M, Tamas A, Reglodi D, Kaleczyc J. Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells. Neurotox Res. 2016;30:633-647 pubmed
  • western blot; human; loading ...; fig 3f
Cunningham C, Li S, Vizeacoumar F, Bhanumathy K, Lee J, Parameswaran S, et al. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016;7:61544-61561 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 7
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; human; loading ...; fig 5b,5c,6b,6c,6d
Pomares H, Palmeri C, Iglesias Serret D, Moncunill Massaguer C, Saura Esteller J, Núñez Vázquez S, et al. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016;7:64987-65000 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2e
Pfister J, D Mello S. Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status. J Biol Chem. 2016;291:20787-97 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Duan H, Lee J, Moon S, Arora D, Li Y, Lim H, et al. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic ?-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem. 2016;59:7783-800 pubmed publisher
  • immunocytochemistry; rat; 1:500; fig s1
Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, et al. Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J. 2016;35:2008-25 pubmed publisher
  • western blot; dogs; 1:500; fig 3a
Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6e
Gerling M, Büller N, Kirn L, Joost S, Frings O, Englert B, et al. Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat Commun. 2016;7:12321 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2a
Strilic B, Yang L, Albarrán Juárez J, Wachsmuth L, Han K, Müller U, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536:215-8 pubmed
  • immunohistochemistry; mouse; 1:300
Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
  • western blot; human; fig 2
Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016;16:559 pubmed publisher
  • western blot; human; fig 7
Jeong H, Cho Y, Kim K, Kim Y, Kim K, Na Y, et al. Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. BMC Complement Altern Med. 2016;16:239 pubmed publisher
  • immunohistochemistry; zebrafish ; fig 6i
Yoo S, Pascoe H, Pereira T, Kondo S, Jacinto A, Zhang X, et al. Plexins function in epithelial repair in both Drosophila and zebrafish. Nat Commun. 2016;7:12282 pubmed publisher
  • western blot; human; loading ...; fig 5g
Wu J, Lei H, Zhang J, Chen X, Tang C, Wang W, et al. Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation. Oncotarget. 2016;7:58995-59005 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig s2
Stergiopoulos A, Politis P. Nuclear receptor NR5A2 controls neural stem cell fate decisions during development. Nat Commun. 2016;7:12230 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig s6a
Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
  • immunohistochemistry; mouse; 1:400; loading ...; fig 5h
Ding L, Hayes M, Photenhauer A, Eaton K, Li Q, Ocadiz Ruiz R, et al. Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest. 2016;126:2867-80 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 3b
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 6h
Huang Z, Hu J, Pan J, Wang Y, Hu G, Zhou J, et al. YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation. Development. 2016;143:2398-409 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2-s3c
Forsberg D, Horn Z, Tserga E, Smedler E, Silberberg G, Shvarev Y, et al. CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig s11a
Stock K, Estrada M, Vidic S, Gjerde K, Rudisch A, Santo V, et al. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery. Sci Rep. 2016;6:28951 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:50; fig 3
  • western blot; rat; 1:1000; fig 3
Bai H, Wang M, Foster T, Hu H, He H, Hashimoto T, et al. Pericardial patch venoplasty heals via attraction of venous progenitor cells. Physiol Rep. 2016;4: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3d
Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, et al. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017;36:618-627 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig s6a
Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann J, Manns M, et al. MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun. 2016;7:11916 pubmed publisher
  • western blot; human; loading ...; fig 3c
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 3a
Rowald K, Mantovan M, Passos J, Buccitelli C, Mardin B, Korbel J, et al. Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. Cell Rep. 2016;15:2679-91 pubmed publisher
  • western blot; rat; 1:1000; fig 1
Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, et al. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Sci Rep. 2016;6:27283 pubmed publisher
  • western blot; mouse; 1:1000; fig s3
Boada Romero E, Serramito Gómez I, Sacristán M, Boone D, Xavier R, Pimentel Muiños F. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nat Commun. 2016;7:11821 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig 7
Shruthi K, Reddy S, Reddy P, Shivalingam P, Harishankar N, Reddy G. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016;33:73-81 pubmed publisher
  • western blot; mouse; fig s2
Park J, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, et al. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. PLoS ONE. 2016;11:e0156334 pubmed publisher
  • western blot; human; fig 6c
  • western blot; mouse; loading ...; fig 1e
Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Roy A, Femel J, Huijbers E, Spillmann D, Larsson E, Ringvall M, et al. Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma. PLoS ONE. 2016;11:e0156151 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig EV1
Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745-60 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1
Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep. 2016;6:26291 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 6d
  • western blot; human; loading ...; fig 6c
Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s6a
Cherepanova O, Gomez D, Shankman L, Swiatlowska P, Williams J, Sarmento O, et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med. 2016;22:657-65 pubmed publisher
  • western blot; human; 1:1000; fig 5d
Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher
  • western blot; human; loading ...; fig 5c
Zhao J, Niu X, Li X, Edwards H, Wang G, Wang Y, et al. Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Oncotarget. 2016;7:34785-99 pubmed publisher
  • western blot; mouse; fig 2
Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
  • western blot; human; 1:500; fig 1
De Filippis L, Halikere A, McGowan H, Moore J, Tischfield J, Hart R, et al. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016;9:51 pubmed publisher
  • immunocytochemistry; fruit fly ; 1:300; fig 5
Le T, Vuong L, Kim A, Hsu Y, Choi K. 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila. Nat Commun. 2016;7:11501 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3g
Zeng X, Han I, Abd El Barr M, Aljuboori Z, Anderson J, Chi J, et al. The Effects of Thermal Preconditioning on Oncogenic and Intraspinal Cord Growth Features of Human Glioma Cells. Cell Transplant. 2016;25:2099-2109 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4
Chen P, Hsiao J, Sirois C, Chamberlain S. RBFOX1 and RBFOX2 are dispensable in iPSCs and iPSC-derived neurons and do not contribute to neural-specific paternal UBE3A silencing. Sci Rep. 2016;6:25368 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 2
Bell C, Hendriks D, Moro S, Ellis E, Walsh J, Renblom A, et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep. 2016;6:25187 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 7
Körbelin J, Dogbevia G, Michelfelder S, Ridder D, Hunger A, Wenzel J, et al. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med. 2016;8:609-25 pubmed publisher
  • western blot; human; 1:1000; fig 3
Silva S, Levy D, Ruiz J, de Melo T, Isaac C, Fidelis M, et al. Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death. J Steroid Biochem Mol Biol. 2017;169:164-175 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4h
Guinot A, Lehmann H, Wild P, Frew I. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016;239:365-73 pubmed publisher
  • western blot; human; fig 2
Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed publisher
  • immunocytochemistry; dogs; 1:200; fig 1
Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, et al. Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun. 2016;7:11373 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Hu Z, Lv G, Li Y, Li E, Li H, Zhou Q, et al. Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound. J Exp Clin Cancer Res. 2016;35:71 pubmed publisher
  • western blot; human; fig 4
Xiao L, Shi X, Zhang Y, Zhu Y, Zhu L, Tian W, et al. YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells. Onco Targets Ther. 2016;9:1105-14 pubmed publisher
  • western blot; human; 1:500; fig 6
Conway A, Van Nostrand E, Pratt G, Aigner S, Wilbert M, Sundararaman B, et al. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 2016;15:666-679 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:300
Hellstrom M, Moreno Moya J, Bandstein S, Bom E, Akouri R, Miyazaki K, et al. Bioengineered uterine tissue supports pregnancy in a rat model. Fertil Steril. 2016;106:487-496.e1 pubmed publisher
  • immunohistochemistry; fruit fly ; 1:50; fig s3
Carrasco Rando M, Atienza Manuel A, Martin P, Burke R, Ruiz Gomez M. Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis. Development. 2016;143:1948-57 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 5b
Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, et al. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia. 2016;59:1533-1541 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; human
Yosef R, Pilpel N, Tokarsky Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun. 2016;7:11190 pubmed publisher
  • immunohistochemistry; fruit fly ; 1:300; fig s4
Upadhyay M, Martino Cortez Y, Wong Deyrup S, Tavares L, Schowalter S, Flora P, et al. Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila. PLoS Genet. 2016;12:e1005918 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Chen S, Wang C, Yeo S, Liang C, Okamoto T, Sun S, et al. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes Dev. 2016;30:856-69 pubmed publisher
  • immunohistochemistry; rat; 1:200; fig 1
Viringipurampeer I, Metcalfe A, Bashar A, Sivak O, Yanai A, Mohammadi Z, et al. NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration. Hum Mol Genet. 2016;25:1501-16 pubmed publisher
  • immunohistochemistry; human; 1:150; fig 5h
Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, et al. Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 2016;8:527-49 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig s4c
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
  • immunohistochemistry; human; 1:100
Galán M, Varona S, Orriols M, Rodríguez J, Aguiló S, Dilmé J, et al. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech. 2016;9:541-52 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1a
Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, et al. NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions. Immunity. 2016;44:553-567 pubmed publisher
