| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockout validation); mouse; fig 1
| Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher |
- western blot (knockdown validation); human; fig 3
- immunoprecipitation; human; fig 1
- immunocytochemistry; human; 1:100; fig 1
| Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed publisher |
- western blot; human; fig 3
| Hansen N, Hjort L, Broholm C, Gillberg L, Schrölkamp M, Schultz H, et al. Metabolic and Transcriptional Changes in Cultured Muscle Stem Cells from Low Birth Weight Subjects. J Clin Endocrinol Metab. 2016;101:2254-64 pubmed publisher |
- western blot; human; fig 4
| Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed publisher |
- western blot; mouse; fig 4
| Li S, Wang F, Yang Y, Tiao M, Chuang J, Huang Y. Microarray Study of Pathway Analysis Expression Profile Associated with MicroRNA-29a with Regard to Murine Cholestatic Liver Injuries. Int J Mol Sci. 2016;17:324 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Parameswaran R, Ramakrishnan P, Moreton S, Xia Z, Hou Y, Lee D, et al. Repression of GSK3 restores NK cell cytotoxicity in AML patients. Nat Commun. 2016;7:11154 pubmed publisher |
- western blot; mouse; 1:2000; fig 6
| Dinger K, Kasper P, Hucklenbruch-Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher |
- western blot; mouse; fig s2
| Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed publisher |
- western blot; rat; 1:1000
| Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher |
- western blot; human; 1:200; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; mouse; 1:2000; fig 6
| Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's pathology in mice. Alzheimers Dement. 2016;: pubmed publisher |
- western blot; mouse; fig s8
| Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed publisher |
- western blot; human; 1:3000; fig 8
| Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher |
- western blot; mouse; fig 6
| Hsu Y, Chang P, Ho C, Huang Y, Shih Y, Wang C, et al. Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling. Sci Rep. 2016;6:30575 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher |
- western blot; human; fig 4
- immunoprecipitation; human; fig 4
| Ogawa F, Murphy L, Malavasi E, O'Sullivan S, Torrance H, Porteous D, et al. NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking. ACS Chem Neurosci. 2016;: pubmed |
- immunoprecipitation; mouse; fig 2
| Thornton T, Delgado P, Chen L, Salas B, Krementsov D, Fernández M, et al. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nat Commun. 2016;7:10553 pubmed publisher |
- western blot; human; fig 4
| Luey B, May F. Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway. Mol Cancer. 2016;15:8 pubmed publisher |
- western blot; mouse; 1:5000; tbl 1
| Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher |
- western blot; human; fig 6
| Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher |
- western blot; human; fig 3
| Kuang J, Li L, Guo L, Su Y, Wang Y, Xu Y, et al. RNF8 promotes epithelial-mesenchymal transition of breast cancer cells. J Exp Clin Cancer Res. 2016;35:88 pubmed publisher |
- western blot; human; fig 5
| Xi Z, Yao M, Li Y, Xie C, Holst J, Liu T, et al. Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation. Cell Death Dis. 2016;7:e2252 pubmed publisher |
- western blot; human; fig 2
| Katoh I, Fukunishi N, Fujimuro M, Kasai H, Moriishi K, Hata R, et al. Repression of Wnt/β-catenin response elements by p63 (TP63). Cell Cycle. 2016;15:699-710 pubmed publisher |
- western blot; human; 1:1000; fig s17
| Yang E, Tacchelly-Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed publisher |
- western blot; mouse; fig s4
| Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Li L, Liu H, Wang C, Liu X, Hu F, Xie N, et al. Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma. Biomed Res Int. 2016;2016:5378567 pubmed publisher |
| Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, et al. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015;36:188-200 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Morris S, Carter K, Baek J, Koszarek A, Yeh M, Knoblaugh S, et al. TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene. 2015;34:3273-82 pubmed publisher |
- western blot; mouse; 1:1000; fig 10
| Porquet D, Andres-Benito P, Griñan-Ferré C, Camins A, Ferrer I, Canudas A, et al. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr). 2015;37:9747 pubmed publisher |
- western blot; human; fig 3
