product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p38 MAPK Antibody
catalog :
9212
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Campylobacter jejuni, human, mouse, rat, bovine, pigs , rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, reverse phase protein lysate microarray
more info or order :
Cell Signaling Technology product webpage
citations: 226
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; fig 3f
Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, et al. OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity. Nat Commun. 2021;12:5913 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Zhu W, Hibbert J, Lin K, Steinert N, Lemens J, Jorgenson K, et al. Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise. Cells. 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Liu M, Shan M, Zhang Y, Guo Z. Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma. J Inflamm Res. 2021;14:3891-3904 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Yang S, Qu Y, Chen J, Chen S, Sun L, Zhou Y, et al. Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion. Front Pharmacol. 2021;12:688073 pubmed publisher
  • western blot; human; loading ...; fig 2a
Chen H, Padia R, Li T, Li Y, Li B, Jin L, et al. Signaling of MK2 sustains robust AP1 activity for triple negative breast cancer tumorigenesis through direct phosphorylation of JAB1. NPJ Breast Cancer. 2021;7:91 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig s2
Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed publisher
  • western blot; mouse; loading ...; fig s2a
Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7c
Kurosaka M, Ogura Y, Sato S, Kohda K, Funabashi T. Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis. Skelet Muscle. 2021;11:14 pubmed publisher
  • western blot; mouse; loading ...; fig 7e
Kim C, Park S, Lee S, Kim Y, Jang S, Woo S, et al. NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. Nucleic Acids Res. 2021;49:5760-5778 pubmed publisher
  • western blot; human; 1:700; loading ...; fig 6
Lee J, Hsu Y, Li Y, Cheng S. Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. Int J Endocrinol. 2021;2021:5583491 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4f
Teufel S, Köckemann P, Fabritius C, Wolff L, Bertrand J, Pap T, et al. Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Cell Death Dis. 2021;12:494 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Lindfors S, Polianskyte Prause Z, Bouslama R, Lehtonen E, Mannerla M, Nisen H, et al. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo. Diabetologia. 2021;64:1866-1879 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher
  • western blot; human; loading ...; fig 6a
Chen X, Ma W, Yao Y, Zhang Q, Li J, Wu X, et al. Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. Cell Death Dis. 2021;12:425 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6d
Low H, Wong Z, Wu B, Kong L, Png C, Cho Y, et al. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nat Commun. 2021;12:2284 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Brea R, Valdecantos P, Rada P, Alen R, García Monzón C, Bosca L, et al. Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Aging (Albany NY). 2021;13:7800-7827 pubmed publisher
  • western blot; mouse; loading ...; fig s4a
Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
Kushioka J, Kaito T, Okada R, Ishiguro H, Bal Z, Kodama J, et al. A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Res. 2020;8:41 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Gu Z, Xie D, Ding R, Huang C, Qiu Y. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells. Aging (Albany NY). 2020;13:4976-4985 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, et al. CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. Clin Transl Immunology. 2020;9:e1162 pubmed publisher
  • western blot; human; loading ...
