product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
N-Myc Antibody
catalog :
9405
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3b
Jung Y, Cackowski F, Yumoto K, Decker A, Wang J, Kim J, et al. CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes. Cancer Res. 2018;78:2026-2039 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5a
  • chromatin immunoprecipitation; human; loading ...; fig 4d
  • western blot; human; loading ...; fig 4a
Zheng G, Li N, Jia X, Peng C, Luo L, Deng Y, et al. MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer. J Mol Med (Berl). 2016;94:1129-1141 pubmed
  • western blot; human; fig s1b
Chipumuro E, Marco E, Christensen C, Kwiatkowski N, Zhang T, Hatheway C, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell. 2014;159:1126-1139 pubmed publisher
Kato F, Fiorentino F, Alibés A, Perucho M, Sánchez Céspedes M, Kohno T, et al. MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells. Oncotarget. 2016;7:77378-77388 pubmed publisher
Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed publisher
Fiorentino F, Tokgün E, Solé Sánchez S, Giampaolo S, Tokgun O, Jauset T, et al. Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation. Oncotarget. 2016;7:31014-28 pubmed publisher
Mobley B, Kwon M, Kraemer B, Hickman F, Qiao J, Chung D, et al. Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis. PLoS ONE. 2015;10:e0133897 pubmed publisher
Olsen R, Mary Sinclair M, Yin Z, Freeman K. Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism. PLoS ONE. 2015;10:e0116998 pubmed publisher
Zhou Z, Patel M, Ng N, Hsieh M, Orth A, Walker J, et al. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer. 2014;14:944 pubmed publisher
Landon A, Muniandy P, Shetty A, Lehrmann E, Volpon L, Houng S, et al. MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Nat Commun. 2014;5:5413 pubmed publisher
Vujic I, Posch C, Sanlorenzo M, Yen A, Tsumura A, Kwong A, et al. Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. Oncotarget. 2014;5:7936-44 pubmed
Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprüssel A, et al. A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene. 2015;34:3357-68 pubmed publisher
Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, et al. Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells. FEBS J. 2013;280:5269-82 pubmed publisher
Lancaster M, Gopal D, Kim J, Saleem S, Silhavy J, Louie C, et al. Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med. 2011;17:726-31 pubmed publisher
Popkie A, Zeidner L, Albrecht A, D Ippolito A, Eckardt S, Newsom D, et al. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem. 2010;285:41337-47 pubmed publisher
Kashiwagi Y, Kato N, Sassa T, Nishitsuka K, Yamamoto T, Takamura H, et al. Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines. Mol Vis. 2010;16:970-82 pubmed
product information
SKU :
9405S
Product-Name :
N-Myc Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
62
Host :
Rabbit
Target :
MycN
Primary-Protein :
N-Myc
Alt-Names :
BHLHE37,Class E basic helix-loop-helix protein 37,MODED,MYCN,N-myc,N-myc proto-oncogene protein,NMYC,ODED,neuroblastoma MYC oncogene,neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene,oncogene NMYC,pp65/67,v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived,v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.