Slug (C19G7) Rabbit mAb | Cell Signaling Technology 9585 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Slug (C19G7) Rabbit mAb

catalog :

9585

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

C19G7

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, ChIP-Seq

more info or order :

Cell Signaling Technology product webpage

citations: 142

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 8e	Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, et al. Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer. Cell Death Dis. 2021;12:912 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5a, 5c	Chen R, Sheng C, Ma R, Zhang L, Yang L, Chen Y. PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer. Mol Med Rep. 2021;24: pubmed publisher
western blot; human; loading ...; fig 6a, 6b	Wang C, Yang Z, Xu E, Shen X, Wang X, Li Z, et al. Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway. Clin Transl Med. 2021;11:e522 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4c	Wang K, Liu S, Dou Z, Zhang S, Yang X. Loss of Krüppel-like factor 9 facilitates stemness in ovarian cancer ascites-derived multicellular spheroids via Notch1/slug signaling. Cancer Sci. 2021;112:4220-4233 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 5e immunocytochemistry; mouse; 1:400; loading ...; fig s6d western blot; mouse; 1:1000; loading ...; fig 6i	Shao C, Lou P, Liu R, Bi X, Li G, Yang X, et al. Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland. Front Cell Dev Biol. 2021;9:691050 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4g	Yu D, Yang X, Lin J, Cao Z, Lu C, Yang Z, et al. Super-Enhancer Induced IL-20RA Promotes Proliferation/Metastasis and Immune Evasion in Colorectal Cancer. Front Oncol. 2021;11:724655 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4c, 4d	Zou J, Zhu X, Xiang D, Zhang Y, Li J, Su Z, et al. LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase. Acta Pharm Sin B. 2021;11:1578-1591 pubmed publisher
western blot; human; loading ...; fig 6d	Cheng X, Wang J, Liu C, Jiang T, Yang N, Liu D, et al. Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway. J Exp Clin Cancer Res. 2021;40:199 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2b	Urdiciain A, Erausquin E, Zelaya M, Zazpe I, Lanciego J, Melendez B, et al. Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines. Biology (Basel). 2021;10: pubmed publisher
western blot; human; loading ...; fig 3b	Lin C, Tsai M, Chen Y, Liu W, Lin C, Hsu K, et al. Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Biomol Ther (Seoul). 2021;29:551-561 pubmed publisher
immunohistochemistry; mouse; loading ...; fig s3b	Carstens J, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews K, et al. Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer. Cell Rep. 2021;35:108990 pubmed publisher
western blot; human; 1:1000; loading ...; fig s5d	Jiang Y, Han Q, Zhao H, Zhang J. Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis. J Exp Clin Cancer Res. 2021;40:13 pubmed publisher
western blot; human; 1:1000; loading ...	Jiang X, Xu Y, Ren H, Jiang J, Wudu M, Wang Q, et al. KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity. Cell Biosci. 2020;10:139 pubmed publisher
western blot; human; fig 5b	Shi H, Tao T, Abraham B, Durbin A, Zimmerman M, Kadoch C, et al. ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv. 2020;6:eaaz3440 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Huang W, Yu D, Wang M, Han Y, Lin J, Wei D, et al. ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma. Cell Prolif. 2020;53:e12836 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5	Liang W, Gao R, Yang M, Wang X, Cheng K, Shi X, et al. MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. Oncol Lett. 2020;19:2272-2280 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5b,	Chen Z, Zhang J, Xue H, Qian M, Guo X, Gao X, et al. Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition. Integr Cancer Ther. 2020;19:1534735419900927 pubmed publisher
western blot; human; loading ...; fig 5e	Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
