Phospho-p70 S6 Kinase (Thr389) Antibody | Cell Signaling Technology 9205 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-p70 S6 Kinase (Thr389) Antibody

catalog :

9205

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat, bovine, pigs , thale cress

application :

western blot, immunohistochemistry - frozen section, reverse phase protein lysate microarray, other, western blot knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 135

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; loading ...; fig 2g	Dong J, Du X, Wang H, Wang J, Lu C, Chen X, et al. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun. 2019;10:829 pubmed publisher
western blot; mouse; loading ...; fig 1d, 3b	Han H, Kim S, Kim Y, Jang S, Kwon Y, Choi D, et al. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. Mol Metab. 2022;55:101402 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s3b	Albanese F, Mercatelli D, Finetti L, Lamonaca G, Pizzi S, Shimshek D, et al. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiol Dis. 2021;159:105487 pubmed publisher
western blot; human; 1:1000; loading ...; fig s8b	Soldati C, Lopez Fabuel I, Wanderlingh L, García Macia M, Monfregola J, Esposito A, et al. Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. EMBO Mol Med. 2021;13:e13742 pubmed publisher
western blot; human; loading ...; fig 2b	Moon S, Lee H, Kim S, Hong J, Chun S, Lee H, et al. Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells. BMC Cancer. 2021;21:931 pubmed publisher
western blot; mouse; loading ...; fig 3f western blot; human; loading ...; fig 3d, 3e	Chen X, Miao M, Zhou M, Chen J, Li D, Zhang L, et al. Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell Death Dis. 2021;12:761 pubmed publisher
western blot; mouse; loading ...; fig 3d, 5d, 4f	Chen H, Zhang Brotzge X, Morozov Y, Li Y, Wang S, Zhang H, et al. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021;6: pubmed publisher
western blot; human; 1:1000; loading ...; fig 7e	Li L, Yang Q, Jiang Y, Yang W, Jiang Y, Li X, et al. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun. 2021;12:4362 pubmed publisher
western blot; mouse; 1:500; loading ...; fig 6a	Barbé C, Loumaye A, Lause P, Ritvos O, Thissen J. p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition. Front Physiol. 2021;12:677746 pubmed publisher
western blot; mouse; loading ...; fig s2	Lee H, Donati A, Feliers D, Sun Y, Ding Y, Madesh M, et al. Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging Cell. 2021;20:e13407 pubmed publisher
western blot; mouse; loading ...; fig 4a, 5a	Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3e	Yang C, Liu Q, Chen Y, Wang X, Ran Z, Fang F, et al. Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve. Commun Biol. 2021;4:534 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5d	Sharma V, Sood R, Lou D, Hung T, Levesque M, Han Y, et al. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4e	Chung L, Liu S, Huang S, Salter D, Lee H, Hsu Y. High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling. Aging (Albany NY). 2020;12:21446-21468 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3c	Kumar A, Xie L, Ta C, Hinton A, Gunasekar S, Minerath R, et al. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. elife. 2020;9: pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
western blot; mouse; loading ...; fig 2c	Hastings J, González Rajal A, Latham S, Han J, McCloy R, O Donnell Y, et al. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. elife. 2020;9: pubmed publisher
western blot; human; loading ...; fig 4f	Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
western blot; bovine; 1:1000; loading ...; fig 4a	Dai W, Zhao F, Liu J, Liu H. Seryl-tRNA synthetase is involved in methionine stimulation of β-casein synthesis in bovine mammary epithelial cells. Br J Nutr. 2020;123:489-498 pubmed publisher
western blot; human; loading ...; fig 5c	Si J, Ma Y, Bi J, Xiong Y, Lv C, Li S, et al. Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties. J Exp Clin Cancer Res. 2019;38:481 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1a	Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed publisher
western blot; rat; 1:1000; loading ...; fig 2d	Neumann B, Baror R, Zhao C, SEGEL M, Dietmann S, Rawji K, et al. Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells. Cell Stem Cell. 2019;25:473-485.e8 pubmed publisher
western blot; mouse; loading ...; fig 6b	Oka S, Chin A, Park J, Ikeda S, Mizushima W, Ralda G, et al. Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart. Cardiovasc Res. 2019;: pubmed publisher
