product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Ki-67 (8D5) Mouse mAb
catalog :
9449
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8D5
reactivity :
human, mouse, domestic horse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, mass cytometry
citations: 34
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; fig 3d
Goel S, Bhatia V, Kundu S, Biswas T, Carskadon S, Gupta N, et al. Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression. Nat Commun. 2021;12:5325 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 6g
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang C, et al. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat Commun. 2021;12:5321 pubmed publisher
  • immunohistochemistry - paraffin section; domestic horse; 1:200; loading ...; fig 7a
Scarlet D, Handschuh S, Reichart U, Podico G, Ellerbrock R, Demyda Peyrás S, et al. Sexual Differentiation and Primordial Germ Cell Distribution in the Early Horse Fetus. Animals (Basel). 2021;11: pubmed publisher
  • immunohistochemistry; human; loading ...; fig s6g
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed publisher
  • immunocytochemistry; human; 1:800; loading ...; fig 5f
Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, et al. The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene. 2021;40:4486-4502 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s5b
Zou Z, Hu X, Luo T, Ming Z, Chen X, Xia L, et al. Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor. Nat Commun. 2021;12:2263 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6e
Cai J, Lin K, Cai W, Lin Y, Liu X, Guo L, et al. Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1. Mol Oncol. 2020;14:3153-3168 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5d
Zhao Z, Wang Y, Yun D, Huang Q, Meng D, Li Q, et al. TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. Am J Cancer Res. 2020;10:114-130 pubmed
  • immunohistochemistry - paraffin section; human; 1:500; fig 4d
Bi J, Ichu T, Zanca C, Yang H, Zhang W, Gu Y, et al. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019;30:525-538.e8 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1a
Hsu C, Altschuler S, Wu L. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019;: pubmed publisher
  • mass cytometry; human; loading ...; fig 3a
Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 3g
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2c
Vera Ramirez L, Vodnala S, Nini R, Hunter K, Green J. Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Nat Commun. 2018;9:1944 pubmed publisher
  • immunocytochemistry; human; fig 3f
Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed publisher
  • immunohistochemistry; human; fig 5c
Berrout J, Kyriakopoulou E, Moparthi L, Hogea A, Berrout L, Ivan C, et al. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p. Nat Commun. 2017;8:947 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1d, 1c
Guo T, Zhao S, Wang P, Xue X, Zhang Y, Yang M, et al. YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma. Oncotarget. 2017;8:48110-48125 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 4F
Wu Q, Yan H, Tao S, Wang X, Mou L, Chen P, et al. XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p. Oncotarget. 2017;8:16784-16800 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig s5b
Fallahi Sichani M, Becker V, Izar B, Baker G, Lin J, Boswell S, et al. Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Mol Syst Biol. 2017;13:905 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4a
Yin P, Shah S, Pasquale N, Garbuzenko O, Minko T, Lee K. Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer. Biomaterials. 2016;81:46-57 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 9
Minas T, Han J, Javaheri T, Hong S, Schlederer M, SaygideÄŸer Kont Y, et al. YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget. 2015;6:37678-94 pubmed publisher
  • immunocytochemistry; human; fig s2
Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton J, et al. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer. 2015;15:444 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 5
Fallahi Sichani M, Moerke N, Niepel M, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015;11:797 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 3
Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Tian E, Stevens S, Guan Y, Springer D, Anderson S, Starost M, et al. Galnt1 is required for normal heart valve development and cardiac function. PLoS ONE. 2015;10:e0115861 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400
Kanemura H, Go M, Shikamura M, Nishishita N, Sakai N, Kamao H, et al. Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration. PLoS ONE. 2014;9:e85336 pubmed publisher
Feng Y, Jin D, Sokol E, Reinhardt F, Miller D, Gupta P. Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Nat Commun. 2017;8:1079 pubmed publisher
Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
Chevrier S, Levine J, Zanotelli V, Silina K, Schulz D, Bacac M, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169:736-749.e18 pubmed publisher
Ling S, Xie H, Yang F, Shan Q, Dai H, Zhuo J, et al. Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1. J Hematol Oncol. 2017;10:59 pubmed publisher
Zhong X, Liu X, Li Y, Cheng M, Wang W, Tian K, et al. HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells. Oncotarget. 2016;7:44365-44380 pubmed publisher
Mohamed A, Sun C, De Mello V, Selfe J, Missiaglia E, Shipley J, et al. The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma. J Pathol. 2016;240:3-14 pubmed publisher
Cheng J, Liu C, Liu L, Chen X, Shan J, Shen J, et al. MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization. Oncotarget. 2016;7:20597-611 pubmed publisher
Rastogi N, Duggal S, Singh S, Porwal K, Srivastava V, Maurya R, et al. Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells. Oncotarget. 2015;6:43310-25 pubmed publisher
Zeng C, Wang Y, Lu Q, Chen J, Zhang J, Liu T, et al. SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer. J Exp Clin Cancer Res. 2014;33:75 pubmed publisher
product information
SKU :
9449S
Product-Name :
Ki-67 (8D5) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
Host :
Mouse
Target :
KI-67
Primary-Protein :
KI-67
Alt-Names :
Antigen KI-67,KI67,KIA,MKI67,antigen identified by monoclonal antibody Ki-67,proliferation-related Ki-67 antigen
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.