| Cheng Y, Chen P, Chiang H, Suen C, Hwang M, Lin T, et al. Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT. Cell Death Dis. 2015;6:e1584 pubmed publisher |
- western blot; human; fig 5
| Harmeier A, Obermueller S, Meyer C, Revel F, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharmacol. 2015;25:2049-61 pubmed publisher |
- western blot; rat; 1:1000; fig 8
| Liu L, Li C, Lu Y, Zong X, Luo C, Sun J, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015;5:14474 pubmed publisher |
- western blot; human; fig 6
| Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher |
- western blot; mouse; fig 2
| Wang Y, Zhang Y, Hu W, Xie S, Gong C, Iqbal K, et al. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Sci Rep. 2015;5:15709 pubmed publisher |
- western blot; mouse; fig 4
| Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed publisher |
- western blot; rat; 1:1000; fig 5
| Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, et al. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE. 2015;10:e0132451 pubmed publisher |
- western blot; human; 1:1000; fig s5
| Leve F, Peres-Moreira R, Binato R, Abdelhay E, Morgado-Diaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed publisher |
- western blot; human; 1:3000; fig 1c
- western blot; mouse; 1:3000; fig 1b
| Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed publisher |
| Azimzadeh O, Sievert W, Sarioglu H, Merl-Pham J, Yentrapalli R, Bakshi M, et al. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction. J Proteome Res. 2015;14:1203-19 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Bian Y, Yang L, Wang Z, Wang Q, Zeng L, Xu G. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice. Neural Plast. 2015;2015:627837 pubmed publisher |
- western blot; mouse; 1:1000
| Angliker N, Burri M, Zaichuk M, Fritschy J, Ruegg M. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur J Neurosci. 2015;42:2595-612 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher |
- western blot; human; fig 13
| Ching J, Amiridis S, Stylli S, Bjorksten A, Kountouri N, Zheng T, et al. The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. Oncotarget. 2015;6:21301-14 pubmed |
- western blot; mouse; fig 6
| Haim Y, Bluher M, Slutsky N, Goldstein N, Kloting N, Harman-Boehm I, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11:2074-2088 pubmed |
- western blot; mouse; 1:1000
| Rodríguez-Seoane C, Ramos A, Korth C, Requena J. DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway. J Neurochem. 2015;135:598-605 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Lin X, Xu W, Shao M, Fan Q, Wen G, Li C, et al. Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration. BMC Complement Altern Med. 2015;15:126 pubmed publisher |
- western blot; rat; 1:20000
| Li M, Yang S, Xing B, Ferguson B, Gulchina Y, Li Y, et al. LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. Exp Neurol. 2015;273:190-201 pubmed publisher |
- western blot; human; 1:1000
| Li F, Song N, Tombran-Tink J, Niyibizi C. Pigment epithelium derived factor suppresses expression of Sost/Sclerostin by osteocytes: implication for its role in bone matrix mineralization. J Cell Physiol. 2015;230:1243-9 pubmed publisher |
- western blot; human; 1:500; fig s3
| Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher |
- western blot; human; fig 6
| Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher |
| Samaan S, Tranchevent L, Dardenne E, Polay Espinoza M, Zonta E, Germann S, et al. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Res. 2014;42:2197-207 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Yu P, Laird A, Du X, Wu J, Won K, Yamaguchi K, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014;13:1078-91 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human; fig 1b
- western blot; mouse; fig 1b
| Sarshad A, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, von Euler A, Lamont D, et al. Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells. PLoS Genet. 2014;10:e1004390 pubmed publisher |
- western blot; mouse; 1:1000
| E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-83 pubmed publisher |
| Gonçalves V, Henriques A, Pereira J, Neves Costa A, Moyer M, Moita L, et al. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells. RNA. 2014;20:474-82 pubmed publisher |
- western blot; mouse; 1:1000
| Chen L, Dai J, Wang Z, Zhang H, Huang Y, Zhao Y. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 β -CREB Signaling Pathway. Evid Based Complement Alternat Med. 2014;2014:506735 pubmed publisher |
- western blot; human; fig 6h
| Gasser J, Inuzuka H, Lau A, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014;56:595-607 pubmed publisher |
