| Published Application/Species/Dilution | Reference |
|---|
- western blot; mouse; fig 5
| Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher |
- western blot; mouse; fig 6
| Li J, Hardy K, Phetsouphanh C, Tu W, Sutcliffe E, McCuaig R, et al. Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation. J Cell Sci. 2016;129:2448-61 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher |
- western blot; human; fig 2
| Wu W, Chen Q, Geng F, Tong L, Yang R, Yang J, et al. Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. Immunol Cell Biol. 2016;94:285-92 pubmed publisher |
- western blot; mouse; fig 4
| Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher |
- western blot; mouse; fig 3
| Barroso-González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher |
- western blot; mouse; 1:1000; fig 8
| Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed publisher |
- western blot; human; fig 5
| Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher |
- western blot; human; fig s2
| Pan D, Jiang C, Ma Z, Blonska M, You M, Lin X. MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2016;35:919-28 pubmed publisher |
- western blot; human; fig 5
| Kupka S, De Miguel D, Dráber P, Martino L, Surinova S, Rittinger K, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16:2271-80 pubmed publisher |
- western blot; human; 1:1000; fig s15
| Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher |
- western blot; human; fig 4
| Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, et al. TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin. Cell Mol Life Sci. 2016;73:1085-101 pubmed publisher |
- western blot; rat; 1:1000
| Tang H, Hua F, Wang J, Yousuf S, Atif F, Sayeed I, et al. Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury. Brain Inj. 2015;:1-10 pubmed |
| Fauster A, Rebsamen M, Huber K, Bigenzahn J, Stukalov A, Lardeau C, et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015;6:e1767 pubmed publisher |
- western blot; human; fig s1
| Yang Y, Kim D, Seo Y, Park D, Jang H, Choi S, et al. Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling. Oncotarget. 2015;6:12529-42 pubmed |
- western blot; mouse; fig 5
| Kaizuka T, Mizushima N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol Cell Biol. 2015;36:585-95 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 5
| Smedlund K, Birnbaumer L, Vazquez G. Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. Proc Natl Acad Sci U S A. 2015;112:E2201-6 pubmed publisher |
| Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher |
- western blot; human; fig f4
| Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed |
- western blot; mouse; fig 1
| Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher |
| Heo D, Lim H, Nam J, Lee M, Kim J. Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia. Cell Signal. 2015;27:177-86 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 4
- western blot; mouse; fig 4
| Cha J, Burnum-Johnson K, Bartos A, Li Y, Baker E, Tilton S, et al. Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. J Biol Chem. 2015;290:15337-49 pubmed publisher |
| Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-36 pubmed publisher |
| Lee S, Kim M, Lim W, Kim T, Kang C. Strenuous exercise induces mitochondrial damage in skeletal muscle of old mice. Biochem Biophys Res Commun. 2015;461:354-60 pubmed publisher |
- other; mouse; 1:2000; fig s1
| Chiang C, Uzoma I, Lane D, Memisevic V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher |
- western blot; human; fig 1
| Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher |
- western blot; human; fig 1
| Simões A, Pereira D, Gomes S, Brito H, Carvalho T, French A, et al. Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation. Cell Death Dis. 2015;6:e1718 pubmed publisher |
- western blot; mouse; 1:1000
| Freeman J, Feng Y, Demehri F, Dempsey P, Teitelbaum D. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015;29:2943-58 pubmed publisher |
- western blot; human; fig 1
| Mashukova A, Kozhekbaeva Z, Forteza R, Dulam V, Figueroa Y, Warren R, et al. The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling. J Cell Sci. 2014;127:3568-77 pubmed publisher |
- western blot; mouse; 1:1000
| Chen R, Zhang F, Song L, Shu Y, Lin Y, Dong L, et al. Transcriptome profiling reveals that the SM22α-regulated molecular pathways contribute to vascular pathology. J Mol Cell Cardiol. 2014;72:263-72 pubmed publisher |
| Huang S, Lee C, Wang H, Chang Y, Lin C, Chen C, et al. 6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. J Agric Food Chem. 2014;62:9171-9 pubmed publisher |
- western blot; human; 1:1000
| Cañeda-Guzmán I, Salaiza-Suazo N, Fernández-Figueroa E, Carrada-Figueroa G, Aguirre-García M, Becker I. NK cell activity differs between patients with localized and diffuse cutaneous leishmaniasis infected with Leishmania mexicana: a comparative study of TLRs and cytokines. PLoS ONE. 2014;9:e112410 pubmed publisher |
- western blot; mouse; fig s2
| Takahashi N, Vereecke L, Bertrand M, Duprez L, Berger S, Divert T, et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature. 2014;513:95-9 pubmed publisher |
| Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher |
- western blot; mouse; 1:1000
| Yu B, Chang J, Liu Y, Li J, Kevork K, Al-Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB. Nat Med. 2014;20:1009-17 pubmed publisher |