Robichon K, Maiwald T, Schilling M, Schneider A, Willemsen J, Salopiata F, et al. Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses. PLoS Pathog. 2020;16:e1008461 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a, 1b
Wueest S, Lucchini F, Haim Y, Rudich A, Konrad D. Depletion of ASK1 blunts stress-induced senescence in adipocytes. Adipocyte. 2020;9:535-541 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2h
Sinha N, Ordureau A, Best K, Saba J, Zinshteyn B, Sundaramoorthy E, et al. EDF1 coordinates cellular responses to ribosome collisions. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 4h
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
  • western blot; human; loading ...; fig 5f
Luo H, Li G, Wang B, Tian B, Gao J, Zou J, et al. Peli1 signaling blockade attenuates congenital zika syndrome. PLoS Pathog. 2020;16:e1008538 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Gee M, Son S, Jeon S, Do J, Kim N, Ju Y, et al. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 2020;12:45 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2k
Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, et al. ERK3/MAPK6 controls IL-8 production and chemotaxis. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 6b
Xu F, Liu Z, Liu R, Lu C, Wang L, Mao W, et al. Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma. Cell Commun Signal. 2020;18:17 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 10c
Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Li Y, Xu S, Xu Q, Chen Y. Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway. Artif Cells Nanomed Biotechnol. 2020;48:452-462 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a, 7b
Kim K, Kim J, Kim I, Seong S, Kim N. Rev-erbα Negatively Regulates Osteoclast and Osteoblast Differentiation through p38 MAPK Signaling Pathway. Mol Cells. 2020;43:34-47 pubmed publisher
  • western blot; mouse; loading ...; fig s1f
Lee J, Hall J, Kroehling L, Wu L, Najar T, Nguyen H, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020;180:79-91.e16 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Kim D, Choi J, Jo I, Kim M, Lee H, Hong S, et al. Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Mol Med Rep. 2020;21:258-266 pubmed publisher
  • western blot; human; loading ...; fig 5b
Weisell J, Ohukainen P, Näpänkangas J, Ohlmeier S, Bergmann U, Peltonen T, et al. Heat shock protein 90 is downregulated in calcific aortic valve disease. BMC Cardiovasc Disord. 2019;19:306 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6d
Jiao W, Ji J, Xu W, Bu W, Zheng Y, Ma A, et al. Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture. Sci Rep. 2019;9:15339 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5b
Wu W, Piao H, Wu F, Han Y, An D, Wu Y, et al. Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways. Am J Transl Res. 2019;11:5998-6006 pubmed
  • western blot; human; loading ...; fig 4c
Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, et al. Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer. Cells. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 4a
Gu C, Wang L, Zurawski S, Oh S. Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation. J Immunol. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 5f
  • western blot; pigs ; fig 1h
Liu Y, Li R, Chen X, Zhi Y, Deng R, Zhou E, et al. Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway. MBio. 2019;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan A, et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019;10:1546 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 6d
Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed publisher
  • western blot; rhesus macaque; loading ...; fig 1d
Hayashi H, Mamun A, Takeyama M, Yamamura A, Zako M, Yagasaki R, et al. Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization. Sci Rep. 2019;9:1560 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Su V, Yang K, Chiou S, Chen N, Mo M, Lin C, et al. Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury. Stem Cells. 2019;37:631-639 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Liu Z, Li C, Kang N, Malhi H, Shah V, Maiers J. Transforming growth factor β (TGFβ) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation. J Biol Chem. 2019;294:3137-3151 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  • western blot; human; 1:1000; fig 2c
Chen Q, Xiang J, Gong R, Fang H, Xu C, Zhang H, et al. Atorvastatin downregulates HSP22 expression in an atherosclerotic model in vitro and in vivo. Int J Mol Med. 2019;43:821-829 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2d
Mu L, Tu Z, Miao L, Ruan H, Kang N, Hei Y, et al. A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing. Nat Commun. 2018;9:4259 pubmed publisher
  • western blot; human; loading ...; fig 7f
Luo H, Winkelmann E, Zhu S, Ru W, Mays E, Silvas J, et al. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. J Clin Invest. 2018;128:4980-4991 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Cao Y, Xu Y, Auchoybur M, Chen W, He S, Qin W, et al. Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages. J Mol Cell Cardiol. 2018;123:1-12 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig s2
Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
  • western blot; mouse; fig 4d
