Phospho-4E-BP1 (Thr70) Antibody | Cell Signaling Technology 9455 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-4E-BP1 (Thr70) Antibody

catalog :

9455

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, reverse phase protein lysate microarray

more info or order :

Cell Signaling Technology product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:50; loading ...; fig s5e	Hu J, Sun F, Handel M. Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biol Reprod. 2018;98:102-114 pubmed publisher
reverse phase protein lysate microarray; human; loading ...; fig st6	Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
western blot; mouse; loading ...; fig 7a	Qiao A, Jin X, Pang J, Moskophidis D, Mivechi N. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017;216:723-741 pubmed publisher
western blot; mouse; loading ...; fig 6b	Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher
western blot; human; 1:1000; fig 2c	Deblois G, Smith H, Tam I, Gravel S, Caron M, Savage P, et al. ERR? mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016;7:12156 pubmed publisher
western blot; human; fig 1	Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
immunohistochemistry; human; 1:100	Demicco E, Wani K, Fox P, Bassett R, Young E, Lev D, et al. Histologic variability in solitary fibrous tumors reflects angiogenic and growth factor signaling pathway alterations. Hum Pathol. 2015;46:1015-26 pubmed publisher
western blot; human; fig 4b	Fonseca B, Zakaria C, Jia J, Graber T, Svitkin Y, Tahmasebi S, et al. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996-6020 pubmed publisher
western blot; human; 1:1000; fig 1	Sharon C, Baranwal S, Patel N, Rodriguez Agudo D, Pandak W, Majumdar A, et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. Oncotarget. 2015;6:15332-47 pubmed
western blot; mouse; 1:1000; fig 2	Milan G, Romanello V, Pescatore F, Armani A, Paik J, Frasson L, et al. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670 pubmed publisher
immunohistochemistry - paraffin section; human; 1:80; fig 1	Furgason J, Li W, Milholland B, Cross E, Li Y, McPherson C, et al. Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation. Mutagenesis. 2014;29:341-50 pubmed publisher
	Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
	Hatanaka M, Maier B, Sims E, Templin A, Kulkarni R, Evans Molina C, et al. Palmitate induces mRNA translation and increases ER protein load in islet ?-cells via activation of the mammalian target of rapamycin pathway. Diabetes. 2014;63:3404-15 pubmed publisher
	Lager S, Samulesson A, Taylor P, Poston L, Powell T, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014;2:e00242 pubmed publisher
	Song Y, Demmer D, Pinniger G, Lavin T, Macmillan M, Pillow J, et al. Effect of maternal steroid on developing diaphragm integrity. PLoS ONE. 2014;9:e93224 pubmed publisher
	Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed publisher
	García Martínez J, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi D, et al. Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice. Br J Cancer. 2011;104:1116-25 pubmed publisher
	Balgi A, Fonseca B, Donohue E, Tsang T, Lajoie P, Proud C, et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS ONE. 2009;4:e7124 pubmed publisher
	Ma D, Yu H, Lin D, Sun Y, Liu L, Liu Y, et al. S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424. J Cell Physiol. 2009;219:31-44 pubmed publisher

product information

SKU :

9455S

Product-Name :

Phospho-4E-BP1 (Thr70) Antibody

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Immunoprecipitation

Product-Category :

Translational Control

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Polyclonal Antibody

MW :

15 to 20

Host :

Rabbit

Target :

4E-BP1 (Thr70) phosphate

Primary-Protein :

4E-BP1

Alt-Names :

4E-BP1,4EBP1,BP-1,EIF4EBP1,Eukaryotic translation initiation factor 4E-binding protein 1,MGC4316,PHAS-I,Phosphorylated heat- and acid-stable protein regulated by insulin 1,eIF4E-binding protein 1,eukaryotic translation initiation factor 4E binding protein 1

more info or order :

Cell Signaling Technology product webpage