| Published Application/Species/Sample/Dilution | Reference |
|---|
- chromatin immunoprecipitation; human; loading ...; fig 3b
- western blot; human; 1:1000; loading ...; fig 3c
| Gibbs Z, Reza L, Cheng C, Westcott J, McGlynn K, Whitehurst A. The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 1c
| Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 5c
| Yang L, Han B, Zhang M, Wang Y, Tao K, Zhu M, et al. Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways. Front Pharmacol. 2020;11:165 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Fu X, Qie J, Fu Q, Chen J, Jin Y, Ding Z. miR-20a-5p/TGFBR2 Axis Affects Pro-inflammatory Macrophages and Aggravates Liver Fibrosis. Front Oncol. 2020;10:107 pubmed publisher |
- western blot; human; 1:100; loading ...; fig 5c
| Wang X, Lu Q, Fei X, Zhao Y, Shi B, Li C, et al. Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma. Onco Targets Ther. 2020;13:1225-1234 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a
| Ye D, Zhu J, Zhao Q, Ma W, Xiao Y, Xu G, et al. LMP1 Up-regulates Calreticulin to Induce Epithelial-mesenchymal Transition via TGF-β/Smad3/NRP1 Pathway in Nasopharyngeal Carcinoma Cells. J Cancer. 2020;11:1257-1269 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Cheng X, Haeberle S, Luca Shytaj I, Gama Brambila R, Theobald J, Ghafoory S, et al. NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice. Commun Biol. 2020;3:10 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 7c
| Tran B, Yu Y, Chang L, Tan B, Jia W, Xiong Y, et al. A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway. Int J Nanomedicine. 2019;14:10061-10077 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 7a
| Reed M, Luissint A, Azcutia V, Fan S, O Leary M, Quirós M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019;10:5004 pubmed publisher |
- western blot; mouse; loading ...; fig s9d
| Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4g
| Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher |
- western blot; mouse; loading ...; fig 4c
| Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019;40:43-55 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6b
| Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher |
- western blot; mouse; loading ...; fig 1k
| Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 5b
| Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher |
- western blot; human; loading ...; fig s6c
| Schwab A, Siddiqui A, Vazakidou M, Napoli F, Böttcher M, Menchicchi B, et al. Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells. Cancer Res. 2018;78:1604-1618 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 2a
| Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher |
- western blot; mouse; loading ...; fig s3d
| Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2e
| Hama T, Nakanishi K, Sato M, Mukaiyama H, Togawa H, Shima Y, et al. Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease. Am J Physiol Renal Physiol. 2017;:ajprenal.00697.2016 pubmed publisher |
- western blot; mouse; loading ...; fig 6a
| Han W, Li X, Zhang H, Yu B, Guo C, Deng C. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia. Int J Biochem Cell Biol. 2017;92:173-182 pubmed publisher |
- western blot; human; loading ...; fig 1e
| Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 9a
| Wu K, Zhao Z, Ma J, Chen J, Peng J, Yang S, et al. Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-? and regulation of the SMAD3 pathway. Oncol Lett. 2017;13:2557-2562 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 8b
| Chatterjee A, Kosmacek E, Oberley Deegan R. MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway. Radiat Res. 2017;187:367-381 pubmed publisher |
- western blot; mouse; loading ...; fig 6a
| Gopinath S. Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor. Skelet Muscle. 2017;7:2 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6b
| Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed publisher |
- western blot; mouse; loading ...; fig 5b
| Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher |
- immunohistochemistry - frozen section; human; loading ...; fig 5a
| Fry C, Johnson D, Ireland M, Noehren B. ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle. J Orthop Res. 2017;35:1876-1885 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 8a
| Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher |
- western blot; bovine; loading ...; fig 6 - s1e
| Heo S, Driscoll T, Thorpe S, Nerurkar N, Baker B, Yang M, et al. Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. elife. 2016;5: pubmed publisher |
- western blot; human; loading ...; fig 3a
| Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7d
| Zhu L, Gómez Durán A, Saretzki G, Jin S, Tilgner K, Melguizo Sanchís D, et al. The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016;215:187-202 pubmed |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1c
| Takai K, Le A, Weaver V, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016;7:82889-82901 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Liu W, Zhou L, Zhou C, Zhang S, Jing J, Xie L, et al. GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. Nat Commun. 2016;7:12794 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 5b