| Tse K, Chow K, Leung W, Wong Y, Wise H. Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways. Neuroscience. 2014;267:241-51 pubmed publisher |
- western blot; mouse; fig 6
| Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, et al. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014;5:4657 pubmed publisher |
- western blot; mouse; 1:1000
| Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko-Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher |
- western blot; mouse; 1:500
| Nteeba J, Ganesan S, Keating A. Progressive obesity alters ovarian folliculogenesis with impacts on pro-inflammatory and steroidogenic signaling in female mice. Biol Reprod. 2014;91:86 pubmed publisher |
| Lo Sasso G, Menzies K, Mottis A, Piersigilli A, Perino A, Yamamoto H, et al. SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. PLoS ONE. 2014;9:e103573 pubmed publisher |
| Tong L, Wu S. The role of constitutive nitric-oxide synthase in ultraviolet B light-induced nuclear factor κB activity. J Biol Chem. 2014;289:26658-68 pubmed publisher |
- western blot; human
- western blot; mouse
| Zhou F, Zhang X, van Dam H, Ten Dijke P, Huang H, Zhang L. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012;287:11002-10 pubmed publisher |
| Feng H, Kang C, Dickman J, Koenig R, Awoyinka I, Zhang Y, et al. Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade. Exp Physiol. 2013;98:784-95 pubmed publisher |
- western blot; human; fig 5
| Wan F, Weaver A, Gao X, Bern M, Hardwidge P, Lenardo M. IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7. Nat Immunol. 2011;12:335-43 pubmed publisher |
| Lecat A, Di Valentin E, Somja J, Jourdan S, Fillet M, Kufer T, et al. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. J Biol Chem. 2012;287:29213-26 pubmed publisher |
| Verhoeven R, Tong S, Zhang G, Zong J, Chen Y, Jin D, et al. NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma. J Virol. 2016;90:6475-88 pubmed publisher |
| Bai X, Yang Q, Shu W, Wang J, Zhang L, Ma J, et al. Prostaglandin E2 upregulates β1 integrin expression via the E prostanoid 1 receptor/nuclear factor κ-light-chain-enhancer of activated B cells pathway in non-small-cell lung cancer cells. Mol Med Rep. 2014;9:1729-36 pubmed publisher |
| Sharma D, Packiriswamy N, Malik A, Lucas P, Parameswaran N. Nonhematopoietic β-Arrestin-1 inhibits inflammation in a murine model of polymicrobial sepsis. Am J Pathol. 2014;184:2297-309 pubmed publisher |
| Shi M, Cho H, Inn K, Yang A, Zhao Z, Liang Q, et al. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014;5:4820 pubmed publisher |
| Fraser B, Maranchuk R, Foley E. A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB. Front Immunol. 2014;5:322 pubmed publisher |
| Saitoh Y, Yamamoto N, Dewan M, Sugimoto H, Martinez Bruyn V, Iwasaki Y, et al. Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood. 2008;111:5118-29 pubmed publisher |
| Vince J, Chau D, Callus B, Wong W, Hawkins C, Schneider P, et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008;182:171-84 pubmed publisher |
| Schultz C, König H, Del Turco D, Politi C, Eckert G, Ghebremedhin E, et al. Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci. 2006;33:68-80 pubmed |
| Basak S, Kim H, Kearns J, Tergaonkar V, O'Dea E, Werner S, et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007;128:369-81 pubmed |
| Forteza R, Wald F, Mashukova A, Kozhekbaeva Z, SALAS P. Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells. Biol Open. 2013;2:1264-9 pubmed publisher |
| Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, et al. Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. EMBO J. 2012;31:3856-70 pubmed publisher |
| Lou H, Kaplowitz N. Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem. 2007;282:29470-81 pubmed |
| Luedde T, Heinrichsdorff J, De Lorenzi R, De Vos R, Roskams T, Pasparakis M. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. Proc Natl Acad Sci U S A. 2008;105:9733-8 pubmed publisher |
| Kwong C, Gilman-Sachs A, Beaman K. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011;186:1781-9 pubmed publisher |
| Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, et al. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol. 2009;11:123-32 pubmed publisher |
| Turner N, Das A, Warburton P, O'Regan D, Ball S, Porter K. Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts. Am J Physiol Heart Circ Physiol. 2009;297:H1117-27 pubmed publisher |
| Chen Y, Pappu B, Zeng H, Xue L, Morris S, Lin X, et al. B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells. J Immunol. 2007;178:49-57 pubmed |
| Chiron D, Pellat-Deceunynck C, Amiot M, Bataille R, Jego G. TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production. J Immunol. 2009;182:4471-8 pubmed publisher |
| Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, et al. p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun. 2012;3:1061 pubmed publisher |
| Gardner A, Fisher A, Richter C, Johnson G, Moisey E, Brodlie M, et al. The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. Am J Pathol. 2012;180:2293-308 pubmed publisher |
| Mabilleau G, Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE. 2009;4:e4173 pubmed publisher |
| Wright A, Reiley W, Chang M, Jin W, Lee A, Zhang M, et al. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell. 2007;13:705-16 pubmed |
