product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SirT1 (D1D7) Rabbit mAb
catalog :
9475
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
D1D7
reactivity :
human, mouse, rat, cow
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 4a
Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 5i
Li Z, Bridges B, Olson J, Weinman S. The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. Oncogene. 2017;36:1887-1898 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 5
Liu M, Shan J, Li J, Zhang Y, Lin X. Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes. Exp Ther Med. 2016;12:1113-1118 pubmed
  • western blot; mouse; 1:1000; fig 2
Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher
  • western blot; mouse; fig 2a
Ting W, Yang J, Kuo C, Xiao Z, Lu X, Yeh Y, et al. Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. Oncotarget. 2016;7:39017-39025 pubmed publisher
  • western blot; mouse; 1:100; tbl 1
Bertoldo M, Guibert E, Faure M, Guillou F, Ramé C, Nadal Desbarats L, et al. Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality. Mol Cell Endocrinol. 2016;423:96-112 pubmed publisher
  • western blot; human
Liu Z, Jiang C, Zhang J, Liu B, Du Q. Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities. J Diabetes. 2016;8:324-35 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
  • western blot; mouse; 1:1000
Hendriks I, D Souza R, Chang J, Mann M, Vertegaal A. System-wide identification of wild-type SUMO-2 conjugation sites. Nat Commun. 2015;6:7289 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
  • western blot; mouse; 1:1000
Huang Z, Han Z, Ye B, Dai Z, Shan P, Lu Z, et al. Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes. Eur J Pharmacol. 2015;762:1-10 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig 7
  • immunocytochemistry; rat; fig 7
  • western blot; rat; 1:1000; fig 6
Zou D, Liu P, Chen K, Xie Q, Liang X, Bai Q, et al. Protective effects of myricetin on acute hypoxia-induced exercise intolerance and mitochondrial impairments in rats. PLoS ONE. 2015;10:e0124727 pubmed publisher
  • western blot; human
Mulens Arias V, Rojas J, Pérez Yagüe S, Morales M, Barber D. Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics. Biomaterials. 2015;52:494-506 pubmed publisher
  • western blot; mouse; fig 1d
  • western blot; human; fig 1c
Lau A, Liu P, Inuzuka H, Gao D. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res. 2014;4:245-55 pubmed
Bo Z, Xiang Q, Shan Ming R, Wang B, De Hou D, Liang X, et al. Investigation on Molecular Mechanism of Fibroblast Regulation and the Treatment of Recurrent Oral Ulcer by Shuizhongcao Granule-Containing Serum. Evid Based Complement Alternat Med. 2015;2015:324091 pubmed publisher
Mulens Arias V, Rojas J, Pérez Yagüe S, Morales M, Barber D. Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells. J Control Release. 2015;216:78-92 pubmed publisher
Cheung K, Cole L, Xiang B, Chen K, Ma X, Myal Y, et al. Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes. J Biol Chem. 2015;290:10981-93 pubmed publisher
Qi Y, Shang J, Ma L, Sun B, Hu X, Liu B, et al. Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats. Respir Res. 2014;15:156 pubmed publisher
Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, et al. Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1. Pharmacol Res. 2014;89:19-28 pubmed publisher
Verma P, Pfister J, Mallick S, D Mello S. HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism. J Neurosci. 2014;34:1599-612 pubmed publisher
product information
SKU :
9475S
Product-Name :
SirT1 (D1D7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, (C, B, Pg, Hr)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
120
Host :
Rabbit
Target :
SirT1
Primary-Protein :
SIRT1
Alt-Names :
NAD-dependent deacetylase sirtuin-1,SIR2-like protein 1,SIR2L1,SIR2alpha,SIRT1,hSIR2,hSIRT1,sir2-like 1,sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae),sirtuin 1,sirtuin type 1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.