western blot; mouse; loading ...; fig s5g	Crosby P, Hamnett R, Putker M, Hoyle N, Reed M, Karam C, et al. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time. Cell. 2019;177:896-909.e20 pubmed publisher
western blot; human; loading ...; fig 7b	Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher
western blot; human; 1:500; loading ...; fig 8a	Forte G, Davie E, Lie S, Franz Wachtel M, Ovens A, Wang T, et al. Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling. J Cell Sci. 2019;132: pubmed publisher
western blot; human; loading ...; fig 7a	Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019;376:198-209 pubmed publisher
western blot; human; loading ...; fig 7c	Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, et al. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Nat Immunol. 2019;20:313-325 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1a, 2e western blot; rat; 1:1000; loading ...; fig 2d	Ranek M, Kokkonen Simon K, Chen A, Dunkerly Eyring B, Vera M, Oeing C, et al. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Nature. 2019;566:264-269 pubmed publisher
western blot; human; loading ...; fig 3a	Nnah I, Wang B, Saqcena C, Weber G, Bonder E, Bagley D, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2019;15:151-164 pubmed publisher
western blot; mouse; loading ...; fig 5k, 5m western blot; human; loading ...; fig 5q	Li W, Yue F, Dai Y, Shi B, Xu G, Jiang X, et al. Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. Cell Death Differ. 2018;: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2d	Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed publisher
western blot; mouse; fig s3a	Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
other; human; loading ...; fig 4c	Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
western blot; mouse; fig 6c	Ka M, Kim W. ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway. Neurobiol Dis. 2018;111:138-152 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7e western blot; mouse; 1:1000; loading ...; fig 7g	Zhang Y, Qu Y, Lin Y, Wu X, Chen H, Wang X, et al. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Nat Commun. 2017;8:464 pubmed publisher
western blot; human; loading ...; fig 4a	Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017;23:1055-1062 pubmed publisher
western blot; human; loading ...; fig 4c	Zabala Letona A, Arruabarrena Aristorena A, Martin Martin N, Fernandez Ruiz S, Sutherland J, Clasquin M, et al. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. 2017;547:109-113 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7a	Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, et al. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nat Commun. 2017;8:15663 pubmed publisher
western blot; human; fig 5c	Miyamoto T, Lo P, Saichi N, Ueda K, Hirata M, Tanikawa C, et al. Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53. Sci Adv. 2017;3:e1603204 pubmed publisher
western blot; human; loading ...; fig 5a	Choi E, Jung B, Lee S, Yoo H, Shin E, Ko H, et al. A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Oncogene. 2017;36:5285-5295 pubmed publisher
western blot; mouse; loading ...; fig 1j	Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 2017;545:365-369 pubmed publisher
western blot; mouse; 1:1000; fig 7e	Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed publisher
reverse phase protein lysate microarray; human; loading ...; fig st6	Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
western blot; human; 1:500; loading ...; fig 2a	Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, et al. Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro. Int J Oncol. 2017;50:1431-1438 pubmed publisher
western blot; human; loading ...; fig 1a western blot; mouse; loading ...; fig s7f	Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher
western blot; mouse; loading ...; fig 4a	Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
western blot; pigs ; loading ...; fig 2a	Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B, et al. Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection. Front Immunol. 2016;7:685 pubmed publisher
western blot; mouse; loading ...; fig 6a	Kissing S, Rudnik S, Damme M, Lüllmann Rauch R, Ichihara A, Kornak U, et al. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy. 2017;13:670-685 pubmed publisher
western blot; rat; loading ...; fig 4b	Zhang Y, Stefanovic B. mTORC1 phosphorylates LARP6 to stimulate type I collagen expression. Sci Rep. 2017;7:41173 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3d	Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed publisher
