| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; loading ...; fig 2g
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- western blot; mouse; loading ...; fig 1d, 3b
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- western blot; mouse; 1:1000; loading ...; fig s3c
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- western blot; human; loading ...; fig 2b
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- western blot; human; 1:1000; loading ...; fig 7e
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- western blot; mouse; loading ...; fig 5m
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- western blot; human; 1:1000; loading ...; fig 3c
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- western blot; mouse; loading ...; fig s2
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- western blot; human; 1:2000; loading ...; fig 3a
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- western blot; mouse; loading ...; fig 4a, 5a
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- western blot; mouse; 1:1000; loading ...; fig 3e
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- western blot; pigs ; loading ...; fig 4a
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- western blot; human; loading ...; fig 2d
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- western blot; mouse; 1:1000; loading ...; fig 3c
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- western blot; human; 1:1000; loading ...; fig 6a
| Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher |
- western blot; human; loading ...; fig 4f
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- western blot; human; 1:1000; loading ...; fig 6b
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- western blot; human; loading ...; fig 5c
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- western blot; human; 1:1000; loading ...; fig 3a
- western blot; mouse; 1:1000; loading ...; fig 4j
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- western blot; rat; 1:1000; loading ...; fig s4e
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- western blot; mouse; loading ...; fig 6b
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- western blot; mouse; loading ...; fig 3b
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- western blot; human; 1:1000; loading ...; fig 1b
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- western blot; mouse; loading ...; fig 10f
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- western blot; human; loading ...; fig 7b
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- western blot; human; 1:100; loading ...; fig 8a
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- western blot; rat; 1:1000; loading ...; fig 2d
- western blot; mouse; 1:1000; loading ...; fig 1a, 2e
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- western blot; human; loading ...; fig 1b
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- western blot; human; loading ...; fig ev3e
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- western blot; mouse; 1:1000; loading ...; fig 7a
| Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2d
| Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed publisher |
- western blot; human; loading ...; fig 10j
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- western blot; mouse; fig s3a
| Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Li H, Ren Y, Mao K, Hua F, Yang Y, Wei N, et al. FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. Biochem Biophys Res Commun. 2018;498:234-239 pubmed publisher |
- western blot; human; loading ...; fig 3c
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- western blot; human; loading ...; fig 5b
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- western blot; mouse; 1:1000; loading ...; fig 7g
- western blot; human; 1:1000; loading ...; fig 7e
| Zhang Y, Qu Y, Lin Y, Wu X, Chen H, Wang X, et al. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Nat Commun. 2017;8:464 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017;23:1055-1062 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7a
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- western blot; human; loading ...; fig 3j
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- western blot; human; loading ...; fig 3a
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- western blot; human; 1:500; loading ...; fig 2a
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- western blot; human; 1:1000; loading ...; fig 2c
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- western blot; mouse; loading ...; fig s7f
- western blot; human; loading ...; fig 1a
| Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher |
- western blot; human; loading ...; fig 7f
| Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch A, Muller S, et al. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. elife. 2017;6: pubmed publisher |
- western blot; mouse; loading ...; fig 4a
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- western blot; mouse; loading ...; fig 7a
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- western blot; mouse; loading ...; fig 6a
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- western blot; human; loading ...; fig 1d
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- western blot; human; 1:2000; loading ...; fig 9a
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- western blot; human; loading ...; fig 4a
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- western blot; mouse; 1:1000; loading ...; fig 4a
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- western blot; human; 1:1000; loading ...; fig 6d
| Yang J, Savvatis K, Kang J, Fan P, Zhong H, Schwartz K, et al. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun. 2016;7:13710 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Zhang H, Wang W, Ren L, Zhao X, Wang Z, Zhuang D, et al. The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis. Cell Physiol Biochem. 2016;40:1079-1093 pubmed |
- western blot; human; loading ...; fig 2a
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- western blot; human; fig 2e
| Cramer S, Saha A, Liu J, Tadi S, Tiziani S, Yan W, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2017;23:120-127 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, et al. The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway. Oncogenesis. 2016;5:e260 pubmed publisher |
- western blot; human; fig 2
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- western blot; human; 1:1000; fig 1
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- western blot; human; 1:1000; loading ...; fig 5b
- western blot; rat; 1:1000; loading ...; fig 5a
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- western blot; mouse; loading ...; fig 6a
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- western blot; mouse; loading ...; fig 5a
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- western blot; mouse; 1:1000; loading ...; fig 5k
| Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, et al. mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes. Antioxid Redox Signal. 2016;25:703-719 pubmed |
- western blot; human; 1:1000; loading ...; fig 4d
| Choi H, Merceron C, Mangiavini L, Seifert E, Schipani E, Shapiro I, et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12:1631-46 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher |
- western blot; mouse; loading ...; fig 1a
| Averous J, Lambert Langlais S, Mesclon F, Carraro V, Parry L, Jousse C, et al. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Sci Rep. 2016;6:27698 pubmed publisher |
- western blot; human; loading ...; fig 1a
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- western blot; human; fig 4
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- western blot; human; 1:1000; fig 6
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- western blot; mouse; 1:1000; fig 3
- western blot; human; 1:1000; fig 3
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- western blot; chicken; fig 7
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- western blot; rat; fig 10
- western blot; mouse; fig 1
| Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;12:1372-89 pubmed publisher |
- western blot; mouse; fig 7
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- western blot; human; 1:3000; fig 8
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- western blot; human; loading ...; fig 7c
| Park J, Jung C, Seo M, Otto N, Grunwald D, Kim K, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12:547-64 pubmed publisher |
- western blot; human; fig 1
- western blot; mouse; fig 1
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- western blot; dogs; 1:1000; fig 3A
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- western blot; mouse; fig s6
| Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher |
- western blot; human; fig 2
| Perumal D, Kuo P, Leshchenko V, Jiang Z, Divakar S, Cho H, et al. Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res. 2016;76:1225-36 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s4c
- western blot; mouse; 1:1000; loading ...; fig s1a
| Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed publisher |
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- western blot; human; 1:1000; fig 2
| Ding M, Bruick R, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol. 2016;18:319-27 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Cipriani G, Gibbons S, Verhulst P, Choi K, Eisenman S, Hein S, et al. Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying. Cell Mol Gastroenterol Hepatol. 2016;2:40-47 pubmed |
- western blot; human; 1:1000; fig 5
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- western blot; human; 1:1000; fig 3
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- western blot; human; 1:1000; fig 1a
- western blot; mouse; 1:1000; fig 1e
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- western blot; human; loading ...; fig 4a
| Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed publisher |
- western blot; mouse; fig 6
| He J, Johnson J, Monfregola J, Ramadass M, Pestonjamasp K, Napolitano G, et al. Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses. Mol Biol Cell. 2016;27:572-87 pubmed publisher |
- western blot; human; fig 4a
| Chen K, Zeng J, Tang K, Xiao H, Hu J, Huang C, et al. miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA. Biol Cell. 2016;108:41-50 pubmed publisher |
- western blot; mouse; fig 8
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- western blot; human; loading ...; fig 1h
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- western blot; human; loading ...; fig 4c
| Fan S, Snell C, Turley H, Li J, McCormick R, Perera S, et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 2016;35:3004-15 pubmed publisher |
- western blot; human; fig 1
- western blot; mouse; fig 6
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- western blot; human; loading ...; fig 4b
| Reuther C, Heinzle V, Spampatti M, Vlotides G, de Toni E, Spöttl G, et al. Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition. Neuroendocrinology. 2016;103:383-401 pubmed publisher |
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- western blot; human; 1:1000; loading ...; fig 3b, 4b
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