product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved PARP (Asp214) Antibody (Mouse Specific)
catalog :
9544
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 36
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 2b
Lee C, Hsieh T. Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts. Cell Signal. 2018;47:16-26 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 7a
Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, et al. CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017;18:1499-1511 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6a
Busada J, Velte E, Serra N, Cook K, Niedenberger B, Willis W, et al. Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice. Reproduction. 2016;152:379-88 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...
Cantú A, Altshuler Keylin S, Laird D. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016;214:215-29 pubmed publisher
  • western blot; mouse; fig 6
Inoue T, Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S, et al. Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. Am J Physiol Heart Circ Physiol. 2016;311:H509-19 pubmed publisher
  • western blot; mouse; fig 7
Roychowdhury S, McCullough R, Sanz Garcia C, Saikia P, Alkhouri N, Matloob A, et al. Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. Hepatology. 2016;64:1518-1533 pubmed publisher
  • western blot; mouse; fig 6
Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed publisher
  • western blot; mouse; fig 1
Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Yufune S, Satoh Y, Akai R, Yoshinaga Y, Kobayashi Y, Endo S, et al. Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain. Sci Rep. 2016;6:21859 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • western blot; mouse; fig s9
Hu X, Garcia C, Fazli L, Gleave M, Vitek M, Jansen M, et al. Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. Sci Rep. 2015;5:15182 pubmed publisher
  • western blot; human; loading ...; fig 3c
Mazzacurati L, Lambert Q, Pradhan A, Griner L, Huszar D, Reuther G. The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells. Oncotarget. 2015;6:40141-57 pubmed publisher
  • western blot; human; fig 4
Ray A, Vasudevan S, Sengupta S. 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death. PLoS ONE. 2015;10:e0137614 pubmed publisher
  • western blot; mouse
Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochem Pharmacol. 2015;98:119-31 pubmed publisher
  • western blot; mouse; fig 2
Yufune S, Satoh Y, Takamatsu I, Ohta H, Kobayashi Y, Takaenoki Y, et al. Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice. Sci Rep. 2015;5:10252 pubmed publisher
  • western blot; human
Charan R, Johnson B, Zaganelli S, Nardozzi J, LaVoie M. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis. 2014;5:e1313 pubmed publisher
  • western blot; mouse
Soares F, Tattoli I, Rahman M, Robertson S, Belcheva A, Liu D, et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem. 2014;289:19317-30 pubmed publisher
  • western blot; human; 1:500
Malaviya A, Sylvester P. Synergistic Antiproliferative Effects of Combined ? -Tocotrienol and PPAR ? Antagonist Treatment Are Mediated through PPAR ? -Independent Mechanisms in Breast Cancer Cells. PPAR Res. 2014;2014:439146 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Hilliard S, Yao X, El Dahr S. Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014;387:1-14 pubmed publisher
  • western blot; mouse
Mahajan I, Chen M, Muro I, Robertson J, Wright C, Bratton S. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS ONE. 2014;9:e84388 pubmed publisher
  • western blot; mouse; fig 5, 7
Zemljic Harpf A, Godoy J, Platoshyn O, Asfaw E, Busija A, Domenighetti A, et al. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014;127:1104-16 pubmed publisher
  • western blot; mouse
Kuchenreuther M, Weber J. The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation. Oncogene. 2014;33:300-7 pubmed publisher
Shi Y, Huang X, Chen G, Wang Y, Zhi Q, Liu Y, et al. Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells. Oncotarget. 2016;7:48027-48037 pubmed publisher
Palumbo T, Poultsides G, Kouraklis G, Liakakos T, Drakaki A, Peros G, et al. A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma. BMC Cancer. 2016;16:353 pubmed publisher
Ward C, Boggio K, Johnson B, Boyd J, Douthwright S, Shaffer S, et al. A loss of FUS/TLS function leads to impaired cellular proliferation. Cell Death Dis. 2014;5:e1572 pubmed publisher
Estornes Y, Aguileta M, Dubuisson C, De Keyser J, Goossens V, Kersse K, et al. RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions. Cell Death Dis. 2014;5:e1555 pubmed publisher
Wennmann D, Vollenbröker B, Eckart A, Bonse J, Erdmann F, Wolters D, et al. The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Cell Death Dis. 2014;5:e1519 pubmed publisher
Mamrosh J, Lee J, Wagner M, Stambrook P, Whitby R, Sifers R, et al. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. elife. 2014;3:e01694 pubmed publisher
Avery Cooper G, Doerr M, Gilbert R, Youssef M, Richard A, Huether P, et al. Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells. Cancer Cell Int. 2014;14:19 pubmed publisher
Herberg S, Shi X, Johnson M, Hamrick M, Isales C, Hill W. Stromal cell-derived factor-1? mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLoS ONE. 2013;8:e58207 pubmed publisher
Kannan S, Sutphin R, Hall M, Golfman L, Fang W, Nolo R, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med. 2013;210:321-37 pubmed publisher
Yuen H, Abramczyk O, Montgomery G, Chan K, Huang Y, Sasazuki T, et al. Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells. Biosci Rep. 2012;32:413-22 pubmed publisher
Liu F, Hu X, Zimmerman M, Waller J, Wu P, Hayes Jordan A, et al. TNF? cooperates with IFN-? to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis. PLoS ONE. 2011;6:e16241 pubmed publisher
Choi H, Shin J, Lee H, Kim J, Huh C, Youn S, et al. Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes. Oxid Med Cell Longev. 2010;3:219-224 pubmed publisher
Benedettini E, Sholl L, Peyton M, Reilly J, Ware C, Davis L, et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010;177:415-23 pubmed publisher
Bachawal S, Wali V, Sylvester P. Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. BMC Cancer. 2010;10:84 pubmed publisher
product information
SKU :
9544S
Product-Name :
Cleaved PARP (Asp214) Antibody (Mouse Specific)
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
89
Host :
Rabbit
Target :
PARP1 (Asp214, 89 kD) cleaved mouse
Primary-Protein :
PARP1
Alt-Names :
5830444G22Rik,ADP-ribosyltransferase (NAD+,ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1,ADPRT 1,AI893648,Adprp,Adprt,Adprt1,C80510,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PPOL,Parp1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,msPARP,poly (ADP-ribose) polymerase family, member 1,poly (ADP-ribose) polymerase) 1,poly[ADP-ribose] synthetase 1,sPARP-1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.