product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CREB (48H2) Rabbit mAb
catalog :
9197
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
48H2
reactivity :
human, mouse, rat, dogs, pigs , domestic sheep
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, proximity ligation assay, other, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 207
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig 7
Luo W, Mizuno H, Iwata R, Nakazawa S, Yasuda K, Itohara S, et al. Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo. Sci Rep. 2016;6:35747 pubmed publisher
  • western blot knockout validation; human; fig 4g
Guo Y, Wang L, Li B, Xu H, Yang J, Zheng L, et al. Wnt/?-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016;7:42513-42526 pubmed publisher
  • western blot; human; loading ...; fig s10f
Ni Y, Hu B, Wu G, Shao Z, Zheng Y, Zhang R, et al. Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI. Theranostics. 2021;11:9431-9451 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Wang Q, Qin F, Wang H, Yang H, Liu Q, Li Z, et al. Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice. Front Neurosci. 2021;15:698967 pubmed publisher
  • western blot; mouse; loading ...; fig 4
Lim D, Kim M, Yoon M, Lee J, Lee C, Um M. 1,3-Dicaffeoylquinic Acid as an Active Compound of Arctium lappa Root Extract Ameliorates Depressive-Like Behavior by Regulating Hippocampal Nitric Oxide Synthesis in Ovariectomized Mice. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 5e
  • western blot; mouse; loading ...; fig 4a
Chen H, Teng Y, Chen X, Liu Z, Geng F, Liu Y, et al. Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase. CNS Neurosci Ther. 2021;27:1300-1312 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 11a
Xiao J, Cai T, Fang Y, Liu R, Flores J, Wang W, et al. Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model. J Neuroinflammation. 2021;18:160 pubmed publisher
  • western blot; mouse; loading ...; fig 5m
Swarnkar S, Avchalumov Y, Espadas I, Grinman E, Liu X, Raveendra B, et al. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. Cell Rep. 2021;36:109369 pubmed publisher
  • western blot; rat; loading ...; fig 2a
Kim Y, Lee J, Kim H, Jang J, Choung Y. Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7e
Qiao Y, Jin T, Guan S, Cheng S, Wen S, Zeng H, et al. Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1. Oncogene. 2021;40:4198-4213 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Al Zahrani K, Abou Hamad J, Pascoal J, Labrèche C, Garland B, Sabourin L. AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res. 2021;23:55 pubmed publisher
  • western blot; human; loading ...; fig 4c
Nakajima W, Miyazaki K, Asano Y, Kubota S, Tanaka N. Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Genes (Basel). 2021;12: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Arveseth C, Happ J, Hedeen D, Zhu J, Capener J, Klatt Shaw D, et al. Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021;19:e3001191 pubmed publisher
  • western blot; human; loading ...; fig 3c
Wang Z, Zhang X, Tian X, Yang Y, Ma L, Wang J, et al. CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Oncol Rep. 2021;45: pubmed publisher
  • western blot; human; fig 2a
Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
  • western blot; rat; loading ...; fig 3n
Ruiz Velasco A, Zi M, Hille S, Azam T, Kaur N, Jiang J, et al. Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Qin Y, Chen W, Jiang G, Zhou L, Yang X, Li H, et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Sci Adv. 2020;6:eaaw9960 pubmed publisher
  • western blot; domestic sheep; 1:1000; loading ...; fig s10c
Schiffner R, Bischoff S, Lehmann T, Irintchev A, Nistor M, Lemke C, et al. Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model. Int J Mol Sci. 2020;21: pubmed publisher
  • western blot; human; loading ...; fig 5f, 7
Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 2c
  • western blot; mouse; 1:1000; loading ...; fig 1m, 5e
Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020;19:e13055 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:6000; loading ...; fig 2i
Lu W, Chen S, Chen X, Hu J, Xuan A, Ding S. Localization of area prostriata and its connections with primary visual cortex in rodent. J Comp Neurol. 2020;528:389-406 pubmed publisher
  • western blot; mouse; 1:250; loading ...; fig 6b
Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, et al. Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone. Arthritis Res Ther. 2019;21:247 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Kim J, Cho J, Kim S, Kang H, Kim D, Kim V, et al. Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy. J Clin Invest. 2019;129:4207-4223 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2k
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, et al. The mechanosensitive Piezo1 channel is required for bone formation. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 4d
Jin H, Xue L, Mo L, Zhang D, Guo X, Xu J, et al. Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer. Cell Adh Migr. 2019;13:236-248 pubmed publisher
  • western blot; human; loading ...; fig 6a
Gu C, Wang L, Zurawski S, Oh S. Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation. J Immunol. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1b
Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher
  • proximity ligation assay; human; loading ...; fig 1e
  • immunohistochemistry - paraffin section; human; loading ...; fig 2a
  • immunoprecipitation; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 1b
Du H, LE Y, Sun F, Li K, Xu Y. ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells. Anal Cell Pathol (Amst). 2019;2019:1575031 pubmed publisher
  • western blot; mouse; fig 3a
Su L, Zhou L, Chen F, Wang H, Qian H, Sheng Y, et al. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019;38: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2h
Joy M, Ben Assayag E, Shabashov Stone D, Liraz Zaltsman S, Mazzitelli J, Arenas M, et al. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury. Cell. 2019;176:1143-1157.e13 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6b
Chen H, Hu B, Lv X, Zhu S, Zhen G, Wan M, et al. Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nat Commun. 2019;10:181 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6b
Wang L, Chai Y, Li C, Liu H, Su W, Liu X, et al. Oxidized phospholipids are ligands for LRP6. Bone Res. 2018;6:22 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6e
Velázquez Villegas L, Perino A, Lemos V, Zietak M, Nomura M, Pols T, et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun. 2018;9:245 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4a
Jana M, Ghosh S, Pahan K. Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis. Neurochem Res. 2018;43:407-419 pubmed publisher
  • western blot; mouse; fig 5a
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, et al. α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. FASEB J. 2018;32:488-499 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, et al. Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction. J Exp Med. 2017;214:1877-1888 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Hossain M, Oomura Y, Katafuchi T. Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Mol Neurobiol. 2018;55:3408-3425 pubmed publisher
  • western blot; human; loading ...; fig 6a
Almeida L, Neto M, Sousa L, Tannous M, Curti C, Leopoldino A. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. Oncotarget. 2017;8:26802-26818 pubmed publisher
  • western blot; human; loading ...; fig 3a
Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Patil M, Sharma B, Elattar S, Chang J, Kapil S, Yuan J, et al. Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning. Diabetes. 2017;66:1611-1625 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Tao C, Hsu W, Ma Y, Cheng S, Lee E. Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. 2017;24:597-614 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
Akhmedov D, Mendoza Rodriguez M, Rajendran K, Rossi M, Wess J, Berdeaux R. Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; rat; loading ...; fig 8a
Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, et al. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 2016;10:569 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:800; fig 1c
Yu X, Curlik D, Oh M, Yin J, Disterhoft J. CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; fig 7
Quinn S, Graves S, Dains McGahee C, Friedman E, Hassan H, Witkowski P, et al. Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells. Mol Carcinog. 2017;56:1344-1360 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a, s3a
Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Yan X, Liu J, Ye Z, Huang J, He F, Xiao W, et al. CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation. PLoS ONE. 2016;11:e0162784 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 5b, 5c
Olianas M, Dedoni S, Onali P. LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells. J Pharmacol Exp Ther. 2016;359:340-353 pubmed
  • western blot; human; loading ...; fig 4b
Wang Y, Lin S, Hsieh P, Hung S. Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. Biochem Biophys Res Commun. 2016;478:689-95 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
  • western blot; rat; 1:1000; fig 4
Zhang Y, Lin R, Tao J, Wu Y, Chen B, Yu K, et al. Electroacupuncture improves cognitive ability following cerebral ischemia reperfusion injury via CaM-CaMKIV-CREB signaling in the rat hippocampus. Exp Ther Med. 2016;12:777-782 pubmed
  • western blot; human; loading ...; fig 3a
Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed publisher
  • western blot; mouse; 1:500; fig 3
Yin Y, Gao D, Wang Y, Wang Z, Wang X, Ye J, et al. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016;113:E3773-81 pubmed publisher
  • western blot; human; 1:1000; fig 3
Qiao Y, Qian Y, Wang J, Tang X. Melanoma cell adhesion molecule stimulates yes-associated protein transcription by enhancing CREB activity via c-Jun/c-Fos in hepatocellular carcinoma cells. Oncol Lett. 2016;11:3702-3708 pubmed
  • western blot; mouse; 1:1000; fig s4
Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:800; fig 1
Antony N, McDougall A, Mantamadiotis T, Cole T, Bird A. Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms. Sci Rep. 2016;6:25569 pubmed publisher
  • western blot; human; fig 2c
Park S, Lee J, Herbst R, Koo J. GSK-3? Is a Novel Target of CREB and CREB-GSK-3? Signaling Participates in Cell Viability in Lung Cancer. PLoS ONE. 2016;11:e0153075 pubmed publisher
  • western blot; human
Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 10a
Anastasiadou S, Knöll B. The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration. Exp Neurol. 2016;279:243-260 pubmed publisher
  • western blot; human; loading ...; fig 4a
Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Antony A, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, et al. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016;7:10955 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Johanns M, Lai Y, Hsu M, Jacobs R, Vertommen D, Van Sande J, et al. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nat Commun. 2016;7:10856 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7
Choi D, Lee K, Lee J. Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia. Mol Med Rep. 2016;13:2981-90 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • western blot; human; fig 5
Urnukhsaikhan E, Cho H, Mishig Ochir T, Seo Y, Park J. Pulsed electromagnetic fields promote survival and neuronal differentiation of human BM-MSCs. Life Sci. 2016;151:130-138 pubmed publisher
  • western blot; rat; 1:1000; fig 4a
Molteni R, Rossetti A, Savino E, Racagni G, Calabrese F. Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices. Neural Plast. 2016;2016:2592319 pubmed publisher
  • chromatin immunoprecipitation; human; fig 4
  • western blot; mouse; 1:2000; fig 4
Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Bian Y, Yang L, Wang Z, Wang Q, Zeng L, Xu G. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice. Neural Plast. 2015;2015:627837 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Bertoldo M, Guibert E, Faure M, Guillou F, Ramé C, Nadal Desbarats L, et al. Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality. Mol Cell Endocrinol. 2016;423:96-112 pubmed publisher
  • western blot; mouse; 1:1000; fig 4a
Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep. 2016;6:18899 pubmed publisher
  • chromatin immunoprecipitation; rat; fig 2
Arango Lievano M, Lambert W, Bath K, Garabedian M, Chao M, Jeanneteau F. Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment. Proc Natl Acad Sci U S A. 2015;112:15737-42 pubmed publisher
  • western blot; mouse; fig 2
Wang Y, Zhang Y, Hu W, Xie S, Gong C, Iqbal K, et al. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Sci Rep. 2015;5:15709 pubmed publisher
  • western blot; mouse; loading ...; fig 5f
Li M, Quan C, Toth R, Campbell D, MacKintosh C, Wang H, et al. Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders. J Biol Chem. 2015;290:30030-41 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 5e
