product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Caspase-9 (C9) Mouse mAb
catalog :
9508
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C9
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot
citations: 63
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5a
Chiang C, Hong Y. In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy. Sci Rep. 2021;11:18172 pubmed publisher
  • western blot; human; loading ...; fig 3e, 3f
Zhang Y, Ma Y, Wu G, Xie M, Luo C, Huang X, et al. SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression. Cell Death Discov. 2021;7:192 pubmed publisher
  • western blot; human; 1:3000; fig s5a
Fisher A, Sangkhae V, Balusikova K, Palaskas N, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021;12:4026 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Liu Y, Jiang B, Cao Y, Chen W, Yin L, Xu Y, et al. High expression levels and localization of Sox5 in dilated cardiomyopathy. Mol Med Rep. 2020;22:948-956 pubmed publisher
  • western blot; rhesus macaque; 1:1000; loading ...; fig 2e
Du T, Zhu G, Chen Y, Shi L, Liu D, Liu Y, et al. Anterior thalamic nucleus stimulation protects hippocampal neurons by activating autophagy in epileptic monkeys. Aging (Albany NY). 2020;12:6324-6339 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Zhang J, Huang J, Zhang Y, Zhang X, Zhao L, Li C, et al. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3. EBioMedicine. 2020;53:102701 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; human; loading ...; fig 3d
Qiao H, Tan X, Lv D, Xing R, Shu F, Zhong C, et al. Phosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis. J Cancer. 2020;11:1027-1037 pubmed publisher
  • western blot; human; loading ...; fig 10
Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
  • western blot; mouse; 1.56 mg/ml; loading ...; fig 4c
Choi J, Zhong X, McAlpine W, Liao T, Zhang D, Fang B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019;364: pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, et al. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation. Toxicology. 2019;414:45-56 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1g
LeBlanc L, Lee B, Yu A, Kim M, Kambhampati A, Dupont S, et al. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. elife. 2018;7: pubmed publisher
  • western blot; mouse; fig 4e
Lee C, Hsieh T. Wuho/WDR4 deficiency inhibits cell proliferation and induces apoptosis via DNA damage in mouse embryonic fibroblasts. Cell Signal. 2018;47:16-26 pubmed publisher
  • western blot; human; 1:1000; fig 5d
Lang M, Jenkins S, Balzano P, Owoyele A, Patel A, Bamezai A. Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4+ T-cell lines. Immun Inflamm Dis. 2017;5:448-460 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6b
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed publisher
  • western blot; human; loading ...; fig 4c
Chhabra A, Mukherji B, Batra D. Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. Expert Opin Ther Targets. 2017;21:117-129 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • western blot; human; loading ...; fig 1d
Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. Mol Cell Biol. 2016;36:3010-3018 pubmed
  • western blot; human; 1:1000; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; 1:1000; fig 1
Anta B, Pérez Rodríguez A, Castro J, García Domínguez C, Ibiza S, Martínez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher
  • western blot; human; 1:1000; fig 2
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, et al. A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria. Mol Med Rep. 2016;14:1970-8 pubmed publisher
  • western blot; human; loading ...; fig 2g
Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork Geleta A, Blecha J, Endaya B, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer. Antioxid Redox Signal. 2017;26:84-103 pubmed publisher
  • western blot; mouse; fig 5
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • western blot; human; fig 4
De Toni E, Ziesch A, Rizzani A, Török H, Hocke S, Lü S, et al. Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptor-mediated apoptosis. Oncotarget. 2016;7:9477-90 pubmed publisher
  • western blot; human; loading ...; fig 3c
Chen M, Yen C, Cheng C, Wu R, Huang S, Yu C, et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget. 2015;6:23594-608 pubmed
  • western blot; human; fig s4
Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher
  • western blot; human; 1:1000; fig 7A
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed publisher
  • western blot; mouse; fig 1
Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M. Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis. 2015;6:e1587 pubmed publisher
  • western blot; human; loading ...; fig 4D
Ma H, Yue X, Gao L, Liang X, Yan W, Zhang Z, et al. ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. Oncotarget. 2015;6:1049-63 pubmed
  • western blot; human
Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, et al. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. BMC Cancer. 2014;14:668 pubmed publisher
  • western blot; human; 1:1000
Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher
Wang L, Li H, Yang S, Ma W, Liu M, Guo S, et al. Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer. Oncotarget. 2016;7:68864-68882 pubmed publisher
Wu J, Guo W, Lin S, Wang Z, Kan J, Chen S, et al. Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity. Cell Death Dis. 2016;7:e2339 pubmed publisher