western blot; human; fig 4e	Chandrasekaran B, Dahiya N, Tyagi A, Kolluru V, Saran U, Baby B, et al. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. 2020;9:23 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 3e western blot; mouse; 1:1000; loading ...; fig 3h	Cheung E, DeNicola G, Nixon C, Blyth K, Labuschagne C, Tuveson D, et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020;37:168-182.e4 pubmed publisher
western blot; human; loading ...; fig 3c	Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, et al. UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop. Cell Death Dis. 2020;11:10 pubmed publisher
western blot; human; loading ...; fig 5a	Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, et al. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020;39:1557-1571 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2k	Cai H, Li J, Zhang Y, Liao Y, Zhu Y, Wang C, et al. LDHA Promotes Oral Squamous Cell Carcinoma Progression Through Facilitating Glycolysis and Epithelial-Mesenchymal Transition. Front Oncol. 2019;9:1446 pubmed publisher
western blot; human; fig 2e	Zhou S, da Silva S, Siegel P, Philip A. CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Sci Rep. 2019;9:16317 pubmed publisher
western blot; human; 1:500; loading ...; fig 3f	Jiao X, Ye J, Wang X, Yin X, Zhang G, Cheng X. KIAA1199, a Target of MicoRNA-486-5p, Promotes Papillary Thyroid Cancer Invasion by Influencing Epithelial-Mesenchymal Transition (EMT). Med Sci Monit. 2019;25:6788-6796 pubmed publisher
western blot; human; loading ...; fig 2a	Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed publisher
western blot; mouse; fig 4a	Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed publisher
western blot; human; loading ...; fig s11b	Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, et al. Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Theranostics. 2019;9:3879-3902 pubmed publisher
western blot; human; 1:500; loading ...; fig s2a	Sonego M, Pellarin I, Costa A, Vinciguerra G, Coan M, Kraut A, et al. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sci Adv. 2019;5:eaav3235 pubmed publisher
western blot; rat; 1:250; loading ...; fig s3b	Jalal S, Shi S, Acharya V, Huang R, Viasnoff V, Bershadsky A, et al. Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement. J Cell Sci. 2019;132: pubmed publisher
western blot; human; loading ...; fig 5a	Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019;376:198-209 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig s4c	Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn L, Rosenthal B, et al. A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019;176:790-804.e13 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig s3d	Pommier A, Anaparthy N, Memos N, Kelley Z, Gouronnec A, Yan R, et al. Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science. 2018;360: pubmed publisher
western blot; human; loading ...; fig 3b	Vl kov K, Vachtenheim J, R da J, Hor k P, Ondru ov L. Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells. J Cell Mol Med. 2018;22:2240-2251 pubmed publisher
western blot; human; 1:1000; fig s6i	Wang J, Ye Q, Cao Y, Guo Y, Huang X, Mi W, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017;8:2207 pubmed publisher
ChIP-Seq; human; loading ...; fig s3a western blot; human; 1:300; loading ...; fig 4e	Noutsou M, Li J, Ling J, Jones J, Wang Y, Chen Y, et al. The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes. Cell Rep. 2017;20:3005-3013 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7j	Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher
western blot; human; loading ...; fig 4b	van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49:1261-1266 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3a	Lu J, Yang Y, Guo G, Liu Y, Zhang Z, Dong S, et al. IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway. Oncotarget. 2017;8:49502-49514 pubmed publisher
immunocytochemistry; human; loading ...; fig 4c western blot; human; loading ...; fig 4a	Yoon C, Cho S, Chang K, Park D, Ryeom S, Yoon S. Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. Mol Cancer Res. 2017;15:1106-1116 pubmed publisher