| Knoblich K, Wang H, Sharma C, Fletcher A, Turley S, Hemler M. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation. Cell Mol Life Sci. 2014;71:1305-14 pubmed publisher |
- western blot; mouse; 1:1000
| Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed publisher |
- western blot; human; fig 5
| Sahlberg S, Spiegelberg D, Glimelius B, Stenerlow B, Nestor M. Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE. 2014;9:e94621 pubmed publisher |
| Abrahamsson A, Geron I, Gotlib J, Dao K, Barroga C, Newton I, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009;106:3925-9 pubmed publisher |
| Chen X, Liu Y, Zhu J, Lei S, Dong Y, Li L, et al. GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion. Sci Rep. 2016;6:20196 pubmed publisher |
| Chen K, Yan M, Wu P, Qing Y, Li S, Li Y, et al. Combination of remote ischemic perconditioning and remote ischemic postconditioning fails to increase protection against myocardial ischemia/reperfusion injury, compared with either alone. Mol Med Rep. 2016;13:197-205 pubmed publisher |
| Gao D, Rahbar R, Fish E. CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells. Open Biol. 2016;6: pubmed publisher |
| Bai L, Yu Z, Zhang J, Yuan S, Liao C, Jeyabal P, et al. OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling. Oncotarget. 2016;7:10402-13 pubmed publisher |
| Kaasbøll O, Moe I, Ahmed M, Stang E, Hagelin E, Attramadal H. CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0149000 pubmed publisher |
| Latouche C, Natoli A, Reddy-Luthmoodoo M, Heywood S, Armitage J, Kingwell B. MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes. PLoS ONE. 2016;11:e0155108 pubmed publisher |
| Martin S, DeMuth T, Miller K, Pugh T, Polewski M, Colman R, et al. Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction. Aging Cell. 2016;15:100-10 pubmed publisher |
| Li N, Liu S, Zhang H, Deng Z, Zhao H, Zhao Q, et al. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int J Mol Sci. 2016;17: pubmed publisher |
| Sparling D, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld A, et al. Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. Mol Metab. 2016;5:113-21 pubmed publisher |
| Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed publisher |
| Qi L, Toyoda H, Xu D, Zhou Y, Sakurai N, Amano K, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int. 2015;15:91 pubmed publisher |
| Theodosakis N, Held M, Marzuka-Alcalá A, Meeth K, Micevic G, Long G, et al. BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume. Mol Cancer Ther. 2015;14:1680-92 pubmed publisher |
| Kusch A, Schmidt M, Gürgen D, Postpieszala D, Catar R, Hegner B, et al. 17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling. PLoS ONE. 2015;10:e0123385 pubmed publisher |
| Gao C, Chen G, Kuan S, Zhang D, Schlaepfer D, Hu J. FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. elife. 2015;4: pubmed publisher |
| Newsom S, Everett A, Park S, Van Pelt D, Hinko A, Horowitz J. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signaling in cultured muscle cells. PLoS ONE. 2015;10:e0120871 pubmed publisher |
| Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, et al. Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. EMBO Mol Med. 2015;7:1048-62 pubmed publisher |
| Zhang H, Li Y, Hu J, Shen W, Singh M, Hou X, et al. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. PLoS ONE. 2015;10:e0138203 pubmed publisher |
| Yen Y, Gassen N, Zellner A, Rein T, Landgraf R, Wotjak C, et al. Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD. Front Behav Neurosci. 2015;9:67 pubmed publisher |
| Schisler J, Grevengoed T, Pascual F, Cooper D, Ellis J, Paul D, et al. Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin. J Am Heart Assoc. 2015;4: pubmed publisher |
| Metge B, Mitra A, Chen D, Shevde L, Samant R. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015;5:11995 pubmed publisher |
| Ying X, Jing L, Ma S, Li Q, Luo X, Pan Z, et al. GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway. Cancer Cell Int. 2015;15:70 pubmed publisher |
| Zhu C, Schwarz P, Abakumova I, Aguzzi A. Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance. PLoS ONE. 2015;10:e0144983 pubmed publisher |
| Sierksma A, Van den Hove D, Pfau F, Philippens M, Bruno O, Fedele E, et al. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. 2014;77:120-30 pubmed publisher |
| Zhang J, Wang C, Yu S, Luo Z, Chen Y, Liu Q, et al. Sevoflurane postconditioning protects rat hearts against ischemia-reperfusion injury via the activation of PI3K/AKT/mTOR signaling. Sci Rep. 2014;4:7317 pubmed publisher |
