product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p38α MAPK Antibody
catalog :
9218
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, pig
application :
western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot; pig; fig 4a
Frank S, Schulz V, Miranti C. A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector. BMC Biotechnol. 2017;17:24 pubmed publisher
  • western blot; mouse; loading ...; fig s5e
Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  • western blot; human; loading ...; fig 2c
Wamsley J, Issaeva N, An H, Lu X, Donehower L, Yarbrough W. LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle. 2017;16:213-223 pubmed publisher
  • western blot; mouse; fig 3d
Han J, Bae J, Choi C, Choi S, Kang H, Jo E, et al. Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Autophagy. 2016;12:2326-2343 pubmed
  • immunohistochemistry; mouse; fig s8
Hinsenkamp I, Schulz S, Roscher M, Suhr A, Meyer B, Munteanu B, et al. Inhibition of Rho-Associated Kinase 1/2 Attenuates Tumor Growth in Murine Gastric Cancer. Neoplasia. 2016;18:500-11 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 7
Segalés J, Islam A, Kumar R, Liu Q, Sousa Victor P, Dilworth F, et al. Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation. Skelet Muscle. 2016;6:9 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig st3
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s4a
Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
  • western blot; human; fig 5
Zhao L, Liu S, Che X, Hou K, Ma Y, Li C, et al. Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors. Int J Mol Med. 2015;36:645-52 pubmed publisher
  • western blot; human; fig S4
Gupta J, Igea A, Papaioannou M, López Casas P, Llonch E, Hidalgo M, et al. Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget. 2015;6:8539-51 pubmed
  • western blot; mouse; 1:1000; fig s2
Wilson C, Jurk D, Fullard N, Banks P, Page A, Luli S, et al. NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818 pubmed publisher
  • western blot; mouse; 1:1000; fig s16a
Aschar Sobbi R, Izaddoustdar F, Korogyi A, Wang Q, Farman G, Yang F, et al. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nat Commun. 2015;6:6018 pubmed publisher
Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher
Alspach E, Flanagan K, Luo X, Ruhland M, Huang H, Pazolli E, et al. p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov. 2014;4:716-29 pubmed publisher
Allen J, Cooke M, Alliston T. ECM stiffness primes the TGF? pathway to promote chondrocyte differentiation. Mol Biol Cell. 2012;23:3731-42 pubmed
Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. Endothelial and macrophage-specific deficiency of P38? MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS ONE. 2011;6:e21055 pubmed publisher
Turpeinen T, Nieminen R, Taimi V, Heittola T, Sareila O, Clark A, et al. Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. Mediators Inflamm. 2011;2011:127587 pubmed publisher
Rasheed Z, Akhtar N, Haqqi T. Pomegranate extract inhibits the interleukin-1?-induced activation of MKK-3, p38?-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis Res Ther. 2010;12:R195 pubmed publisher
Hendriks B, Seidl K, Chabot J. Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro. BMC Syst Biol. 2010;4:23 pubmed publisher
Elsea C, Roberts D, Druker B, Wood L. Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity. PLoS ONE. 2008;3:e2355 pubmed publisher
product information
SKU :
9218P
Product-Name :
p38α MAPK Antibody
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
40
Host :
Rabbit
Target :
p38-alpha MAPK
Primary-Protein :
p38-alpha
Alt-Names :
CSAID-binding protein,CSBP,CSBP1,CSBP2,CSPB1,Csaids binding protein,Cytokine suppressive anti-inflammatory drug-binding protein,EXIP,MAP kinase 14,MAP kinase MXI2,MAP kinase p38 alpha,MAPK 14,MAPK14,MAX-interacting protein 2,MK14,MXI2,Mitogen-activated protein kinase 14,Mitogen-activated protein kinase p38 alpha,PRKM14,PRKM15,RK,SAPK2A,cytokine suppressive anti-inflammatory drug binding protein,p38,p38 MAP kinase,p38 mitogen activated protein kinase,p38ALPHA,p38alpha Exip,stress-activated protein kinase 2A
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.