  • EMSA; mouse; loading ...; fig 5d
Zhang Y, Li W, Zhu M, Li Y, Xu Z, Zuo B. FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB. Cell Signal. 2016;28:60-73 pubmed publisher
  • western blot; mouse; fig 6
Yang C, Lowther K, Lalioti M, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology. 2016;157:405-16 pubmed publisher
  • western blot; mouse; fig 5
Yang L, McKnight G. Hypothalamic PKA regulates leptin sensitivity and adiposity. Nat Commun. 2015;6:8237 pubmed publisher
  • western blot; human; fig 5
Harmeier A, Obermueller S, Meyer C, Revel F, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharmacol. 2015;25:2049-61 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
  • western blot; mouse; fig 3
Chen B, Ma X, Geng Z, Huang S, Zhai L, Guo Y, et al. Up-regulation of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) contributes to BDNF-enhanced neurotransmitter release. J Neurochem. 2015;135:453-65 pubmed publisher
  • western blot; rat; fig 5
Kim K, Byeon G, Kim H, Baek S, Shin S, Koo S. Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model. J Korean Med Sci. 2015;30:1189-96 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Cheng C, Lin J, Tang N, Kao S, Hsieh C. Electroacupuncture at different frequencies (5Hz and 25Hz) ameliorates cerebral ischemia-reperfusion injury in rats: possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 2015;15:241 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Zhang R, Huang M, Cao Z, Qi J, Qiu Z, Chiang L. MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 2015;11:19 pubmed publisher
  • western blot; human
Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  • western blot; human; 1:1000; fig 3
Chakraborty A, Diefenbacher M, Mylona A, Kassel O, Behrens A. The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nat Commun. 2015;6:6782 pubmed publisher
  • western blot; human; fig 2
Shoshan E, Mobley A, Braeuer R, Kamiya T, Huang L, Vasquez M, et al. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat Cell Biol. 2015;17:311-21 pubmed publisher
  • western blot; rat; fig 3
Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Subbanna S, Nagre N, Umapathy N, Pace B, Basavarajappa B. Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
  • western blot; human; fig 4
Iwano S, Satou A, Matsumura S, Sugiyama N, Ishihama Y, Toyoshima F. PCTK1 regulates integrin-dependent spindle orientation via protein kinase A regulatory subunit KAP0 and myosin X. Mol Cell Biol. 2015;35:1197-208 pubmed publisher
  • chromatin immunoprecipitation; human
Chae H, Mitton B, Lacayo N, Sakamoto K. Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA. Leukemia. 2015;29:1379-89 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Wu C, Hung T, Chen C, Ke C, Lee C, Wang P, et al. Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling. PLoS ONE. 2014;9:e113397 pubmed publisher
  • western blot; dogs; fig 3
  • western blot; human; fig 3
Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, et al. Analysis of microRNA-203 function in CREB/MITF/RAB27a pathway: comparison between canine and human melanoma cells. Vet Comp Oncol. 2016;14:384-394 pubmed publisher
  • western blot; human; 1:1000; fig 6
Leung C, Yeung T, Yip K, Pradeep S, Balasubramanian L, Liu J, et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014;5:5092 pubmed publisher
  • western blot; mouse; fig s2b
Chu Y, Gómez Rosso L, Huang P, Wang Z, Xu Y, Yao X, et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014;24:1250-65 pubmed publisher
  • western blot; mouse; 1:1000
Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed publisher
  • western blot; pigs ; fig 3
Chen Y, Zheng Z, Zhu X, Shi Y, Tian D, Zhao F, et al. Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and Polysialylation. Mol Neurobiol. 2015;52:256-69 pubmed publisher
  • western blot; human; 1:1000
Morris M, Gilliam E, Button J, Li L. Dynamic modulation of innate immune response by varying dosages of lipopolysaccharide (LPS) in human monocytic cells. J Biol Chem. 2014;289:21584-90 pubmed publisher
  • western blot; mouse; 1:1000
Ramos A, Rodríguez Seoane C, Rosa I, Trossbach S, Ortega Alonso A, Tomppo L, et al. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet. 2014;23:5859-65 pubmed publisher
  • western blot; human; fig 2