| Gao X, He Y, Gao L, Feng J, Xie Y, Liu X, et al. Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner. Biochem Cell Biol. 2014;92:349-56 pubmed publisher |
| Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, et al. Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate cancer cells. Oncotarget. 2014;5:6289-99 pubmed |
| Fappi A, Godoy T, Maximino J, Rizzato V, Neves J, Chadi G, et al. The effects of omega-3 fatty acid supplementation on dexamethasone-induced muscle atrophy. Biomed Res Int. 2014;2014:961438 pubmed publisher |
| Jahn S, LAW M, Corsino P, Davis B, Harrison J, Law B. Signaling mechanisms that suppress the cytostatic actions of rapamycin. PLoS ONE. 2014;9:e99927 pubmed publisher |
| Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014;508:541-5 pubmed publisher |
| Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, et al. Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis. PLoS ONE. 2014;9:e112529 pubmed publisher |
| Lappas M. GSK3β is increased in adipose tissue and skeletal muscle from women with gestational diabetes where it regulates the inflammatory response. PLoS ONE. 2014;9:e115854 pubmed publisher |
| Liu Z, Chen X, Song H, Wang H, Zhang G, Wang H, et al. Snail regulated by PKC/GSK-3β pathway is crucial for EGF-induced epithelial-mesenchymal transition (EMT) of cancer cells. Cell Tissue Res. 2014;358:491-502 pubmed publisher |
| Kjaersgaard G, Madsen K, Marcussen N, Jensen B. Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2. Physiol Rep. 2014;2:e00202 pubmed publisher |
| Lee Y, Dominy J, Choi Y, Jurczak M, Tolliday N, Camporez J, et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014;510:547-51 pubmed publisher |
| He M, Li Y, Zhang L, Li L, Shen Y, Lin L, et al. Curcumin suppresses cell proliferation through inhibition of the Wnt/β-catenin signaling pathway in medulloblastoma. Oncol Rep. 2014;32:173-80 pubmed publisher |
| Yu H, Deng J, Zuo Z. High-fat diet reduces neuroprotection of isoflurane post-treatment: Role of carboxyl-terminal modulator protein-Akt signaling. Obesity (Silver Spring). 2014;22:2396-405 pubmed publisher |
| Kim J. Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid β-induced apoptosis in neuroblastoma cells. Exp Ther Med. 2014;8:1891-1895 pubmed |
| Ikushima Y, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, et al. Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood. 2013;121:1995-2007 pubmed publisher |
| Broholm C, Mathur N, Hvid T, Grøndahl T, Frøsig C, Pedersen B, et al. Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training. Physiol Rep. 2013;1:e00060 pubmed publisher |
| Cui G, Shan L, Hung M, Lei S, Choi I, Zhang Z, et al. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol. 2013;168:1349-59 pubmed publisher |
| Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, et al. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 2013;1:532-44 pubmed publisher |
| Weissinger D, Tagscherer K, Macher-Göppinger S, Haferkamp A, Wagener N, Roth W. The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol Cancer. 2013;12:120 pubmed publisher |
| Traister A, Walsh M, Aafaqi S, Lu M, Dai X, Henkleman M, et al. Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex. PLoS ONE. 2013;8:e77331 pubmed publisher |
| Maclean J, Hu Z, Welborn J, Song H, Rao M, Wayne C, et al. The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem. 2013;288:34809-25 pubmed publisher |
| Op den Kamp C, Langen R, Snepvangers F, de Theije C, Schellekens J, Laugs F, et al. Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia. Am J Clin Nutr. 2013;98:738-48 pubmed publisher |
| Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed publisher |
| Maurin H, Lechat B, Dewachter I, Ris L, Louis J, Borghgraef P, et al. Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase. Mol Brain. 2013;6:27 pubmed publisher |
| Wang J, Chen J, Chen Y, Chen M, Hsieh C, Teng S, et al. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. PLoS ONE. 2013;8:e65586 pubmed publisher |
| Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, et al. Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway. Biochim Biophys Acta. 2013;1832:2035-43 pubmed publisher |
| Loiselle A, Lloyd S, Paul E, Lewis G, Donahue H. Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice. PLoS ONE. 2013;8:e81399 pubmed publisher |
| Dufour J, Pommier A, Alves G, de Boussac H, Lours-Calet C, Volle D, et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS ONE. 2013;8:e58876 pubmed publisher |