He L, Gao S, Zhu Z, Chen S, Gu H. Ikaros expression sensitizes leukemic cells to the chemotherapeutic drug doxorubicin. Oncol Lett. 2016;12:1178-1182 pubmed
Cheng C, Cheng Y, Chang I, Chen H, Wu C, Hsieh C. Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells. Mol Med Rep. 2016;13:1495-500 pubmed publisher
Li Y, He X, Yang X, Huang K, Luo Y, Zhu L, et al. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Sci Rep. 2015;5:14277 pubmed publisher
Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, et al. Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis. Sci Rep. 2015;5:13737 pubmed publisher
van Roosmalen I, Reis C, Setroikromo R, Yuvaraj S, Joseph J, Tepper P, et al. The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma. Springerplus. 2014;3:495 pubmed publisher
Oliván S, Calvo A, Gasco S, Muñoz M, Zaragoza P, Osta R. Time-Point Dependent Activation of Autophagy and the UPS in SOD1G93A Mice Skeletal Muscle. PLoS ONE. 2015;10:e0134830 pubmed publisher
Liu Z, Zhao W, Zhang Q, Li L, Lai L, Jiang S, et al. OGG1 Involvement in High Glucose-Mediated Enhancement of Bupivacaine-Induced Oxidative DNA Damage in SH-SY5Y Cells. Oxid Med Cell Longev. 2015;2015:683197 pubmed publisher
Zhang C, Jiang Y, Zhang J, Huang J, Wang J. 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells. Int J Mol Sci. 2015;16:14979-96 pubmed publisher
Zhang M, Harashima N, Moritani T, Huang W, Harada M. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PLoS ONE. 2015;10:e0127386 pubmed publisher
Bustany S, Cahu J, Guardiola P, Sola B. Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway. BMC Cancer. 2015;15:262 pubmed publisher
Estornes Y, Aguileta M, Dubuisson C, De Keyser J, Goossens V, Kersse K, et al. RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions. Cell Death Dis. 2014;5:e1555 pubmed publisher
Deegan S, Saveljeva S, Logue S, Pakos Zebrucka K, Gupta S, Vandenabeele P, et al. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10:1921-36 pubmed publisher
Nie C, Luo Y, Zhao X, Luo N, Tong A, Liu X, et al. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis. Cell Death Dis. 2014;5:e1495 pubmed publisher
Li Z, Yu J, Liu L, Wei Z, Ehrlich E, Liu G, et al. Coxsackievirus A16 infection induces neural cell and non-neural cell apoptosis in vitro. PLoS ONE. 2014;9:e111174 pubmed publisher
KENNEDY D, Mnich K, Samali A. Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM. FEBS Open Bio. 2014;4:813-21 pubmed publisher
Tamaki H, Harashima N, Hiraki M, Arichi N, Nishimura N, Shiina H, et al. Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition. Oncotarget. 2014;5:11399-412 pubmed
Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero J, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS ONE. 2014;9:e110979 pubmed publisher
Gaudichon J, Milano F, Cahu J, DaCosta L, Martens A, Renoir J, et al. Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche. PLoS ONE. 2014;9:e107009 pubmed publisher
Amin B, Hajhashemi V, Abnous K, Hosseinzadeh H. Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain. Biomed Res Int. 2014;2014:937568 pubmed publisher
Kim J, Bae J. MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis. PLoS ONE. 2013;8:e79626 pubmed publisher
Buchmaier B, Bibi A, Müller G, Dihazi G, Eltoweissy M, Kruegel J, et al. Renal cells express different forms of vimentin: the independent expression alteration of these forms is important in cell resistance to osmotic stress and apoptosis. PLoS ONE. 2013;8:e68301 pubmed publisher
Sahu U, Sidhar H, Ghate P, Advirao G, Raghavan S, Giri R. A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways. PLoS ONE. 2013;8:e66430 pubmed publisher
Fang E, Zhang C, Zhang L, Wong J, Chan Y, Pan W, et al. Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis. PLoS ONE. 2012;7:e41592 pubmed publisher
Lee Y, Yu Y, Gunawardena H, Xie L, Chen X. BCLAF1 is a radiation-induced H2AX-interacting partner involved in ?H2AX-mediated regulation of apoptosis and DNA repair. Cell Death Dis. 2012;3:e359 pubmed publisher
Hussain A, Ahmed S, Ahmed M, Khan O, Al Abdulmohsen S, Platanias L, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS ONE. 2012;7:e39945 pubmed publisher
Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh D. LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway. Cell Death Dis. 2012;3:e316 pubmed publisher
Schmukler E, Shai B, Ehrlich M, Pinkas Kramarski R. Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition. PLoS ONE. 2012;7:e36828 pubmed publisher
Xie Z, Bi C, Cheong L, Liu S, Huang G, Zhou J, et al. Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. PLoS ONE. 2011;6:e21583 pubmed publisher
Maas C, de Vries E, Tait S, Borst J. Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53. Oncogene. 2011;30:3636-47 pubmed publisher
Guidi M, Muiños Gimeno M, Kagerbauer B, Marti E, Estivill X, Espinosa Parrilla Y. Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol Biol. 2010;11:95 pubmed publisher
product information
SKU :
9508S
Product-Name :
Caspase-9 (C9) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Hm, Mk
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
47 /37/35 (H). 51 /39/37 (R,M).
Host :
Mouse
Target :
Casp9
Primary-Protein :
Casp9
Alt-Names :
APAF-3,APAF3,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,CASP-9,CASP9,CASPASE-9c,Caspase-9,Caspase-9 subunit p10,Caspase-9 subunit p35,ICE-LAP6,ICE-like apoptotic protease 6,MCH6,apoptotic protease activating factor 3,caspase 9, apoptosis-related cysteine peptidase,caspase 9, apoptosis-related cysteine protease
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.