  • western blot; rat; fig 3
Huang Y, Chen C, Tang K, Sheen J, Tiao M, Tain Y, et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci. 2016;17:369 pubmed publisher
  • western blot; rat; 1:500; fig 4
Prause M, Mayer C, Brorsson C, Frederiksen K, Billestrup N, Størling J, et al. JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. J Diabetes Res. 2016;2016:1312705 pubmed publisher
  • western blot; human; loading ...; fig 1f
Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 9
Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed publisher
  • western blot; human; fig 6b
Kemp M, Sancar A. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. J Biol Chem. 2016;291:9330-42 pubmed publisher
  • western blot; human; fig 2
Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Wang W, Jossin Y, Chai G, Lien W, Tissir F, Goffinet A. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:330; fig 7
Cárdenas H, Arango D, Nicholas C, Duarte S, Nuovo G, He W, et al. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. Int J Mol Sci. 2016;17:323 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Wu J, Chi L, Chen Z, Lu X, Xiao S, Zhang G, et al. Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death. Mol Med Rep. 2016;13:3173-80 pubmed publisher
  • western blot; human; fig 4
  • western blot; mouse; fig 4
Persaud S, Park S, Ishigami Yuasa M, Koyano Nakagawa N, Kagechika H, Wei L. All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation. Sci Rep. 2016;6:22396 pubmed publisher
  • western blot; human; fig 1
Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed publisher
  • western blot; human; fig 8d
Hong J, Lee J, Chung I. Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. J Cell Sci. 2016;129:1566-79 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5a
Yufune S, Satoh Y, Akai R, Yoshinaga Y, Kobayashi Y, Endo S, et al. Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain. Sci Rep. 2016;6:21859 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 8
  • western blot; mouse; 1:1000; fig 9
Ma Y, Guo H, Zhang L, Tao L, Yin A, Liu Z, et al. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Sci Rep. 2016;6:21467 pubmed publisher
  • western blot; human; fig 5
Stojcheva N, Schechtmann G, Sass S, Roth P, Florea A, Stefanski A, et al. MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget. 2016;7:12937-50 pubmed publisher
  • immunocytochemistry; mouse; fig s2
Zhang W, Kim P, Chen Z, Lokman H, Qiu L, Zhang K, et al. MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. elife. 2016;5: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Zhang W, Shi H, Zhang M, Liu B, Mao S, Li L, et al. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. Int J Biochem Cell Biol. 2016;73:127-136 pubmed publisher
  • western blot; human; fig 2
Braun D, Sadowski C, Kohl S, Lovric S, Astrinidis S, Pabst W, et al. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nat Genet. 2016;48:457-65 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; fig 3
Bouilloux F, Thireau J, Ventéo S, Farah C, Karam S, Dauvilliers Y, et al. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5e
Davidson S, Papagiannakopoulos T, Olenchock B, Heyman J, Keibler M, Luengo A, et al. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab. 2016;23:517-28 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig s1b
Franco C, Jones M, Bernabeu M, Vion A, Barbacena P, Fan J, et al. Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling. elife. 2016;5:e07727 pubmed publisher
  • immunohistochemistry; human; 1:750; fig 1
  • western blot; human; fig 1
Flanagan L, Meyer M, Fay J, Curry S, Bacon O, Duessmann H, et al. Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. Cell Death Dis. 2016;7:e2087 pubmed publisher
  • western blot; human; fig 3
Dos Santos E, Carneiro Lobo T, Aoki M, Levantini E, Bassères D. Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016;15:12 pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:1000; fig 7
Ophelders D, Gussenhoven R, Lammens M, Küsters B, Kemp M, Newnham J, et al. Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure. J Neuroinflammation. 2016;13:29 pubmed publisher
  • western blot; human; fig 1b
Jiang P, Gan M, Yen S, Moussaud S, McLean P, Dickson D. Proaggregant nuclear factor(s) trigger rapid formation of ?-synuclein aggregates in apoptotic neurons. Acta Neuropathol. 2016;132:77-91 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig s1d
Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 5
Ottesen E, Howell M, Singh N, Seo J, Whitley E, Singh R. Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy. Sci Rep. 2016;6:20193 pubmed publisher
  • immunohistochemistry; fruit fly ; 1:1000; fig 3
Bouge A, Parmentier M. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Dis Model Mech. 2016;9:307-19 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1
Powell E, Shao J, Yuan Y, Chen H, Cai S, Echeverria G, et al. p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Res. 2016;18:13 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig s6
  • western blot; human; fig s6
Couderc C, Boin A, Fuhrmann L, Vincent Salomon A, Mandati V, Kieffer Y, et al. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. Neoplasia. 2016;18:10-24 pubmed publisher
  • western blot; human; fig 2d
Heo J, Kim W, Choi K, Bae S, Jeong J, Kim K. XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. Oncotarget. 2016;7:5118-30 pubmed publisher
  • western blot; human; fig 5
Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, et al. BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 2016;7:9188-221 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Baer A, Lundberg L, Swales D, Waybright N, Pinkham C, Dinman J, et al. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. J Virol. 2016;90:3558-72 pubmed publisher
  • western blot; mouse; fig 5
Villarroel Espíndola F, Tapia C, González Stegmaier R, Concha I, Slebe J. Polyglucosan Molecules Induce Mitochondrial Impairment and Apoptosis in Germ Cells Without Affecting the Integrity and Functionality of Sertoli Cells. J Cell Physiol. 2016;231:2142-52 pubmed publisher
  • western blot; mouse; fig s1
Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
  • immunohistochemistry; mouse; 1:800; fig s3
Loebel D, Plageman T, Tang T, Jones V, Muccioli M, Tam P. Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biol Open. 2016;5:130-9 pubmed publisher
  • western blot; mouse; fig 6
Wang S, Ni H, Dorko K, Kumer S, Schmitt T, Nawabi A, et al. Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury. Oncotarget. 2016;7:17681-98 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 6
Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Chhibber Goel J, Coleman Vaughan C, Agrawal V, Sawhney N, Hickey E, Powell J, et al. γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. J Biol Chem. 2016;291:5971-85 pubmed publisher
  • western blot; human; fig 3
Terranova Barberio M, Roca M, Zotti A, Leone A, Bruzzese F, Vitagliano C, et al. Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression. Oncotarget. 2016;7:7715-31 pubmed publisher
  • immunohistochemistry; human; fig 7
  • western blot; human; fig 7
Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, et al. Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2016;7:5366-82 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 3a
Cao L, Li H, Lin W, Tan H, Xie L, Zhong Z, et al. Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma xenografts. Sci Rep. 2016;6:18706 pubmed publisher
  • western blot; human; fig 5g
Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 1
Benedykcinska A, Ferreira A, Lau J, Broni J, Richard Loendt A, Henriquez N, et al. Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen. Dis Model Mech. 2016;9:211-20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong R, Miller K, et al. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016;6:188-201 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 2
Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, et al. Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development. 2016;143:24-34 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3e
Schill E, Lake J, Tusheva O, Nagy N, Bery S, Foster L, et al. Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Dev Biol. 2016;409:473-88 pubmed publisher
  • western blot; human; fig 4
Huang Y, Chen Y, Lai Y, Cheng C, Lin T, Su Y, et al. Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro. Int J Mol Med. 2016;37:83-91 pubmed publisher
  • western blot; mouse; 1:1000; fig S5A
Sin J, Andres A, Taylor D, Weston T, Hiraumi Y, Stotland A, et al. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2016;12:369-80 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2d
Ko T, Chin H, Chuah C, Huang J, Ng K, Khaw S, et al. The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. Oncotarget. 2016;7:2721-33 pubmed publisher
  • western blot; rat; fig 2
Sabirzhanov B, Stoica B, Zhao Z, Loane D, Wu J, Dorsey S, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654-68 pubmed publisher
  • immunohistochemistry; mouse; fig s15
Norlin S, Parekh V, Naredi P, Edlund H. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Diabetes. 2016;65:110-9 pubmed publisher
  • western blot; human; 1:1000; fig 4c
Blanco F, Jimbo M, Wulfkuhle J, Gallagher I, Deng J, Enyenihi L, et al. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene. 2016;35:2529-41 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
James R, Hillis J, Adorján I, Gration B, Mundim M, Iqbal A, et al. Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis. Glia. 2016;64:105-21 pubmed publisher
  • western blot; human
Li X, Liang Q, Liu W, Zhang N, Xu L, Zhang X, et al. Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. Oncogene. 2016;35:2453-64 pubmed publisher
  • western blot; human; fig 1k
Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, et al. Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival. Oncogene. 2016;35:2441-52 pubmed publisher
  • immunohistochemistry; mouse; fig 6
Chu Y, Ko C, Wang W, Wang S, Gean P, Kuo Y, et al. Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a. Mol Neurobiol. 2016;53:4173-4188 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; fig 1g
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  • immunocytochemistry; human; fig 3
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  • western blot; mouse; fig 2
Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed publisher
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product information
SKU :
9661S
Product-Name :
Cleaved Caspase-3 (Asp175) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (B, Dg, Pg)
Applications :
Flow cytometry
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
17, 19
Host :
Rabbit
Target :
Casp3 (Asp175) cleaved
Primary-Protein :
Casp3
Alt-Names :
Apopain,CASP-3,CASP3,CPP-32,CPP32,CPP32B,Caspase-3,Caspase-3 subunit p12,Caspase-3 subunit p17,Cysteine protease CPP32,PARP cleavage protease,Protein Yama,SCA-1,SREBP cleavage activity 1,Yama,caspase 3, apoptosis-related cysteine peptidase,caspase 3, apoptosis-related cysteine protease,procaspase3
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.