| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 5e
| Wilmes S, Hafer M, Vuorio J, Tucker J, Winkelmann H, Löchte S, et al. Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science. 2020;367:643-652 pubmed publisher |
- western blot; mouse; loading ...; fig 1h
- western blot; human; loading ...; fig 1a
| Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao Shen H, et al. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019;130:1596-1611 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5a
| Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s8
| Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher |
- western blot; mouse; fig s2d
| Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed publisher |
- western blot; mouse; loading ...; fig 2a
| Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, et al. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018;128:125-140 pubmed publisher |
- western blot; human; loading ...; fig 5d
| Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Gopinath S. Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor. Skelet Muscle. 2017;7:2 pubmed publisher |
- western blot; human; loading ...; fig 5c
- western blot; mouse; fig 5c
| Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher |
- western blot; bovine; 1:1000; loading ...; tbl 2
| Ontsouka C, Huang X, Aliyev E, Albrecht C. In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland. Mol Cell Endocrinol. 2017;439:35-45 pubmed publisher |
- immunohistochemistry; human; 1:50; tbl 2
| Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2017;35:187-197 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Southworth T, Plumb J, Gupta V, Pearson J, Ramis I, Lehner M, et al. Anti-inflammatory potential of PI3K? and JAK inhibitors in asthma patients. Respir Res. 2016;17:124 pubmed |
- western blot; human; fig 2
| Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...
| Chakhtoura Z, Laki F, Bernadet M, Cherifi I, Chiche A, Pigat N, et al. Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk. J Clin Endocrinol Metab. 2016;101:4449-4460 pubmed |
- western blot; mouse; 1:500; loading ...; fig 7c
| O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher |
| Schwarzer M, Makki K, Storelli G, Machuca Gayet I, Srůtková D, Hermanova P, et al. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science. 2016;351:854-7 pubmed publisher |
- western blot; human; fig 2
- western blot; mouse; fig 2
| Chen K, Yang J, Li J, Wang X, Chen Y, Huang S, et al. eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. Oncotarget. 2016;7:10073-89 pubmed publisher |
- western blot; mouse; 1:200; fig 4a
| Bothur E, Raifer H, Haftmann C, Stittrich A, Brüstle A, Brenner D, et al. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015;6:8576 pubmed publisher |
- western blot; bovine; fig 1
| Ao J, Wei C, Si Y, Luo C, Lv W, Lin Y, et al. Tudor-SN Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells. Int J Mol Sci. 2015;16:29936-47 pubmed publisher |
- western blot; mouse; fig 1
- western blot; human; fig 2
| Wen Q, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider R, et al. Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015;21:1473-80 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2d
| Ko T, Chin H, Chuah C, Huang J, Ng K, Khaw S, et al. The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. Oncotarget. 2016;7:2721-33 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher |
- western blot; human; loading ...; fig s5d
| Saliba J, Saint Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, et al. Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies. Nat Genet. 2015;47:1131-40 pubmed publisher |
- western blot; mouse; 1:1000; fig 7a
| He C, Medley S, Hu T, Hinsdale M, Lupu F, Virmani R, et al. PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun. 2015;6:7770 pubmed publisher |
- immunohistochemistry; mouse; 1:300; tbl 2
| Bernichtein S, Pigat N, Capiod T, Boutillon F, Verkarre V, Camparo P, et al. High milk consumption does not affect prostate tumor progression in two mouse models of benign and neoplastic lesions. PLoS ONE. 2015;10:e0125423 pubmed publisher |
| Zhang C, Nygaard M, Haxholm G, Boutillon F, Bernadet M, Hoos S, et al. A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling. J Biol Chem. 2015;290:11890-904 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Nasr R, Hmadi R, El Eit R, Iskandarani A, Jabbour M, Zaatari G, et al. ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model. Int J Cancer. 2015;137:698-709 pubmed publisher |
| Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher |
- immunohistochemistry; mouse
| Dabydeen S, Kang K, DÃaz Cruz E, Alamri A, Axelrod M, Bouker K, et al. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis. 2015;36:122-32 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Jay J, Hammer A, Nestor Kalinoski A, Diakonova M. JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein. Mol Cell Biol. 2015;35:111-31 pubmed publisher |
