product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p70 S6 Kinase Antibody
catalog :
9202L
quantity :
300 ul
price :
574 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 22
Published Application/Species/DilutionReference
  • western blot; mouse
Dungan C, Li Z, Wright D, Williamson D. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve. 2016;53:107-17 pubmed publisher
  • western blot; human
Zhang L, Dai F, Cui L, Jing H, Fan P, Tan X, et al. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells. Biochim Biophys Acta. 2015;1853:377-87 pubmed publisher
  • western blot; human
Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed publisher
  • western blot; mouse
Krokowski D, Jobava R, Guan B, Farabaugh K, Wu J, Majumder M, et al. Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. J Biol Chem. 2015;290:17822-37 pubmed publisher
  • western blot; rat
  • immunocytochemistry; human
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
  • western blot; human; fig 9
  • western blot; mouse; fig 2
Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, et al. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol Cell Biol. 2015;35:1299-313 pubmed publisher
  • western blot; human; 1:1000; fig 6a,b
Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
  • western blot; human; 1:1000
Peng G, Yuan X, Yuan J, Liu Q, Dai M, Shen C, et al. miR-25 promotes glioblastoma cell proliferation and invasion by directly targeting NEFL. Mol Cell Biochem. 2015;409:103-11 pubmed publisher
  • western blot; human; fig 1
Chiang K, Chen H, Hsu S, Pang J, Wang S, Hsu J, et al. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther. 2015;9:4631-8 pubmed publisher
  • western blot; mouse; 1:1000
Bejarano E, Yuste A, Patel B, Stout R, Spray D, Cuervo A. Connexins modulate autophagosome biogenesis. Nat Cell Biol. 2014;16:401-14 pubmed publisher
  • western blot; mouse
Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos M, Pardo V, Miquilena-Colina M, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5:e1179 pubmed publisher
  • western blot; rat
Serizawa Y, Oshima R, Yoshida M, Sakon I, Kitani K, Goto A, et al. Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles. Biochem Biophys Res Commun. 2014;453:81-5 pubmed publisher
  • western blot; human
Subramani R, Lopez-Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
  • western blot; human; 1:1000
Jordan N, Dutkowski C, Barrow D, Mottram H, Hutcheson I, Nicholson R, et al. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Res. 2014;16:R12 pubmed publisher
  • western blot; human; fig 4
Su W, Chao T, Huang Y, Weng S, Jeng K, Lai M. Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol. 2011;85:10561-71 pubmed publisher
Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed publisher
Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors. 2009;27:12-21 pubmed publisher
Park J, Arakawa-Takeuchi S, Jinno S, Okayama H. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem. 2011;286:23132-41 pubmed publisher
Roczniak-Ferguson A, Petit C, Froehlich F, Qian S, Ky J, Angarola B, et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal. 2012;5:ra42 pubmed publisher
Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011;44:290-303 pubmed publisher
Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, et al. mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest. 2011;91:1584-95 pubmed publisher
Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli R, et al. Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res. 2010;13:571-9 pubmed publisher
product information
SKU :
9202L
Product-Name :
p70 S6 Kinase Antibody
Size :
300 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
70, 85
Host :
Rabbit
Target :
p70 S6k1
Primary-Protein :
p70S6K
Alt-Names :
70 kDa ribosomal protein S6 kinase 1,KS6B1,P70S6K1,PS6K,RPS6KB1,Ribosomal protein S6 kinase I,Ribosomal protein S6 kinase beta-1,S6K,S6K-beta-1,S6K1,STK14A,Serine/threonine-protein kinase 14A,p70 S6 kinase alpha,p70 S6 kinase, alpha 1,p70 S6 kinase, alpha 2,p70 S6K-alpha,p70 S6KA,p70 ribosomal S6 kinase alpha,p70(S6K)-alpha,p70-S6K,p70-S6K 1,p70-alpha,ribosomal protein S6 kinase, 70kDa, polypeptide 1,serine/threonine kinase 14 alpha
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.