western blot; human; 1:500; loading ...; fig 4C	Hu X, Zhang Z, Liang Z, Xie D, Zhang T, Yu D, et al. Downregulation of feline sarcoma-related protein inhibits cell migration, invasion and epithelial-mesenchymal transition via the ERK/AP-1 pathway in bladder urothelial cell carcinoma. Oncol Lett. 2017;13:686-694 pubmed publisher
immunocytochemistry; mouse; 1:200; loading ...; fig 1a	Jang S, Choubey S, Furchtgott L, Zou L, Doyle A, Menon V, et al. Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. elife. 2017;6: pubmed publisher
western blot; human; 1:1000; loading ...; fig 6d	Li X, Liu W, Chen X, Wang Y, Shi D, Zhang H, et al. Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer. Int J Mol Med. 2017;39:927-935 pubmed publisher
western blot; human; 1:1000; loading ...; fig s1e	Kim N, Cha Y, Lee J, Lee S, Yang J, Yun J, et al. Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress. Nat Commun. 2017;8:14374 pubmed publisher
western blot; human; loading ...; fig s2	Qiu X, Pascal L, Song Q, Zang Y, Ai J, O Malley K, et al. Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. Neoplasia. 2017;19:207-215 pubmed publisher
western blot; human; loading ...	Zhai S, Liu C, Zhang L, Zhu J, Guo J, Zhang J, et al. PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Neoplasia. 2017;19:154-164 pubmed publisher
western blot; human; loading ...; fig 3d	Gonzalez M, Martin E, Anwar T, Arellano Garcia C, Medhora N, Lama A, et al. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep. 2017;18:1215-1228 pubmed publisher
immunohistochemistry; chicken; 1:100; loading ...; fig 4g	Schiffmacher A, Xie V, Taneyhill L. Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. J Cell Biol. 2016;215:735-747 pubmed
western blot; human; fig 1a	Zhao X, Li L, Wang X, Fu R, Lv Y, Jin W, et al. Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells. PLoS ONE. 2016;11:e0164752 pubmed publisher
western blot; human; loading ...; fig 2h	Matkar P, Singh K, Rudenko D, Kim Y, Kuliszewski M, Prud homme G, et al. Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Oncotarget. 2016;7:69489-69506 pubmed publisher
western blot; human; loading ...; fig 4a	Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3b	Chiang K, Hsu S, Lin S, Yeh C, Pang J, Wang S, et al. PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model. Anticancer Res. 2016;36:3997-4005 pubmed
western blot; human; 1:1000; loading ...; fig 3a	Yang S, Tsai C, Pan Y, Yeh C, Pang J, Takano M, et al. MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells. Drug Des Devel Ther. 2016;10:1995-2002 pubmed publisher
immunocytochemistry; mouse; loading ...; fig 3b	Berens E, Sharif G, Schmidt M, Yan G, Shuptrine C, Weiner L, et al. Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene. 2017;36:593-605 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 8j	Zhang Q, Liu S, Parajuli K, Zhang W, Zhang K, Mo Z, et al. Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. Oncogene. 2017;36:687-699 pubmed publisher
western blot; human; loading ...; fig 1b	Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4a	Tisza M, Zhao W, Fuentes J, Prijic S, Chen X, Levental I, et al. Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts. Oncotarget. 2016;7:51553-51568 pubmed publisher
western blot; rat; 1:1000; fig 3	Chuang H, Su H, Li C, Lin S, Yen S, Huang M, et al. The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration. Front Pharmacol. 2016;7:112 pubmed publisher
western blot; human; fig 2	Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher
western blot; human; 1:1000; fig 6	Chiang K, Yeh T, Chen S, Pang J, Yeh C, Hsu J, et al. The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential. Int J Mol Sci. 2016;17: pubmed publisher
western blot; human; fig s3	Zhuang L, Yang Y, Ma X, Han B, Wang Z, Zhao Q, et al. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. Cell Death Dis. 2016;7:e2203 pubmed publisher
