| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; loading ...; fig 2j
| Shi X, Jiang Y, Kitano A, Hu T, Murdaugh R, Li Y, et al. Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Sci Adv. 2021;7: pubmed publisher |
- immunohistochemistry; mouse; 1:1000; loading ...; fig 3d
| Chronowski C, Akhanov V, CHAN D, Catic A, Finegold M, Sahin E. Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss. Metabolites. 2021;11: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2j
| Roliński M, Montaldo N, Aksu M, Fordyce Martin S, Brambilla A, Kunath N, et al. Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Res. 2021;: pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 2h
| Dewhurst M, Ow J, Zafer G, Van Hul N, Wollmann H, Bisteau X, et al. Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020;16:e1009084 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s7
| Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher |
- western blot; human; loading ...; fig 3a
| Moses N, Zhang M, Wu J, Hu C, Xiang S, Geng X, et al. HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1. Cells. 2020;9: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s5c
| Marin Navarro A, Pronk R, van der Geest A, Oliynyk G, Nordgren A, Arsenian Henriksson M, et al. p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Cell Death Dis. 2020;11:52 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Guo S, Liu R, Wen Y, Liu L, Yuan L, Li Y, et al. Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis. Cancer Lett. 2020;468:27-40 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1a
| Martínez J, Tarallo D, Martinez Palma L, Victoria S, Bresque M, Rodriguez Bottero S, et al. Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells. Biochem J. 2019;476:2463-2486 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s2c
| Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher |
- western blot; human; 1:500; loading ...; fig s4d
| Sonego M, Pellarin I, Costa A, Vinciguerra G, Coan M, Kraut A, et al. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sci Adv. 2019;5:eaav3235 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 3b
| Chan E, Shibue T, McFarland J, Gaeta B, Ghandi M, Dumont N, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568:551-556 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Cheruiyot A, Li S, Nickless A, Roth R, Fitzpatrick J, You Z. Compound C inhibits nonsense-mediated RNA decay independently of AMPK. PLoS ONE. 2018;13:e0204978 pubmed publisher |
- western blot; rat; loading ...; fig 6a
- western blot; human; loading ...; fig 6a
| Wang Z, Ding Y, Wang X, Lu S, Wang C, He C, et al. Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. Cancer Lett. 2018;428:21-33 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, et al. Protein kinase A determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017;127:4338-4351 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 4b
- western blot; human; 1:1000; fig 4a
| Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1c
| Kang H, Park J, Choi K, Kim Y, Choi H, Jung C, et al. Chemical screening identifies ATM as a target for alleviating senescence. Nat Chem Biol. 2017;13:616-623 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed publisher |
- western blot; human; loading ...; fig 2d
| Wamsley J, Issaeva N, An H, Lu X, Donehower L, Yarbrough W. LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle. 2017;16:213-223 pubmed publisher |
- western blot; human; loading ...; fig 5
| Ren Z, Aerts J, Vandenplas H, Wang J, Gorbenko O, Chen J, et al. Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis. 2016;7:e2560 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Marmisolle I, MartÃnez J, Liu J, Mastrogiovanni M, Fergusson M, Rovira I, et al. Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Arch Biochem Biophys. 2017;613:12-22 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 4a
| Yang J, Platt L, Maity B, Ahlers K, Luo Z, Lin Z, et al. RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation. Oncotarget. 2016;7:69159-69172 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Weber A, Drobnitzky N, Devery A, Bokobza S, Adams R, Maughan T, et al. Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. Oncotarget. 2016;7:60807-60822 pubmed publisher |
- western blot; roundworm ; fig s3b
| Shikuma N, Antoshechkin I, Medeiros J, Pilhofer M, Newman D. Stepwise metamorphosis of the tubeworm Hydroides elegans is mediated by a bacterial inducer and MAPK signaling. Proc Natl Acad Sci U S A. 2016;113:10097-102 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Park J, Yang S, Park J, Ka S, Kim J, Kong Y, et al. Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun. 2016;7:12513 pubmed publisher |
- western blot; human; loading ...; fig 1d
| Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, et al. Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep. 2016;6:31758 pubmed publisher |
- western blot; human; fig 2
| Kazantseva J, Sadam H, Neuman T, Palm K. Targeted alternative splicing of TAF4: a new strategy for cell reprogramming. Sci Rep. 2016;6:30852 pubmed publisher |
- western blot; human; fig 5
| Ah Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed publisher |
- western blot; human; loading ...; fig 5f
| Luo H, Cowen L, Yu G, Jiang W, Tang Y. SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov. 2016;2:15042 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Lee W, Jo S, Lee M, Won C, Lee M, Choi J, et al. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int J Mol Sci. 2016;17: pubmed publisher |
- immunocytochemistry; human; 1:500; fig 4
| Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016;14:159-64 pubmed publisher |
- western blot; mouse; fig s1
| Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed publisher |
- western blot; human; fig 6
| Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed publisher |
- western blot; mouse; fig 3
| He D, Xiang J, Li B, Liu H. The dynamic behavior of Ect2 in response to DNA damage. Sci Rep. 2016;6:24504 pubmed publisher |
