product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Smad3 Antibody
catalog :
9513
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1e
Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
  • western blot; human; loading ...; fig s2d
Sun J, Liu X, Gao H, Zhang L, Ji Q, Wang Z, et al. Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis. Oncotarget. 2017;8:11489-11506 pubmed publisher
  • western blot; mouse; loading ...; fig 4
Yang T, Wang J, Pang Y, Dang X, Ren H, Liu Y, et al. Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. Mol Med Rep. 2016;14:4643-4649 pubmed publisher
  • western blot; human; fig 3
Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed publisher
  • western blot; human; 1:1000; fig s10
Evrard S, Lecce L, Michelis K, Nomura Kitabayashi A, Pandey G, Purushothaman K, et al. Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nat Commun. 2016;7:11853 pubmed publisher
  • western blot; human; 1:1000; fig 3a
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016;14:159-64 pubmed publisher
  • western blot; mouse; 1:1000; fig s2
Zhou Z, Tang A, Wong W, Bamezai S, Goddard L, Shenkar R, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016;532:122-6 pubmed publisher
  • western blot; mouse; fig 5
Sun J, Chen X, Zhang L, Wang J, Diehn M. Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling. Oncotarget. 2016;7:9692-706 pubmed publisher
  • western blot; human; 1:1000; fig 5
Buczek M, Miles A, Green W, Johnson C, Boocock D, Pockley A, et al. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 2016;35:3465-75 pubmed publisher
  • western blot; mouse; fig 5
Subathra M, Korrapati M, Howell L, Arthur J, Shayman J, Schnellmann R, et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015;309:F204-15 pubmed publisher
  • western blot; rat; loading ...; fig 5b
Huang W, Li L, Tian X, Yan J, Yang X, Wang X, et al. Astragalus and Paeoniae radix rubra extract inhibits liver fibrosis by modulating the transforming growth factor‑β/Smad pathway in rats. Mol Med Rep. 2015;11:805-14 pubmed publisher
  • western blot; human; loading ...; fig 4a
Zhang X, Ma Y, You T, Tian X, Zhang H, Zhu Q, et al. Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture. Connect Tissue Res. 2015;56:9-17 pubmed publisher
  • western blot; mouse; 1:1000; fig 2e
Feuerborn A, Mathow D, Srivastava P, Gretz N, Grone H. Basonuclin-1 modulates epithelial plasticity and TGF-?1-induced loss of epithelial cell integrity. Oncogene. 2015;34:1185-95 pubmed publisher
  • western blot; mouse; fig 4a
Yang Y, Ahn Y, Gibbons D, Zang Y, Lin W, Thilaganathan N, et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest. 2011;121:1373-85 pubmed publisher
Kim C, Kim Y, Lee M, Kim I, Choi Y, Nam T. Pyropia yezoensis peptide promotes collagen synthesis by activating the TGF-?/Smad signaling pathway in the human dermal fibroblast cell line Hs27. Int J Mol Med. 2017;39:31-38 pubmed publisher
Speight P, Kofler M, Szaszi K, Kapus A. Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGF?-regulated Smad3. Nat Commun. 2016;7:11642 pubmed publisher
Li C, Wang Q, Li J, Hu M, Shi S, Li Z, et al. Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway. Int J Nanomedicine. 2016;11:373-86 pubmed publisher
Doyle J, Doyle A, Wilson N, Habashi J, Bedja D, Whitworth R, et al. A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. elife. 2015;4: pubmed publisher
Suresh Babu S, Valdez Y, Xu A, O Byrne A, Calvo F, Lei V, et al. TGF?-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 2014;14:113 pubmed publisher
Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, et al. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013;19:421-8 pubmed publisher
Zode G, Sethi A, Brun Zinkernagel A, Chang I, Clark A, Wordinger R. Transforming growth factor-?2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway. Mol Vis. 2011;17:1745-58 pubmed
Van Themsche C, Chaudhry P, Leblanc V, Parent S, Asselin E. XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer. 2010;9:216 pubmed publisher
product information
SKU :
9513S
Product-Name :
Smad3 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
52
Host :
Rabbit
Target :
Smad3
Primary-Protein :
Smad3
Alt-Names :
DKFZp586N0721,DKFZp686J10186,HSPC193,HsT17436,JV15-2,MAD homolog 3,MAD, mothers against decapentaplegic homolog 3,MADH3,MGC60396,Mad3,Mothers against DPP homolog 3,Mothers against decapentaplegic homolog 3,SMA- and MAD-related protein 3,SMAD 3,SMAD family member 3,SMAD, mothers against DPP homolog 3,SMAD3,hMAD-3,hSMAD3,mad homolog JV15-2,mad protein homolog
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.