western blot; human; 1:1000; fig 1	Bassey Archibong B, Kwiecien J, Milosavljevic S, Hallett R, Rayner L, Erb M, et al. Kaiso depletion attenuates transforming growth factor-? signaling and metastatic activity of triple-negative breast cancer cells. Oncogenesis. 2016;5:e208 pubmed publisher
western blot; human; fig 7	Ananthula S, Sinha A, El Gassim M, Batth S, Marshall G, Gardner L, et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget. 2016;7:20869-89 pubmed publisher
western blot; human; fig 6	Tsui K, Lin Y, Chung L, Chuang S, Feng T, Chiang K, et al. Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells. Cancer Lett. 2016;375:142-151 pubmed publisher
western blot; human; 1:1000; fig 4	Chang T, Chen C, Wu Y, Liu J, Kuo Y, Lee K, et al. Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. PLoS ONE. 2016;11:e0149897 pubmed publisher
western blot; human; 1:1000; fig 3	Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed publisher
chromatin immunoprecipitation; human; 1:500; fig 3 western blot; human; 1:500; fig 2	Weyemi U, Redon C, Choudhuri R, Aziz T, Maeda D, Boufraqech M, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4h	Yan L, Liu Y, Xiang J, Wu Q, Xu L, Luo X, et al. PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer. Int J Oncol. 2016;48:471-84 pubmed publisher
western blot; human; 1:500; fig 3	Werner A, Iwasaki S, McGourty C, Medina Ruiz S, Teerikorpi N, Fedrigo I, et al. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015;525:523-7 pubmed publisher
western blot; human; loading ...; fig 3c	Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin S, et al. SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene. 2016;35:2824-33 pubmed publisher
western blot; human; fig 6a	Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher
western blot; mouse; 1:1000; fig 1	Zhao Y, Londono P, Cao Y, Sharpe E, Proenza C, O Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015;6:8243 pubmed publisher
western blot; human; 1:1000; fig 4	Chiang K, Kuo S, Chen C, Ng S, Lin S, Yeh C, et al. MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential. Cancer Lett. 2015;369:76-85 pubmed publisher
western blot; human; fig 7a	Tsui K, Hsu S, Chung L, Lin Y, Feng T, Lee T, et al. Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells. Sci Rep. 2015;5:12870 pubmed publisher
western blot; human; fig 4	Seo G, Ho M, Bui N, Kim Y, Koh D, Lim Y, et al. Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci. 2015;22:47 pubmed publisher
immunohistochemistry - paraffin section; human; 1:30; fig 2	Cheung S, Boey Y, Koh V, Thike A, Lim J, Iqbal J, et al. Role of epithelial-mesenchymal transition markers in triple-negative breast cancer. Breast Cancer Res Treat. 2015;152:489-98 pubmed publisher
western blot; mouse; fig 1	Castillo Lluva S, Hontecillas Prieto L, Blanco GÃ³mez A, Del Mar SÃ¡ez Freire M, GarcÃa Cenador B, GarcÃa Criado J, et al. A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene. 2015;34:4777-90 pubmed publisher
western blot; human; fig s7	Min K, Liggett J, Silva G, Wu W, Wang R, Shen R, et al. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene. 2016;35:377-88 pubmed publisher
western blot; human; fig 6	Li S, Wu X, Dong C, Xie X, Wu J, Zhang X. The differential expression of OCT4 isoforms in cervical carcinoma. PLoS ONE. 2015;10:e0118033 pubmed publisher
immunohistochemistry - paraffin section; mouse western blot; mouse	Knezevic J, Pfefferle A, Petrovic I, Greene S, Perou C, Rosen J. Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. Oncogene. 2015;34:5997-6006 pubmed publisher
western blot; human; fig 3	Cheng Y, Chen P, Chiang H, Suen C, Hwang M, Lin T, et al. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death Dis. 2015;6:e1584 pubmed publisher
flow cytometry; human	Satelli A, Mitra A, Brownlee Z, Xia X, Bellister S, Overman M, et al. Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression. Clin Cancer Res. 2015;21:899-906 pubmed publisher
western blot; mouse	Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, et al. Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes. Stem Cells. 2015;33:742-50 pubmed publisher
