product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved PARP (Asp214) (19F4) Mouse mAb (Human Specific)
catalog :
9546
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
19F4
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, reverse phase protein lysate microarray
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3e
Kabir S, Cidado J, Andersen C, Dick C, Lin P, Mitros T, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2d
Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk S, Fulda S. Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Cell Death Differ. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e
Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández Mateos J, Khan K, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018;359:920-926 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; human; loading ...; fig 1e
Chaabane W, Appell M. Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species. Oncotarget. 2016;7:75616-75634 pubmed publisher
  • western blot; human; loading ...; fig 4a
Heulot M, Chevalier N, Puyal J, Margue C, Michel S, Kreis S, et al. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget. 2016;7:64342-64359 pubmed publisher
  • western blot; human; loading ...; fig s1b
Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling. J Mol Med (Berl). 2016;94:1167-1179 pubmed
  • western blot; human; 1:1000; fig 6c
Mazur P, Herner A, Mello S, Wirth M, Hausmann S, Sánchez Rivera F, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015;21:1163-71 pubmed publisher
  • immunohistochemistry; human; fig 3
Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015;520:363-7 pubmed publisher
  • western blot; human
Wang S, Chen X, Hu J, Jiang J, Li Y, Chan Salis K, et al. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015;14:877-88 pubmed publisher
  • western blot; human
FitzGerald J, Murillo L, O Brien G, O Connell E, O Connor A, Wu K, et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS ONE. 2014;9:e98891 pubmed publisher
  • western blot; human
Shats I, Gatza M, Liu B, Angus S, You L, Nevins J. FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. Cancer Res. 2013;73:6056-67 pubmed publisher
  • western blot; mouse; fig 6
Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, et al. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS ONE. 2011;6:e24341 pubmed publisher
  • western blot; human
Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Ueno K, et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer. 2011;128:1793-803 pubmed publisher
Wang Y, Gable T, Ma M, Clark D, Zhao J, Zhang Y, et al. A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma. Mol Ther Nucleic Acids. 2017;6:269-278 pubmed publisher
Liu J, Chen Z, He J, Zhang Y, Zhang T, Jiang Y. Anti-oxidative and anti-apoptosis effects of egg white peptide, Trp-Asn-Trp-Ala-Asp, against H2O2-induced oxidative stress in human embryonic kidney 293 cells. Food Funct. 2014;5:3179-88 pubmed publisher
Shi K, An J, Shan L, Jiang Q, Li F, Ci Y, et al. Survivin-2B promotes autophagy by accumulating IKK alpha in the nucleus of selenite-treated NB4 cells. Cell Death Dis. 2014;5:e1071 pubmed publisher
Malhotra U, Zaidi A, Kosovec J, Kasi P, Komatsu Y, Rotoloni C, et al. Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium. PLoS ONE. 2013;8:e78343 pubmed publisher
Liu R, Dong Z, Liu J, Zhou L, Huang W, Khoo S, et al. Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells. Mol Cancer Ther. 2013;12:2157-66 pubmed publisher
Orre L, Panizza E, Kaminskyy V, Vernet E, Gräslund T, Zhivotovsky B, et al. S100A4 interacts with p53 in the nucleus and promotes p53 degradation. Oncogene. 2013;32:5531-40 pubmed publisher
Ueno T, Tsukuda K, Toyooka S, Ando M, Takaoka M, Soh J, et al. Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer. Lung Cancer. 2012;76:26-31 pubmed publisher
Kobayashi N, Toyooka S, Soh J, Yamamoto H, Dote H, Kawasaki K, et al. The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor. Lung Cancer. 2012;75:161-6 pubmed publisher
product information
SKU :
9546S
Product-Name :
Cleaved PARP (Asp214) (19F4) Mouse mAb (Human Specific)
Size :
200 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
89
Host :
Mouse
Target :
PARP1 (Asp214, 89 kD) cleaved
Primary-Protein :
PARP1
Alt-Names :
ADP-ribosyltransferase (NAD+,ADP-ribosyltransferase NAD(+),ADPRT,ADPRT 1,ADPRT1,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PARP1,PPOL,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,pADPRT-1,poly (ADP-ribose) polymerase 1,poly (ADP-ribose) polymerase family, member 1,poly (ADP-ribose) polymerase),poly(ADP-ribose) polymerase,poly(ADP-ribose) synthetase,poly(ADP-ribosyl)transferase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.