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  • western blot; mouse; loading ...; fig 2i
Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, et al. An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med. 2018;24:814-822 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Huang M, Qi W, Fang S, Jiang P, Yang C, Mo Y, et al. Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating Aβ42. Neurotherapeutics. 2018;15:728-741 pubmed publisher
  • western blot; human; loading ...; fig 6f
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Markussen L, Winther S, Wicksteed B, Hansen J. GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep. 2018;8:3469 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8b
Lu Y, Kim N, Jiang Y, Zhang H, Zheng D, Zhu F, et al. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol. 2018;175:1085-1099 pubmed publisher
  • western blot; human; 1:1000; fig 2a
Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3
Lu F, Shao G, Wang Y, Guan S, Burlingame A, Liu X, et al. Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain. Exp Neurol. 2018;299:65-74 pubmed publisher
  • western blot; mouse; fig 6d
Naik S, Padhi A, Ganguli G, Sengupta S, Pati S, Das D, et al. Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway. Infect Immun. 2017;85: pubmed publisher
  • western blot; human; loading ...; fig 1d
Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
  • western blot; human; loading ...; fig 1e
Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
  • western blot; human; 1:2000; fig s5f
Tian H, Ketova T, Hardy D, Xu X, Gao X, Zijlstra A, et al. Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. Arterioscler Thromb Vasc Biol. 2017;37:1115-1126 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Kim D, Ko H, Park G, Hur D, Kim Y, Yang J. Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway. Exp Ther Med. 2017;13:1415-1425 pubmed publisher
  • western blot; mouse; fig 1a
Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, et al. p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep. 2017;7:45964 pubmed publisher
  • western blot; human; fig 4c
Perrott K, Wiley C, Desprez P, Campisi J. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. GeroScience. 2017;39:161-173 pubmed publisher
  • western blot; mouse; 1:500; fig 7b
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
  • western blot; rat; loading ...; fig 1c
Chambers T, Santiesteban L, Gomez D, Chambers J. Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity. Toxicology. 2017;382:24-35 pubmed publisher
  • western blot; mouse; loading ...; fig 3
Balmer D, Bapst Wicht L, Pyakurel A, Emery M, Nanchen N, Bochet C, et al. Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis. Front Aging Neurosci. 2017;9:43 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, et al. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. Nat Commun. 2017;8:14654 pubmed publisher
  • western blot; mouse; loading ...; fig EV4a
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
  • western blot; human; loading ...; fig 1g
Li L, Baxter S, Gu N, Ji M, Zhan X. Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 2017;130:1475-1485 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
  • western blot; human; fig 4a
Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Kang S, Yi H, Choi M, Ryu M, Jung S, Chung H, et al. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol. 2017;233:105-118 pubmed publisher
  • western blot; mouse; 1:1000; loading ...
Gautam J, Nirwane A, Yao Y. Laminin differentially regulates the stemness of type I and type II pericytes. Stem Cell Res Ther. 2017;8:28 pubmed publisher
  • western blot; human; loading ...; fig 3a
Ni Y, Teng T, Li R, Simonyi A, Sun G, Lee J. TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK. PLoS ONE. 2017;12:e0170346 pubmed publisher
  • western blot; human; loading ...; fig 5g
Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
  • western blot; human; loading ...; fig 5B
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed publisher
  • western blot; human; loading ...; fig 1b
Neganova I, Chichagova V, Armstrong L, Lako M. A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs. Sci Rep. 2017;7:41693 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3
Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed publisher
  • western blot; human; loading ...; fig 4a
Yang H, Ju F, Guo X, Ma S, Wang L, Cheng B, et al. RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Sci Rep. 2017;7:41738 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed publisher
  • western blot; human; loading ...; fig 3b
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • western blot; human; 1:1000; fig 8c
Schober T, Magg T, Laschinger M, Rohlfs M, Linhares N, Puchalka J, et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017;8:14209 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Feng L, Xue D, Chen E, Zhang W, Gao X, Yu J, et al. HMGB1 promotes the secretion of multiple cytokines and potentiates the osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Exp Ther Med. 2016;12:3941-3947 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5
Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed publisher
  • western blot; human; fig 7i
