product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Akt Substrate (RXXS*/T*) (110B7E) Rabbit mAb
catalog :
9614
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
110B7E
reactivity :
Dictyostelium discoideum, human, mouse, pigs
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; pigs ; loading ...; fig 5i
Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed publisher
  • western blot; human; loading ...; fig 4c
Tian L, Chen C, Guo Y, Zhang F, Mi J, Feng Q, et al. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. Neoplasia. 2021;23:643-652 pubmed publisher
  • western blot; human; loading ...; fig 2e
Yoo S, Lee C, An H, Lee J, Lee H, Kang H, et al. RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity. Int J Mol Sci. 2019;20: pubmed publisher
  • western blot; Dictyostelium discoideum; loading ...; fig 3d
Nichols J, Paschke P, Peak Chew S, Williams T, Tweedy L, Skehel M, et al. The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module. Dev Cell. 2019;48:491-505.e9 pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Kim M, Morales L, Baek M, Slaga T, DiGiovanni J, Kim D. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3? axis inhibits keratinocyte survival and proliferation. Oncotarget. 2017;8:90674-90692 pubmed publisher
  • western blot; human; loading ...; fig 5b
Li X, Dai X, Wan L, Inuzuka H, Sun L, North B. Smurf1 regulation of DAB2IP controls cell proliferation and migration. Oncotarget. 2016;7:26057-69 pubmed publisher
  • western blot; mouse; 1:1000
Kim K, Qiang L, Hayden M, Sparling D, Purcell N, Pajvani U. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nat Commun. 2016;7:10255 pubmed publisher
  • western blot; human; 1:1000; fig 2
Tollenaere M, Villumsen B, Blasius M, Nielsen J, Wagner S, Bartek J, et al. p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun. 2015;6:10075 pubmed publisher
  • western blot; mouse; fig 3
Kleinert M, Sylow L, Fazakerley D, Krycer J, Thomas K, Oxbøll A, et al. Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Mol Metab. 2014;3:630-41 pubmed publisher
  • western blot; human
Choi Y, Kim Y, Jeong H, Jin Y, Yeo C, Lee K. Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation. FEBS J. 2014;281:3656-66 pubmed publisher
  • western blot; human; fig 1b
Dai X, North B, Inuzuka H. Negative regulation of DAB2IP by Akt and SCFFbw7 pathways. Oncotarget. 2014;5:3307-15 pubmed
  • western blot; human; fig 9
Lu J, Zavorotinskaya T, Dai Y, Niu X, Castillo J, Sim J, et al. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood. 2013;122:1610-20 pubmed publisher
  • western blot; mouse
Wang Y, Li G, Goode J, Paz J, Ouyang K, Screaton R, et al. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature. 2012;485:128-32 pubmed publisher
Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, et al. TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell. 2016;27:397-409 pubmed publisher
Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, et al. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. elife. 2015;4:e10510 pubmed publisher
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
Hamaguchi T, Nakamuta S, Funahashi Y, Takano T, Nishioka T, Shohag M, et al. In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Struct Funct. 2015;40:1-12 pubmed publisher
Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed publisher
Koumanov F, Richardson J, Murrow B, Holman G. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. J Biol Chem. 2011;286:16574-82 pubmed publisher
product information
SKU :
9614S
Product-Name :
Phospho-Akt Substrate (RXXS*/T*) (110B7E) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
All
Applications :
ELISA Peptide
Product-Category :
Motif Antibodies
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
Host :
Rabbit
Target :
Akt-phosphate Substrate (Ser/Thr) phosphate
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.