| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; fig 4
| Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 2m
- western blot; human; loading ...; fig 2k
| Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, et al. CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner. Mol Cancer. 2021;20:114 pubmed publisher |
- western blot; rat; loading ...; fig s2
| Chen Y, Li J, Menon R, Jayaraman A, Lee K, Huang Y, et al. Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes. 2021;13:1972756 pubmed publisher |
- western blot; human; loading ...; fig 3e, 3f
| Zhang Y, Ma Y, Wu G, Xie M, Luo C, Huang X, et al. SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression. Cell Death Discov. 2021;7:192 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2n
| Shi X, Jiang Y, Kitano A, Hu T, Murdaugh R, Li Y, et al. Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Sci Adv. 2021;7: pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 3b
| Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 2h
| Dewhurst M, Ow J, Zafer G, Van Hul N, Wollmann H, Bisteau X, et al. Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020;16:e1009084 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Osei Amponsa V, Sridharan V, Tandon M, Evans C, Klarmann K, Cheng K, et al. Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity. Mol Cell Biol. 2020;: pubmed publisher |
- western blot; human; loading ...; fig 6d
| Zhao Z, Wang Y, Yun D, Huang Q, Meng D, Li Q, et al. TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. Am J Cancer Res. 2020;10:114-130 pubmed |
- western blot; human; loading ...; fig 1a
| Shimada Y, Kudo Y, Maehara S, Matsubayashi J, Otaki Y, Kajiwara N, et al. Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers. Cancer Sci. 2020;111:610-620 pubmed publisher |
- western blot; human; loading ...; fig 11
| Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher |
- western blot; human; loading ...
| Gao R, Chakraborty A, Geater C, Pradhan S, Gordon K, Snowden J, et al. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 7a
- immunocytochemistry; pigs ; 1:1000; loading ...; fig 7f
| Li H, Feng J, Zhang Y, Feng J, Wang Q, Zhao S, et al. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway. Redox Biol. 2019;20:261-274 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5a
| De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s5e
| Taparra K, Wang H, Malek R, Lafargue A, Barbhuiya M, Wang X, et al. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest. 2018;128:4924-4937 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- immunoprecipitation; human; 1:200; loading ...; fig 3a, 3b
| Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- western blot; mouse; fig EV1C-E
| Hui X, Zhang M, Gu P, Li K, Gao Y, Wu D, et al. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO Rep. 2017;18:645-657 pubmed publisher |
- western blot; human; fig 4a
| Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed publisher |
- western blot; human; loading ...
| Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 6b
- western blot; human; loading ...; fig 6c
| Cholewa B, Ndiaye M, Huang W, Liu X, Ahmad N. Small molecule inhibition of polo-like kinase 1 by volasertib (BI 6727) causes significant melanoma growth delay and regression in vivo. Cancer Lett. 2017;385:179-187 pubmed publisher |
- western blot; human; loading ...; fig 7a
| Dey K, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, et al. S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer Gene Ther. 2016;23:382-391 pubmed publisher |
- western blot; human; fig 2
| Hrgovic I, Doll M, Kleemann J, Wang X, Zoeller N, Pinter A, et al. The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. BMC Cancer. 2016;16:763 pubmed |
- western blot; human; 1:200; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; human; fig s7a
| Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, et al. ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy. 2016;12:2167-2182 pubmed |
- western blot; human; fig 2
| Surtees R, Dowall S, Shaw A, Armstrong S, Hewson R, Carroll M, et al. Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle. J Virol. 2016;90:9305-16 pubmed publisher |
- western blot; human; fig 5
| Ah Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed |
- western blot; mouse; loading ...; fig s4a
| Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, et al. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016;113:E4681-7 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Edmondson R, Adcock A, Yang L. Influence of Matrices on 3D-Cultured Prostate Cancer Cells' Drug Response and Expression of Drug-Action Associated Proteins. PLoS ONE. 2016;11:e0158116 pubmed publisher |
- immunocytochemistry; human; 1:500; fig 4
- western blot; human; 1:1000; fig 3a
| Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016;14:159-64 pubmed publisher |
- western blot; human; fig 1
| Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed publisher |
- immunohistochemistry; human; 1:100; fig s5
- western blot; human; 1:500; fig 4
| Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, et al. Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy. 2016;12:999-1014 pubmed publisher |
- western blot; human; loading ...; fig 1i
| Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed publisher |
- western blot; mouse; fig 5d
| Bai G, Smolka M, Schimenti J. Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation. PLoS Genet. 2016;12:e1005787 pubmed publisher |
- western blot; human; fig 5A
| Wang Z, Ma B, Li H, Xiao X, Zhou W, Liu F, et al. Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC. Oncotarget. 2016;7:509-23 pubmed publisher |
- western blot; human; fig 1k
| Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, et al. Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival. Oncogene. 2016;35:2441-52 pubmed publisher |
| Hsu J, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, et al. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018;23:700-713.e6 pubmed publisher |
| Liu J, Ben Q, Lu E, He X, Yang X, Ma J, et al. Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer. Cell Death Dis. 2018;9:168 pubmed publisher |
| Jangi M, Fleet C, Cullen P, Gupta S, Mekhoubad S, Chiao E, et al. SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. Proc Natl Acad Sci U S A. 2017;114:E2347-E2356 pubmed publisher |
| Deng Z, Liu X, Jin J, Xu H, Gao Q, Wang Y, et al. Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. Int J Biol Sci. 2016;12:1298-1308 pubmed |
| Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016;7:71841-71855 pubmed publisher |
| Nagaria P, Robert C, Park T, Huo J, Zambidis E, Rassool F. High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Stem Cells Int. 2016;2016:3826249 pubmed publisher |
| Moureau S, Luessing J, Harte E, Voisin M, Lowndes N. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol. 2016;6: pubmed |
| Du Y, Shang B, Sheng W, Zhang S, Li Y, Miao Q, et al. A recombinantly tailored β-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer. Oncotarget. 2016;7:58418-58434 pubmed publisher |
| Fransson A, Glaessgen D, Alfredsson J, Wiman K, Bajalica Lagercrantz S, Mohell N. Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer. J Ovarian Res. 2016;9:27 pubmed publisher |
| Lupini L, Pepe F, Ferracin M, Braconi C, Callegari E, Pagotto S, et al. Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma. Oncotarget. 2016;7:31361-71 pubmed publisher |
| Feng F, Zhang Y, Kothari V, Evans J, Jackson W, Chen W, et al. MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner. Neoplasia. 2016;18:213-22 pubmed publisher |
| Wang P, Liu B, Xia Y, Pan C, Ma T, Chen Y. Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression. Mol Med Rep. 2016;13:3074-82 pubmed publisher |
| Bargiela Iparraguirre J, Prado Marchal L, Fernandez Fuente M, Gutierrez González A, Moreno Rubio J, Muñoz Fernandez M, et al. CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response. Sci Rep. 2016;6:21519 pubmed publisher |
