| Published Application/Species/Sample/Dilution | Reference |
|---|
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; mouse; loading ...; fig 2e
| Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017;67:922-935.e5 pubmed publisher |
- western blot; human; loading ...; fig s5f
| Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, et al. Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Nat Commun. 2017;8:15580 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- western blot; human; loading ...; fig 1a
- western blot; mouse; loading ...; fig s9e
| Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig 3a
| . Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang L, Dai F, Cui L, Zhou B, Guo Y. Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:613-624 pubmed publisher |
- western blot; human; loading ...
| Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher |
- western blot; human; fig 5
| Rasmussen M, Lyskjær I, Jersie Christensen R, Tarpgaard L, Primdal Bengtson B, Nielsen M, et al. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells. Nat Commun. 2016;7:12436 pubmed publisher |
- immunohistochemistry - frozen section; mouse
- western blot; mouse; loading ...; fig 7b
| Zhang L, Justus S, Xu Y, Pluchenik T, Hsu C, Yang J, et al. Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa. Hum Mol Genet. 2016;25:4244-4255 pubmed publisher |
- western blot; human; fig 5c
| Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher |
- immunohistochemistry; human; fig 3h
- western blot; human; loading ...; fig s2c
| Green A, Maciel T, Hospital M, Yin C, Mazed F, Townsend E, et al. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Sci Adv. 2015;1:e1500221 pubmed publisher |
- western blot; mouse; 1:5000; fig 3
| Li S, TANG J, Chen J, Zhang P, Wang T, Chen T, et al. Regulation of bone formation by baicalein via the mTORC1 pathway. Drug Des Devel Ther. 2015;9:5169-83 pubmed publisher |
- western blot; rat; 1:500; loading ...; fig 5a
| Xie R, He W, Shen M, Shou X, Wang Y, Bao W, et al. Specific inhibition of mTOR pathway induces anti-proliferative effect and decreases the hormone secretion in cultured pituitary adenoma cells. J Neurooncol. 2015;125:79-89 pubmed publisher |
- western blot; human; fig 4
| Zhang L, Dai F, Sheng P, Chen Z, Xu Q, Guo Y. Resveratrol analogue 3,4,4'-trihydroxy-trans-stilbene induces apoptosis and autophagy in human non-small-cell lung cancer cells in vitro. Acta Pharmacol Sin. 2015;36:1256-65 pubmed publisher |
- western blot; human; fig 1
| Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner L. Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. Sci Signal. 2015;8:ra27 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 6c
| Li X, Gu S, Ling Y, Shen C, Cao X, Xie R. p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling. Brain Res. 2015;1605:31-8 pubmed publisher |
| Wang S, Chen X, Hu J, Jiang J, Li Y, Chan Salis K, et al. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015;14:877-88 pubmed publisher |
| Zhang L, Dai F, Cui L, Jing H, Fan P, Tan X, et al. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells. Biochim Biophys Acta. 2015;1853:377-87 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4a
| Chen K, Wang C, Tsai M, Wu C, Yang H, Chen L, et al. Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma. Cell Death Dis. 2014;5:e1244 pubmed publisher |
| Reineke L, Cheema S, Dubrulle J, Neilson J. Chronic starvation induces noncanonical pro-death stress granules. J Cell Sci. 2018;131: pubmed publisher |
| Yang H, Wang J, Liu M, Chen X, Huang M, Tan D, et al. 4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1. Protein Cell. 2016;7:878-887 pubmed publisher |
| Brunen D, Garcia Barchino M, Malani D, Jagalur Basheer N, Lieftink C, Beijersbergen R, et al. Intrinsic resistance to PIM kinase inhibition in AML through p38?-mediated feedback activation of mTOR signaling. Oncotarget. 2016;7:37407-37419 pubmed publisher |
| Knight Z, Schmidt S, Birsoy K, Tan K, Friedman J. A critical role for mTORC1 in erythropoiesis and anemia. elife. 2014;3:e01913 pubmed publisher |
| Groenendijk F, Mellema W, van der Burg E, Schut E, Hauptmann M, Horlings H, et al. Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Int J Cancer. 2015;136:1434-44 pubmed publisher |
| Karlsson E, Pérez Tenorio G, Amin R, Bostner J, Skoog L, Fornander T, et al. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res. 2013;15:R96 pubmed |
| Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, et al. Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation. Mol Cancer Ther. 2012;11:1082-91 pubmed publisher |
| Gomez Abad C, Pisonero H, Blanco Aparicio C, Roncador G, Gonzalez Menchen A, Martinez Climent J, et al. PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma. Blood. 2011;118:5517-27 pubmed publisher |
