| Published Application/Species/Dilution | Reference |
|---|
- western blot; mouse; fig 6
| Augello M, Berman-Booty L, Carr R, Yoshida A, Dean J, Schiewer M, et al. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015;7:628-47 pubmed publisher |
- western blot; human; 1:1000
| Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, et al. A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo. Biochim Biophys Acta. 2015;1850:1676-84 pubmed publisher |
- western blot; human; 1:2000
| Zhang W, Cai J, Chen S, Zheng X, Hu S, Dong W, et al. Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. Mol Med Rep. 2015;12:1506-14 pubmed publisher |
- western blot; human; 1:5000
| Demel H, Feuerecker B, Piontek G, Seidl C, Blechert B, Pickhard A, et al. Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. Am J Cancer Res. 2015;5:1649-64 pubmed |
| Waters A, Stewart J, Atigadda V, Mroczek-Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015;14:1559-69 pubmed publisher |
| Yeh J, Kreimer S, Walker S, Emori M, Krystal H, Richardson A, et al. Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. Genes Cancer. 2015;6:153-68 pubmed |
- western blot; human; fig 2
| Sun Y, Ponz-Sarvise M, Chang S, Chang W, Chen C, Hsu J, et al. Proteasome inhibition enhances the killing effect of BikDD gene therapy. Am J Transl Res. 2015;7:319-27 pubmed |
- immunocytochemistry; human
- western blot; rat
| Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher |
| Stewart J, Ma X, Megison M, Nabers H, Cance W, Kurenova E, et al. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog. 2015;54:9-23 pubmed publisher |
| Xu H, Zhou Y, Coughlan K, Ding Y, Wang S, Wu Y, et al. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta. 2015;1853:65-73 pubmed publisher |
| Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochem Pharmacol. 2015;98:119-31 pubmed publisher |
- western blot; human; 1:1000
| Han M, Woo S, Min K, Kim S, Park J, Kim D, et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression. Chem Biol Interact. 2015;228:69-78 pubmed publisher |
- western blot; human; 1:1000
| Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, et al. Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res. 2015;94:1-9 pubmed publisher |
| Kim S, Kim W, Yoon J, Ji J, Morgan M, Cho H, et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol. 2015;135:2021-30 pubmed publisher |
| Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher |
- western blot; mouse; 1:1000
| Reigada D, Nieto-Diaz M, Navarro-Ruiz R, Caballero-López M, Del Águila A, Munoz-Galdeano T, et al. Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury. Neuroscience. 2015;300:404-17 pubmed publisher |
| Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T. Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. J Virol. 2015;89:5040-59 pubmed publisher |
- western blot; human; 1:1000; fig s12
| Pang B, de Jong J, Qiao X, Wessels L, Neefjes J. Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015;11:472-80 pubmed publisher |
- western blot; human; fig 3 a-c
| Philipp S, Sosna J, Plenge J, Kalthoff H, Adam D. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal. 2015;13:25 pubmed publisher |
| Keller B, Garcia-Sevilla J. Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:54-62 pubmed publisher |
| Smithline Z, Nikonova A, Hensley H, Cai K, Egleston B, Proia D, et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS ONE. 2014;9:e114403 pubmed publisher |
- western blot; human; 1:1000
| Gu H, Mickler E, Cummings O, Sandusky G, Weber D, Gracon A, et al. Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis. FASEB J. 2014;28:4223-34 pubmed publisher |
- western blot; human; 1:1000
| Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed publisher |
| Yousuf S, Duan M, Moen E, Cross-Knorr S, Brilliant K, Bonavida B, et al. Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. PLoS ONE. 2014;9:e92478 pubmed publisher |
| Beierle E, Ma X, Stewart J, Megison M, Cance W, Kurenova E. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog. 2014;53:230-42 pubmed publisher |
| Wei N, Chu E, Wipf P, Schmitz J. Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Mol Cancer Ther. 2014;13:1130-41 pubmed publisher |
- western blot; human; 1:1000; fig 1b
| Martino-Echarri E, Henderson B, Brocardo M. Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget. 2014;5:9889-900 pubmed |
| Hamouda M, Belhacene N, Puissant A, Colosetti P, Robert G, Jacquel A, et al. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget. 2014;5:6252-66 pubmed |