Chandravanshi B, Bhonde R. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. J Cell Biochem. 2017;118:2672-2683 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; mouse; loading ...; fig 4
Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7
Milara J, Cervera A, de Diego A, Sanz C, Juan G, Gavaldá A, et al. Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients. Respir Res. 2016;17:145 pubmed
  • western blot; human; loading ...; fig 7a
Dey K, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, et al. S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer Gene Ther. 2016;23:382-391 pubmed publisher
  • western blot; rat; loading ...; fig 4a
Ulbrich F, Kaufmann K, Meske A, Lagrèze W, Augustynik M, Buerkle H, et al. The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells. PLoS ONE. 2016;11:e0165182 pubmed publisher
  • western blot; human; loading ...; fig 5
Guan S, Zhao Y, Lu J, Yu Y, Sun W, Mao X, et al. Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis. Oncotarget. 2016;7:75914-75925 pubmed publisher
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Gupta S, Zeglinski M, Rattan S, Landry N, Ghavami S, Wigle J, et al. Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts. Oncotarget. 2016;7:78516-78531 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6a
Wu X, Gu W, Lu H, Liu C, Yu B, Xu H, et al. Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways. Oxid Med Cell Longev. 2016;2016:1015390 pubmed
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Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
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Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Qin Y, Liu Y, Hao W, Decker Y, Tomic I, Menger M, et al. Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice. J Immunol. 2016;197:3281-3292 pubmed
  • western blot; rat; fig 5
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed publisher
  • western blot; rat; fig 5
Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS ONE. 2016;11:e0161867 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Jiao Z, Wu J, Liu C, Wen B, Zhao W, Du X. Nicotinic ?7 receptor inhibits the acylation stimulating protein?induced production of monocyte chemoattractant protein?1 and keratinocyte?derived chemokine in adipocytes by modulating the p38 kinase and nuclear factor??B signaling pathways. Mol Med Rep. 2016;14:2959-66 pubmed publisher
  • western blot; human; loading ...; fig 2c
Gómez Puerto M, Verhagen L, Braat A, Lam E, Coffer P, Lorenowicz M. Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation. Autophagy. 2016;12:1804-1816 pubmed
  • western blot; mouse; loading ...; fig s4a
Nadeau Vallée M, Boudreault A, Leimert K, Hou X, Obari D, Madaan A, et al. Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth. Biol Reprod. 2016;95:72 pubmed
  • western blot; rat; loading ...; fig s2
Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed publisher
  • western blot; mouse; fig 4c
Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher
  • western blot; rat; fig 4
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Lie E, Ko J, Choi S, Roh J, Cho Y, Noh R, et al. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. Nat Commun. 2016;7:12328 pubmed publisher
  • western blot; human; loading ...; fig 4a
Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
  • western blot; human; loading ...; fig 4a
Ciaraldi T, Ryan A, Mudaliar S, Henry R. Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS ONE. 2016;11:e0158209 pubmed publisher
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Jiao K, Zeng G, Niu L, Yang H, Ren G, Xu X, et al. Activation of ?2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint. Sci Rep. 2016;6:30085 pubmed publisher
  • western blot; human; 1:1000; fig 3
Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed
  • western blot; mouse; 1:1000; fig s6c
Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
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  • western blot; rat; loading ...; fig 4a
Babica P, Zurabian R, Kumar E, Chopra R, Mianecki M, Park J, et al. Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells. Toxicol Sci. 2016;153:174-85 pubmed publisher
  • western blot; human; fig 6
Huang C, Lee C, Lin H, Chang J. Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep. 2016;6:29256 pubmed publisher
  • western blot; human; loading ...; fig 6a
Shen P, Chen M, He M, Chen L, Song Y, Xiao P, et al. Inhibition of ER?/ERK/P62 cascades induces "autophagic switch" in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 2016;7:48501-48516 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Lukjanenko L, Jung M, Hegde N, Perruisseau Carrier C, Migliavacca E, Rozo M, et al. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med. 2016;22:897-905 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6a
Heckler M, Zeleke T, Divekar S, Fernandez A, Tiek D, Woodrick J, et al. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget. 2016;7:47201-47220 pubmed publisher
  • western blot; human; fig 1
Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  • western blot; human; 1:1000; fig 3
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  • western blot; Campylobacter jejuni; fig 4
Faber E, Gripp E, Maurischat S, Kaspers B, Tedin K, Menz S, et al. Novel Immunomodulatory Flagellin-Like Protein FlaC in Campylobacter jejuni and Other Campylobacterales. mSphere. 2016;1: pubmed publisher