western blot; human; 1:3000; fig s3c	Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman Colin C, et al. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014;5:5496 pubmed publisher
western blot; human	Shriver M, Stroka K, Vitolo M, Martin S, Huso D, Konstantopoulos K, et al. Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis. Oncogene. 2015;34:4248-59 pubmed publisher
immunohistochemistry - paraffin section; human; 1:10	Sun Y, Hu L, Zheng H, Bagnoli M, Guo Y, Rupaimoole R, et al. MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer. J Pathol. 2015;235:25-36 pubmed publisher
western blot; human; 1:500	Lee J, Chung L, Chen Y, Feng T, Juang H. N-myc downstream-regulated gene 1 downregulates cell proliferation, invasiveness, and tumorigenesis in human oral squamous cell carcinoma. Cancer Lett. 2014;355:242-52 pubmed publisher
western blot; human	Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher
western blot; human; 1:500	Liang W, Hao Z, Han J, Zhu D, Jin Z, Xie W. CAV-1 contributes to bladder cancer progression by inducing epithelial-to-mesenchymal transition. Urol Oncol. 2014;32:855-63 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Adham S, Al Harrasi I, Al Haddabi I, Al Rashdi A, Al Sinawi S, Al Maniri A, et al. Immunohistological insight into the correlation between neuropilin-1 and epithelial-mesenchymal transition markers in epithelial ovarian cancer. J Histochem Cytochem. 2014;62:619-31 pubmed publisher
western blot; human	Subramani R, Lopez Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
immunohistochemistry; human; 1:100	Fukai J, Fujita K, Yamoto T, Sasaki T, Uematsu Y, Nakao N. Intracranial extension of adenoid cystic carcinoma: potential involvement of EphA2 expression and epithelial-mesenchymal transition in tumor metastasis: a case report. BMC Res Notes. 2014;7:131 pubmed publisher
immunocytochemistry; human western blot; human	Li A, Morton J, Ma Y, Karim S, Zhou Y, Faller W, et al. Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology. 2014;146:1386-96.e1-17 pubmed publisher
western blot; human	Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, et al. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Cancer Res. 2014;74:829-39 pubmed publisher
immunohistochemistry; human; 1:100	Shintaku M, Yoneda H, Hirato J, Nagaishi M, Okabe H. Gliosarcoma with ependymal and PNET-like differentiation. Clin Neuropathol. 2013;32:508-14 pubmed publisher
western blot; human; 1:1000	Devine D, Rostas J, Metge B, Das S, Mulekar M, Tucker J, et al. Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-?/SMAD signaling. Oncogene. 2014;33:2620-8 pubmed publisher
immunohistochemistry - frozen section; mouse	Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed publisher
western blot; human	Chu I, Lai W, Aprelikova O, El Touny L, Kouros Mehr H, Green J. Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß. PLoS ONE. 2013;8:e61125 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Nagaishi M, Nobusawa S, Tanaka Y, Ikota H, Yokoo H, Nakazato Y. Slug, twist, and E-cadherin as immunohistochemical biomarkers in meningeal tumors. PLoS ONE. 2012;7:e46053 pubmed publisher
western blot; human	Wu C, Tang S, Wang P, Lee H, Ko J. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012;287:25292-302 pubmed publisher
	Hu X, Villodre E, Larson R, Rahal O, Wang X, Gong Y, et al. Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Commun Biol. 2021;4:72 pubmed publisher
	Fahlbusch S, Keil S, Epplen J, Zanker K, Dittmar T. Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties. BMC Cancer. 2020;20:446 pubmed publisher
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product information

SKU :

9585S

Product-Name :

Slug (C19G7) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

Developmental Biology

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

Slug

Primary-Protein :

Snail2

Alt-Names :

MGC10182,Neural crest transcription factor Slug,Protein snail homolog 2,SLUG,SLUGH,SLUGH1,SNAI2,WS2D,Zinc finger protein SNAI2,slug (chicken homolog), zinc finger protein,snail 2,snail homolog 2 (Drosophila)

more info or order :

Cell Signaling Technology product webpage