Moody S, Schinzel A, Singh S, Izzo F, Strickland M, Luo L, et al. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 2015;34:2061-71 pubmed publisher
  • western blot; rat; fig e3
Madiraju A, Erion D, Rahimi Y, Zhang X, Braddock D, Albright R, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014;510:542-6 pubmed publisher
  • western blot; human; loading ...; fig 2d
Shaiken T, Opekun A. Dissecting the cell to nucleus, perinucleus and cytosol. Sci Rep. 2014;4:4923 pubmed publisher
  • western blot; mouse
Bruno N, Kelly K, Hawkins R, Bramah Lawani M, Amelio A, Nwachukwu J, et al. Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J. 2014;33:1027-43 pubmed publisher
  • western blot; human
Ihunnah C, Wada T, Philips B, Ravuri S, Gibbs R, Kirisci L, et al. Estrogen sulfotransferase/SULT1E1 promotes human adipogenesis. Mol Cell Biol. 2014;34:1682-94 pubmed publisher
  • western blot; mouse; 1:1000
Chen L, Dai J, Wang Z, Zhang H, Huang Y, Zhao Y. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 ? -CREB Signaling Pathway. Evid Based Complement Alternat Med. 2014;2014:506735 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human
Lambert W, Xu C, Neubert T, Chao M, Garabedian M, Jeanneteau F. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol. 2013;33:3700-14 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Antony N, Weir J, McDougall A, Mantamadiotis T, Meikle P, Cole T, et al. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS ONE. 2013;8:e59763 pubmed publisher
Wang L, Cho Y, Tang Y, Wang J, Park J, Wu Y, et al. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018;28:787-802 pubmed publisher
Yang Y, Liu N, He Y, Liu Y, Ge L, Zou L, et al. Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP. Nat Commun. 2018;9:1504 pubmed publisher
Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, et al. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Oncogene. 2017;36:5829-5839 pubmed publisher
Ham S, Lee Y, Jo M, Kim H, Kang H, Jo A, et al. Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model. Sci Rep. 2017;7:525 pubmed publisher
Carroll S, Zhang E, Wang B, Leclair K, Rahman A, Cohen D, et al. Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling. PLoS ONE. 2017;12:e0173823 pubmed publisher
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
Zhou M, Greenhill S, Huang S, Silva T, Sano Y, Wu S, et al. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. elife. 2016;5: pubmed publisher
Cho W, Han J. Differences in the Flexibility of Switching Learning Strategies and CREB Phosphorylation Levels in Prefrontal Cortex, Dorsal Striatum and Hippocampus in Two Inbred Strains of Mice. Front Behav Neurosci. 2016;10:176 pubmed
Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, et al. Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain. Aging Cell. 2017;16:39-51 pubmed publisher
Chen C, Chen N, Feng C, Cheng S, Hung H, Tsui K, et al. A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects. Mar Drugs. 2016;14: pubmed publisher
Harada N, Ishihara M, Horiuchi H, Ito Y, Tabata H, Suzuki Y, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS ONE. 2016;11:e0162252 pubmed publisher
Gallardo Montejano V, Saxena G, Kusminski C, Yang C, McAfee J, Hahner L, et al. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1?/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun. 2016;7:12723 pubmed publisher
Lannes J, L hôte D, Fernandez Vega A, Garrel G, Laverrière J, Cohen Tannoudji J, et al. A regulatory loop between miR-132 and miR-125b involved in gonadotrope cells desensitization to GnRH. Sci Rep. 2016;6:31563 pubmed publisher
Gomes J, Nogueira R, Vieira M, Santos S, Ferraz Nogueira J, Relvas J, et al. Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death Differ. 2016;23:1749-1764 pubmed publisher
Li D, Cao W. Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett's Esophageal Adenocarcinoma Cells. Sci Rep. 2016;6:31538 pubmed publisher
Brandt N, Gunnarsson T, Hostrup M, Tybirk J, Nybo L, Pilegaard H, et al. Impact of adrenaline and metabolic stress on exercise-induced intracellular signaling and PGC-1? mRNA response in human skeletal muscle. Physiol Rep. 2016;4: pubmed publisher
Steven A, Leisz S, Sychra K, Hiebl B, Wickenhauser C, Mougiakakos D, et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization. Oncotarget. 2016;7:52061-52084 pubmed publisher
Li K, Liang J, Lin Y, Zhang H, Xiao X, Tan Y, et al. A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1. Oncotarget. 2016;7:48443-48455 pubmed publisher
