| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; rat; 1:1000; loading ...; fig 5b
| Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020;19:e13055 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Sun Y, Liu Z, Cao X, Lu Y, Mi Z, He C, et al. Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Sci Adv. 2019;5:eaaw3593 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5a
| Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1s1b
| Turnham R, Smith F, Kenerson H, Omar M, Golkowski M, Garcia I, et al. An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5b
| Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan A, et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019;10:1546 pubmed publisher |
- western blot; human; loading ...; fig 4g
| Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, et al. Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction. EMBO J. 2019;38: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig st2
| Sundaresan S, Meininger C, Kang A, Photenhauer A, Hayes M, Sahoo N, et al. Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology. 2017;153:1555-1567.e15 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2c
| Smith F, Esseltine J, Nygren P, Veesler D, Byrne D, Vonderach M, et al. Local protein kinase A action proceeds through intact holoenzymes. Science. 2017;356:1288-1293 pubmed publisher |
- western blot; human; loading ...; fig 6c
| Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher |
- western blot; human; loading ...; tbl 4
| Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Brzezinski J, Felkner R, Modi A, Liu M, Roth M. Phosphorylation Requirement of Murine Leukemia Virus p12. J Virol. 2016;90:11208-11219 pubmed |
| Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher |
- western blot; human; loading ...; fig 4g
| Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed publisher |
- western blot; mouse; loading ...; fig s2b
| Gallardo Montejano V, Saxena G, Kusminski C, Yang C, McAfee J, Hahner L, et al. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1?/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun. 2016;7:12723 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Johanns M, Lai Y, Hsu M, Jacobs R, Vertommen D, Van Sande J, et al. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nat Commun. 2016;7:10856 pubmed publisher |
- western blot; human; fig 4
| Kaya Okur H, Das A, Taylor R, Bagchi I, Bagchi M. Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization. Mol Endocrinol. 2016;30:302-13 pubmed publisher |
- western blot; rat; 1:2000; loading ...; fig s3a
| Peres T, Ong L, Costa A, Eyng H, Venske D, Colle D, et al. Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese. Metallomics. 2016;8:597-604 pubmed publisher |
- chromatin immunoprecipitation; African green monkey
| Kilisch M, Lytovchenko O, Arakel E, Bertinetti D, Schwappach B. A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1. J Cell Sci. 2016;129:831-42 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Liu K, Frazier W. Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. PLoS ONE. 2015;10:e0129667 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher |
- western blot; mouse; 1:1000
| Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford R, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med. 2015;21:166-72 pubmed publisher |
- western blot; mouse; fig 1,2,3,4,5,6
| Izzo F, Mercogliano F, Venturutti L, Tkach M, Inurrigarro G, Schillaci R, et al. Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. Breast Cancer Res. 2014;16:491 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
- western blot; mouse
| Martin S, Fernandez Rojo M, Stanley A, Bastiani M, Okano S, Nixon S, et al. Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS ONE. 2012;7:e46242 pubmed publisher |
| Wang Y, Li G, Goode J, Paz J, Ouyang K, Screaton R, et al. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature. 2012;485:128-32 pubmed publisher |
| Zhao X, Nedvetsky P, Stanchi F, Vion A, Popp O, Zühlke K, et al. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. elife. 2019;8: pubmed publisher |
| Sakai Y, Hanafusa H, Pastuhov S, Shimizu T, Li C, Hisamoto N, et al. TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor. EMBO Rep. 2019;20:e47517 pubmed publisher |
| Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta Hirashima N, Kanno S, et al. A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Proc Natl Acad Sci U S A. 2018;115:10458-10463 pubmed publisher |
| Stival C, Ritagliati C, Xu X, Gervasi M, Luque G, Baró Graf C, et al. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J Biol Chem. 2018;293:9435-9447 pubmed publisher |
| Isensee J, Kaufholz M, Knape M, Hasenauer J, Hammerich H, Gonczarowska Jorge H, et al. PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination. J Cell Biol. 2018;217:2167-2184 pubmed publisher |
| Tarumoto Y, Lu B, Somerville T, Huang Y, Milazzo J, Wu X, et al. LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell. 2018;69:1017-1027.e6 pubmed publisher |
| Young S, Miyata H, Satouh Y, Aitken R, Baker M, Ikawa M. CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. J Cell Sci. 2016;129:4379-4387 pubmed |
| Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li J, et al. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016;126:1704-16 pubmed publisher |
| Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher |
| Hamaguchi T, Nakamuta S, Funahashi Y, Takano T, Nishioka T, Shohag M, et al. In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Struct Funct. 2015;40:1-12 pubmed publisher |
| He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, et al. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med. 2014;20:1035-42 pubmed publisher |
| Wertheimer E, Krapf D, de la Vega Beltrán J, Sanchez Cardenas C, Navarrete F, Haddad D, et al. Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. J Biol Chem. 2013;288:35307-20 pubmed publisher |
| Guibinga G, Murray F, Barron N. HPRT-deficiency dysregulates cAMP-PKA signaling and phosphodiesterase 10A expression: mechanistic insight and potential target for Lesch-Nyhan Disease?. PLoS ONE. 2013;8:e63333 pubmed publisher |
| Bradshaw N, Soares D, Carlyle B, Ogawa F, Davidson Smith H, Christie S, et al. PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci. 2011;31:9043-54 pubmed publisher |
| Park J, Arakawa Takeuchi S, Jinno S, Okayama H. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem. 2011;286:23132-41 pubmed publisher |
| Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-? feedforward signaling. Cell. 2011;145:92-103 pubmed publisher |
| Moir R, Lee J, Haeusler R, Desai N, Engelke D, Willis I. Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1. Proc Natl Acad Sci U S A. 2006;103:15044-9 pubmed |
| Li X, Huston E, Lynch M, Houslay M, Baillie G. Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes. Biochem J. 2006;394:427-35 pubmed |