| Kodama T, Tsukaguchi T, Yoshida M, Kondoh O, Sakamoto H. Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance. Cancer Lett. 2014;351:215-21 pubmed publisher |
| Tajuddin N, Moon K, Marshall S, Nixon K, Neafsey E, Kim H, et al. Neuroinflammation and neurodegeneration in adult rat brain from binge ethanol exposure: abrogation by docosahexaenoic acid. PLoS ONE. 2014;9:e101223 pubmed publisher |
- western blot; mouse; fig 3
| Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher |
| Eldeeb M, Fahlman R. The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway. Oncotarget. 2014;5:2714-22 pubmed |
| Subramani R, Lopez-Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher |
| Li C, Egloff A, Sen M, Grandis J, Johnson D. Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol. 2014;8:1220-30 pubmed publisher |
| Knubel K, Pernu B, Sufit A, Nelson S, Pierce A, Keating A. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Oncotarget. 2014;5:1338-51 pubmed |
- western blot; human
- immunoprecipitation; human
| Cross-Knorr S, Lu S, Perez K, Guevara S, Brilliant K, Pisano C, et al. RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. BMC Cancer. 2013;13:463 pubmed publisher |
| Hsin I, Hsiao Y, Wu M, Jan M, Tang S, Lin Y, et al. Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. Toxicol Appl Pharmacol. 2012;263:330-7 pubmed publisher |
| Colangelo T, Polcaro G, Ziccardi P, Muccillo L, Galgani M, Pucci B, et al. The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells. Cell Death Dis. 2016;7:e2108 pubmed publisher |
| Chang T, Tseng H, Liu M, Chang Y, Hsieh M, Chuang L. Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation. Sci Rep. 2016;6:23403 pubmed publisher |
| Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, et al. PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation. Mol Cancer. 2016;15:3 pubmed publisher |
| Nakanishi T, Song Y, He C, Wang D, Morita K, Tsukada J, et al. Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. Peerj. 2016;4:e2026 pubmed publisher |
| Holczer M, Márton M, Kurucz A, Banhegyi G, Kapuy O. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589 pubmed publisher |
| Wang N, Li Z, Zhao H, Tao Y, Xu L, Lu J, et al. Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int J Mol Sci. 2015;16:1266-92 pubmed publisher |
| Guo L, Shen Y, Zhao X, Guo L, Yu Z, Wang D, et al. Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. Phytother Res. 2015;29:357-65 pubmed publisher |
| Megison M, Gillory L, Stewart J, Nabers H, Mrozcek-Musulman E, Beierle E. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014;12:514-26 pubmed publisher |
| Lavorgna A, Matsuoka M, Harhaj E. A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation. PLoS Pathog. 2014;10:e1004418 pubmed publisher |
| Fatfat M, Merhi R, Rahal O, Stoyanovsky D, Zaki A, Haidar H, et al. Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species. BMC Cancer. 2014;14:527 pubmed publisher |
| Kapuy O, Vinod P, Bánhegyi G. mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress - An experimental and modeling study. FEBS Open Bio. 2014;4:704-13 pubmed publisher |
| Ge D, Kong X, Liu W, Zhao J, Su L, Zhang S, et al. Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contribute to apoptosis in vascular endothelial cells. Apoptosis. 2013;18:1120-31 pubmed publisher |
| Ren X, Song W, Liu W, Guan X, Miao F, Miao S, et al. Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3. FEBS Lett. 2013;587:1793-8 pubmed publisher |
| Smith C, Haucke V, McCluskey A, Robinson P, Chircop M. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013;12:4 pubmed publisher |
| He S, Wang L, Miao L, Wang T, Du F, Zhao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137:1100-11 pubmed publisher |
| Thomé C, Dos Santos G, Ferreira G, Scheucher P, Izumi C, Leopoldino A, et al. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity. Mol Cell Proteomics. 2012;11:1898-912 pubmed publisher |
| McClendon A, Dean J, Rivadeneira D, Yu J, Reed C, Gao E, et al. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle. 2012;11:2747-55 pubmed publisher |
| May K, Paton J, Paton A. Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak. Infect Immun. 2010;78:4691-6 pubmed publisher |
| Jak M, van Bochove G, Reits E, Kallemeijn W, Tromp J, Umana P, et al. CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101. Blood. 2011;118:5178-88 pubmed publisher |
| Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell. 2011;145:92-103 pubmed publisher |