Hallenborg P, Siersbæk M, Barrio Hernandez I, Nielsen R, Kristiansen K, Mandrup S, et al. MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3. Cell Death Dis. 2016;7:e2289 pubmed publisher
Akhmedov D, Rajendran K, Mendoza Rodriguez M, Berdeaux R. Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity. PLoS ONE. 2016;11:e0158274 pubmed publisher
Cheng C, Tang N, Kao S, Hsieh C. Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats. PLoS ONE. 2016;11:e0155748 pubmed publisher
Shen Z, Wang B, Jiang K, Ye C, Cheng C, Yan Y, et al. Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. Oncotarget. 2016;7:35092-105 pubmed publisher
Kitaoka K, Kawata S, Yoshida T, Kadoriku F, Kitamura M. Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line. PLoS ONE. 2016;11:e0154167 pubmed publisher
Jiang Y, Yang S, Tao J, Lin Z, Ye X, You Y, et al. Opposing needling promotes behavior recovery and exerts neuroprotection via the cAMP/PKA/CREB signal transduction pathway in transient MCAO rats. Mol Med Rep. 2016;13:2060-70 pubmed publisher
Sunkel B, Wu D, Chen Z, Wang C, Liu X, Ye Z, et al. Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic Acids Res. 2016;44:4105-22 pubmed publisher
Ru Y, Huang Y, Liu H, Du J, Meng Z, Dou Z, et al. α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways. Sci Rep. 2015;5:18619 pubmed publisher
Bartolotti N, Segura L, Lazarov O. Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice. J Alzheimers Dis. 2016;50:477-89 pubmed publisher
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed publisher
Dho S, Kim J, Kwon E, Lim J, Park S, Kwon K. NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin. Oncotarget. 2015;6:39235-46 pubmed publisher
Ikoma Seki K, Nakamura K, Morishita S, Ono T, Sugiyama K, Nishino H, et al. Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes. PLoS ONE. 2015;10:e0141378 pubmed publisher
Garcia Alvarez G, Shetty M, Lu B, Yap K, Oh Hora M, Sajikumar S, et al. Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes. Front Behav Neurosci. 2015;9:180 pubmed publisher
Zheng Y, Wu J, Feng X, Jia Y, Huang J, Hao Z, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS ONE. 2015;10:e0130055 pubmed publisher
Namkoong S, Lee K, LEE J, Park R, Lee E, Jang I, et al. The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase. Autophagy. 2015;11:756-68 pubmed publisher
Devi L, Ohno M. TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice. Transl Psychiatry. 2015;5:e562 pubmed publisher
Crawford R, Prescott E, Sylvester C, Higdon A, Shan J, Kilberg M, et al. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. J Biol Chem. 2015;290:15878-91 pubmed publisher
Munari L, Provensi G, Passani M, Galeotti N, Cassano T, Benetti F, et al. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Int J Neuropsychopharmacol. 2015;18:pyv045 pubmed publisher
Lin L, Lee J, Bongmba O, Ma X, Zhu X, Sheikh Hamad D, et al. The suppression of ghrelin signaling mitigates age‐associated thermogenic impairment. Aging (Albany NY). 2014;6:1019-32 pubmed
Shin S, Kim T, Lee H, Kang J, Lee J, Cho K, et al. The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes. Nat Commun. 2014;5:5777 pubmed publisher
Altmann P, Mildner M, Haider T, Traxler D, Beer L, Ristl R, et al. Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia. F1000Res. 2014;3:131 pubmed publisher
Müller I, Beissert S, Kulms D. Anti-apoptotic NF-κB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production. J Invest Dermatol. 2015;135:851-860 pubmed publisher
Musazzi L, Seguini M, Mallei A, Treccani G, Pelizzari M, Tornese P, et al. Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine. BMC Neurosci. 2014;15:119 pubmed publisher
Yong S, Lim M, Low C, Wong B. Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. Sci Rep. 2014;4:6580 pubmed publisher
Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R. S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo). 2014;60:291-6 pubmed
Lin X, Feng L, Xie C, Chen D, Pei Z, Liang X, et al. Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado-Joseph disease. Int J Dev Neurosci. 2014;38:17-22 pubmed publisher
Roy A, Modi K, Khasnavis S, Ghosh S, Watson R, Pahan K. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. PLoS ONE. 2014;9:e101883 pubmed publisher
Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, et al. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain. 2014;10:45 pubmed publisher
Li B, Jie W, Huang L, Wei P, Li S, Luo Z, et al. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci. 2014;17:1055-63 pubmed publisher
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, et al. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014;4:5312 pubmed publisher
Izumi Y, Burg M, Ferraris J. 14-3-3-? and -{varepsilon} contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity. Physiol Rep. 2014;2:e12000 pubmed publisher
Singh R, Shankar B, Sainis K. TGF-?1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal. 2014;26:1604-15 pubmed publisher
Kasinski A, Dong X, Khuri F, BOSS J, Fu H. Transcriptional regulation of YWHAZ, the gene encoding 14-3-3?. PLoS ONE. 2014;9:e93480 pubmed publisher
Kunda S, Cheriyan J, Hur M, Balsara R, Castellino F. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PLoS ONE. 2013;8:e81405 pubmed publisher
Kovacevic Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014;47:197-202 pubmed
Hu W, Jin L, Jiang C, Long G, Scolyer R, Wu Q, et al. AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma. Cell Death Dis. 2013;4:e914 pubmed publisher
Shin M, Jung W, Kim H, Roh S, Kwak C, Kim C, et al. The ganglioside GQ1b regulates BDNF expression via the NMDA receptor signaling pathway. Neuropharmacology. 2014;77:414-21 pubmed publisher
Fu J, Akhmedov D, Berdeaux R. The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. PLoS ONE. 2013;8:e78522 pubmed publisher
Devi L, Ohno M. Deletion of the eIF2? Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease. PLoS ONE. 2013;8:e77335 pubmed publisher
Yoshida K, Fujino H, Otake S, Seira N, Regan J, Murayama T. Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to G?i and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. Eur J Pharmacol. 2013;718:408-17 pubmed publisher
Huang Z, Li S, Song W, Li X, Li Q, Zhang Z, et al. Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/?-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. PLoS ONE. 2013;8:e70077 pubmed publisher
Tian X, Hua F, Sandhu H, Chao D, Balboni G, Salvadori S, et al. Effect of ?-opioid receptor activation on BDNF-TrkB vs. TNF-? in the mouse cortex exposed to prolonged hypoxia. Int J Mol Sci. 2013;14:15959-76 pubmed publisher
Pérez Gómez A, Tasker R. Transient domoic acid excitotoxicity increases BDNF expression and activates both MEK- and PKA-dependent neurogenesis in organotypic hippocampal slices. BMC Neurosci. 2013;14:72 pubmed publisher
Zhang Y, Yang J, Cui X, Chen Y, Zhu V, Hagan J, et al. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med. 2013;5:1322-34 pubmed publisher
Tian X, Guo J, Zhu M, Li M, Wu G, Xia Y. ?-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat. PLoS ONE. 2013;8:e69252 pubmed publisher
Thorsell A, Tapocik J, Liu K, Zook M, Bell L, Flanigan M, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013;33:10132-42 pubmed publisher
Wang H, Li Y, Dun L, Xu Y, Jin S, Du J, et al. Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain. Phytomedicine. 2013;20:1039-45 pubmed publisher
Shi Z, Chen L, Li S, Chen S, Sun X, Sun L, et al. Chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus. Psychopharmacology (Berl). 2013;230:245-60 pubmed publisher
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol. 2013;33:2996-3010 pubmed publisher
Everett L, Le Lay J, Lukovac S, Bernstein D, Steger D, Lazar M, et al. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. BMC Genomics. 2013;14:337 pubmed publisher
Melas P, Lennartsson A, Vakifahmetoglu Norberg H, Wei Y, Aberg E, Werme M, et al. Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. Transl Psychiatry. 2013;3:e255 pubmed publisher
Dammen R, Damen R, Haugen M, Svejda B, Alaimo D, Brenna O, et al. The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease. PLoS ONE. 2013;8:e62607 pubmed publisher
Sampurno S, Bijenhof A, Cheasley D, Xu H, Robine S, Hilton D, et al. The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. Cell Death Dis. 2013;4:e605 pubmed publisher
Ueno K, Hirata H, Shahryari V, Deng G, Tanaka Y, Tabatabai Z, et al. microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer. Br J Cancer. 2013;108:1659-67 pubmed publisher
Yang L, Zou B, Xiong X, Pascual C, Xie J, Malik A, et al. Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice. J Neurosci. 2013;33:5275-84 pubmed publisher