| Mencarelli A, Renga B, D'Amore C, Santorelli C, Graziosi L, Bruno A, et al. Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents. Diabetes. 2013;62:3384-93 pubmed publisher |
| Albers J, Schulze J, Beil F, Gebauer M, Baranowsky A, Keller J, et al. Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol. 2011;192:1057-72 pubmed publisher |
| Perez-Costas E, Gandy J, Melendez-Ferro M, Roberts R, Bijur G. Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS ONE. 2010;5:e8911 pubmed publisher |
| Wang J, Wang X, Gong W, Mi B, Liu S, Jiang B. Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors. J Histochem Cytochem. 2009;57:363-71 pubmed publisher |
| Dan L, Klimenkova O, Klimiankou M, Klusman J, van den Heuvel-Eibrink M, Reinhardt D, et al. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica. 2012;97:551-9 pubmed publisher |
| Palmer M, Mahajan V, Chen J, Irvine D, Lauffenburger D. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011;89:581-94 pubmed publisher |
| Sawitzky M, Zeissler A, Langhammer M, Bielohuby M, Stock P, Hammon H, et al. Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. PLoS ONE. 2012;7:e39711 pubmed publisher |
| Hurtado D, Molina-Porcel L, Carroll J, Macdonald C, Aboagye A, Trojanowski J, et al. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. J Neurosci. 2012;32:7392-402 pubmed publisher |
| Biensø R, Ringholm S, Kiilerich K, Aachmann-Andersen N, Krogh-Madsen R, Guerra B, et al. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090-9 pubmed publisher |
| Li Z, Rana T. A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun. 2012;3:1085 pubmed publisher |
| Yoshida K, Okamura H, Ochiai K, Hoshino Y, Haneji T, Yoshioka M, et al. PKR plays a positive role in osteoblast differentiation by regulating GSK-3β activity through a β-catenin-independent pathway. Mol Cell Endocrinol. 2012;361:99-105 pubmed publisher |
| Mizuarai S, Kawagishi A, Kotani H. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines. Mol Cancer. 2009;8:44 pubmed publisher |
| Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed publisher |
| Laguë M, Paquet M, Fan H, Kaartinen M, Chu S, Jamin S, et al. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. 2008;29:2062-72 pubmed publisher |
| Bhandari D, Seo K, Roh K, Jung J, Kang S, Kang K. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS ONE. 2010;5:e10493 pubmed publisher |
| Koch A, Holaska J. Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS ONE. 2012;7:e37262 pubmed publisher |
| Gujral T, MacBeath G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PLoS ONE. 2010;5:e10024 pubmed publisher |
| Holden P, Horton W. Crude subcellular fractionation of cultured mammalian cell lines. BMC Res Notes. 2009;2:243 pubmed |
| Chen Y, Guan Y, Zhang Z, Liu H, Wang S, Yu L, et al. Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice. Neurol Res. 2012;34:390-9 pubmed publisher |
| MacNeil L, Melov S, Hubbard A, Baker S, Tarnopolsky M. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS ONE. 2010;5:e10695 pubmed publisher |
| Singh B, Xu Y, McLaughlin T, Singh V, Martinez J, Krishnan A, et al. Resistance to trophic neurite outgrowth of sensory neurons exposed to insulin. J Neurochem. 2012;121:263-76 pubmed publisher |
| Hou J, Wang L. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS ONE. 2012;7:e36252 pubmed publisher |
| Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher |
| Merabova N, Kaminski R, Krynska B, Amini S, Khalili K, Darbinyan A. JCV agnoprotein-induced reduction in CXCL5/LIX secretion by oligodendrocytes is associated with activation of apoptotic signaling in neurons. J Cell Physiol. 2012;227:3119-27 pubmed publisher |
| Wu M, Katta A, Gadde M, Liu H, Kakarla S, Fannin J, et al. Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS ONE. 2009;4:e6430 pubmed publisher |
| Reddiconto G, Toto C, Palamà I, De Leo S, de Luca E, De Matteis S, et al. Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Blood. 2012;119:2335-45 pubmed publisher |
| Smith K, Tong X, Abu-Yousif A, Mikulec C, Gottardi C, Fischer S, et al. UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes. Mol Carcinog. 2012;51:734-45 pubmed publisher |
| Farina A, Bong Y, Feltes C, Byers S. Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. PLoS ONE. 2009;4:e4797 pubmed publisher |
| Peña-Ortega F, Solis-Cisneros A, Ordaz B, Balleza-Tapia H, Javier Lopez-Guerrero J. Amyloid beta 1-42 inhibits entorhinal cortex activity in the beta-gamma range: role of GSK-3. Curr Alzheimer Res. 2012;9:857-63 pubmed |
