product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Perilipin (D1D8) XP® Rabbit mAb
catalog :
9349
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D1D8
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 43
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...
Stoffel W, Binczek E, Schmidt Soltau I, Brodesser S, Wegner I. High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis-inactivated Δ6-fatty acid desaturase-deficient mouse. Mol Metab. 2021;54:101335 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 3a
Cheng C, Xue F, Sui W, Meng L, Xie L, Zhang C, et al. Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice. J Cell Mol Med. 2021;25:9837-9850 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4a
Wu T, Liu Q, Li Y, Li H, Chen L, Yang X, et al. Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. J Exp Med. 2021;218: pubmed publisher
  • western blot; mouse; 1:2000; fig s6a
Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, et al. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun. 2020;11:4150 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1s1e
Zhong L, Yao L, Tower R, Wei Y, Miao Z, Park J, et al. Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 4c
Shao Q, Esseltine J, Huang T, Novielli Kuntz N, Ching J, SAMPSON J, et al. Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. Biomolecules. 2019;9: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1d
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan A, et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019;10:1546 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y, et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019;668:310-317 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 1a
Flaherty S, Grijalva A, Xu X, Ables E, Nomani A, Ferrante A. A lipase-independent pathway of lipid release and immune modulation by adipocytes. Science. 2019;363:989-993 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3a
Matesanz N, Nikolic I, Leiva M, Pulgarín Alfaro M, Santamans A, Bernardo E, et al. p38α blocks brown adipose tissue thermogenesis through p38δ inhibition. PLoS Biol. 2018;16:e2004455 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig s1c
Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez N, Birbrair A, et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19:214-223 pubmed publisher
  • immunohistochemistry; human; fig s3
Morandi E, Verstappen R, Zwierzina M, Geley S, Pierer G, Ploner C. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells. Sci Rep. 2016;6:28889 pubmed publisher
  • immunohistochemistry; human; fig s3
Semplici F, Mondragon A, Macintyre B, Madeyski Bengston K, Persson Kry A, Barr S, et al. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia. 2016;59:1938-47 pubmed publisher
  • immunocytochemistry; mouse; 1:300; loading ...; fig 2a
Vazirani R, Verma A, Sadacca L, Buckman M, Picatoste B, Beg M, et al. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016;65:1577-89 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig s15a
Lombardi R, Chen S, Ruggiero A, Gurha P, Czernuszewicz G, Willerson J, et al. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016;119:41-54 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 3
Stewart M, Plante I, Penuela S, Laird D. Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. PLoS ONE. 2016;11:e0154162 pubmed publisher
  • western blot; mouse; loading ...; fig s5g
Liu Y, Takahashi Y, Desai N, Zhang J, Serfass J, Shi Y, et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016;6:20453 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig s4c
Sorrell S, Golder Z, Johnstone D, Frankl F. Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis. Kidney Int. 2016;89:105-112 pubmed publisher
  • western blot; mouse; 1:2000; fig 5a
Abreu Vieira G, Fischer A, Mattsson C, de Jong J, Shabalina I, Ryden M, et al. Cidea improves the metabolic profile through expansion of adipose tissue. Nat Commun. 2015;6:7433 pubmed publisher
  • western blot; mouse; fig 3c
DiPilato L, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum M. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Mol Cell Biol. 2015;35:2752-60 pubmed publisher
  • western blot; mouse; fig 5
Mo X, Yang C, Wang X, Burkhardt B, Li Y, Xia H, et al. F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression. PLoS ONE. 2015;10:e0117156 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Buchner D, Charrier A, Srinivasan E, Wang L, Paulsen M, Ljungman M, et al. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem. 2015;290:6376-86 pubmed publisher
  • western blot; mouse
Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, et al. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS ONE. 2014;9:e100559 pubmed publisher
  • immunohistochemistry; mouse
Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, et al. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014;29:340-9 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Naito M, Mikami Y, Takagi M, Takahashi T. Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells. Cell Tissue Res. 2013;354:761-70 pubmed publisher
  • western blot; mouse
Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed publisher
Duta Mare M, Sachdev V, Leopold C, Kolb D, Vujić N, Korbelius M, et al. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:467-478 pubmed publisher
Boutant M, Kulkarni S, Joffraud M, Ratajczak J, Valera Alberni M, Combe R, et al. Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J. 2017;36:1543-1558 pubmed publisher
Miyata Y, Otsuki M, Kita S, Shimomura I. Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells. Sci Rep. 2016;6:21041 pubmed publisher
Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, et al. Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity. Cell Rep. 2015;13:2756-67 pubmed publisher
Templeman N, Clee S, Johnson J. Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity. Diabetologia. 2015;58:2392-402 pubmed publisher
Brännmark C, Paul A, Ribeiro D, Magnusson B, Brolén G, Enejder A, et al. Increased adipogenesis of human adipose-derived stem cells on polycaprolactone fiber matrices. PLoS ONE. 2014;9:e113620 pubmed publisher
Kumar S, Kumar D, Raina K, Agarwal R, Agarwal C. Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells. Oncotarget. 2014;5:10151-69 pubmed
Pillai H, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton H, et al. Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect. 2014;122:1225-32 pubmed publisher
Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, et al. Generation of muscular dystrophy model rats with a CRISPR/Cas system. Sci Rep. 2014;4:5635 pubmed publisher
Brown M, Yukata K, Farnsworth C, Chen D, Awad H, Hilton M, et al. Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. PLoS ONE. 2014;9:e99656 pubmed publisher
Nishigori K, Temma T, Onoe S, Sampei S, Kimura I, Ono M, et al. Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4. PLoS ONE. 2014;9:e94668 pubmed publisher
Chou W, Galmozzi A, Partida D, Kwan K, Yeung H, Su A, et al. Identification of regulatory elements that control PPAR? expression in adipocyte progenitors. PLoS ONE. 2013;8:e72511 pubmed publisher
Takahashi A, Morita M, Yokoyama K, Suzuki T, Yamamoto T. Tob2 inhibits peroxisome proliferator-activated receptor ?2 expression by sequestering Smads and C/EBP? during adipocyte differentiation. Mol Cell Biol. 2012;32:5067-77 pubmed publisher
product information
SKU :
9349S
Product-Name :
Perilipin (D1D8) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
62
Host :
Rabbit
Target :
perilipin
Primary-Protein :
perilipin
Alt-Names :
Lipid droplet-associated protein,PERI,PLIN,PLIN1,Perilipin-1,perilipin 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.