Ishida E, Hashimoto K, Shimizu H, Okada S, Satoh T, Kato I, et al. Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line. PLoS ONE. 2012;7:e50918 pubmed publisher
Hirata H, Ueno K, Shahryari V, Tanaka Y, Tabatabai Z, Hinoda Y, et al. Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer. PLoS ONE. 2012;7:e51056 pubmed publisher
Tan X, Wang S, Yang B, Zhu L, Yin B, Chao T, et al. The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. PLoS ONE. 2012;7:e49570 pubmed publisher
Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed publisher
Klinz F, Korkmaz Y, Cho B, Raab W, Addicks K. Transcription factor CREB is phosphorylated in human molar odontoblasts and cementoblasts in vivo. Histochem Cell Biol. 2013;139:615-20 pubmed publisher
Liu L, Alonso V, Guo L, Tourkova I, Henderson S, Almarza A, et al. Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis. J Biol Chem. 2012;287:43312-21 pubmed publisher
Okun E, Barak B, Saada Madar R, Rothman S, Griffioen K, Roberts N, et al. Evidence for a developmental role for TLR4 in learning and memory. PLoS ONE. 2012;7:e47522 pubmed publisher
Kenney J, Poole R, Adoff M, Logue S, Gould T. Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus. PLoS ONE. 2012;7:e39939 pubmed publisher
Budick Harmelin N, Anavi S, Madar Z, Tirosh O. Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes. Lipids Health Dis. 2012;11:66 pubmed publisher
Kondo M, Inamura H, Matsumura K, Matsuoka M. Cadmium activates extracellular signal-regulated kinase 5 in HK-2 human renal proximal tubular cells. Biochem Biophys Res Commun. 2012;421:490-3 pubmed publisher
Huang Y, Sitwala K, Bronstein J, Sanders D, Dandekar M, Collins C, et al. Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood. 2012;119:388-98 pubmed publisher
Chung Y, Kim H, Kim I, Yim M, Chock P. Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respe. J Biol Chem. 2011;286:29681-90 pubmed publisher
Martin E, Betuing S, Pages C, Cambon K, Auregan G, Déglon N, et al. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter. Hum Mol Genet. 2011;20:2422-34 pubmed publisher
Davies J, Klein D, Carter D. Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. J Biol Chem. 2011;286:15227-39 pubmed publisher
Hong S, Oh H, Valera V, Baba M, Schmidt L, Linehan W. Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. PLoS ONE. 2010;5:e15793 pubmed publisher
Gehani S, Agrawal Singh S, Dietrich N, Christophersen N, Helin K, Hansen K. Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell. 2010;39:886-900 pubmed publisher
Almeida L, Murray P, Zielke H, Roby C, Kingsbury T, Krueger B. Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. J Neurosci. 2009;29:12702-10 pubmed publisher
Chen L, Lukas T, Hernandez M. Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors. Mol Vis. 2009;15:1664-72 pubmed
Gaddini L, Villa M, Matteucci A, Mallozzi C, Petrucci T, Di Stasi A, et al. Early effects of high glucose in retinal tissue cultures Renin-Angiotensin system-dependent and -independent signaling. Neurobiol Dis. 2009;35:278-85 pubmed publisher
Boyle K, Hadaschik D, Virtue S, Cawthorn W, Ridley S, O Rahilly S, et al. The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ. 2009;16:782-9 pubmed publisher
Ghosh R, Garcia G, Crosby K, Inoue H, Thompson I, Troyer D, et al. Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. Neoplasia. 2007;9:893-9 pubmed
Banno Y, Nemoto S, Murakami M, Kimura M, Ueno Y, Ohguchi K, et al. Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. J Neurochem. 2008;104:1372-86 pubmed
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed
Kumar A, Bhaskaran S, Ganapathy M, Crosby K, Davis M, Kochunov P, et al. Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract. Clin Cancer Res. 2007;13:2784-94 pubmed
product information
SKU :
9197L
Product-Name :
CREB (48H2) Rabbit mAb
Size :
300 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Mk, Dm
Applications :
Chromatin Immunoprecipitation
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
43
Host :
Rabbit
Target :
CREB
Primary-Protein :
CREB
Alt-Names :
CREB,CREB-1,CREB1,Cyclic AMP-responsive element-binding protein 1,MGC9284,active transcription factor CREB,cAMP responsive element binding protein 1,cAMP-response element-binding protein-1,cAMP-responsive element-binding protein 1,transactivator protein
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.