western blot; human; 1:2000; loading ...; fig 9a	Yoo S, Latifkar A, Cerione R, Antonyak M. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. J Biol Chem. 2017;292:3947-3957 pubmed publisher
western blot; mouse; loading ...; fig 6a	Chamoto K, Chowdhury P, Kumar A, Sonomura K, Matsuda F, Fagarasan S, et al. Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E761-E770 pubmed publisher
western blot; human; 1:500; loading ...; fig 1b	Muranen T, Iwanicki M, Curry N, Hwang J, DuBois C, Coloff J, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989 pubmed publisher
western blot; human; loading ...	Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
western blot; mouse; loading ...; fig 2a	Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4a	Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
western blot; human; fig 1a	Cao J, Tyburczy M, Moss J, Darling T, Widlund H, Kwiatkowski D. Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. J Clin Invest. 2017;127:349-364 pubmed publisher
western blot; human; loading ...; fig 2a	Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3a	Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al. Regulation of mTORC1 by lysosomal calcium and calmodulin. elife. 2016;5: pubmed publisher
western blot; human; 1:1000; loading ...; fig 3c	Chen Y, Xu J, Skanderup A, Dong Y, Brannon A, Wang L, et al. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nat Commun. 2016;7:13131 pubmed publisher
western blot; human; loading ...; fig 5c	Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, et al. The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway. Oncogenesis. 2016;5:e260 pubmed publisher
western blot; human; fig 2	Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 5a western blot; human; 1:1000; loading ...; fig 5b	Wang S, Jiang L, Han Y, Chew S, Ohara Y, Akatsuka S, et al. Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget. 2016;7:69565-69578 pubmed publisher
western blot; mouse; loading ...; fig 6a	Hong J, Shin M, Douglas I, Chung K, Kim E, Jung J, et al. Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury. Clin Sci (Lond). 2016;130:1993-2003 pubmed
western blot; rat; loading ...; fig 1	Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Rousseau A, Bertolotti A. An evolutionarily conserved pathway controls proteasome homeostasis. Nature. 2016;536:184-9 pubmed
western blot; mouse; loading ...; fig 5a	Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
western blot; mouse	Zhang Z, Yan J, Shi H. Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiol Dis. 2016;95:82-92 pubmed publisher
western blot; mouse; loading ...; fig 1e	Diez H, Benitez M, Fernandez S, Torres Aleman I, Garrido J, Wandosell F. Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation. Biochim Biophys Acta. 2016;1863:2574-2583 pubmed publisher
western blot; mouse; loading ...; fig 1c	Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
western blot; thale cress; fig s1	Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, et al. Integration of light and metabolic signals for stem cell activation at the shoot apical meristem. elife. 2016;5: pubmed publisher
western blot; mouse; loading ...; fig 7d	Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, et al. IRF3 promotes adipose inflammation and insulin resistance and represses browning. J Clin Invest. 2016;126:2839-54 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2o	Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, et al. mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes. Antioxid Redox Signal. 2016;25:703-719 pubmed
western blot; human; 1:1000; loading ...; fig 4d	Choi H, Merceron C, Mangiavini L, Seifert E, Schipani E, Shapiro I, et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12:1631-46 pubmed publisher
western blot; mouse; loading ...; fig 1a	Averous J, Lambert Langlais S, Mesclon F, Carraro V, Parry L, Jousse C, et al. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Sci Rep. 2016;6:27698 pubmed publisher
western blot; human; loading ...; fig 1a	Wu X, Zhao L, Chen Z, Ji X, Qiao X, Jin Y, et al. FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. PLoS ONE. 2016;11:e0157100 pubmed publisher
western blot; human; fig 4	Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
western blot; mouse; loading ...; fig 6a	Rao E, Zhang Y, Li Q, Hao J, Egilmez N, Suttles J, et al. AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget. 2016;7:33783-95 pubmed publisher
western blot; mouse; fig 2	Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed publisher
western blot; mouse; 1:1000; fig 2	Walter C, Clemens L, MÃ¼ller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher
western blot; human; fig 2	Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed publisher
western blot; human; loading ...; fig 7c	Park J, Jung C, Seo M, Otto N, Grunwald D, Kim K, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12:547-64 pubmed publisher
western blot; human; fig 6	Strickland S, Vande Pol S. The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. J Virol. 2016;90:5611-5621 pubmed publisher
western blot; mouse; fig 1 western blot; human; fig 1	Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li J, et al. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016;126:1704-16 pubmed publisher
western blot; human; 1:1000; fig 2	Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher
western blot; human; loading ...; fig 3a	Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, et al. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int J Oncol. 2016;48:1825-36 pubmed publisher
western blot; human; fig 1b	Singh A, Joshi S, Zulcic M, Alcaraz M, GARLICH J, Morales G, et al. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma. PLoS ONE. 2016;11:e0150836 pubmed publisher
western blot; human; fig 4	Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2Î± kinases. Sci Signal. 2016;9:ra18 pubmed publisher
western blot; human; fig 2	Perumal D, Kuo P, Leshchenko V, Jiang Z, Divakar S, Cho H, et al. Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res. 2016;76:1225-36 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s1a western blot; human; 1:1000; loading ...; fig s4c	Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed publisher
western blot; mouse; loading ...; fig 1a	Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed publisher
western blot; mouse; 1:1000; fig 1 western blot; human; 1:1000; fig 2	Ding M, Bruick R, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol. 2016;18:319-27 pubmed publisher
western blot; mouse; 1:1000; fig 3b	Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2Î± suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
western blot; human; 1:1000; fig 1	Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed publisher
western blot; mouse; 1:1000; fig 1	Puente C, Hendrickson R, Jiang X. Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy. J Biol Chem. 2016;291:6026-35 pubmed publisher
western blot; human; 1:1000; fig 2	Cipriani G, Gibbons S, Verhulst P, Choi K, Eisenman S, Hein S, et al. Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying. Cell Mol Gastroenterol Hepatol. 2016;2:40-47 pubmed
western blot; human; 1:1000; fig 3	Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1Î±. J Cell Sci. 2016;129:817-30 pubmed publisher
western blot; human; 1:1000; fig 1a western blot; mouse; 1:1000; fig 1e	Carroll B, Maetzel D, Maddocks O, Otten G, Ratcliff M, Smith G, et al. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. elife. 2016;5: pubmed publisher
western blot; human; fig 4a	Chen K, Zeng J, Tang K, Xiao H, Hu J, Huang C, et al. miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA. Biol Cell. 2016;108:41-50 pubmed publisher
western blot; human; 1:1000; fig 6	Verbrugge S, Al M, Assaraf Y, Kammerer S, Chandrupatla D, Honeywell R, et al. Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Oncotarget. 2016;7:5240-57 pubmed publisher
western blot; human; loading ...; fig 1h	van Geldermalsen M, Wang Q, Nagarajah R, Marshall A, Thoeng A, Gao D, et al. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene. 2016;35:3201-8 pubmed publisher
western blot; human; loading ...; fig 4c	Fan S, Snell C, Turley H, Li J, McCormick R, Perera S, et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 2016;35:3004-15 pubmed publisher
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product information

SKU :

9205S

Product-Name :

Phospho-p70 S6 Kinase (Thr389) Antibody

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Western blot

Product-Category :

PI3K / Akt Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Polyclonal Antibody

MW :

70, 85

Host :

Rabbit

Target :

p70 S6k1 (Thr412) phosphate

Primary-Protein :

p70S6K

Alt-Names :

70 kDa ribosomal protein S6 kinase 1,KS6B1,P70S6K1,PS6K,RPS6KB1,Ribosomal protein S6 kinase I,Ribosomal protein S6 kinase beta-1,S6K,S6K-beta-1,S6K1,STK14A,Serine/threonine-protein kinase 14A,p70 S6 kinase alpha,p70 S6 kinase, alpha 1,p70 S6 kinase, alpha 2,p70 S6K-alpha,p70 S6KA,p70 ribosomal S6 kinase alpha,p70(S6K)-alpha,p70-S6K,p70-S6K 1,p70-alpha,ribosomal protein S6 kinase, 70kDa, polypeptide 1,serine/threonine kinase 14 alpha

more info or order :

Cell Signaling Technology product webpage