- flow cytometry; rat; fig 8
| Xie L, Choudhury G, Winters A, Yang S, Jin K. Cerebral regulatory TÂ cells restrain microglia/macrophage-mediated inflammatory responses via IL-10. Eur J Immunol. 2015;45:180-91 pubmed publisher |
| Sackmann Sala L, Chiche A, Mosquera Garrote N, Boutillon F, Cordier C, Pourmir I, et al. Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors. Am J Pathol. 2014;184:3105-19 pubmed publisher |
| Côté Maurais G, Bernier J. Silver and fullerene nanoparticles' effect on interleukin-2-dependent proliferation of CD4 (+) T cells. Toxicol In Vitro. 2014;28:1474-81 pubmed publisher |
- western blot; mouse; fig s16a
| Wu N, Kurosu T, Oshikawa G, Nagao T, Miura O. PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells. Int J Oncol. 2013;42:419-28 pubmed publisher |
| Choi M, Yi J, Kim S, Ryu J, Lee J, Kwon W, et al. Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis. BMC Complement Altern Med. 2019;19:347 pubmed publisher |
| Zhou X, Yu J, Cheng X, Zhao B, Manyam G, Zhang L, et al. The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming. Nat Immunol. 2019;20:879-889 pubmed publisher |
| Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed publisher |
| Seamons A, Treuting P, Meeker S, Hsu C, Paik J, Brabb T, et al. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. Am J Pathol. 2018;188:1536-1554 pubmed publisher |
| Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, et al. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127:4449-4461 pubmed publisher |
| Umezawa Y, Akiyama H, Okada K, Ishida S, Nogami A, Oshikawa G, et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). J Biol Chem. 2017;292:19639-19655 pubmed publisher |
| Williams M, Vaught D, Joly M, Hicks D, Sanchez V, Owens P, et al. ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation. Breast Cancer Res. 2017;19:105 pubmed publisher |
| Edlinger L, Berger Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, et al. Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1. Br J Haematol. 2017;179:229-241 pubmed publisher |
| Rauzan M, Chuah C, Ko T, Ong S. The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia. PLoS ONE. 2017;12:e0174107 pubmed publisher |
| Li G, Hayward I, Jenkins B, Rothfuss H, Young C, Nevalainen M, et al. Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland. PLoS ONE. 2016;11:e0147503 pubmed publisher |
| Lu L, Gasteiger G, Yu I, Chaudhry A, Hsin J, Lu Y, et al. A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 2015;43:52-64 pubmed publisher |
| McDonald L, Ferrari N, Terry A, Bell M, Mohammed Z, Orange C, et al. RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Dis Model Mech. 2014;7:525-34 pubmed publisher |
| Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H, Tone M. TGF-?-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J Immunol. 2014;192:475-83 pubmed publisher |
| Obr A, Grimm S, Bishop K, Pike J, Lydon J, Edwards D. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol. 2013;27:1808-24 pubmed publisher |
| Yentrapalli R, Azimzadeh O, Sriharshan A, Malinowsky K, Merl J, Wojcik A, et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS ONE. 2013;8:e70024 pubmed publisher |
| Zhao C, Gao X, Xue J, Cong Z, Zhang W, Chen T, et al. Interleukin-21 up-regulates interleukin-21R expression and interferon gamma production by CD8+ cells in SHIV-infected macaques. Exp Biol Med (Maywood). 2013;238:400-9 pubmed publisher |
| Weisberg E, Liu Q, Zhang X, Nelson E, Sattler M, Liu F, et al. Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells. PLoS ONE. 2013;8:e56473 pubmed publisher |
| Brandao L, Winges A, Christoph S, Sather S, Migdall Wilson J, Schlegel J, et al. Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia. Blood Cancer J. 2013;3:e101 pubmed publisher |
| Iguchi Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, et al. Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-?B and increased STAT5 signals. PLoS ONE. 2011;6:e27020 pubmed publisher |
| Dellon E, Bower J, Keku T, Chen X, Miller C, Woosley J, et al. Markers of tyrosine kinase activity in eosinophilic esophagitis: a pilot study of the FIP1L1-PDGFR? fusion gene, pERK 1/2, and pSTAT5. Dis Esophagus. 2012;25:166-74 pubmed publisher |
| Lee J, Li L, Gretz N, Gebert J, Dihlmann S. Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. Oncogene. 2012;31:1242-53 pubmed publisher |
| Rubert J, Qian Z, Andraos R, Guthy D, Radimerski T. Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer. 2011;11:24 pubmed publisher |
| Peng S, Lai Y, Huang H, Huang H, Huang Y. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Nucleic Acids Res. 2010;38:7446-57 pubmed publisher |
