| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig s3
| Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, et al. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015;11:1486-500 pubmed publisher |
- western blot; human; fig 1
| Gilmore J, Sardiu M, Groppe B, Thornton J, Liu X, Dayebgadoh G, et al. WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS ONE. 2016;11:e0155492 pubmed publisher |
- western blot; human; fig 3
| Chen Z, Wang Z, Pang J, Yu Y, Bieerkehazhi S, Lu J, et al. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep. 2016;6:29090 pubmed publisher |
- western blot; human; fig 7
| Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;: pubmed publisher |
- western blot; human; fig 1
| Yalon M, Tuval-Kochen L, Castel D, Moshe I, Mazal I, Cohen O, et al. Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. PLoS ONE. 2016;11:e0155711 pubmed publisher |
- western blot; mouse; fig 10e
| Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher |
- western blot; human; 1:1000
| Tao Y, Xu L, Lu J, Hu S, Fang F, Cao L, et al. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia. J Exp Clin Cancer Res. 2015;34:4 pubmed publisher |
- western blot; rat; fig 1f
| Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher |
- western blot; human; 1:1000
| Zanotto-Filho A, Braganhol E, Klafke K, Figueiró F, Terra S, Paludo F, et al. Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. Cancer Lett. 2015;358:220-31 pubmed publisher |
- western blot; human; 1:250; fig 4c
| Krossa S, Schmitt A, Hattermann K, Fritsch J, Scheidig A, Mehdorn H, et al. Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1. Oncotarget. 2015;6:21029-45 pubmed |
- immunocytochemistry; human; fig 1
| Young L, Marzio A, Pérez-Durán P, Reid D, Meredith D, Roberti D, et al. TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response. Cell Rep. 2015;13:451-9 pubmed publisher |
- western blot; mouse; fig s1
- western blot; rat; fig 1
| Wang S, Park S, Kodali V, Han J, Yip T, Chen Z, et al. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell. 2015;26:594-604 pubmed publisher |
- western blot; mouse; 1:2000
| Dahlhoff M, Schafer M, Muzumdar S, Rose C, Schneider M. ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis. Mol Oncol. 2015;9:1825-33 pubmed publisher |
- western blot; rat; 1:1000; fig 4
| Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher |
- western blot; human; 1:1000
| Zhang X, Cheng S, Bian K, Wang L, Zhang X, Yan B, et al. MicroRNA-26a promotes anoikis in human hepatocellular carcinoma cells by targeting alpha5 integrin. Oncotarget. 2015;6:2277-89 pubmed |
- western blot; human; fig 3
| Kumar S, Ingle H, Mishra S, Mahla R, Kumar A, Kawai T, et al. IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death Dis. 2015;6:e1758 pubmed publisher |
| Girotti M, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015;27:85-96 pubmed publisher |
- immunoprecipitation; human; fig 4a
| Krukenberg K, Jiang R, Steen J, Mitchison T. Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. Cell Rep. 2014;8:1808-18 pubmed publisher |
- western blot; human; 1:1000
| Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher |
- western blot; human; fig 6
| Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, et al. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle. 2014;13:3878-91 pubmed publisher |
- western blot; human; fig 3
| Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh A, et al. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A. 2014;111:E3287-96 pubmed publisher |
| Bhattacharyya S, Ghosh S, Sil P. Amelioration of aspirin induced oxidative impairment and apoptotic cell death by a novel antioxidant protein molecule isolated from the herb Phyllanthus niruri. PLoS ONE. 2014;9:e89026 pubmed publisher |
| Casella C, Miller D, Lynch K, Brodsky A. Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. Gynecol Oncol. 2014;135:333-41 pubmed publisher |
| Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014;5:e1513 pubmed publisher |
| Cazanave S, Wang X, Zhou H, Rahmani M, Grant S, Durrant D, et al. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ. 2014;21:1303-12 pubmed publisher |
- western blot; human; fig 6
| Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher |
| Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher |
| Kung C, Khaku S, Jennis M, Zhou Y, Murphy M. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Mol Cancer Res. 2015;13:250-62 pubmed publisher |
| Suganya R, Chakraborty A, Miriyala S, Hazra T, Izumi T. Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst). 2015;27:40-8 pubmed publisher |
| Zhang H, Dou J, Yu Y, Zhao Y, Fan Y, Cheng J, et al. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling. Apoptosis. 2015;20:50-62 pubmed publisher |
| Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, et al. Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-Cells. J Cell Biochem. 2015;116:998-1006 pubmed publisher |
| Sweeney E, Fan P, Jordan V. Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: an insight into the women's health initiative study. Cancer Res. 2014;74:7060-8 pubmed publisher |
| Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, et al. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors. Cancer Sci. 2014;105:1609-15 pubmed publisher |
| Singh R, Shankar B, Sainis K. TGF-β1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal. 2014;26:1604-15 pubmed publisher |
| Matthess Y, Raab M, Knecht R, Becker S, Strebhardt K. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. Mol Oncol. 2014;8:596-608 pubmed publisher |
| Erttmann S, Gekara N, Fallman M. Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism. PLoS ONE. 2014;9:e87859 pubmed publisher |
| Soderquist R, Danilov A, Eastman A. Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. J Biol Chem. 2014;289:16190-9 pubmed publisher |
| Yang D, Meng X, Xue B, Liu N, Wang X, Zhu H. MiR-942 mediates hepatitis C virus-induced apoptosis via regulation of ISG12a. PLoS ONE. 2014;9:e94501 pubmed publisher |
| Soderquist R, Pletnev A, Danilov A, Eastman A. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis. 2014;19:201-9 pubmed publisher |
| Olarerin-George A, Anton L, Hwang Y, Elovitz M, Hogenesch J. A functional genomics screen for microRNA regulators of NF-kappaB signaling. BMC Biol. 2013;11:19 pubmed publisher |
| Fan Y, Cheng J, Vasudevan S, Patel R, Liang L, Xu X, et al. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy. Apoptosis. 2013;18:1224-34 pubmed publisher |
| Fedorchenko O, Stiefelhagen M, Peer-Zada A, Barthel R, Mayer P, Eckei L, et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood. 2013;121:4126-36 pubmed publisher |
| Liu C, Wu J, Paudyal S, You Z, Yu X. CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res. 2013;41:1698-710 pubmed publisher |
| Amengual J, Clark-Garvey S, Kalac M, Scotto L, Marchi E, Neylon E, et al. Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma. Blood. 2013;122:2104-13 pubmed publisher |
| Zhang Y, Li X, Huang Z, Zheng W, Fan C, Chen T. Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration. Nanomedicine. 2013;9:74-84 pubmed publisher |
| Cai Y, Cui W, Chen W, Wei P, Chi Y, Zhang P, et al. The effects of a histone deacetylase inhibitor on biological behavior of diffuse large B-cell lymphoma cell lines and insights into the underlying mechanisms. Cancer Cell Int. 2013;13:57 pubmed publisher |
| Niegisch G, Knievel J, Koch A, Hader C, Fischer U, Albers P, et al. Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers. Urol Oncol. 2013;31:1770-9 pubmed publisher |
| Covy J, Waxman E, Giasson B. Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants. J Neurosci Res. 2012;90:2306-16 pubmed publisher |
| Possemato R, Marks K, Shaul Y, Pacold M, Kim D, Birsoy K, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011;476:346-50 pubmed publisher |