  • western blot; mouse; fig 5
Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
  • western blot; human; fig 2
Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed publisher
  • western blot; human; 1:1000; fig 7
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  • western blot; mouse; fig 3
de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher
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Ribeiro J, Schorl C, Yano N, Romano N, Kim K, Singh R, et al. HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells. J Ovarian Res. 2016;9:28 pubmed publisher
  • western blot; human; loading ...; fig s2b
Park S, Yi H, Suh N, Park Y, Koh J, Jeong S, et al. Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-?B. Oncotarget. 2016;7:39796-39808 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10b
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed publisher
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Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed publisher
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Hu L, Tan J, Yang X, Tan H, Xu X, You M, et al. Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice. Evid Based Complement Alternat Med. 2016;2016:5137386 pubmed publisher
  • western blot; human; fig 9e
  • western blot; bovine; loading ...; fig 9f
Ishizuka S, Askew E, Ishizuka N, Knudson C, Knudson W. 4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition. J Biol Chem. 2016;291:12087-104 pubmed publisher
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  • western blot; human; loading ...; fig 1c
Afonina I, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Staal J, et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 2016;17:914-27 pubmed publisher
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Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, et al. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016;6:24256 pubmed publisher
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Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, et al. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS ONE. 2016;11:e0152538 pubmed publisher
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Federspiel J, Codreanu S, Palubinsky A, Winland A, Betanzos C, McLaughlin B, et al. Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Mol Cell Proteomics. 2016;15:1947-61 pubmed publisher
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Woo J, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016;113:2762-7 pubmed publisher
  • western blot; human; fig 4
Chusri P, Kumthip K, Hong J, Zhu C, Duan X, Jilg N, et al. HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response. Sci Rep. 2016;6:22487 pubmed publisher
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Cao L, Qin X, Peterson M, Haller S, Wilson K, Hu N, et al. CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. J Mol Cell Cardiol. 2016;92:185-95 pubmed publisher
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Lee M, Goralczyk A, Kriszt R, Ang X, Badowski C, Li Y, et al. ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs. Sci Rep. 2016;6:21173 pubmed publisher
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Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed
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Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed publisher
  • western blot; mouse
Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, et al. cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation. Sci Rep. 2016;6:20930 pubmed publisher
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Hayashi H, Al Mamun A, Sakima M, Sato M. Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis. J Cell Sci. 2016;129:1210-22 pubmed publisher
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Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher
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Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, et al. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep. 2016;6:20007 pubmed publisher
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van der Mijn J, Broxterman H, Knol J, Piersma S, de Haas R, Dekker H, et al. Sunitinib activates Axl signaling in renal cell cancer. Int J Cancer. 2016;138:3002-10 pubmed publisher
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Ishibashi T, Yaguchi A, Terada K, Ueno Yokohata H, Tomita O, Iijima K, et al. Ph-like ALL-related novel fusion kinase ATF7IP-PDGFRB exhibits high sensitivity to tyrosine kinase inhibitors in murine cells. Exp Hematol. 2016;44:177-88.e5 pubmed publisher
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Wu R, Chen H, Ma J, He Q, Huang Q, Liu Q, et al. c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death. Cell Death Differ. 2016;23:542-52 pubmed publisher
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product information
SKU :
9212L
Product-Name :
p38 MAPK Antibody
Size :
600 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Mk, GP, (C)
Applications :
Flow cytometry
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
43
Host :
Rabbit
Target :
p38-alpha MAPK/p38-beta MAPK/p38-gamma MAPK
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.