product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CREB (48H2) Rabbit mAb
catalog :
9197L
quantity :
300 ul
price :
574 USD
clonality :
monoclonal
host :
rabbit
reactivity :
, human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 40
Published Application/Species/DilutionReference
  • western blot; human
Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
  • western blot; human; fig 4
Iwano S, Satou A, Matsumura S, Sugiyama N, Ishihama Y, Toyoshima F. PCTK1 regulates integrin-dependent spindle orientation via protein kinase A regulatory subunit KAP0 and myosin X. Mol Cell Biol. 2015;35:1197-208 pubmed publisher
  • chromatin immunoprecipitation; rat; fig 2
Arango-Lievano M, Lambert W, Bath K, Garabedian M, Chao M, Jeanneteau F. Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment. Proc Natl Acad Sci U S A. 2015;112:15737-42 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
  • western blot; human
Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  • western blot; mouse; 1:1000
Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed publisher
  • chromatin immunoprecipitation; human
Chae H, Mitton B, Lacayo N, Sakamoto K. Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA. Leukemia. 2015;29:1379-89 pubmed publisher
  • western blot; mouse
Bruno N, Kelly K, Hawkins R, Bramah-Lawani M, Amelio A, Nwachukwu J, et al. Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J. 2014;33:1027-43 pubmed publisher
  • western blot; mouse; fig s2b
Chu Y, Gomez Rosso L, Huang P, Wang Z, Xu Y, Yao X, et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014;24:1250-65 pubmed publisher
  • western blot; human
Ihunnah C, Wada T, Philips B, Ravuri S, Gibbs R, Kirisci L, et al. Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis. Mol Cell Biol. 2014;34:1682-94 pubmed publisher
  • western blot; mouse; 1:1000
Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach S, Ortega-Alonso A, Tomppo L, et al. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet. 2014;23:5859-65 pubmed publisher
  • western blot; human; fig 3
  • western blot; dog; fig 3
Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, et al. Analysis of microRNA-203 function in CREB/MITF/RAB27a pathway: comparison between canine and human melanoma cells. Vet Comp Oncol. 2014;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Antony N, Weir J, McDougall A, Mantamadiotis T, Meikle P, Cole T, et al. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS ONE. 2013;8:e59763 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human
Lambert W, Xu C, Neubert T, Chao M, Garabedian M, Jeanneteau F. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol. 2013;33:3700-14 pubmed publisher
Shoshan E, Mobley A, Braeuer R, Kamiya T, Huang L, Vasquez M, et al. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat Cell Biol. 2015;17:311-21 pubmed publisher
Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014;47:197-202 pubmed
Singh R, Shankar B, Sainis K. TGF-β1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal. 2014;26:1604-15 pubmed publisher
Lin X, Feng L, Xie C, Chen D, Pei Z, Liang X, et al. Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado-Joseph disease. Int J Dev Neurosci. 2014;38:17-22 pubmed publisher
Musazzi L, Seguini M, Mallei A, Treccani G, Pelizzari M, Tornese P, et al. Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine. BMC Neurosci. 2014;15:119 pubmed publisher
Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R. S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo). 2014;60:291-6 pubmed
Shin M, Jung W, Kim H, Roh S, Kwak C, Kim C, et al. The ganglioside GQ1b regulates BDNF expression via the NMDA receptor signaling pathway. Neuropharmacology. 2014;77:414-21 pubmed publisher
Shi Z, Chen L, Li S, Chen S, Sun X, Sun L, et al. Chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus. Psychopharmacology (Berl). 2013;230:245-60 pubmed publisher
Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed publisher
Yoshida K, Fujino H, Otake S, Seira N, Regan J, Murayama T. Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. Eur J Pharmacol. 2013;718:408-17 pubmed publisher
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol. 2013;33:2996-3010 pubmed publisher
Thorsell A, Tapocik J, Liu K, Zook M, Bell L, Flanigan M, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013;33:10132-42 pubmed publisher
Kunda S, Cheriyan J, Hur M, Balsara R, Castellino F. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PLoS ONE. 2013;8:e81405 pubmed publisher
Klinz F, Korkmaz Y, Cho B, Raab W, Addicks K. Transcription factor CREB is phosphorylated in human molar odontoblasts and cementoblasts in vivo. Histochem Cell Biol. 2013;139:615-20 pubmed publisher
Wang H, Li Y, Dun L, Xu Y, Jin S, Du J, et al. Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain. Phytomedicine. 2013;20:1039-45 pubmed publisher
Ghosh R, Garcia G, Crosby K, Inoue H, Thompson I, Troyer D, et al. Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. Neoplasia. 2007;9:893-9 pubmed
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed
Chung Y, Kim H, Kim I, Yim M, Chock P. Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respective. J Biol Chem. 2011;286:29681-90 pubmed publisher
Banno Y, Nemoto S, Murakami M, Kimura M, Ueno Y, Ohguchi K, et al. Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. J Neurochem. 2008;104:1372-86 pubmed
Kumar A, Bhaskaran S, Ganapathy M, Crosby K, Davis M, Kochunov P, et al. Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract. Clin Cancer Res. 2007;13:2784-94 pubmed
Ishida E, Hashimoto K, Shimizu H, Okada S, Satoh T, Kato I, et al. Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line. PLoS ONE. 2012;7:e50918 pubmed publisher
Gehani S, Agrawal-Singh S, Dietrich N, Christophersen N, Helin K, Hansen K. Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell. 2010;39:886-900 pubmed publisher
Huang Y, Sitwala K, Bronstein J, Sanders D, Dandekar M, Collins C, et al. Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood. 2012;119:388-98 pubmed publisher
Almeida L, Murray P, Zielke H, Roby C, Kingsbury T, Krueger B. Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. J Neurosci. 2009;29:12702-10 pubmed publisher
Kondo M, Inamura H, Matsumura K, Matsuoka M. Cadmium activates extracellular signal-regulated kinase 5 in HK-2 human renal proximal tubular cells. Biochem Biophys Res Commun. 2012;421:490-3 pubmed publisher
Gaddini L, Villa M, Matteucci A, Mallozzi C, Petrucci T, Di Stasi A, et al. Early effects of high glucose in retinal tissue cultures Renin-Angiotensin system-dependent and -independent signaling. Neurobiol Dis. 2009;35:278-85 pubmed publisher
product information
SKU :
9197L
Product-Name :
CREB (48H2) Rabbit mAb
Size :
300 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Mk, Dm
Applications :
Chromatin Immunoprecipitation
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
43
Host :
Rabbit
Target :
CREB
Primary-Protein :
CREB
Alt-Names :
CREB,CREB-1,CREB1,Cyclic AMP-responsive element-binding protein 1,MGC9284,active transcription factor CREB,cAMP responsive element binding protein 1,cAMP-response element-binding protein-1,cAMP-responsive element-binding protein 1,transactivator protein
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.