- western blot; human; fig 1
| Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher |
- western blot; human; fig 1
| Pandiri I, Chen Y, Joe Y, Kim H, Park J, Chung H, et al. Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. Breast Cancer Res Treat. 2016;156:57-64 pubmed publisher |
- western blot; mouse; loading ...; fig 2e
| Li T, Liu X, Jiang L, MANFREDI J, Zha S, Gu W. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. 2016;7:11838-49 pubmed publisher |
- western blot; mouse; fig s1
| Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher |
- western blot; human; fig 1b
| Kemp M, Sancar A. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. J Biol Chem. 2016;291:9330-42 pubmed publisher |
- western blot; human; fig 1
| Pecháčková S, Burdova K, Benada J, Kleiblova P, Jenikova G, Macurek L. Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget. 2016;7:14458-75 pubmed publisher |
| Delmas E, Jah N, Pirou C, Bouleau S, Le Floch N, Vayssière J, et al. FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities. Cell Death Dis. 2016;7:e2079 pubmed publisher |
- western blot; human; fig 5j
| Capell B, Drake A, Zhu J, Shah P, Dou Z, Dorsey J, et al. MLL1 is essential for the senescence-associated secretory phenotype. Genes Dev. 2016;30:321-36 pubmed publisher |
- western blot; mouse; fig s1c
| Llanos S, GarcÃa Pedrero J, Morgado Palacin L, Rodrigo J, Serrano M. Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2a
| Esfandiari A, Hawthorne T, Nakjang S, Lunec J. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016;15:379-91 pubmed publisher |
- western blot; human; 1:1000; fig 4d
| Walter D, Hoffmann S, Komseli E, Rappsilber J, Gorgoulis V, Sørensen C. SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication. Nat Commun. 2016;7:10530 pubmed publisher |
- western blot; human; fig 4d
| Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. J Biol Chem. 2016;291:6281-91 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Koppaka V, Chen Y, Mehta G, Orlicky D, Thompson D, Jester J, et al. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis. PLoS ONE. 2016;11:e0146433 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Gupta Y, Pasupuleti V, Du W, Welford S. Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells. PLoS ONE. 2016;11:e0146482 pubmed publisher |
- western blot; mouse; 1:1000; fig s4
| Kucab J, Zwart E, van Steeg H, Luijten M, Schmeiser H, Phillips D, et al. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts. DNA Repair (Amst). 2016;39:21-33 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Min J, Guo K, Suryadevara P, Zhu F, Holbrook G, Chen Y, et al. Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. J Med Chem. 2016;59:559-77 pubmed publisher |
- western blot; human; fig s5
| Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher |
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| Ortega Atienza S, Wong V, Deloughery Z, Luczak M, Zhitkovich A. ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res. 2016;44:198-209 pubmed publisher |
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| Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed publisher |
- western blot; human; fig 3a
| Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher |
| Mortusewicz O, Evers B, Helleday T. PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites. Oncogene. 2016;35:761-70 pubmed publisher |
| Hsu J, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, et al. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018;23:700-713.e6 pubmed publisher |
| Pai P, Kuo C, Ho T, Lin J, Lin D, Tsai F, et al. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure. Cell Death Dis. 2017;8:e2990 pubmed publisher |
| Pacini L, Ceraolo M, Venuti A, Melita G, Hasan U, Accardi R, et al. UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 Oncoproteins. J Virol. 2017;91: pubmed publisher |
| Chen X, Clark J, Wunderlich M, Fan C, Davis A, Chen S, et al. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy. 2017;13:955-966 pubmed publisher |
| Okuda A, Kurokawa S, Takehashi M, Maeda A, Fukuda K, Kubo Y, et al. Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells. BMC Neurosci. 2017;18:14 pubmed publisher |
| Tao F, Ruan S, Liu W, Wang L, Xiong Y, Shen M. Fuling Granule, a Traditional Chinese Medicine Compound, Suppresses Cell Proliferation and TGF?-Induced EMT in Ovarian Cancer. PLoS ONE. 2016;11:e0168892 pubmed publisher |
| Smith J, Lee L, Read A, Li Q, Yu B, Lee C, et al. One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation. Cell Biosci. 2016;6:57 pubmed publisher |
| Wang H, Chen T, Weng C, Yang C, Tang M. Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells. Oncotarget. 2016;7:80450-80464 pubmed publisher |
| Tran T, Lowman X, Reid M, Mendez Dorantes C, Pan M, Yang Y, et al. Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction. Oncogene. 2017;36:1991-2001 pubmed publisher |
| Ding X, Ray Chaudhuri A, Callen E, Pang Y, Biswas K, Klarmann K, et al. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nat Commun. 2016;7:12425 pubmed publisher |
| Milewski D, Pradhan A, Wang X, Cai Y, Le T, Turpin B, et al. FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21Cip1 CDK inhibitor. Oncogene. 2017;36:850-862 pubmed publisher |
| Drummond C, Esfandiari A, Liu J, Lu X, Hutton C, Jackson J, et al. TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation. Oncotarget. 2016;7:46203-46218 pubmed publisher |
| Kang J, Lee J, Hong D, Lee S, Kim N, Lee W, et al. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell Death Dis. 2016;7:e2163 pubmed publisher |
| Garcia C, Videla Richardson G, Dimopoulos N, Fernandez Espinosa D, Miriuka S, Sevlever G, et al. Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199. PLoS ONE. 2016;11:e0152607 pubmed publisher |
| Wang Y, Xu Q, Sack L, Kang C, Elledge S. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016;30:293-306 pubmed publisher |
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