| Xiao X, Senavirathna L, Gou X, Huang C, Liang Y, Liu L. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis. Physiol Rep. 2016;4: pubmed publisher |
- western blot; mouse; 1:1000; tbl 2
| Muñoz Félix J, Pérez Roque L, Núñez Gómez E, Oujo B, Arevalo M, Ruiz Remolina L, et al. Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction. Biochim Biophys Acta. 2016;1862:1801-14 pubmed publisher |
- western blot; rat; loading ...; fig 3e
| Kang L, Zhang D, Ma C, Zhang J, Jia K, Liu J, et al. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Sci Rep. 2016;6:27460 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:50; fig 6
| Terakawa J, Rocchi A, Serna V, Bottinger E, Graff J, Kurita T. FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct. Mol Endocrinol. 2016;30:783-95 pubmed publisher |
- western blot; mouse; 1:1000; fig s2
| Zhou Z, Tang A, Wong W, Bamezai S, Goddard L, Shenkar R, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016;532:122-6 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Xu X, Tan X, Hulshoff M, Wilhelmi T, Zeisberg M, Zeisberg E. Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells. FEBS Lett. 2016;590:1222-33 pubmed publisher |
- western blot; human; 1:500; fig 1a
| Yang W, Deng Y, Hsieh Y, Wu K, Kuo M. Thrombin Activates Latent TGF?1 via Integrin ?v?1 in Gingival Fibroblasts. J Dent Res. 2016;95:939-45 pubmed publisher |
- western blot; mouse; fig 2
| Hwang S, Jang S, Kim M, Kim L, Kim B, Kim H, et al. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun. 2016;7:10789 pubmed publisher |
- western blot; mouse; fig 6
| Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, et al. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling. Oncogene. 2016;35:4641-52 pubmed publisher |
- western blot; human; fig 4
| Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. 2016;35:4388-98 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Huan C, Yang T, Liang J, Xie T, Cheng L, Liu N, et al. Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo. Sci Rep. 2015;5:14910 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Zhou X, Tao Y, Liang C, Zhang Y, Li H, Chen Q. BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015;16:20344-59 pubmed publisher |
| Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, et al. Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation. Cell Physiol Biochem. 2015;36:2198-216 pubmed publisher |
- immunocytochemistry; mouse; fig 8
- western blot; mouse
| Thomas A, Eijgelaar W, Daemen M, Newby A. Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLoS ONE. 2015;10:e0128163 pubmed publisher |
- proximity ligation assay; mouse; fig s12
- chromatin immunoprecipitation; mouse; fig s14
| Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher |
- western blot; human; 1:1000
| Carthy J, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin C, et al. Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2. J Cell Physiol. 2015;230:3084-92 pubmed publisher |
- western blot; mouse; loading ...; fig 3d, 4a
| Yi H, Eun H, Lee Y, Jung J, Park S, Park K, et al. Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice. PLoS ONE. 2015;10:e0127946 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Egerman M, Cadena S, Gilbert J, Meyer A, Nelson H, Swalley S, et al. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab. 2015;22:164-74 pubmed publisher |
| Cohen T, Kollias H, Liu N, Ward C, Wagner K. Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration. J Physiol. 2015;593:2479-97 pubmed publisher |
| Zhang Z, Zhang T, Zhou Y, Wei X, Zhu J, Zhang J, et al. Activated phosphatidylinositol 3-kinase/Akt inhibits the transition of endothelial progenitor cells to mesenchymal cells by regulating the forkhead box subgroup O-3a signaling. Cell Physiol Biochem. 2015;35:1643-53 pubmed publisher |
- western blot; mouse; loading ...; fig S4a
| Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed publisher |
- western blot; human; fig 1
| Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y. Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. J Biol Chem. 2015;290:6086-105 pubmed publisher |
- western blot; mouse; 1:1000; fig 7
| Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher |
- western blot; mouse; loading ...; fig s1i
| Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, et al. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Clin Sci (Lond). 2015;128:761-74 pubmed publisher |
| Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher |
- western blot; rat; loading ...; fig 5b
| Huang W, Li L, Tian X, Yan J, Yang X, Wang X, et al. Astragalus and Paeoniae radix rubra extract inhibits liver fibrosis by modulating the transforming growth factor‑β/Smad pathway in rats. Mol Med Rep. 2015;11:805-14 pubmed publisher |
| Chen R, Xu B, Chen S, Chen S, Zhang T, Ren J, et al. Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. World J Gastroenterol. 2014;20:14895-903 pubmed publisher |
- western blot; fission yeast; 1:1000; fig 7
| Oujo B, Muñoz Félix J, Arévalo M, Núñez Gómez E, Pérez Roque L, Pericacho M, et al. L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction. PLoS ONE. 2014;9:e110365 pubmed publisher |
| Zhang M, Zhang J, Liu S, Wang Q, Lin G, Qiu R, et al. NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression. Inflammation. 2015;38:278-89 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang X, Ma Y, You T, Tian X, Zhang H, Zhu Q, et al. Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture. Connect Tissue Res. 2015;56:9-17 pubmed publisher |
| Isogaya K, Koinuma D, Tsutsumi S, Saito R, Miyazawa K, Aburatani H, et al. A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. Cell Res. 2014;24:994-1008 pubmed publisher |
| Kapur N, Qiao X, Paruchuri V, Mackey E, Daly G, Ughreja K, et al. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014;3: pubmed publisher |
- western blot; mouse; 1:1000
| Watatani H, Maeshima Y, Hinamoto N, Yamasaki H, Ujike H, Tanabe K, et al. Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction. Physiol Rep. 2014;2: pubmed publisher |
| Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, et al. Hepatocyte growth factor regulates the TGF-?1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med. 2014;34:381-90 pubmed publisher |
| Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa Ishizawa Y, et al. Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction. PLoS ONE. 2014;9:e89355 pubmed publisher |
| Beaudoin M, Snook L, Arkell A, Stefanson A, Wan Z, Simpson J, et al. Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats. Obesity (Silver Spring). 2014;22:1632-42 pubmed publisher |
- western blot; rat; 1:1000
| Borkham Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-? signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher |
| Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-? signaling. J Biol Chem. 2014;289:2072-83 pubmed publisher |
- western blot; human; fig 1
| Holtzhausen A, Golzio C, How T, Lee Y, Schiemann W, Katsanis N, et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014;28:1248-67 pubmed publisher |
- western blot; mouse; 1:1000; fig 7
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- western blot; rat; 1:1000
| Mitchell K, Shah J, Tsytsikova L, Campbell A, Affram K, Symes A. LPS antagonism of TGF-? signaling results in prolonged survival and activation of rat primary microglia. J Neurochem. 2014;129:155-68 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Hall B, Wankhade U, Konkel J, Cherukuri K, Nagineni C, Flanders K, et al. Transforming growth factor-?3 (TGF-?3) knock-in ameliorates inflammation due to TGF-?1 deficiency while promoting glucose tolerance. J Biol Chem. 2013;288:32074-92 pubmed publisher |
| Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed publisher |
| Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T, Harada K, et al. miR-655 Is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2. PLoS ONE. 2013;8:e62757 pubmed publisher |
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- western blot; mouse; fig 4a
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| Fenizia C, Bottino C, Corbetta S, Fittipaldi R, Floris P, Gaudenzi G, et al. SMYD3 promotes the epithelial-mesenchymal transition in breast cancer. Nucleic Acids Res. 2019;47:1278-1293 pubmed publisher |
| Paw M, Wnuk D, Kądziołka D, Sęk A, Lasota S, Czyz J, et al. Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization. Int J Mol Sci. 2018;19: pubmed publisher |
| Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak A, et al. Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling. elife. 2017;6: pubmed publisher |
| Frick C, Yarka C, Nunns H, Goentoro L. Sensing relative signal in the Tgf-?/Smad pathway. Proc Natl Acad Sci U S A. 2017;114:E2975-E2982 pubmed publisher |
| Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed publisher |
| Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, et al. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017;8:14570 pubmed publisher |
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| Schwentner R, Herrero Martín D, Kauer M, Mutz C, Katschnig A, Sienski G, et al. The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma. Oncotarget. 2017;8:10980-10993 pubmed publisher |
| Zhao B, Guan H, Liu J, Zheng Z, Zhou Q, Zhang J, et al. Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-?1/Smad3 pathway. Int J Mol Med. 2017;39:153-159 pubmed publisher |
| Xu M, He J, Li J, Feng W, Zhou H, Wei H, et al. Methyl-CpG-binding domain 3 inhibits epithelial-mesenchymal transition in pancreatic cancer cells via TGF-β/Smad signalling. Br J Cancer. 2017;116:91-99 pubmed publisher |
| Rao S, Zhang X, Shi M, Xiao Y, Zhang Y, Wang Y, et al. Suberoylanilide hydroxamic acid attenuates paraquat-induced pulmonary fibrosis by preventing Smad7 from deacetylation in rats. J Thorac Dis. 2016;8:2485-2494 pubmed |
| Yang P, Schmit B, Fu C, Desart K, Oh S, Berceli S, et al. Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events. Sci Rep. 2016;6:35444 pubmed publisher |
| Seo E, Kim W, Hur J, Kim H, Nam S, Choi A, et al. The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Sci Rep. 2016;6:31931 pubmed publisher |
| Rodríguez Nieves J, Patalano S, Almanza D, Gharaee Kermani M, Macoska J. CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. PLoS ONE. 2016;11:e0159490 pubmed publisher |
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